L David Sibley

Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013-16 West Africa epidemic.

Authors:

T R W Tipton Y Hall J A Bore A White L S Sibley C Sarfas Y Yuki M Martin S Longet J Mellors K Ewer S Günther M Carrington M K Kondé M W Carroll

Nat Commun 2021 02 19;12(1):1153. Epub 2021 Feb 19.

National Infection Service, Public Health England, Porton Down, Salisbury, UK.

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February 2021

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies.

Authors:

Andrew D White Laura Sibley Charlotte Sarfas Alexandra Morrison Jennie Gullick Simon Clark Fergus Gleeson Anthony McIntyre Cecilia Lindestam Arlehamn Alessandro Sette Francisco J Salguero Emma Rayner Esteban Rodriguez Eugenia Puentes Dominick Laddy Ann Williams Mike Dennis Carlos Martin Sally Sharpe

NPJ Vaccines 2021 Jan 4;6(1). Epub 2021 Jan 4.

Public Health England, National Infection Service, Porton Down, Salisbury, SP4 0JG, UK.

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January 2021

Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells.

Authors:

Kelli L VanDussen Lisa J Funkhouser-Jones Marianna E Akey Deborah A Schaefer Kevin Ackman Michael W Riggs Thaddeus S Stappenbeck L David Sibley

mBio 2020 12 15;11(6). Epub 2020 Dec 15.

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA

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December 2020

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

Authors:

Jaya Bhushan Joshua B Radke Yi-Chieh Perng Michael Mcallaster Deborah J Lenschow Herbert W Virgin L David Sibley

mBio 2020 10 6;11(5). Epub 2020 Oct 6.

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA

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October 2020

An Important Role for CD4 T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3.

Authors:

Roxane Tussiwand Michael S Behnke Nicole M Kretzer Gary E Grajales-Reyes Theresa L Murphy Robert D Schreiber Kenneth M Murphy L David Sibley

mSphere 2020 07 15;5(4). Epub 2020 Jul 15.

Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA

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July 2020

Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.

BMC Pediatr 2020 06 26;20(1):308. Epub 2020 Jun 26.

Duke Clinical Research Institute, Duke University, Durham, NC, 27710, USA.

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June 2020

Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.

Authors:

James W Janetka Allen T Hopper Ziping Yang Jennifer Barks Mary Savari Dhason Qiuling Wang L David Sibley

J Med Chem 2020 06 1;63(11):6144-6163. Epub 2020 Jun 1.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

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June 2020

Protective Efficacy of Inhaled BCG Vaccination Against Ultra-Low Dose Aerosol Challenge in Rhesus Macaques.

Authors:

Andrew D White Charlotte Sarfas Laura S Sibley Jennie Gullick Simon Clark Emma Rayner Fergus Gleeson Martí Català Isabel Nogueira Pere-Joan Cardona Cristina Vilaplana Mike J Dennis Ann Williams Sally A Sharpe

Pharmaceutics 2020 Apr 25;12(5). Epub 2020 Apr 25.

Public Health England, National Infection Service, Porton Down, Salisbury SP4 0JG, UK.

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April 2020

Defining Stage-Specific Activity of Potent New Inhibitors of Cryptosporidium parvum Growth .

Authors:

Lisa J Funkhouser-Jones Soumya Ravindran L David Sibley

mBio 2020 03 3;11(2). Epub 2020 Mar 3.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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March 2020

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in .

Authors:

Alex Rosenberg Madeline R Luth Elizabeth A Winzeler Michael Behnke L David Sibley

Proc Natl Acad Sci U S A 2019 Dec 5. Epub 2019 Dec 5.

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110;

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December 2019

High-Throughput Measurement of Microneme Secretion in Toxoplasma gondii.

Authors:

Kevin M Brown L David Sibley Sebastian Lourido

Methods Mol Biol 2020 ;2071:157-169

Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

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January 2021

Assays for Monitoring Toxoplasma gondii Infectivity in the Laboratory Mouse.

Authors:

Qiuling Wang L David Sibley

Methods Mol Biol 2020 ;2071:99-116

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

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January 2021

Kangaroo Mother Care implementation research to develop models for accelerating scale-up in India and Ethiopia: study protocol for an adequacy evaluation.

BMJ Open 2019 11 21;9(11):e025879. Epub 2019 Nov 21.

Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland

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November 2019

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells.

Cell 2019 11 7;179(5):1144-1159.e15. Epub 2019 Nov 7.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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November 2019

' : a case study of monitoring and evaluation of integrated family planning services in urban areas of Togo.

Authors:

Helen Baker Roger Rochat Kenneth Hepburn Monique Hennink Macoumba Thiam Cyrille Guede Andre Koalaga Eloi Amegan Koffi Fombo Bolatito Ogunbiyi Lynn Sibley

Gates Open Res 2019 1;3:1451. Epub 2019 May 1.

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, 30322, USA.

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May 2019

In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers.

Authors:

Georgia Wilke Yi Wang Soumya Ravindran Thaddeus Stappenbeck William H Witola L David Sibley

Methods Mol Biol 2020 ;2052:351-372

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

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November 2020

Protozoan persister-like cells and drug treatment failure.

Authors:

Michael P Barrett Dennis E Kyle L David Sibley Joshua B Radke Rick L Tarleton

Nat Rev Microbiol 2019 10 23;17(10):607-620. Epub 2019 Aug 23.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.

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October 2019

effector TgIST blocks type I interferon signaling to promote infection.

Authors:

Sumit K Matta Philipp Olias Zhou Huang Qiuling Wang Eugene Park Wayne M Yokoyama L David Sibley

Proc Natl Acad Sci U S A 2019 08 14;116(35):17480-17491. Epub 2019 Aug 14.

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130;

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August 2019

Characterising innovations in maternal and newborn health based on a common theory of change: lessons from developing and applying a characterisation framework in Nigeria, Ethiopia and India.

Authors:

Krystyna Makowiecka Tanya Marchant Wuleta Betemariam Anuraag Chaturvedi Laboni Jana Audu Liman Bereket Mathewos Fatima B Muhammad Katherine Semrau Sita Shankar Wunnava Lynn M Sibley Della Berhanu Meenakshi Gautham Nasir Umar Neil Spicer Joanna Schellenberg

BMJ Glob Health 2019 18;4(4):e001405. Epub 2019 Jul 18.

Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.

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July 2019

infection drives conversion of NK cells into ILC1-like cells.

Authors:

Eugene Park Swapneel Patel Qiuling Wang Prabhakar Andhey Konstantin Zaitsev Sophia Porter Maxwell Hershey Michael Bern Beatrice Plougastel-Douglas Patrick Collins Marco Colonna Kenneth M Murphy Eugene Oltz Maxim Artyomov L David Sibley Wayne M Yokoyama

Elife 2019 08 8;8. Epub 2019 Aug 8.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, United States.

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August 2019

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration.

Authors:

Lisa L Drewry Nathaniel G Jones Quiling Wang Michael D Onken Mark J Miller L David Sibley

Nat Microbiol 2019 11 22;4(11):1951-1963. Epub 2019 Jul 22.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

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November 2019

CRTAM Protects Against Intestinal Dysbiosis During Pathogenic Parasitic Infection by Enabling Th17 Maturation.

Authors:

Luisa Cervantes-Barragan Victor S Cortez Qiuling Wang Keely G McDonald Jiani N Chai Blanda Di Luccia Susan Gilfillan Chyi-Song Hsieh Rodney D Newberry L David Sibley Marco Colonna

Front Immunol 2019 2;10:1423. Epub 2019 Jul 2.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.

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July 2020

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability.

Authors:

Georgia Wilke Lisa J Funkhouser-Jones Yi Wang Soumya Ravindran Qiuling Wang Wandy L Beatty Megan T Baldridge Kelli L VanDussen Bang Shen Mark S Kuhlenschmidt Theresa B Kuhlenschmidt William H Witola Thaddeus S Stappenbeck L David Sibley

Cell Host Microbe 2019 07 20;26(1):123-134.e8. Epub 2019 Jun 20.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63130, USA. Electronic address:

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July 2019

The hitchhiker's guide to parasite dissemination.

Authors:

Lisa L Drewry L David Sibley

Cell Microbiol 2019 11 8;21(11):e13070. Epub 2019 Jul 8.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri.

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November 2019

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques.

Authors:

Laura Sibley Karen Gooch Alice Wareham Susan Gray Andrew Chancellor Stuart Dowall Simon Bate Anthony Marriott Mike Dennis Andrew D White Philip D Marsh Helen Fletcher Sally Sharpe

Sci Rep 2019 03 4;9(1):3340. Epub 2019 Mar 4.

National Infection Service, Public Health England, Porton Down, Wiltshire, UK.

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March 2019

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii.

Authors:

Iti Saraav Qiuling Wang Kevin M Brown L David Sibley

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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February 2019

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.

Authors:

Allen T Hopper Adam Brockman Andy Wise Julie Gould Jennifer Barks Joshua B Radke L David Sibley Yongmao Zou Stephen Thomas

J Med Chem 2019 02 24;62(3):1562-1576. Epub 2019 Jan 24.

Vyera Pharmaceuticals, LLC , 600 Third Avenue, 10th Floor , New York , New York 10016 , United States.

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February 2019

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase.

Authors:

Kevin M Brown L David Sibley

Cell Host Microbe 2018 12 15;24(6):804-816.e6. Epub 2018 Nov 15.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. Electronic address:

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December 2018

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

Science 2018 11;362(6415):694-699

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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November 2018

The Effect of Prior Work Experiences on the Preparation and Employment of Early-Career Midwives.

Authors:

Kate Woeber Lynn Sibley

J Midwifery Womens Health 2018 Nov 7;63(6):668-677. Epub 2018 Oct 7.

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November 2018

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