Kyun-Hwan Kim

Kyun-Hwan Kim

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Kyun-Hwan Kim

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Publisher Correction: PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway.

Nat Commun 2019 Aug 16;10(1):3776. Epub 2019 Aug 16.

Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, 1 Hwayang-Dong, Kwangjin-Gu, Seoul, 143-701, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-019-11824-3DOI Listing
August 2019

PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway.

Nat Commun 2019 Jul 18;10(1):3185. Epub 2019 Jul 18.

Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, 1 Hwayang-Dong, Kwangjin-Gu, Seoul, 143-701, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-019-11019-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639383PMC
July 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Jun 20;70(6):1093-1102. Epub 2019 Feb 20.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Republic of Korea; KU Open Innovation Center, Konkuk University, Seoul, Republic of Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
June 2019

Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain.

Int J Mol Sci 2019 Jun 11;20(11). Epub 2019 Jun 11.

Department of Biotechnology, College of Life Sciences and Biotechnology, Yonsei University, Seoul 03722, Korea.

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http://dx.doi.org/10.3390/ijms20112847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600415PMC
June 2019

Conversion of a soluble protein into a potent chaperone in vivo.

Sci Rep 2019 Feb 25;9(1):2735. Epub 2019 Feb 25.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

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http://dx.doi.org/10.1038/s41598-019-39158-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389997PMC
February 2019

The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis.

Stem Cell Res Ther 2019 Jan 11;10(1):21. Epub 2019 Jan 11.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea.

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-018-1127-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330392PMC
January 2019

Multiple Functions of Cellular FLIP Are Essential for Replication of Hepatitis B Virus.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Republic of Korea

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http://dx.doi.org/10.1128/JVI.00339-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069189PMC
August 2018

Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.

Nat Commun 2018 08 16;9(1):3284. Epub 2018 Aug 16.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-018-05782-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095909PMC
August 2018

Generation and Characterization of a Neutralizing Human Monoclonal Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library.

J Microbiol Biotechnol 2018 Aug;28(8):1376-1383

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

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http://dx.doi.org/10.4014/jmb.1803.03056DOI Listing
August 2018

Hepatitis B virus-triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response.

Autophagy 2016 12 14;12(12):2451-2466. Epub 2016 Oct 14.

a Department of Pharmacology , Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University , Seoul , Korea.

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http://dx.doi.org/10.1080/15548627.2016.1239002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173271PMC
December 2016

Roles of hepatocyte nuclear factors in hepatitis B virus infection.

World J Gastroenterol 2016 Aug;22(31):7017-29

Doo Hyun Kim, Hong Seok Kang, Kyun-Hwan Kim, Department of Pharmacology, and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul 143-701, South Korea.

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http://dx.doi.org/10.3748/wjg.v22.i31.7017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988315PMC
August 2016

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.

PLoS One 2015 31;10(8):e0136728. Epub 2015 Aug 31.

Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136728PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556173PMC
June 2016

The efficacy of tenofovir-based therapy in patients showing suboptimal response to entecavir-adefovir combination therapy.

Clin Mol Hepatol 2016 Jun 15;22(2):241-9. Epub 2016 Jun 15.

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3350/cmh.2015.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946405PMC
June 2016

Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors.

J Hepatol 2016 Feb 25;64(2):268-277. Epub 2015 Sep 25.

Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Republic of Korea; KU Open Innovation Center, Konkuk University, Seoul, Republic of Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278150063
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http://dx.doi.org/10.1016/j.jhep.2015.09.012DOI Listing
February 2016

Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.

Liver Int 2015 11 13;35(11):2370-83. Epub 2015 May 13.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/liv.12845DOI Listing
November 2015

Phosphatidylcholine alteration identified using MALDI imaging MS in HBV-infected mouse livers and virus-mediated regeneration defects.

PLoS One 2014 7;9(8):e103955. Epub 2014 Aug 7.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125171PMC
April 2015

Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α.

Biochim Biophys Acta 2014 Sep 25;1842(9):1648-57. Epub 2014 Apr 25.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Republic of Korea; Institute of Functional Genomics, Konkuk University, Seoul, Republic of Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439140010
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http://dx.doi.org/10.1016/j.bbadis.2014.04.016DOI Listing
September 2014

Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.

Clin Mol Hepatol 2014 Sep 25;20(3):251-60. Epub 2014 Sep 25.

Deparment of Internal medicine, Yonsei University College of Medicine, Seoul, Korea. ; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. ; Liver Cirrhosis Clinical Research Center, Seoul, Korea.

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http://dx.doi.org/10.3350/cmh.2014.20.3.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197173PMC
September 2014

Host defense mechanism-based rational design of live vaccine.

PLoS One 2013 2;8(10):e75043. Epub 2013 Oct 2.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075043PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788757PMC
June 2014

The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene.

J Virol 2014 Jun 2;88(12):6805-18. Epub 2014 Apr 2.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, South Korea Institute of Functional Genomics, Konkuk University, Seoul, South Korea Research Institute of Medical Sciences, Konkuk University, Seoul, South Korea

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http://dx.doi.org/10.1128/JVI.00635-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054353PMC
June 2014

Molecular diagnosis and treatment of drug-resistant hepatitis B virus.

World J Gastroenterol 2014 May;20(19):5708-20

Jeong Han Kim, Digestive Disease Center, Department of Internal Medicine, School of Medicine, Konkuk University, Seoul 143-729, South Korea.

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http://dx.doi.org/10.3748/wjg.v20.i19.5708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024781PMC
May 2014

Protein folding in vivo revisited.

Curr Protein Pept Sci 2013 Dec;14(8):721-33

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.

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December 2013

Hepatocystin/80K-H inhibits replication of hepatitis B virus through interaction with HBx protein in hepatoma cell.

Biochim Biophys Acta 2013 Oct 2;1832(10):1569-81. Epub 2013 May 2.

Department of Pharmacology, Konkuk University School of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbadis.2013.04.026DOI Listing
October 2013

HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO.

PLoS One 2013 4;8(3):e57331. Epub 2013 Mar 4.

Department of Pharmacology, and Center for Cancer Research and Diagnostic Medicine, IBST, Konkuk University School of Medicine, Seoul, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057331PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587578PMC
September 2013

Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator.

Hepatology 2013 Aug 24;58(2):762-76. Epub 2013 Jun 24.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, Konkuk University School of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1002/hep.26379DOI Listing
August 2013

Analysis of the biochemical role of Lys-11 in polyubiquitin chain formation using quantitative mass spectrometry.

Rapid Commun Mass Spectrom 2013 Jan;27(2):339-46

Department of Molecular Biotechnology, Konkuk University, Seoul 143-701, Korea.

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http://dx.doi.org/10.1002/rcm.6447DOI Listing
January 2013

A new combination MALDI matrix for small molecule analysis: application to imaging mass spectrometry for drugs and metabolites.

Analyst 2012 Dec;137(24):5757-62

Department of Molecular Biotechnology, WCU program, Konkuk University, Seoul, 143-701, Korea.

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http://dx.doi.org/10.1039/c2an35782hDOI Listing
December 2012

Long-term impact of entecavir monotherapy in chronic hepatitis B patients with a partial virologic response to entecavir therapy.

Scand J Gastroenterol 2012 Nov 31;47(11):1362-7. Epub 2012 Aug 31.

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3109/00365521.2012.719927DOI Listing
November 2012

Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.

World J Gastroenterol 2012 Nov;18(44):6437-46; discussion p.6445

Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, South Korea.

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http://dx.doi.org/10.3748/wjg.v18.i44.6437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508638PMC
November 2012

Global changes in phospholipids identified by MALDI MS in rats with focal cerebral ischemia.

J Lipid Res 2012 Sep 29;53(9):1823-31. Epub 2012 Jun 29.

Department of Molecular Biotechnology, WCU Program, Konkuk University, Seoul 143-701, Korea.

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http://dx.doi.org/10.1194/jlr.M022558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413223PMC
September 2012

Selective enrichment and mass spectrometric identification of nitrated peptides using fluorinated carbon tags.

Anal Chem 2011 Jan 13;83(1):157-63. Epub 2010 Dec 13.

Department of Molecular Biotechnology, WCU Program, Konkuk University School of Medicine, Seoul 143-701, Korea.

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http://dx.doi.org/10.1021/ac102080dDOI Listing
January 2011

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.

Bioorg Med Chem 2010 Oct 6;18(19):7092-100. Epub 2010 Aug 6.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2010.07.072DOI Listing
October 2010

Discovery and development of anti-HBV agents and their resistance.

Molecules 2010 Aug 27;15(9):5878-908. Epub 2010 Aug 27.

Department of Pharmacology, School of Medicine, and Center for Cancer Research and Diagnostic Medicine, IBST, Konkuk University, Seoul 143-701, Korea.

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http://dx.doi.org/10.3390/molecules15095878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257723PMC
August 2010

Production and characterization of active hepatitis C virus RNA-dependent RNA polymerase.

Protein Expr Purif 2010 Jun 8;71(2):147-52. Epub 2010 Jan 8.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.pep.2010.01.004DOI Listing
June 2010

[Pro-apoptotic function of hepatitis B virus X protein].

Authors:
Kyun-Hwan Kim

Korean J Hepatol 2010 Jun;16(2):112-22

Department of Pharmacology, School of Medicine and Center for Cancer Research and Diagnostic Medicine, IBST, Konkuk University, Seoul, Korea.

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http://dx.doi.org/10.3350/kjhep.2010.16.2.112DOI Listing
June 2010

Pharmacophore-based virtual screening: a review of recent applications.

Expert Opin Drug Discov 2010 Mar 27;5(3):205-22. Epub 2010 Jan 27.

Konkuk University, IBST, Center for Cancer Research and Diagnostic Medicine, School of Medicine, Department of Pharmacology, Seoul, 143-701, Korea.

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http://dx.doi.org/10.1517/17460441003592072DOI Listing
March 2010

Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study.

Antivir Ther 2009 ;14(4):585-90

Department of Internal Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, South Korea.

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August 2009

Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation.

Bioorg Med Chem 2009 Apr 18;17(8):2975-82. Epub 2009 Mar 18.

Department of Biotechnology, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2009.03.024DOI Listing
April 2009

Assessment of substrate-stabilizing factors for DnaK on the folding of aggregation-prone proteins.

Biochem Biophys Res Commun 2008 Aug 12;373(1):74-9. Epub 2008 Jun 12.

Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0801109
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http://dx.doi.org/10.1016/j.bbrc.2008.05.186DOI Listing
August 2008

Comparative analysis of cell surface proteins in chronic and acute leukemia cell lines.

Biochem Biophys Res Commun 2007 Jun 9;357(3):620-6. Epub 2007 Apr 9.

Department of Molecular Biotechnology, Institute of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.191DOI Listing
June 2007

Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.

J Med Chem 2006 Sep;49(19):5664-70

Department of Biotechnology, College of Engineering, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1021/jm050761iDOI Listing
September 2006

Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion.

Virology 2005 Feb;332(1):216-24

The Liver Research Center, Rhode Island Hospital and Brown Medical School, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA.

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http://dx.doi.org/10.1016/j.virol.2004.11.029DOI Listing
February 2005

Hepatitis B Virus e Antigen Variants.

Int J Med Sci 2005 5;2(1):2-7. Epub 2005 Jan 5.

1. Liver Research Center, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142218PMC
http://dx.doi.org/10.7150/ijms.2.2DOI Listing
January 2005

Hepatitis B virus infection after renal transplantation in the presence of antibody to hepatitis B surface antigen immunity.

J Gastroenterol Hepatol 2004 Aug;19(8):847-53

Yonsei Medical Research Center and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

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http://doi.wiley.com/10.1111/j.1440-1746.2003.03303.x
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http://dx.doi.org/10.1111/j.1440-1746.2003.03303.xDOI Listing
August 2004

Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.

J Med Virol 2003 Nov;71(3):367-75

Institute of Gastroenterology, College of Medicine, Department of Internal Medicine, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea.

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http://dx.doi.org/10.1002/jmv.10503DOI Listing
November 2003

Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal.

EMBO J 2003 May;22(9):2104-16

Department of Biotechnology, College of Engineering and Bioproducts Research Center, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1093/emboj/cdg210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156082PMC
May 2003

Immunogenetics of hepatitis B virus infection.

J Gastroenterol Hepatol 2002 Dec;17 Suppl 3:S329-32

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

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December 2002