Kyle A Totaro

Kyle A Totaro

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Kyle A Totaro

Kyle A Totaro

Publications by authors named "Kyle A Totaro"

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Amide-forming chemical ligation via -acyl hydroxamic acids.

Proc Natl Acad Sci U S A 2018 04 26;115(15):3752-3757. Epub 2018 Mar 26.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1718356115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899448PMC
April 2018

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

ACS Infect Dis 2017 02 5;3(2):176-181. Epub 2016 Dec 5.

Department of Chemistry, Brown University , 324 Brook Street, Box H, Providence, Rhode Island 02912, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410965PMC
February 2017

Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates.

Bioconjug Chem 2016 Apr 24;27(4):994-1004. Epub 2016 Mar 24.

Department of Chemistry, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00043DOI Listing
April 2016

Macrocyclization of Unprotected Peptide Isocyanates.

Org Lett 2016 Mar 7;18(6):1226-9. Epub 2016 Mar 7.

Department of Chemistry, Massachusetts Institute of Technology , 18-563, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.orglett.5b03626DOI Listing
March 2016

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Bioorg Med Chem 2015 Sep 26;23(18):6218-22. Epub 2015 Jul 26.

Department of Chemistry, Brown University, 324 Brook Street, Providence, RI 02912, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562813PMC
September 2015

Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction.

Org Lett 2014 Jul 17;16(13):3488-91. Epub 2014 Jun 17.

Department of Chemistry, Brown University , 324 Brook Street, Providence, Rhode Island 02912, United States.

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http://dx.doi.org/10.1021/ol501425bDOI Listing
July 2014

Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites.

Chembiochem 2012 May 13;13(7):987-91. Epub 2012 Apr 13.

Chemistry Department, Brown University, 324 Brook Street, Providence, RI 02914, USA.

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http://dx.doi.org/10.1002/cbic.201200035DOI Listing
May 2012