Kuresh Youdim

Kuresh Youdim

UNVERIFIED PROFILE

Are you Kuresh Youdim?   Register this Author

Register author
Kuresh Youdim

Kuresh Youdim

Publications by authors named "Kuresh Youdim"

Are you Kuresh Youdim?   Register this Author

28Publications

538Reads

11Profile Views

Optimum designs for non-linear mixed effects models in the presence of covariates.

Biometrics 2017 09 28;73(3):927-937. Epub 2017 Jan 28.

Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/biom.12660DOI Listing
September 2017

Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes.

Drug Metab Dispos 2015 Jan 8;43(1):163-81. Epub 2014 Oct 8.

Worldwide Research and Development, Pharmacokinetics, Pharmacodynamics, and Metabolism, Pfizer Inc., San Diego, California (M.A.Z.); and Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, F. Hoffmann-La Roche Ltd, Roche Innovation Center Basel, Basel, Switzerland (K.Y.).

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.114.058750
Publisher Site
http://dx.doi.org/10.1124/dmd.114.058750DOI Listing
January 2015

Simultaneous determination of multiple CYP inhibition constants using a cocktail-probe approach.

Methods Mol Biol 2013 ;987:11-23

Pfizer Inc., La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-321-3_2DOI Listing
August 2013

Application of PBPK modelling in drug discovery and development at Pfizer.

Xenobiotica 2012 Jan 30;42(1):94-106. Epub 2011 Oct 30.

Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/00498254.2011.627477DOI Listing
January 2012

Optimum design of experiments for enzyme inhibition kinetic models.

J Biopharm Stat 2011 May;21(3):555-72

School of Mathematical Sciences, Queen Mary, University of London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10543406.2010.489979DOI Listing
May 2011

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.

Drug Metab Dispos 2010 Aug 5;38(8):1322-7. Epub 2010 May 5.

Pharmacokinetics, Pharmacodynamics, and Drug Metabolism Pfizer Inc., La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.110.033555DOI Listing
August 2010

Potential application of D-optimal designs in the efficient investigation of cytochrome P450 inhibition kinetic models.

Drug Metab Dispos 2010 Jul 16;38(7):1019-23. Epub 2010 Apr 16.

Pfizer Global Research and Development, Sandwich, Kent, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.110.033142DOI Listing
July 2010

Cytochrome P450 metabolism and inhibition: analysis for drug discovery.

Prog Med Chem 2009 ;47:239-63

Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0079-6468(08)00206-3DOI Listing
June 2010

A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 May 17;878(17-18):1326-36. Epub 2010 Feb 17.

Pfizer Global Research and Development, Pharmacokinetics Dynamics and Metabolism, Sandwich, Kent CT13 9NJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2010.02.013DOI Listing
May 2010

An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.

J Pharm Biomed Anal 2008 Sep 17;48(1):92-9. Epub 2008 May 17.

Pfizer Global Research and Development, Pharmacokinetics Dynamic and Metabolism, Sandwich, Kent, UK CT13 9NJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2008.05.011DOI Listing
September 2008

Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay.

Drug Metab Dispos 2007 Feb 15;35(2):275-82. Epub 2006 Nov 15.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, Kent, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.106.012864DOI Listing
February 2007

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism.

Drug Metab Dispos 2006 Sep 8;34(9):1516-22. Epub 2006 Jun 8.

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Groton, CT 06340, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.105.008714DOI Listing
September 2006

Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system.

Free Radic Biol Med 2004 Dec;37(11):1683-93

Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London SE1 9RT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2004.08.002DOI Listing
December 2004

Flavonoid permeability across an in situ model of the blood-brain barrier.

Free Radic Biol Med 2004 Mar;36(5):592-604

Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Centre for Neuroscience Research, Guy's King's and St Thomas's School of Biomedical Sciences, King's College, London SE1 1UL, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S089158490300765
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2003.11.023DOI Listing
March 2004

In vitro trans-monolayer permeability calculations: often forgotten assumptions.

Drug Discov Today 2003 Nov;8(21):997-1003

Antioxidant Research Group Wolfson Centre for Age-Related Diseases Guy's, King's and St Thomas' School of Biomedical Sciences King's College, London, SE1 1UL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(03)02873-3DOI Listing
November 2003

Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.

Photochem Photobiol 2003 Sep;78(3):256-61

Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, St. Thomas' Street, London SE1 9RT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1562/0031-8655(2003)078<0256:hgapaa>2.0.co;2DOI Listing
September 2003

Interaction between flavonoids and the blood-brain barrier: in vitro studies.

J Neurochem 2003 Apr;85(1):180-92

Antioxidant Research Group, Wolfson Center for Age-Related Diseases, Centre for Neuroscience Research, Guy's, King's and St Thomas's School of Biomedical Sciences, King's College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1471-4159.2003.01652.xDOI Listing
April 2003

Dietary flavonoids as potential neuroprotectants.

Biol Chem 2002 Mar-Apr;383(3-4):503-19

Wolfson Center for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2002.052DOI Listing
November 2002

Roles of vitamins E and C on neurodegenerative diseases and cognitive performance.

Nutr Rev 2002 Oct;60(10 Pt 1):308-26

Neuroscience Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging,Tufts University, Boston, MA 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1301/002966402320583433DOI Listing
October 2002

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ( small star, filled).

J Nutr Biochem 2002 May;13(5):282-288

Human Nutrition Research Center on Aging at Tufts University, United States Department of Agriculture, 711 Washington Street, 02111, Boston, MA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0955-2863(01)00221-2DOI Listing
May 2002

Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits.

Ann N Y Acad Sci 2002 Apr;959:128-32

USDA-ARS, HNRCA at Tufts University, Boston, Massachusetts 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb02089.xDOI Listing
April 2002