Publications by authors named "Kutsal Devrim Secinti"

3 Publications

  • Page 1 of 1

Pregabalin Does Not Cause Midline Closure Defects But It Is Not As Innocent As Thought.

Turk Neurosurg 2020 Dec 10. Epub 2020 Dec 10.

Kahramanmaras Sutcu Imam University School of Medicine, Department of Neurosurgery, Kahramanmaraş, Turkey.

Aim: Pregabalin binds specifically to α2-δ subunits of voltage gated Ca++ channels. Tissues which are rich in these subunits are the target for possible effects and side effects of Pregabalin. The effect of Pregabalin used during pregnancy was investigated on chicken embryo model against causing neural tube closure defect and other potential effects on other organ systems which are rich in α2-δ subunits.

Material And Methods: Fertilized chicken eggs were divided in to groups and different doses of pregabalin was administered. All embryos were harvested in the 8th day of incubation and investigated both macroscopically and microscopically against any developmental malformations caused by Pregabalin.

Results: Macroscopically not any malformations were detected but macrosomia was statistically significant in medium and high dose groups. Microscopically, vertebral lamina ossification was delayed in some embryos in high dose group but not interpreted as midline closure defect and also not statistically significant. Decrease in the number of renal glomerulus and increase in the tubular damage was statistically significant in medium and high dose groups. Cardiomegaly was also found in some embryos in middle and high dose groups but not statistically significant.

Conclusion: The use of Pregabalin does not cause neural tube closure defect in the embryo unless not exceed recommended maximum dose. Causing macrosomia instead of developmental retardation by Pregabalin is in conflict with the literature. This study revealed that Pregabalin causes fetal nephrotoxicity and macrosomia. These findings indicate that the use of Pregabalin in pregnancy still needs to be accounted as suspicious.
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December 2020

Nanoparticle silver ion coatings inhibit biofilm formation on titanium implants.

J Clin Neurosci 2011 Mar 20;18(3):391-5. Epub 2011 Jan 20.

Department of Neurosurgery, School of Medicine, University of Ankara, Samanpazari, Sihhiye, Ankara 06100, Turkey.

The formation of bacterial biofilm on the surface of implanted metal objects is a major clinical problem. The antibacterial and antifungal effect of silver ions has been long known, and seems to give silver the capability to inhibit biofilm formation. To test the effect of silver ions, 20 New Zealand rabbits had bacteria applied to a screw insertion site at the iliac crest, and were then randomly divided into two groups: Group I, which had silver-coated screws applied, and Group II, which had uncoated titanium screws. After the rabbits were sacrificed on day 28, we examined the screws, the bone adjacent to the screws, and the liver, kidneys, brain and corneas of both groups under transmission (TEM) and scanning electron microscopy (SEM). We also analysed microbiological samples from the screw holes. All silver-coated screws, but only 10% of uncoated titanium screws, were sterile. All tissue samples appeared ultrastructurally normal in both groups. Biofilm formation was inhibited on all silver-coated screws, but all uncoated screws developed a biofilm on their surfaces. Our findings suggest that nanoparticle silver ion-coated implants are as safe as uncoated titanium screws and that they can help prevent both biofilm formation and infection.
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March 2011

Antibacterial effects of electrically activated vertebral implants.

J Clin Neurosci 2008 Apr 20;15(4):434-9. Epub 2008 Feb 20.

Department of Neurosurgery, Ankara University School of Medicine, Ankara, Turkey.

Bio-implants in the human body act as passive surfaces that are prone to bacterial adhesion potentially leading to deep body infections. Pedicle screws made of uncoated or silver-coated titanium alloy were used both in vitro and in vivo to determine whether silver-coated materials have antimicrobial properties when they are anodized. Twenty-four New Zealand Albino rabbits were divided into four groups with six in each. In Group 1, the rabbits were exposed to 8 muA direct current (DC) via silver-coated screws. In Group 2, the rabbits were not exposed to any electrical current, but silver-coated screws were used. In Group 3, the rabbits were exposed to 8 muA DC using uncoated screws. In Group 4, the rabbits were not exposed to any electrical current, but uncoated screws were used. Staphylococcus aureus (106 cfu) was inoculated into the rabbits before any electrical current was applied. All the animals were killed, and the areas surrounding the screws were histologically and microbiologically examined. Silver-coated titanium screws prevented implant-associated deep bone infections when they were polarized anodically. The antibacterial effects of the same screws with the same bacterium were confirmed in in vitro experiments on agar plates. When the screws were anodized with the same electrical parameters in vitro, a marked inhibition zone was detected around the silver-coated screws but not around the uncoated screws. Our findings suggest that silver-coated titanium implants can be used to prevent implant-associated deep bone infections when they are polarized anodically.
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April 2008