Kunio Matsumoto

Kunio Matsumoto

UNVERIFIED PROFILE

Are you Kunio Matsumoto?   Register this Author

Register author
Kunio Matsumoto

Kunio Matsumoto

Publications by authors named "Kunio Matsumoto"

Are you Kunio Matsumoto?   Register this Author

100Publications

1489Reads

39Profile Views

New insights into human endometrial aminopeptidases in both implantation and menstruation.

Biochim Biophys Acta Proteins Proteom 2020 Feb 23;1868(2):140332. Epub 2019 Nov 23.

Department of Obstetrics and Gynecology, Bantane Hospital, Fujita Health University, 3-6-10 Odobashi, Nakagawa-ku, Nagoya 454-8509, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2019.140332DOI Listing
February 2020

Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.

Cancer Sci 2019 Oct 13;110(10):3340-3349. Epub 2019 Aug 13.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778621PMC
October 2019

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.

Nat Chem Biol 2019 06 17;15(6):598-606. Epub 2019 May 17.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41589-019-0285-7DOI Listing
June 2019

Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.

Int J Mol Sci 2019 Jun 17;20(12). Epub 2019 Jun 17.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20122955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628191PMC
June 2019

MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.

Int J Mol Sci 2018 Oct 12;19(10). Epub 2018 Oct 12.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19103141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213957PMC
October 2018

Hepatocyte growth factor in physiology and infectious diseases.

Cytokine 2017 10 13;98:97-106. Epub 2017 Jan 13.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2016.12.025DOI Listing
October 2017

Targeting the hepatocyte growth factor/Met pathway in cancer.

Biochem Soc Trans 2017 08 3;45(4):855-870. Epub 2017 Jul 3.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20160132DOI Listing
August 2017

Hepatocyte growth factor/MET in cancer progression and biomarker discovery.

Cancer Sci 2017 Mar;108(3):296-307

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378267PMC
March 2017

Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma.

Oncotarget 2016 Oct;7(43):70779-70793

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.12221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342589PMC
October 2016

Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.

Sci Rep 2016 09 9;6:33149. Epub 2016 Sep 9.

Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep33149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017023PMC
September 2016

Pharmacokinetics and pharmacodynamics following intravenous administration of recombinant human hepatocyte growth factor in rats with renal injury.

Pharmacology 2014 31;94(3-4):190-7. Epub 2014 Oct 31.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000363412DOI Listing
October 2015

A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.

Springerplus 2015 16;4:358. Epub 2015 Jul 16.

Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717 Japan ; Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

View Article

Download full-text PDF

Source
http://www.springerplus.com/content/4/1/358
Publisher Site
http://dx.doi.org/10.1186/s40064-015-1123-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503710PMC
July 2015

Hepatocyte growth factor and Met in drug discovery.

J Biochem 2015 May 13;157(5):271-84. Epub 2015 Mar 13.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; and Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka-shi, Fukuoka 820-8502, Japan

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvv027DOI Listing
May 2015

Artificial human Met agonists based on macrocycle scaffolds.

Nat Commun 2015 Mar 11;6:6373. Epub 2015 Mar 11.

Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms7373
Publisher Site
http://dx.doi.org/10.1038/ncomms7373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382702PMC
March 2015

HGF-Met Pathway in Regeneration and Drug Discovery.

Biomedicines 2014 Oct 31;2(4):275-300. Epub 2014 Oct 31.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biomedicines2040275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344275PMC
October 2014

Novel long-acting prostacyclin agonist (ONO-1301) with an angiogenic effect: promoting synthesis of hepatocyte growth factor and increasing cyclic AMP concentration via IP-receptor signaling.

J Pharmacol Sci 2013 30;123(4):392-401. Epub 2013 Nov 30.

Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1254/jphs.13073fpDOI Listing
September 2014

Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.

Exp Cell Res 2014 Aug 26;326(2):267-79. Epub 2014 Apr 26.

Graduate School of Integrated Science, Yokohama City University, 641-12, Maioka-cho, Totsuka-ku, Yokohama 244-0813, Japan; Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144827140016
Publisher Site
http://dx.doi.org/10.1016/j.yexcr.2014.04.009DOI Listing
August 2014

Suppression of fibrogenic gene expression and liver fibrosis using a synthetic prostacyclin agonist.

Biomed Res 2013 ;34(5):241-50

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2220/biomedres.34.241DOI Listing
June 2014

Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation.

J Thorac Oncol 2014 Jun;9(6):775-83

Divisions of *Medical Oncology and †Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan; and ‡Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Tsukuba, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTO.0000000000000170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132034PMC
June 2014

Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer.

Cancer Sci 2013 Dec 13;104(12):1640-6. Epub 2013 Nov 13.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.12301DOI Listing
December 2013

Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model.

Cancer Sci 2013 Nov 25;104(11):1440-6. Epub 2013 Oct 25.

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.12284DOI Listing
November 2013

α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells.

Cancer Lett 2013 Jul 16;335(2):472-8. Epub 2013 Mar 16.

Division of Material Engineering, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2013.03.008DOI Listing
July 2013

Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes.

Cytokine 2013 Jun 22;62(3):446-52. Epub 2013 Apr 22.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2013.04.006DOI Listing
June 2013

Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans.

J Pharm Sci 2013 Jan 9;102(1):237-49. Epub 2012 Oct 9.

Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jps.23337DOI Listing
January 2013

Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.

Eur J Pharmacol 2013 Jan 5;699(1-3):81-7. Epub 2012 Dec 5.

Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-city, Tokushima 770-8503, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2012.11.045DOI Listing
January 2013

Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer.

Mol Cancer Ther 2012 Oct 25;11(10):2149-57. Epub 2012 Jul 25.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-0195DOI Listing
October 2012

Repair of segmental bone defects in rabbit tibia promoted by a complex of β-tricalcium phosphate and hepatocyte growth factor.

J Orthop Sci 2012 Sep 5;17(5):639-48. Epub 2012 Jul 5.

Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00776-012-0262-4DOI Listing
September 2012

A novel prostacyclin agonist protects against airway hyperresponsiveness and remodeling in mice.

Am J Respir Cell Mol Biol 2012 Aug 8;47(2):170-7. Epub 2012 Mar 8.

Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2011-0350OCDOI Listing
August 2012

Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.

J Thorac Oncol 2012 Jul;7(7):1078-85

Division of Medical Oncology, †Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTO.0b013e3182519a2cDOI Listing
July 2012

Sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model.

Am J Physiol Renal Physiol 2012 Jun 14;302(12):F1616-29. Epub 2012 Mar 14.

Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00538.2011DOI Listing
June 2012

Arterial shear stress augments the differentiation of endothelial progenitor cells adhered to VEGF-bound surfaces.

Biochem Biophys Res Commun 2012 Jun 23;423(1):91-7. Epub 2012 May 23.

Genome Biotechnology Laboratories, Kanazawa Institute of Technology, 3-1 Yatsukaho, Hakusan, Ishikawa 924-0838, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0006291X1200978
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2012.05.088DOI Listing
June 2012

Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.

J Thorac Oncol 2012 Feb;7(2):272-80

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S155608641533228
Publisher Site
http://dx.doi.org/10.1097/JTO.0b013e3182398e69DOI Listing
February 2012

Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression.

Am J Physiol Gastrointest Liver Physiol 2012 Feb 8;302(4):G420-9. Epub 2011 Dec 8.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa Univ., Kakuma, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00216.2011DOI Listing
February 2012

A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.

Eur J Pharmacol 2012 Jan 9;674(2-3):352-8. Epub 2011 Nov 9.

Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2011.10.038DOI Listing
January 2012

Use of liposome encapsulated hemoglobin as an oxygen carrier for fetal and adult rat liver cell culture.

J Biosci Bioeng 2011 Nov 2;112(5):485-90. Epub 2011 Aug 2.

LIMMS/CNRS-IIS UMI 2820, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiosc.2011.07.004DOI Listing
November 2011

3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin β1 function and matrix stiffness.

Biochem Biophys Res Commun 2011 Aug 23;412(1):98-103. Epub 2011 Jul 23.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2011.07.050DOI Listing
August 2011

Cellular Injury of Cardiomyocytes during Hepatocyte Growth Factor Gene Transfection with Ultrasound-Triggered Bubble Liposome Destruction.

J Drug Deliv 2011 9;2011:453619. Epub 2010 Dec 9.

Department of Cardiovascular Dynamics, Research Institute, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai,Suita, Osaka 565-8565, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2011/453619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065913PMC
July 2011

Promotion of rabbit ligament healing by local delivery of hepatocyte growth factor.

J Orthop Sci 2011 Jul 25;16(4):451-7. Epub 2011 May 25.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00776-011-0101-zDOI Listing
July 2011

NK4 gene expression enhances 5-fluorouracil-induced apoptosis of murine colon cancer cells.

Anticancer Res 2011 Jun;31(6):2217-24

Department of Digestive Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/content/31/6/2217.full.pdf
Web Search
June 2011

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

Clin Cancer Res 2011 Apr 10;17(8):2260-9. Epub 2011 Jan 10.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-10-1993DOI Listing
April 2011

Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells.

Anticancer Res 2011 Apr;31(4):1279-87

Department of Surgery and Oncology, Kyushu University, Fukuoka 812-8582, Japan.

View Article

Download full-text PDF

Source
April 2011

Recombinant human hepatocyte growth factor (HGF), but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism.

Clin Exp Pharmacol Physiol 2011 Mar;38(3):192-201

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, OsakaSaito Laboratory, Research & Development, Kringle Pharma Inc., IbarakiKringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, SuitaDivision of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1440-1681.2011.05483.xDOI Listing
March 2011

Hepatocyte growth factor twenty years on: Much more than a growth factor.

J Gastroenterol Hepatol 2011 Jan;26 Suppl 1:188-202

Cancer Research Institute, Kanazawa University, Kakuma-machi, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1440-1746.2010.06549.xDOI Listing
January 2011

Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.

Int J Cancer 2010 Oct;127(8):1948-57

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.25197DOI Listing
October 2010

p27 Nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells.

Biochem Biophys Res Commun 2010 Feb 13;392(3):403-8. Epub 2010 Jan 13.

Osaka University, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.01.035DOI Listing
February 2010

Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.

Clin Cancer Res 2010 Jan 15;16(1):174-83. Epub 2009 Dec 15.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-09-1204DOI Listing
January 2010

Anti-cancer approach with NK4: Bivalent action and mechanisms.

Anticancer Agents Med Chem 2010 Jan;10(1):36-46

Cancer Research Institute, Kanazawa University, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871520611009010036DOI Listing
January 2010

Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits.

Arthroscopy 2010 Jan;26(1):84-90

Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arthro.2009.06.029DOI Listing
January 2010

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.

Clin Cancer Res 2009 Nov 20;15(21):6630-8. Epub 2009 Oct 20.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-1001DOI Listing
November 2009

Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.

Neurosci Res 2009 Oct 10;65(2):194-200. Epub 2009 Jul 10.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neures.2009.06.016DOI Listing
October 2009

Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy.

Cancer Sci 2009 Oct 17;100(10):1902-7. Epub 2009 Jun 17.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1349-7006.2009.01245.x
Publisher Site
http://dx.doi.org/10.1111/j.1349-7006.2009.01245.xDOI Listing
October 2009

Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association.

J Biol Chem 2009 Aug 24;284(33):22491-9. Epub 2009 Jun 24.

Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M109.025148
Publisher Site
http://dx.doi.org/10.1074/jbc.M109.025148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755970PMC
August 2009

Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models.

Cancer Sci 2009 Jul 12;100(7):1351-8. Epub 2009 May 12.

Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1349-7006.2009.01184.x
Publisher Site
http://dx.doi.org/10.1111/j.1349-7006.2009.01184.xDOI Listing
July 2009

Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes.

Pharm Res 2009 Apr 6;26(4):1012-21. Epub 2009 Jan 6.

Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-008-9810-1DOI Listing
April 2009

Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor.

Clin Chim Acta 2009 Apr 14;402(1-2):42-6. Epub 2008 Dec 14.

Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2008.12.011DOI Listing
April 2009

Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer.

Cancer Sci 2009 Apr 11;100(4):722-9. Epub 2009 Mar 11.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1349-7006.2009.01101.xDOI Listing
April 2009

Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1-dependent mechanism.

Biochem Biophys Res Commun 2009 Mar 24;380(2):333-7. Epub 2009 Jan 24.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, 2-2-B7 Yamadaoka, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2009.01.080DOI Listing
March 2009

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice.

Mol Brain 2009 Mar 27;2. Epub 2009 Mar 27.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6606-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673217PMC
March 2009

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.

Proteomics 2008 Aug;8(16):3360-70

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200800156DOI Listing
August 2008

Hepatocyte growth factor gene therapy for hypertension.

Methods Mol Biol 2008 ;423:393-404

Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-59745-194-9_31
Publisher Site
http://dx.doi.org/10.1007/978-1-59745-194-9_31DOI Listing
June 2008

HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease.

Front Biosci 2008 May 1;13:7072-86. Epub 2008 May 1.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/3211DOI Listing
May 2008

Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice.

Int Arch Allergy Immunol 2008 14;145(4):324-39. Epub 2007 Nov 14.

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/110891
Publisher Site
http://dx.doi.org/10.1159/000110891DOI Listing
April 2008

Regulation of cell migration and cytokine production by HGF-like protein (HLP) / macrophage stimulating protein (MSP) in primary microglia.

Biomed Res 2008 Apr;29(2):77-84

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2220/biomedres.29.77DOI Listing
April 2008

Hepatocyte growth factor improves synaptic localization of the NMDA receptor and intracellular signaling after excitotoxic injury in cultured hippocampal neurons.

Exp Neurol 2008 Mar 13;210(1):83-94. Epub 2007 Oct 13.

Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2007.10.001DOI Listing
March 2008

Generation of engineered recombinant hepatocyte growth factor cleaved and activated by Genenase I.

J Biotechnol 2008 Feb 22;133(4):478-85. Epub 2007 Nov 22.

Saito Laboratory, Research & Development, Kringle Pharma, Inc., 7-7-15 Saitoasagi, Ibaraki, Osaka 567-0085, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2007.11.006DOI Listing
February 2008

NK4 gene therapy targeting HGF-Met and angiogenesis.

Front Biosci 2008 Jan 1;13:1943-51. Epub 2008 Jan 1.

Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, 13-1 Takaramachi, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/2813DOI Listing
January 2008

Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons.

Exp Neurol 2007 Oct 26;207(2):195-202. Epub 2007 Jun 26.

Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2007.06.007DOI Listing
October 2007

Hepatocyte growth factor prevents pulmonary ischemia-reperfusion injury in mice.

J Heart Lung Transplant 2007 Sep;26(9):935-43

Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2007.06.010DOI Listing
September 2007

Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice.

Biochem Biophys Res Commun 2007 Jun 23;358(1):117-23. Epub 2007 Apr 23.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2007.04.098DOI Listing
June 2007

Stimulation of hepatocyte growth factor production by heparin-derived oligosaccharides.

J Biochem 2007 May 22;141(5):653-60. Epub 2007 Feb 22.

Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvm067DOI Listing
May 2007

Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules.

Biomed Microdevices 2007 Feb;9(1):91-9

Food Engineering Division, National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-006-9011-9DOI Listing
February 2007

Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression.

J Nanosci Nanotechnol 2006 Sep-Oct;6(9-10):2853-9

Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1166/jnn.2006.466DOI Listing
December 2006