Publications by authors named "L David Sibley"

375 Publications

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

mBio 2020 10 6;11(5). Epub 2020 Oct 6.

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA

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October 2020

Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.

J Med Chem 2020 06 1;63(11):6144-6163. Epub 2020 Jun 1.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

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June 2020

Defining Stage-Specific Activity of Potent New Inhibitors of Cryptosporidium parvum Growth .

mBio 2020 03 3;11(2). Epub 2020 Mar 3.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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March 2020

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in .

Proc Natl Acad Sci U S A 2019 Dec 5. Epub 2019 Dec 5.

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110;

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December 2019

High-Throughput Measurement of Microneme Secretion in Toxoplasma gondii.

Methods Mol Biol 2020 ;2071:157-169

Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

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January 2021

Assays for Monitoring Toxoplasma gondii Infectivity in the Laboratory Mouse.

Methods Mol Biol 2020 ;2071:99-116

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

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January 2021

In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers.

Methods Mol Biol 2020 ;2052:351-372

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

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November 2020

Protozoan persister-like cells and drug treatment failure.

Nat Rev Microbiol 2019 10 23;17(10):607-620. Epub 2019 Aug 23.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.

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October 2019

effector TgIST blocks type I interferon signaling to promote infection.

Proc Natl Acad Sci U S A 2019 08 14;116(35):17480-17491. Epub 2019 Aug 14.

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130;

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August 2019

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration.

Nat Microbiol 2019 11 22;4(11):1951-1963. Epub 2019 Jul 22.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

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November 2019

The hitchhiker's guide to parasite dissemination.

Cell Microbiol 2019 11 8;21(11):e13070. Epub 2019 Jul 8.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri.

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November 2019

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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February 2019

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.

J Med Chem 2019 02 24;62(3):1562-1576. Epub 2019 Jan 24.

Vyera Pharmaceuticals, LLC , 600 Third Avenue, 10th Floor , New York , New York 10016 , United States.

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February 2019

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase.

Cell Host Microbe 2018 12 15;24(6):804-816.e6. Epub 2018 Nov 15.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. Electronic address:

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December 2018