Kwok-Kin Wong

Kwok-Kin Wong

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Kwok-Kin Wong

Kwok-Kin Wong

Publications by authors named "Kwok-Kin Wong"

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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.

Cell Rep 2019 Jul;28(2):512-525.e6

State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; CAS Center for Excellence in Molecular Cell Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.026DOI Listing
July 2019

EZH2 Inhibitors: Take It EZy, It Is All About Context.

Cancer Discov 2019 Apr;9(4):472-475

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0090DOI Listing
April 2019

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.

Cell Rep 2019 Apr;27(3):806-819.e5

Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193039
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http://dx.doi.org/10.1016/j.celrep.2019.03.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719696PMC
April 2019

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1.

J Clin Invest 2019 Mar 28;129(3):972-987. Epub 2019 Jan 28.

State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.

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https://www.jci.org/articles/view/122779
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http://dx.doi.org/10.1172/JCI122779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391098PMC
March 2019

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Nat Commun 2019 03 21;10(1):1296. Epub 2019 Mar 21.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1038/s41467-019-09179-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428878PMC
March 2019

Intron retention is a source of neoepitopes in cancer.

Nat Biotechnol 2018 12 16;36(11):1056-1058. Epub 2018 Aug 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.4239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226333PMC
December 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Cancer Cell 2018 12;34(6):954-969.e4

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.11.007DOI Listing
December 2018

False-Positive Plasma Genotyping Due to Clonal Hematopoiesis.

Clin Cancer Res 2018 09 22;24(18):4437-4443. Epub 2018 Mar 22.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0143DOI Listing
September 2018

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.

J Invest Dermatol 2018 07 8;138(7):1582-1590. Epub 2018 Feb 8.

Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019629PMC
July 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer Cell 2018 07 28;34(1):69-84.e14. Epub 2018 Jun 28.

Stem Cell Biology, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.001DOI Listing
July 2018

Targeting Aberrations in Non-Small Cell Lung Cancer with Osimertinib.

Clin Cancer Res 2018 06 3;24(11):2594-2604. Epub 2018 Jan 3.

Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-1875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434713PMC
June 2018

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Cell 2018 04 22;173(2):499-514.e23. Epub 2018 Mar 22.

Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643283PMC
April 2018

In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.

Proc Natl Acad Sci U S A 2018 04 9;115(17):E3978-E3986. Epub 2018 Apr 9.

State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China;

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http://dx.doi.org/10.1073/pnas.1716589115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924887PMC
April 2018

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

JCI Insight 2018 04 19;3(8). Epub 2018 Apr 19.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.98674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931128PMC
April 2018

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms.

Cancer Discov 2018 03 9;8(3):276-287. Epub 2018 Jan 9.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835190PMC
March 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.

Cell Chem Biol 2018 02 21;25(2):135-142.e5. Epub 2017 Dec 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389506PMC
February 2018

Synergy of WEE1 and mTOR Inhibition in Mutant -Driven Lung Cancers.

Clin Cancer Res 2017 Nov 18;23(22):6993-7005. Epub 2017 Aug 18.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690829PMC
November 2017

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer.

Theranostics 2017 1;7(1):67-80. Epub 2017 Jan 1.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

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http://dx.doi.org/10.7150/thno.16752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196886PMC
October 2017

Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.

Sci Rep 2017 09 4;7(1):10407. Epub 2017 Sep 4.

State Key laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41598-017-10891-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583260PMC
September 2017

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

Cell Chem Biol 2017 Aug 3;24(8):1005-1016.e3. Epub 2017 Aug 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.017DOI Listing
August 2017

MUC1-C activates EZH2 expression and function in human cancer cells.

Sci Rep 2017 08 7;7(1):7481. Epub 2017 Aug 7.

Dana-Farber Cancer Institute Harvard Medical School Boston, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41598-017-07850-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547076PMC
August 2017

Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib.

Eur J Radiol 2017 Mar 26;88:15-20. Epub 2016 Dec 26.

Department of Medical Oncology and Department of Medicine Dana-Farber Cancer Institute and Brigham and Women's Hospital 450 Brookline Ave., Boston MA, 02215, USA.

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http://dx.doi.org/10.1016/j.ejrad.2016.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560072PMC
March 2017

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.

Immunity 2017 02;46(2):197-204

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408320PMC
February 2017

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

Oncotarget 2016 May;7(22):31681-8

Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.18632/oncotarget.9426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077968PMC
May 2016

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.

Cancer Cell 2016 Mar;29(3):255-269

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794996PMC
March 2016

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Mol Cell 2015 Nov 17;60(4):571-83. Epub 2015 Oct 17.

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656111PMC
November 2015