Publications by authors named "Kyle B Brothers"

60Publications

Fostering Responsible Research on Ancient DNA.

Am J Hum Genet 2020 Aug;107(2):183-195

Professional Practice and Social Implications Committee (formerly the Social Issues Committee), American Society of Human Genetics, Bethesda, MD 20814, USA; Responsible Ancient DNA Research Working Group, American Society of Human Genetics, Bethesda, MD 20814, USA; Institute for Society and Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.ajhg.2020.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413888PMC
August 2020

Online Pediatric Research: Addressing Consent, Assent, and Parental Permission.

J Law Med Ethics 2020 03;48(1_suppl):129-137

Kyle B. Brothers, M.D., Ph.D., is an Associate Professor in the Department of Pediatrics at the University of Louisville, where he is also affiliated with the Institute for Bioethics, Health Policy, and Law. Ellen Wright Clayton, M.D., J.D., is the Craig-Weaver Professor of Pediatrics, Professor of Health Policy, and Member of the Center for Biomedical Ethics and Society at Vanderbilt University Medical Center, and Professor of Law at the Vanderbilt University School of Law. Aaron J. Goldenberg, Ph.D., is an Associate Professor and Vice Chair for the Department of Bioethics at Case Western Reserve University (CWRU). He is also Co-Director of the Center for Genetic Research Ethics and Law at CWRU.

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http://dx.doi.org/10.1177/1073110520917038DOI Listing
March 2020

Unregulated Health Research Using Mobile Devices: Ethical Considerations and Policy Recommendations.

J Law Med Ethics 2020 03;48(1_suppl):196-226

Mark A. Rothstein, J.D., is Herbert F. Boehl Chair of Law and Medicine and Director of the Institute for Bioethics, Health Policy and Law at the University of Louisville School of Medicine. John T. Wilbanks is Chief Commons Officer of Sage Bionetworks. Laura M. Beskow, M.P.H., Ph.D., is Professor and Ann Geddes Stahlman Chair in Medical Ethics at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center Kathleen M. Brelsford, Ph.D., M.P.H., is Research Assistant Professor at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. Kyle B. Brothers, M.D., Ph.D., is Endowed Chair of Pediatric Clinical and Translational Research, University of Louisville School of Medicine. Megan Doerr, M.S., L.G.C., is Principal Scientist, Governance at Sage Bionetworks. Barbara J. Evans, J.D., Ph.D., is Mary Ann and Lawrence E. Faust Professor of Law, Professor of Electrical and Computer Engineering, and Director of the Center for Biotechnology and Law, University of Houston. Catherine M. Hammack-Aviran, M.A., J.D., is Associate in Health Policy at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. Michelle L. McGowan, Ph.D., is Associate Professor, Department of Pediatrics and Department of Women's, Gender, and Sexuality Studies, Cincinnati Children's Hospital Medical Center. Stacey A. Tovino, J.D., Ph.D., is Judge Jack and Lulu Lehman Professor of Law at the William S. Boyd School of Law, University of Nevada-Las Vegas.

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http://dx.doi.org/10.1177/1073110520917047DOI Listing
March 2020

A Process-Based Approach to Responding to Parents or Guardians Who Hope for a Miracle.

Pediatrics 2020 03 19;145(3). Epub 2020 Feb 19.

University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1542/peds.2019-2319DOI Listing
March 2020

Legal and Ethical Challenges of International Direct-to-Participant Genomic Research: Conclusions and Recommendations.

J Law Med Ethics 2019 12;47(4):705-731

Mark A. Rothstein, J.D., is Herbert F. Boehl Chair of Law and Medicine and Director of the Institute for Bioethics, Health Policy and Law, University of Louisville School of Medicine. Ma'n H. Zawati, Ph.D. (D.C.L.), is Executive Director of the Centre of Genomics and Policy and Assistant Professor, Department of Human Genetics, McGill University Faculty of Medicine. Laura M. Beskow, M.P.H., Ph.D., is Professor and Ann Geddes Stahlman Chair in Medical Ethics at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. Kathleen M. Brelsford, Ph.D., M.P.H., is Research Assistant Professor at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. Kyle B. Brothers, M.D., Ph.D., is Endowed Chair of Pediatric Clinical and Translational Research, University of Louisville School of Medicine. Catherine M. Hammack-Aviran, J.D., M.A., is Associate in Health Policy at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. James W. Hazel, J.D., Ph.D., is a Post-Doctoral Fellow at the Center for Biomedical Ethics and Society, Vanderbilt University Medical Center. Yann Joly, Ph.D. (D.C.L.), is Research Director of the Centre of Genomics and Policy and Associate Professor, Department of Human Genetics, McGill University Faculty of Medicine. Michael Lang, B.C.L., LL.B., is a Research Assistant at the Centre of Genomics and Policy, Department of Human Genetics, McGill University Faculty of Medicine. Dimitri Patrinos, B.Sc., LL.B., J.D., is a Research Assistant at the Centre of Genomics and Policy, Department of Human Genetics, McGill University Faculty of Medicine. Andrea Saltzman, B.S.N., M.A., is Director, Office of Research Subject Protection, Broad Institute of Massachusetts Institute of Technology and Harvard University. Bartha Maria Knoppers, Ph.D. (Comparative Medical Law), is Canada Research Chair in Law and Medicine, Professor and Director of the Centre of Genomics and Policy, Department of Human Genetics, McGill University Faculty of Medicine.

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http://dx.doi.org/10.1177/1073110519898297DOI Listing
December 2019

Participant Engagement in Translational Genomics Research: Respect for Persons-and Then Some.

Ethics Hum Res 2019 Sep;41(5):2-15

Endowed chair of pediatric clinical and translational research at the University of Louisville School of Medicine and a faculty affiliate at the Institute for Bioethics, Health Policy, and Law at the University of Louisville.

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http://dx.doi.org/10.1002/eahr.500029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199158PMC
September 2019

Bespoke Babies: Genome Editing in Cystic Fibrosis Embryos.

Ann Thorac Surg 2019 10 29;108(4):995-999. Epub 2019 May 29.

Department of Surgery, Medical University of South Carolina, Charleston, South Carolina; Institute of Human Values in Health Care, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2019.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931252PMC
October 2019

A Belmont Reboot: Building a Normative Foundation for Human Research in the 21st Century.

J Law Med Ethics 2019 03;47(1):165-172

Kyle B. Brothers, M.D., Ph.D., is an Associate Professor in the Department of Pediatrics at the University of Louisville, where he is also affiliated with the Institute for Bioethics, Health Policy, and Law. Suzanne M. Rivera, Ph.D., is Vice President for Research and Technology Management at Case Western Reserve University School of Medicine and an Associate Professor in the Department of Bioethics. R. Jean Cadigan, Ph.D., is an Associate Professor in the Department of Social Medicine at the University of North Carolina-Chapel Hill, as well as a core faculty member in UNC's Center for Bioethics. Richard R. Sharp, Ph.D., directs the Biomedical Ethics Program, the Center for Individualized Medicine Bioethics Program and the Clinical and Translational Research Ethics Program at the Mayo Clinic in Rochester, MN. Aaron J. Goldenberg, Ph.D., is an Associate Professor in the Department of Bioethics at Case Western Reserve University (CWRU). He is also Co-Director of the Center for Genetic Research Ethics and Law at CWRU.

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http://dx.doi.org/10.1177/1073110519840497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587582PMC
March 2019

The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.

Am J Hum Genet 2019 04;104(4):578-595

Social Issues Committee, American Society of Human Genetics, Rockville, MD 20852, USA; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ajhg.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451731PMC
April 2019

Reconciling Opportunistic and Population Screening in Clinical Genomics.

Mayo Clin Proc 2019 01;94(1):103-109

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA.

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http://dx.doi.org/10.1016/j.mayocp.2018.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339566PMC
January 2019

How Should Primary Care Physicians Respond to Direct-to-Consumer Genetic Test Results?

AMA J Ethics 2018 09 1;20(9):E812-818. Epub 2018 Sep 1.

A pediatric hematologist-oncologist at the University of Louisville School of Medicine in Louisville, Kentucky.

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http://dx.doi.org/10.1001/amajethics.2018.812DOI Listing
September 2018

Research Consent at the Age of Majority: Preferable but not Obligatory.

Pediatrics 2018 08 6;142(2). Epub 2018 Jul 6.

Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, Washington; and.

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http://dx.doi.org/10.1542/peds.2017-3038DOI Listing
August 2018

Physicians' perspectives on receiving unsolicited genomic results.

Genet Med 2019 02 5;21(2):311-318. Epub 2018 Jul 5.

Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/s41436-018-0047-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294706PMC
February 2019

Tensions in ethics and policy created by National Precision Medicine Programs.

Hum Genomics 2018 04 17;12(1):22. Epub 2018 Apr 17.

Centre for Health, Law and Emerging Technologies (HeLEX), Nuffield Department of Population Health, University of Oxford, Ewert House, Ewert Place, Banbury Road, Oxford, OX2 7DD, UK.

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http://dx.doi.org/10.1186/s40246-018-0151-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904987PMC
April 2018

Ethics and Brain Death in Pediatrics: Recent Controversy and Practical Suggestions.

J Pediatr Intensive Care 2017 Dec 27;6(4):240-244. Epub 2017 Jun 27.

Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, United States.

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http://dx.doi.org/10.1055/s-0037-1604012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260314PMC
December 2017

Providers' Behaviors and Beliefs on Prescribing Antipsychotic Medication to Children: A Qualitative Study.

Community Ment Health J 2018 01 31;54(1):17-26. Epub 2017 Mar 31.

Child and Adolescent Research Design and Support (CAHRDS) Unit, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s10597-017-0125-8DOI Listing
January 2018

Ethical and legal considerations for pediatric biobank consent: current and future perspectives.

Per Med 2016 Nov 13;13(6):597-607. Epub 2016 Oct 13.

Department of Bioethics, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.2217/pme-2016-0028DOI Listing
November 2016

Factors Associated with Attendance after Referral to a Pediatric Weight Management Program.

J Pediatr 2016 05 2;172:35-9. Epub 2016 Mar 2.

Children's Mercy Hospitals and Clinics, Kansas City, MO; Department of Pediatrics, University of Missouri Kansas City School of Medicine, Kansas City, MO.

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http://dx.doi.org/10.1016/j.jpeds.2016.02.011DOI Listing
May 2016

Citizen Science on Your Smartphone: An ELSI Research Agenda.

J Law Med Ethics 2015 ;43(4):897-903

Assistant Professor of Pediatrics at the University of Louisville School of Medicine.

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http://dx.doi.org/10.1111/jlme.12327DOI Listing
February 2017

Professionally Responsible Disclosure of Genomic Sequencing Results in Pediatric Practice.

Pediatrics 2015 Oct 14;136(4):e974-82. Epub 2015 Sep 14.

Department of Pediatrics, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1542/peds.2015-0624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586726PMC
October 2015

State-offered ethnically targeted reproductive genetic testing.

Genet Med 2016 Feb 4;18(2):126-7. Epub 2015 Jun 4.

Institute for Bioethics, Health Policy, and Law, University of Louisville, Louisville, Kentucky, USA.

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http://dx.doi.org/10.1038/gim.2015.74DOI Listing
February 2016

Ethical, legal and social implications of incorporating personalized medicine into healthcare.

Per Med 2015;12(1):43-51

Institute for Bioethics, Health Policy & Law, University of Louisville School of Medicine, Louisville, KY, USA ; Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.

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http://dx.doi.org/10.2217/pme.14.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296905PMC
January 2015

Erratum to: How can psychological science inform research about genetic counseling for clinical genomic sequencing?

J Genet Couns 2015 Apr;24(2):372

Department of Health Behavior, University of North Carolina-Chapel Hill, 312 Rosenau Hall, CB#7440, Chapel Hill, NC, 27599-7440, USA,

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http://dx.doi.org/10.1007/s10897-014-9814-4DOI Listing
April 2015

How can psychological science inform research about genetic counseling for clinical genomic sequencing?

J Genet Couns 2015 Apr 9;24(2):193-204. Epub 2014 Dec 9.

Department of Health Behavior, University of North Carolina-Chapel Hill, 312 Rosenau Hall, CB#7440, Chapel Hill, NC, 27599-7440, USA,

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http://link.springer.com/10.1007/s10897-014-9804-6
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http://dx.doi.org/10.1007/s10897-014-9804-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777349PMC
April 2015

Patient awareness and approval for an opt-out genomic biorepository.

Per Med 2013 Jun;10(4)

Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA ; Department of Pediatrics, Vanderbilt University & the Monroe Carell Jr.Children's Hospital at Vanderbilt, Nashville, TN, USA.

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http://dx.doi.org/10.2217/pme.13.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882901PMC
June 2013

Ethical issues in pediatric pharmacogenomics.

Authors:
Kyle B Brothers

J Pediatr Pharmacol Ther 2013 Jul;18(3):192-8

Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky; Institute for Bioethics, Health Policy, and Law, University of Louisville School of Medicine, Louisville, Kentucky.

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http://dx.doi.org/10.5863/1551-6776-18.3.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775553PMC
July 2013

Ethical, legal, and social implications of incorporating genomic information into electronic health records.

Genet Med 2013 Oct 12;15(10):810-6. Epub 2013 Sep 12.

Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1038/gim.2013.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926430PMC
October 2013

Implications of the incidentalome for clinical pharmacogenomics.

Pharmacogenomics 2013 Aug;14(11):1353-62

Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, University of Louisville School of Medicine, 231 East Chestnut Street, N-97, Louisville, KY 40202, USA.

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http://dx.doi.org/10.2217/pgs.13.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881234PMC
August 2013

Informed consent in the era of biobanks.

Authors:
Kyle B Brothers

Genome Med 2013 25;5(1). Epub 2013 Jan 25.

Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1186/gm408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706834PMC
May 2014

Parental Perspectives on a Pediatric Human Non-Subjects Biobank.

AJOB Prim Res 2012 Jan 19;3(3):21-29. Epub 2012 Jun 19.

Vanderbilt University.

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http://dx.doi.org/10.1080/21507716.2012.662576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501745PMC
January 2012

Two large-scale surveys on community attitudes toward an opt-out biobank.

Am J Med Genet A 2011 Dec 7;155A(12):2982-90. Epub 2011 Nov 7.

Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.

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http://dx.doi.org/10.1002/ajmg.a.34304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222722PMC
December 2011

Dependent rational providers.

Authors:
Kyle B Brothers

J Med Philos 2011 Apr 21;36(2):133-47. Epub 2011 Feb 21.

Department of Pediatrics, Vanderbilt University, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1093/jmp/jhr002DOI Listing
April 2011

Reviving the conversation around CPR/DNR.

Am J Bioeth 2010 Jan;10(1):61-7

Vanderbilt University Medical Center, Center for Biomedical Ethics and Society, 2525 West End Ave, Suite 400, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1080/15265160903469328DOI Listing
January 2010

Finite knowledge/finite power: "death panels" and the limits of medicine.

Am J Bioeth 2010 Jan;10(1):W7-9

Vanderbilt University Medical Center, Center for Biomedical Ethics and Society, 2525 West End Ave, Suite 400, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1080/15265160903493070DOI Listing
January 2010

Biobanks: too long to wait for consent.

Science 2009 Nov;326(5954):798; author reply 799

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http://dx.doi.org/10.1126/science.326_798aDOI Listing
November 2009

Coping with religious coping.

Authors:
Kyle B Brothers

Virtual Mentor 2009 Oct 1;11(10):767-71. Epub 2009 Oct 1.

Department of Pediatrics at Vanderbilt Children's Hospital and the Vanderbilt Center for Biomedical Ethics and Society in Nashville.

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http://dx.doi.org/10.1001/virtualmentor.2009.11.10.jdsc1-0910DOI Listing
October 2009

PEDS: developmental milestones--an accurate brief tool for surveillance and screening.

Clin Pediatr (Phila) 2008 Apr 5;47(3):271-9. Epub 2007 Dec 5.

Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1177/0009922807309419DOI Listing
April 2008