Kurt Ballmer-Hofer

Kurt Ballmer-Hofer

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Kurt Ballmer-Hofer

Kurt Ballmer-Hofer

Publications by authors named "Kurt Ballmer-Hofer"

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48Publications

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Vascular Endothelial Growth Factor, from Basic Research to Clinical Applications.

Int J Mol Sci 2018 Nov 26;19(12). Epub 2018 Nov 26.

Biomolecular Research, Paul Scherrer Institute, 5232 Villigen, Switzerland.

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http://dx.doi.org/10.3390/ijms19123750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320928PMC
November 2018

Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling.

Angiogenesis 2018 08 3;21(3):533-543. Epub 2018 Mar 3.

Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232, Villigen, Switzerland.

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http://dx.doi.org/10.1007/s10456-018-9606-9DOI Listing
August 2018

ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling.

Int J Mol Sci 2018 May 1;19(5). Epub 2018 May 1.

Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232 Villigen, Switzerland.

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http://dx.doi.org/10.3390/ijms19051334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983656PMC
May 2018

Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A.

Structure 2017 02 19;25(2):341-352. Epub 2017 Jan 19.

Paul Scherrer Institute, Laboratory of Biomolecular Research, 5232 Villigen, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.12.012DOI Listing
February 2017

Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist.

Oncotarget 2016 Jun;7(23):35353-68

Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, 25123, Italy.

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http://dx.doi.org/10.18632/oncotarget.9286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085234PMC
June 2016

VEGFR-2 conformational switch in response to ligand binding.

Elife 2016 Apr 7;5:e13876. Epub 2016 Apr 7.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.13876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829425PMC
April 2016

Subcellular object quantification with Squassh3C and SquasshAnalyst.

Biotechniques 2015 Nov 1;59(5):309-12. Epub 2015 Nov 1.

Paul Scherrer Institute, Biomolecular Research, Molecular Cell Biology, Villigen, Switzerland.

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http://dx.doi.org/10.2144/000114352DOI Listing
November 2015

Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration.

Clin Sci (Lond) 2015 Oct;129(8):741-56

School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, U.K. Arthritis Research UK Pain Centre and School of Life Sciences, The Medical School QMC, University of Nottingham, Nottingham NG7 2UH, U.K.

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http://dx.doi.org/10.1042/CS20150124DOI Listing
October 2015

Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation.

FASEB J 2014 Nov 11;28(11):4914-23. Epub 2014 Aug 11.

Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, Villigen, Switzerland

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http://dx.doi.org/10.1096/fj.14-256206DOI Listing
November 2014

High-level secretion of recombinant full-length streptavidin in Pichia pastoris and its application to enantioselective catalysis.

Protein Expr Purif 2014 Jan 31;93:54-62. Epub 2013 Oct 31.

Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.pep.2013.10.015DOI Listing
January 2014

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12960-5. Epub 2013 Jul 22.

Translational Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1301415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740881PMC
August 2013

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.

Blood 2012 Feb 29;119(7):1781-8. Epub 2011 Dec 29.

Biomolecular Research, Molecular Cell Biology Paul Scherrer Institut, Villigen, Switzerland.

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http://dx.doi.org/10.1182/blood-2011-11-390922DOI Listing
February 2012

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering.

FASEB J 2011 Sep 25;25(9):2980-6. Epub 2011 May 25.

Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.

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http://dx.doi.org/10.1096/fj.11-185397DOI Listing
September 2011

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.

Blood 2011 Jul 17;118(3):816-26. Epub 2011 May 17.

Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, Villigen, Switzerland.

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http://dx.doi.org/10.1182/blood-2011-01-328773DOI Listing
July 2011

The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling.

J Cell Mol Med 2011 Feb;15(2):307-15

Molecular Cell Biology, Paul Scherrer Institut, Villigen, Switzerland.

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http://dx.doi.org/10.1111/j.1582-4934.2009.00967.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822797PMC
February 2011

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Blood 2011 Feb 8;117(5):1507-15. Epub 2010 Dec 8.

Molecular Cancer Biology Program, Research Programs Unit, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2010-08-301549DOI Listing
February 2011

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2.

Blood 2010 Nov 21;116(18):3677-80. Epub 2010 Jul 21.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, Brescia, Italy.

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http://dx.doi.org/10.1182/blood-2010-06-291930DOI Listing
November 2010

A plasmid-based multigene expression system for mammalian cells.

Nat Commun 2010 Nov 16;1:120. Epub 2010 Nov 16.

Paul Scherrer Institute, Biomolecular Research, Molecular Cell Biology, Villigen CH-5232, Switzerland.

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http://dx.doi.org/10.1038/ncomms1120DOI Listing
November 2010

Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

Biochim Biophys Acta 2010 Mar 15;1804(3):567-80. Epub 2009 Sep 15.

Paul Scherrer Institut, Biomolecular Research, 5232 Villigen PSI, Switzerland.

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http://dx.doi.org/10.1016/j.bbapap.2009.09.002DOI Listing
March 2010

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Proc Natl Acad Sci U S A 2010 Feb;107(6):2425-30

Molecular Cancer Biology Program, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, PO Box 63, University of Helsinki, Haartmaninkatu 8, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.0914318107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823880PMC
February 2010

Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers.

FASEB J 2010 Jan 2;24(1):32-8. Epub 2009 Sep 2.

Paul Scherrer Institut, 5232-Villigen, AG, Switzerland.

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http://dx.doi.org/10.1096/fj.09-132670DOI Listing
January 2010

Structure and function of VEGF receptors.

IUBMB Life 2009 Sep;61(9):915-22

Paul Scherrer Institut, Biomolecular Research, Molecular Cell Biology, Villigen, Switzerland.

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http://dx.doi.org/10.1002/iub.234DOI Listing
September 2009

The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.

Int J Biochem Cell Biol 2009 Jul 20;41(7):1572-80. Epub 2009 Jan 20.

Center for Radiopharmaceutical Science ETH-PSI-USZ, Paul Scherrer Institute, Villigen, Switzerland.

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http://dx.doi.org/10.1016/j.biocel.2009.01.006DOI Listing
July 2009

Recombinant human VEGF165b protein is an effective anti-cancer agent in mice.

Eur J Cancer 2008 Sep 24;44(13):1883-94. Epub 2008 Jul 24.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2008.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565644PMC
September 2008

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

FASEB J 2008 Aug 8;22(8):3078-86. Epub 2008 May 8.

Paul Scherrer Institut, Laboratory of Biomolecular Research, Molecular Cell Biology, 5232 Villigen-PSI Switzerland.

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http://dx.doi.org/10.1096/fj.08-107219DOI Listing
August 2008

Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis.

Oncol Rep 2007 Oct;18(4):933-41

Paul Scherrer Institute, Biomolecular Research, Molecular Cell Biology, 8093 Zurich, Switzerland.

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October 2007

Structure of a VEGF-VEGF receptor complex determined by electron microscopy.

Nat Struct Mol Biol 2007 Mar 11;14(3):249-50. Epub 2007 Feb 11.

Paul Scherrer Institut, Biomolecular Research, Molecular Cell Biology, CH-5232 Villigen-PSI, Switzerland.

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http://dx.doi.org/10.1038/nsmb1202DOI Listing
March 2007

Structure determination of VEGF-E by sulfur SAD.

Acta Crystallogr D Biol Crystallogr 2006 Nov 18;62(Pt 11):1430-4. Epub 2006 Oct 18.

Swiss Light Source, Paul Scherrer Institut, Villigen-PSI, Switzerland.

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http://dx.doi.org/10.1107/S0907444906036742DOI Listing
November 2006

Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy.

Cancer Lett 2006 Apr 13;235(2):298-308. Epub 2005 Jun 13.

Paul Scherrer Institut, Biomolecular Research, Molecular Cell Biology, OFLC-102, CH-5232 Villigen, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350500456
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http://dx.doi.org/10.1016/j.canlet.2005.04.029DOI Listing
April 2006

Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function.

J Biol Chem 2005 Apr 11;280(16):16066-75. Epub 2005 Feb 11.

Paul Scherrer Institut, Biomolecular Research, CH5232 Villigen, Switzerland.

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http://dx.doi.org/10.1074/jbc.M414481200DOI Listing
April 2005

Targeting human cancer cells with VEGF receptor-2-directed liposomes.

Oncol Rep 2005 Feb;13(2):319-24

Laboratory of Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, CH-5232 Villigen-PSI, Switzerland.

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February 2005

HIV TAT basic peptide is not a high-affinity ligand for VEGF receptor 2.

Biol Chem 2003 Oct-Nov;384(10-11):1435-41

Laboratory for Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, CH-5232 Villigen-PSI, Switzerland.

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http://dx.doi.org/10.1515/BC.2003.159DOI Listing
October 2004

Preliminary study of plasma vascular endothelial growth factor (VEGF) during low- and high-dose radiation therapy of dogs with spontaneous tumors.

Vet Radiol Ultrasound 2004 May-Jun;45(3):247-54

Section of Diagnostic Imaging and Radio-Oncology, Faculty of Veterinary Medicine, University of Zurich, Switzerland.

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July 2004