Publications by authors named "László Kiss"

159 Publications

A significant event of the pre-Semmelweis era: the dissertation of Ferenc Ross on puerperal fever in 1833

Authors:
László Kiss

Orv Hetil 2021 07 4;162(27):1099-1102. Epub 2021 Jul 4.

1 SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2021.HO2683DOI Listing
July 2021

HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

Eur J Med Chem 2021 Oct 29;222:113560. Epub 2021 May 29.

Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.

HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vitro potency, but also in vivo efficacy in the mouse place recognition test. The advanced hit molecule 11 was further optimized by the elimination of the putatively mutagenic aromatic-amine building block that resulted in a novel, aminomethylindole compound family. The most balanced physico-chemical and pharmacological profile was found in case of compound 55. Docking study revealed an intersubunit binding site to be the most probable for our compounds. 55 demonstrated favorable cognitive enhancing profile not only in scopolamine-induced amnesia (place recognition test in mice) but also in natural forgetting (novel object recognition test in rats). Compound 55 was, furthermore, active in a cognitive paradigm of high translational value, namely in the rat touch screen visual discrimination test. Therefore, 55 was selected as a lead compound for further optimization. Based on the obtained favorable results, the invented aminomethylindole cluster may provide a viable approach for cognitive enhancement through positive allosteric modulation of α7 nAChRs.
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http://dx.doi.org/10.1016/j.ejmech.2021.113560DOI Listing
October 2021

A novel three-dimensional volumetric method to measure indirect decompression after percutaneous cement discoplasty.

J Orthop Translat 2021 May 1;28:131-139. Epub 2021 Apr 1.

Department of Spine Surgery, Semmelweis University, Budapest, Hungary.

Purpose: Percutaneous cement discoplasty (PCD) is a minimally invasive surgical option to treat patients who suffer from the consequences of advanced disc degeneration. As the current two-dimensional methods can inappropriately measure the difference in the complex 3D anatomy of the spinal segment, our aim was to develop and apply a volumetric method to measure the geometrical change in the surgically treated segments.

Methods: Prospective clinical and radiological data of 10 patients who underwent single- or multilevel PCD was collected. Pre- and postoperative CT scan-based 3D reconstructions were performed. The injected PMMA (Polymethylmethacrylate) induced lifting of the cranial vertebra and the following volumetric change was measured by subtraction of the geometry of the spinal canal from a pre- and postoperatively predefined cylinder. The associations of the PMMA geometry and the volumetric change of the spinal canal with clinical outcome were determined.

Results: Change in the spinal canal volume (ΔV) due to the surgery proved to be significant (mean ΔV = 2266.5 ± 1172.2 mm, n = 16; p = 0.0004). A significant, positive correlation was found between ΔV, the volume and the surface of the injected PMMA. A strong, significant association between pain intensity (low back and leg pain) and the magnitude of the volumetric increase of the spinal canal was shown (ρ = 0.772, p = 0.009 for LBP and ρ = 0.693, p = 0.026 for LP).

Conclusion: The developed method is accurate, reproducible and applicable for the analysis of any other spinal surgical method. The volume and surface area of the injected PMMA have a predictive power on the extent of the indirect spinal canal decompression. The larger the ΔV the higher clinical benefit was achieved with the PCD procedure.

The Translational Potential Of This Article: The developed method has the potential to be integrated into clinical software's to evaluate the efficacy of different surgical procedures based on indirect decompression effect such as PCD, anterior lumbar interbody fusion (ALIF), lateral lumbar interbody fusion (LLIF), oblique lumbar interbody fusion (OLIF), extreme lateral interbody fusion (XLIF). The intraoperative use of the method will allow the surgeon to respond if the decompression does not reach the desired level.
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http://dx.doi.org/10.1016/j.jot.2021.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050383PMC
May 2021

[Prix Montyon, forerunner of Nobel prize in the 19th century: the Hungarian prizewinners].

Authors:
László Kiss

Orv Hetil 2021 03;162(12):471-473

1 SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2021.HO2672DOI Listing
March 2021

János Bársony the third successor to the chair of Semmelweis

Authors:
László Kiss

Orv Hetil 2021 02 21;162(8):316-319. Epub 2021 Feb 21.

1 SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2021.HO2675DOI Listing
February 2021

Development of a Computer-Aided Design and Finite Element Analysis Combined Method for Affordable Spine Surgical Navigation With 3D-Printed Customized Template.

Front Surg 2020 25;7:583386. Epub 2021 Jan 25.

National Center for Spinal Disorders, Buda Health Center, Budapest, Hungary.

Revision surgery of a previous lumbosacral non-union is highly challenging, especially in case of complications, such as a broken screw at the first sacral level (S1). Here, we propose the implementation of a new method based on the CT scan of a clinical case using 3D reconstruction, combined with finite element analysis (FEA), computer-assisted design (CAD), and 3D-printing technology to provide accurate surgical navigation to aid the surgeon in performing the optimal surgical technique by inserting a pedicle screw at the S1 level. A step-by-step approach was developed and performed as follows: (1) Quantitative CT based patient-specific FE model of the sacrum was created. (2) The CAD model of the pedicle screw was inserted into the sacrum model in a bicortical convergent and a monocortical divergent position, by overcoming the geometrical difficulty caused by the broken screw. (3) Static FEAs (Abaqus, Dassault Systemes) were performed using 500 N tensile load applied to the screw head. (4) A template with two screw guiding structures for the sacrum was designed and manufactured using CAD design and 3D-printing technologies, and investment casting. (5) The proposed surgical technique was performed on the patient-specific physical model created with the FDM printing technology. The patient-specific model was CT scanned and a comparison with the virtual plan was performed to evaluate the template accuracy FEA results proved that the modified bicortical convergent insertion is stiffer (6,617.23 N/mm) compared to monocortical divergent placement (2,989.07 N/mm). The final template was created via investment casting from cobalt-chrome. The template design concept was shown to be accurate (grade A, Gertzbein-Robbins scale) based on the comparison of the simulated surgery using the patient-specific physical model and the 3D virtual surgical plan. Compared to the conventional surgical navigation techniques, the presented method allows the consideration of the patient-specific biomechanical parameters; is more affordable, and the intraoperative X-ray exposure can be reduced. This new patient- and condition-specific approach may be widely used in revision spine surgeries or in challenging primary cases after its further clinical validation.
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http://dx.doi.org/10.3389/fsurg.2020.583386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873739PMC
January 2021

DiThe dispute about the infectivity of cholera in Orvosi Tár – its effect on the acceptance of Semmelweis’ doctrine

Authors:
László Kiss

Orv Hetil 2020 09;161(36):1534-1536

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2020.HO2659DOI Listing
September 2020

Outcome of group physical therapy treatment for non-specific low back pain patients can be predicted with the cross-culturally adapted and validated Hungarian version STarT back screening tool.

Disabil Rehabil 2020 Jul 31:1-9. Epub 2020 Jul 31.

Department of Research and Development, National Center for Spinal Disorders, Budapest, Hungary.

Purpose: The STarT Back Tool was developed to identify the specific modifiable prognostic factors for non-specific low back pain and to classify the patients into risk groups; low, medium and high risk of chronicity. Applied therapeutic approaches often involve group physical therapy. The aim of this study was the cross-cultural adaptation and validation of the Hungarian version of the STarT Back Tool and to investigate the predictive ability for global treatment outcome.

Materials And Methods: A prospective cohort study ( = 133) was carried out involving non-specific low back pain patients. Internal consistency, construct validity, reliability and prognostic discriminative ability have been investigated. After 3 months of treatment global outcome was evaluated.

Results: A 2-factor structure was found, with moderate internal consistency (Cronbach α = 0.89 for the total and psychosocial subscale 0.62). Between the Hungarian STarT Back Tool, the Oswestry Disability Index, leg pain, low back pain, Tampa Scale for Kinesiophobia, Fear Avoidance Beliefs Questionnaire and the physical subscale of the quality of life questionnaire, significant good to excellent- correlation was found ( > 0.41). The test-retest analysis showed excellent reliability (Intraclass Correlation Coefficient = 0.93) with standard error measurement being 0.49 (minimal detectable change = 1.37). The Area Under the Curve for baseline STarT Back Tool scores was 0.7 and 0.8 for global treatment outcome and distress, respectively. The Area Under the Curve for global treatment outcome versus STarT risk groups proved to be 0.76 representing adequate discriminative ability.

Conclusion: The successful cross-cultural adaptation was followed by the validity analysis and as a result the Hungarian version of the STarT Back Tool proved to be a reliable and valid tool in the identification of risk groups of chronicity for patients with low back pain. Patients allocated to the high-risk group were more likely experiencing poor outcome at 3 months follow up, thus it can be used to predict outcome if treated with group physical therapy.Implication for rehabilitationLow back pain is a multifactorial disease where physical and psychosocial risk factors play a role in the development and prognosis of the disease.The STarT-H can be considered as a reliable, valid measurement tool in the identification of risk groups of chronicity for patients with low back pain.Clinical relevance of the STarT-H is that it can be used to stratify patients into risk groups of chronicity in different Hungarian speaking healthcare settings.According to our findings the STarT-H can also be applied to predict global treatment outcome in low back pain patients if treated with group physical therapy.
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http://dx.doi.org/10.1080/09638288.2020.1799248DOI Listing
July 2020

Az orvosi kar 1846-1847-ben - Vállas Antal (1809-1869) Nemzeti Encyclopaediája szerint.

Authors:
László Kiss

Orv Hetil 2020 01;161(3):116-118

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2020.ho2647DOI Listing
January 2020

Evaluation of Nitrogen Nutrition in Diminishing Water Deficiency at Different Growth Stages of Maize by Chlorophyll Fluorescence Parameters.

Plants (Basel) 2020 May 27;9(6). Epub 2020 May 27.

Department of Agricultural Botany, Crop Physiology and Biotechnology, Institute of Crop Sciences, University of Debrecen, H-4032 Debrecen, Hungary.

Efficient nitrogen (N) nutrition has been reported to have the potential to alleviate the drought stress damages by maintaining metabolic activities even at low tissue water potential. The goal of our research was to find a correlation on the genotype level between the effect of different amounts of nitrogen nutrition and water supply at different growth stages. A small-plot experiment was established with three maize hybrids and three levels of nitrogen, and two different amounts of water supply were applied during the vegetation period of 2018 and 2019. Chlorophyll fluorescence parameters were detected, as well as potential and actual photochemical efficiency of PSII, at three growth stages: eight-leaf stage, tasseling, silking. At physiological maturity, the yield of hybrids was also measured. While only genotype differences were described among the investigated parameters in the V8 stage, treatment effects were also realized based on the measured chlorophyll fluorescence parameters during the tasseling and silking stages. Beyond the significant effect of irrigation, a similar impact was declared in the case of 80 kg ha N treatment at the later growth stages. Pronounced correlation was described between chlorophyll fluorescence parameters and yield mainly under irrigated conditions. Our result suggested that lower N nutrition may be sufficient mainly under irrigated conditions, and in vivo chlorophyll fluorescence parameters are appropriate for detecting the effect of environmental factors in different growth stages.
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http://dx.doi.org/10.3390/plants9060676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356538PMC
May 2020

Global Treatment Outcome after Surgical Site Infection in Elective Degenerative Lumbar Spinal Operations.

Surg Infect (Larchmt) 2021 Mar 23;22(2):193-199. Epub 2020 Apr 23.

National Center for Spinal Disorders, Buda Health Center, Budapest, Hungary.

Surgical site infection (SSI) is a serious complication after routine lumbar spinal operations, and its effect on global treatment outcome (GTO) is less reported. The aim of the current study was to measure the impact of SSI on outcome, which was evaluated with patient reported outcome measures (PROMs) and patients' subjective judgment (GTO). A total of 910 patients underwent primary a single- or two-level lumbar decompression or instrumented fusion surgical procedure. Patients completed Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and Core Outcome Measurement Index (COMI) at baseline and at two-year follow-up. The rate of improvement in PROMs was measured for the total cohort and the group of patients with SSI. Patients evaluated GTO on a five-point Likert scale. This study was approved by the Scientific and Research Ethics Committee of the Medical Research Council (number: 29970-3/2015/EKU) and the Institutional Review Board. Regardless of the presence of SSI, significant improvement was measured in all PROMs without any difference in the rate of change between the clinical subgroups (non-SSI vs. SSI, dODI: p = 0.370, dCOMI: p = 0.383, dVAS: p = 0.793). In the total cohort, 87.3% of patients reported good outcome (N% = 87.3%). After an SSI, however, more patients (25.7%) reported poor outcome compared with those without the complication (chi-square test: value = 5.66; df = 1; p = 0.017; odds ratio = 2.49). Patients with successfully treated SSI can expect as good objective clinical result as patients without SSI while the subjective treatment outcome can be worse. The GTO could also be improved in complicated cases, however, with more extensive peri-operative patient education and information considering the patients' expectations, too.
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http://dx.doi.org/10.1089/sur.2019.344DOI Listing
March 2021

He was interested not only in midwifery – the pioneer of Hungarian archeology in Transylvania: András Lugosi Fodor (1780?–1858)

Authors:
László Kiss

Orv Hetil 2020 04 1;161(16):637-640. Epub 2020 Apr 1.

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2020.ho2652DOI Listing
April 2020

Geometrical accuracy evaluation of an affordable 3D printing technology for spine physical models.

J Clin Neurosci 2020 Feb 3;72:438-446. Epub 2020 Jan 3.

National Center for Spinal Disorders, Királyhágó u. 1-3, H-1126 Budapest, Hungary.

Objective: The aim of the study is to develop a workflow to establish geometrical quality criteria for 3D printed anatomical models as a guidance for selecting the most suitable 3D printing technologies available in a clinical environment.

Methods: We defined the 3D geometry of a 25-year-old male patient's L4 vertebra and the geometry was then printed using two technologies, which differ in printing resolution and affordability: Fused Deposition Modelling (FDM) and Digital Light Processing (DLP). In order to measure geometrical accuracy, the 3D scans of two physical models were compared to the virtual input model. To compare surface qualities of these printing technologies we determined surface roughness for two regions of interest. Finally, we present our experience in the clinical application of a physical model in a congenital deformity case.

Results: The analysis of the distribution of the modified Hausdorff distance values along the vertebral surface meshes (99% of values <1 mm) of the 3D printed models provides evidence for high printing accuracy in both printing techniques. Our results demonstrate that the surface qualities, measured by roughness are adequate (~99% of values <0.1 mm) for both physical models. Finally, we implemented the FDM physical model for surgical planning.

Conclusion: We present a workflow capable of determining the quality of 3D printed models and the application of a high quality and affordable 3D printed spine physical model in the pre operative planning. As a result of the visual guidance provided by the physical model, we were able to define the optimal trajectory of the screw insertion during surgery.
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http://dx.doi.org/10.1016/j.jocn.2019.12.027DOI Listing
February 2020

Attitude of spine surgeons towards the application of 3D technologies - a survey of AOSpine members.

Ideggyogy Sz 2019 Jul;72(7-8):227-235

National Center for Spinal Disorders, Budapest.

Background And Purpose: 3D technologies (3D virtual and physical model, 3D printing, computer aided engineering, finite element analysis based simulations) play an important role in personalized spine surgery. Objective - In collaboration with AOSpine a global, online survey-based study was performed in order to determine the acceptance rate and the factors which stand against the wider spread of 3D technologies.

Methods: A survey containing 21 questions was developed and divided into five pages, every page corresponding to one chapter. Our analysis is based on the responses of 282 spine surgeons from 57 countries. To interpret our results in a global context, we used the Human Development Index of the respondent's countries in comparisons.

Results: Significant difference between the AOSpine regions (p ≤ 0.05) was found, with the highest acceptance in Asia-Pacific region. There was no significant difference in acceptance score according to the field of spine surgery, or the surgical experience in years (p=0.77, and p=0.19). In the case of public practice, we found significantly higher acceptance compared to private and mixed (public and private) surgical practice (p ≤ 0.05). The acceptance of the technology varied based on the respondent's resident country's Human Development Index and was significantly different between "Medium" vs "Very high" (p = 0.0005) and "High" vs "Very high" (p=0.019) category. Significant positive correlation was found between the acceptance score and the HDI score (Spearman test, ρ = 0.37, p = 0.007). The main limitation factor was identified as the lack of information.

Conclusion: There is high interest among spine surgeons towards the incorporation of 3D technologies into the clinical practice. Education, the healthcare system, and the economic environment plays a major role in acceptance. Our results provide the basis of a strategy to promote the application of 3D technologies.
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http://dx.doi.org/10.18071/isz.72.0227DOI Listing
July 2019

Indirect foraminal decompression and improvement in the lumbar alignment after percutaneous cement discoplasty.

Eur Spine J 2019 06 20;28(6):1441-1447. Epub 2019 Apr 20.

National Center for Spinal Disorders, Buda Health Center, Királyhágó St. 1-3, Budapest, 1126, Hungary.

Purpose: Percutaneous cement discoplasty (PCD) is a minimally invasive surgical procedure, that can provide a segmental stabilizing and indirect decompression effect in case of severely degenerated discs characterized by vacuum phenomenon. The objective of this study was to evaluate the effects of PCD on spinopelvic radiological parameters and their associations with the clinical outcome.

Methods: Retrospective analysis of prospectively collected dataset of 28 patients (112 lumbar segments) who underwent single- or multilevel PCD was performed. Spinopelvic, intrasegmental and intersegmental parameters were measured on lumbar X-rays pre-, postoperatively and 6 months after the surgery. Correlations between radiological parameters and clinical outcome data were determined.

Results: Sacral slope significantly increased (p < .001), and pelvic tilt (p < .05) was decreased after the PCD procedure. Segmental and total lordosis (p < .05, p < .05) disc and foraminal height showed significantly increase (p < .001, p < .001) after procedure. Pain and disability (ODI) significantly decreased due to PCD. An association was found between postoperative increase in SS and improvement in ODI (r = 0.39, p < .05). The change in low back pain was correlated with segmental scoliosis correction (p < .001). Moderate correlation was detected between the increase in disc height and ODI (p < .05) as well as leg pain (p < .01).

Conclusion: PCD is an effective minimally invasive technique to treat axial pain and disability related to severe lumbar disc degeneration. Our study shows that an improvement in lumbar alignment and a significant indirect foraminal decompression could be achieved with the procedure. These changes can significantly contribute to the pain relief and increase in the patients' functional capacity. These slides can be retrieved under Electronic Supplementary Material.
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http://dx.doi.org/10.1007/s00586-019-05966-7DOI Listing
June 2019

[Being the first to research the history of the 250-year-old medicine faculty in Hungary - Gábor Kátai (1831-1878)].

Authors:
László Kiss

Orv Hetil 2019 04;160(16):638-640

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2019.HO2623DOI Listing
April 2019

[A glowing course of life - Gusztáv Láng (1838-1869), the Hungarian pioneer of urology, parasitology and microscoping].

Authors:
László Kiss

Orv Hetil 2019 03;160(12):475-478

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2019.HO2622DOI Listing
March 2019

Label-free drug screening assay multiplexed with an orthogonal time-resolved fluorescence labeled assay.

Anal Biochem 2019 02 16;566:126-132. Epub 2018 Nov 16.

Gedeon Richter Plc, Gyömrői út 19-21, 1103, Budapest, Hungary. Electronic address:

Cell-based assays against cell surface receptor targets are essential in vitro models of target-based drug discovery. At the lead generation phase large-scale functional screening assays monitoring individual cellular readouts detect interactions between the compounds and the predefined pathways but might lack sufficient sensitivity owing to the complexity of downstream signaling pathways. Cellular label-free assays offer advantages over labeled detection approaches as they reflect whole-cell responses without the prerequisite of detecting only a single cellular analyte and introducing additional genetic manipulations in favor of the chosen detection method. The combination of a label-free assay and labeled assays might integrate the advantageous characteristics of both approaches with regards to added pharmacological information and a bigger pool of chemical starting material. Here we report multiplexing of dynamic mass redistribution label-free technology with HTRF-based cAMP detection on an alpha2c adrenergic receptor expressing cell line. Besides describing the challenging assay development work associated with the set goal, a pilot screening campaign on ca. 1600 compounds is also presented. The combined assay demonstrated the ability to detect relevant activities in both readouts. Interpretation of the results as well as an outlook for further possible opportunities and applications are also discussed.
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http://dx.doi.org/10.1016/j.ab.2018.11.012DOI Listing
February 2019

["Short" history of the medical faculty of Erzsébet University in Pozsony (Bratislava)].

Authors:
László Kiss

Orv Hetil 2018 Oct;159(40):1645-1648

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2018.HO2610DOI Listing
October 2018

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase.

ChemMedChem 2018 10 11;13(20):2177-2188. Epub 2018 Sep 11.

Laboratory of Pharmacology, Department of Research and Development, BIAL-Portela & Cª., S.A., À Avenida da Siderurgia Nacional, 4745-457, Coronado (S. Romão and S. Mamede), Portugal.

Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic-N-carboxamide FAAH inhibitors that have a good alignment of potency, metabolic stability and selectivity for FAAH over monoacylglycerol lipase (MAGL) and carboxylesterases (CEs). Lead optimization efforts carried out with benzotriazolyl- and imidazolyl-N-carboxamide series led to the discovery of clinical candidate 8 l (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide; BIA 10-2474) as a potent and long-acting inhibitor of FAAH. However, during a Phase I clinical trial with compound 8 l, unexpected and unpredictable serious neurological adverse events occurred, affecting five healthy volunteers, including the death of one subject.
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http://dx.doi.org/10.1002/cmdc.201800393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582431PMC
October 2018

[Ignác Semmelweis and the Hungarian Medical Weekly Journal].

Authors:
László Kiss

Orv Hetil 2018 Jul;159(26):1065-1070

Szent Erzsébet Egészségügyi és Szociális Munka Főiskola Pozsony (Bratislava, Szlovákia).

Ignác Semmelweis did not publish his discovery in Vienna - i.e., that the puerperal fever may be prevented by careful washing of the hand in chlorine solution (asepsis) - for ten years. The Medical Weekly started its publications edited by Lajos Markusovszky in Pest in 1857. Semmelweis as a professor of theoretical and practical obstetrics at the University of Pest published a study about puerperal fever in the first volume, and Hungarian physicians became familiar with Semmelweis' opinion from this medical journal. Semmelweis was not only an author of the Medical Weekly, but he also edited a supplement of the Medical Weekly entitled Gynaecology and Paediatry. The Medical Weekly published regular accounts of the work of the clinic written by lecturers of Semmelweis and articles describing the most interesting cases of the clinic. Orv Hetil. 2018; 159(26): 1065-1070.
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http://dx.doi.org/10.1556/650.2018.31086DOI Listing
July 2018

[Rehabilitation of an "old fashioned" pathologist - Antal Genersich (1845-1918) died hundred years ago].

Authors:
László Kiss

Orv Hetil 2018 Jun;159(22):885-887

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2018.HO2602DOI Listing
June 2018

[Appreciation of Semmelweis in the countryside in 1861 - his honorary membership in Bars County Medical Society].

Authors:
László Kiss

Orv Hetil 2017 Aug;158(34):1357-1358

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2017.HO2578DOI Listing
August 2017

[Semmelweis of the 17th century or Jean Baptiste Denis and the first human transfusion (1667)].

Authors:
László Kiss

Orv Hetil 2017 Jun;158(22):870-873

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2017.HO2572DOI Listing
June 2017

Experimental Determination of the Thermal Diffusivity of α-Cryolite up to 810 K and Comparison with First Principles Predictions.

ACS Omega 2017 May 22;2(5):2224-2230. Epub 2017 May 22.

CRCT-Polytechnique Montréal, P.O. Box 6079, Station Downtown, Montréal, Québec H3C 3A7, Canada.

In aluminum electrolysis cells, a ledge of frozen electrolyte is formed on the sides. Controlling the side ledge thickness (a few centimeters) is essential to maintain a reasonable life span of the electrolysis cell, as the ledge acts as a protective layer against chemical attacks from the electrolyte bath used to dissolve alumina. The numerical modeling of the side ledge thickness, by using, for example, finite element analysis, requires some input data on the thermal transport properties of the side ledge. Unfortunately, there is a severe lack of experimental data, in particular, for the main constituent of the side ledge, the cryolite (NaAlF). The aim of this study is twofold. First, the thermal transport properties of cryolite, not available in the literature, were measured experimentally. Second, the experimental data were compared with previous theoretical predictions based on first principle calculations. This was carried out to evaluate the capability of first principle methods in predicting the thermal transport properties of complex insulating materials. The thermal diffusivity of a porous synthetic cryolite sample containing 0.9 wt % of alumina was measured over a wide range of temperature (473-810 K), using the monotone heating method. Because of limited computational resources, the first principle method can be used only to determine the thermal properties of single crystals. The dependence of thermal diffusivity of the NaAlF + 0.9 wt % AlO mixture on the microstructural parameters is discussed. A simple analytical function describing both thermal diffusivity and thermal conductivity of cryolite as a function of temperature is proposed.
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http://dx.doi.org/10.1021/acsomega.7b00206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641121PMC
May 2017

[Supporting Semmelweis in French in 1849 in Strasbourg - the unfairly forgotten Friedrich Wieger (1821-1890)].

Authors:
László Kiss

Orv Hetil 2017 Apr;158(16):634-638

SK-93 008 Csilizradvány 284., Szlovákia.

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http://dx.doi.org/10.1556/650.2017.HO2567DOI Listing
April 2017
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