Publications by authors named "Kun Yang"

1,353 Publications

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Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather: a review and perspective.

Natl Sci Rev 2020 Mar 6;7(3):500-515. Epub 2020 Jan 6.

School of Atmospheric Sciences, Sun Yat-sen University, Guangzhou 519082, China.

Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau (TP) is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement. In order to show the achievements that have been made, this paper reviews the progress on the observations for the atmospheric boundary layer, land-surface heat fluxes, cloud-precipitation distributions and vertical structures by using ground- and space-based multiplatform, multisensor instruments and the effect of the cloud system in the TP on the downstream weather. The results show that the form drag related to the topography, land-atmosphere momentum and scalar fluxes is an important part of the parameterization process. The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures. Observations show that the cloud and precipitation over the TP have a strong diurnal variation. Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration, and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions. In addition, the influence of the TP on severe weather downstream is preliminarily understood from the mechanism. It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud, precipitation and weather in the downstream regions.
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http://dx.doi.org/10.1093/nsr/nwz226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288947PMC
March 2020

Application of the entropy-DEMATEL-VIKOR multicriteria decision-making method in public charging infrastructure.

Authors:
Hua Dong Kun Yang

PLoS One 2021 21;16(10):e0258209. Epub 2021 Oct 21.

School of Economics and Management, North China Electric Power University Beijing, Beijing, China.

As an energy-saving and environmentally friendly means of transportation, electric vehicles have been advocated and promoted by various countries, resulting in an increase in the number of electric vehicles. The improvement of public charging infrastructure not only drives the development of the electric vehicle industry but also solves the problems of user difficulty in charging and the low utilization rate of charging piles. From the perspective of electric vehicle (EV) user experience, this research establishes a framework of indicators, including the reputation level, service quality, convenience, economy and safety. Second, the objective entropy weight method and the subjective decision-making trial and evaluation laboratory (DEMATEL) method are combined to weight the indicators. Among the indicators, the comprehensive weights of market share (C2), app operation interface (C3), and charging mode (C5) are 0.107, 0.088, and 0.090, respectively, ranking in the top three. These three indicators should be given more attention by public charging infrastructure operators. Finally, three alternative public charging infrastructures are sorted by using the VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) method. Since the positive ideal solution Si of h1 (state grid) is 0.084, the negative ideal solution Ri is 0.248, and the comprehensive index Qi is 0.000. All ranking first, this finding indicates that the public charging infrastructure of this operator has strong competitiveness in the market. In addition, the results are consistent with actual news reports, which also proves the effectiveness of the index system and model.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0258209PLOS
October 2021

Olfactory dysfunction and face processing of social cognition in first-episode psychosis.

Neurosci Res 2021 Oct 13. Epub 2021 Oct 13.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address:

Olfactory functional deficits have been reported in psychotic disorders. Olfactory dysfunction has a predictive value for prognosis and disease course. Thus, it is important to know which specific symptoms and cognitive changes are associated with olfactory dysfunction in early-stage psychosis. Deficits in social cognition are a difficult problem in psychosis. Here we conduct a detailed assessment of odor function and face processing and show that odor discrimination capacity is specifically associated with face processing function in patients with first episode psychosis. This finding indicates that the high-throughput olfactory assessment may aid a prediction of the difficult clinical dimension from early-stage psychosis.
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http://dx.doi.org/10.1016/j.neures.2021.10.003DOI Listing
October 2021

Effectiveness and safety of robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer: a meta-analysis of 12,401 gastric cancer patients.

Updates Surg 2021 Oct 16. Epub 2021 Oct 16.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan Province, China.

Advanced minimally invasive techniques, such as robotic surgeries, are applied increasingly frequently around the world and are primarily used to improve the surgical outcomes of laparoscopic gastrectomy (LG). Against that background, we conducted a meta-analysis to evaluate the feasibility, safety, and effectiveness of robotic gastrectomy (RG). Studies comparing surgical outcomes between LG and RG patients were retrieved from medical databases, including RCTs and non-RCTs. The primary outcome of this study was overall survival, which was obtained by evaluating the 3-year survival rate and the 5-year survival rate. In addition, postoperative complications, mortality, length of hospital stay, and harvested lymph nodes were also assessed. We also conducted subgroup analyses stratified by resection type, body mass index, age, depth of invasion and tumour size. Ultimately, 31 articles met the criterion for our study through an attentive check of each text, including 1 RCT and 30 non-RCTs. A total of 12,401 patients were included in the analysis, with 8127 (65.5%) undergoing LG and 4274 (34.5%) undergoing RG. Compared with LG, RG was associated with fewer postoperative complications (OR 0.81; 95% CI 0.71-0.93; P = 0.002), especially pancreas-related complications (OR 0.376; 95% CI 0.156-0.911; P = 0.030), increased harvested lymph nodes (WMD 2.03; 95% CI 0.95-3.10; P < 0.001), earlier time to first flatus (WMD - 0.105 days; 95% CI - 0.207 to - 0.003; P = 0.044), longer operation time (WMD 40.192 min, 95% CI 32.07-48.31; P < 0.001), less intraoperative blood loss (WMD - 20.09 ml; 95% CI - 26.86 to - 13.32; P < 0.001), and higher expense (WMD 19,141.68 RMB; 95% CI 11,856.07-26,427.29; P < 0.001). There was no significant difference between RG and LG regarding 3-year overall survival (OR 1.030; 95% CI 0.784-1.353; P = 0.832), 5-year overall survival (OR 0.862; 95% CI 0.721-1.031; P = 0.105), conversion rate (OR 0.857; 95% CI 0.443-1.661; P = 0.648), postoperative hospital stay (WMD - 0.368 days; 95% CI - 0.75-0.013; P = 0.059), mortality (OR 1.248; 95% CI 0.514-3.209; P = 0.592), and reoperation (OR 0.855; 95% CI 0.479-1.525; P = 0.595). Our study revealed that postoperative complications, especially pancreas-related complications, occurred less often with RG than with LG. However, long-term outcomes between the two surgical techniques need to be further examined, particularly regarding the oncological adequacy of robotic gastric cancer resections.
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http://dx.doi.org/10.1007/s13304-021-01176-3DOI Listing
October 2021

Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex.

Schizophr Res 2021 Oct 11;238:99-107. Epub 2021 Oct 11.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States of America; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address:

The clinical importance of social cognition is well acknowledged in patients with psychosis, in particular those with first episode psychosis (FEP). Nevertheless, its brain substrates and circuitries remain elusive, lacking precise analysis between multimodal brain characteristics and behavioral sub-dimensions within social cognition. In the present study, we examined face processing of social cognition in 71 FEP patients and 77 healthy controls (HCs). We looked for a possible correlation between face processing and multimodal MRI characteristics such as resting-state functional connectivity (rsFC) and brain volume. We observed worse recognition accuracy, longer recognition response time, and longer memory response time in FEP patients when compared with HCs. Of these, memory response time was selectively correlated with specific rsFCs, which included the right subcallosal sub-region of BA24 in the ACC (scACC), only in FEP patients. The volume of this region was also correlated with memory response time in FEP patients. The scACC is functionally and structurally important in FEP-associated abnormalities of face processing measures in social cognition.
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http://dx.doi.org/10.1016/j.schres.2021.09.027DOI Listing
October 2021

A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance.

Mol Psychiatry 2021 Oct 12. Epub 2021 Oct 12.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Treatment resistant (TR) psychosis is considered to be a significant cause of disability and functional impairment. Numerous efforts have been made to identify the clinical predictors of TR. However, the exploration of molecular and biological markers is still at an early stage. To understand the TR condition and identify potential molecular and biological markers, we analyzed demographic information, clinical data, structural brain imaging data, and molecular brain imaging data in 7 Tesla magnetic resonance spectroscopy from a first episode psychosis cohort that includes 136 patients. Age, gender, race, smoking status, duration of illness, and antipsychotic dosages were controlled in the analyses. We found that TR patients had a younger age at onset, more hospitalizations, more severe negative symptoms, a reduction in the volumes of the hippocampus (HP) and superior frontal gyrus (SFG), and a reduction in glutathione (GSH) levels in the anterior cingulate cortex (ACC), when compared to non-TR patients. The combination of multiple markers provided a better classification between TR and non-TR patients compared to any individual marker. Our study shows that ACC-GSH, HP and SFG volumes, and age at onset, could potentially be biomarkers for TR diagnosis, while hospitalization and negative symptoms could be used to evaluate the progression of the disease. Multimodal cohorts are essential in obtaining a comprehensive understanding of brain disorders.
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http://dx.doi.org/10.1038/s41380-021-01331-7DOI Listing
October 2021

Safety of endovascular therapy for symptomatic intracranial artery stenosis: a national prospective registry.

Stroke Vasc Neurol 2021 Oct 12. Epub 2021 Oct 12.

Department of Neurology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, China.

Introduction: The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown. The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis (CRTICAS) was a prospective, multicentre, real-world registry designed to assess these outcomes and the impact of centre experience.

Methods: 1140 severe, symptomatic intracranial arterial stenosis (ICAS) patients treated with endovascular therapy were included from 26 centres, further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years: (1) high volume for ≥25 cases/year; (2) moderate volume for 10-25 cases/year and (3) low volume for <10 cases/year.

Results: The rate of 30-day stroke, transient ischaemic attack or death was 9.7% (111), with 5.4%, 21.1% and 9.7% in high-volume, moderate-volume and low-volume centres, respectively (p<0.05). Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres (OR=0.187, 95% CI: 0.056 to 0.627; p≤0.0001), while moderate-volume and low-volume centres showed no significant difference (p=0.8456).

Conclusion: Compared with the preceding randomised controlled trials, this real-world, prospective, multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS. Non-uniform utilisation in endovascular technology, institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment.
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http://dx.doi.org/10.1136/svn-2021-000979DOI Listing
October 2021

Role of molecular size of volatile organic compounds on their adsorption by KOH-activated micro-mesoporous carbon.

J Hazard Mater 2021 Sep 29;424(Pt B):127355. Epub 2021 Sep 29.

Department of Environmental Science, Zhejiang University, Hangzhou 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China; Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China. Electronic address:

KOH-activated carbon (KAC) with high surface area and abundant micropores are widely used in adsorbing volatile organic compounds (VOCs). Kinetic diameters (σ) of VOCs are an important factor controlling diffusion of VOCs into pores of adsorbent. Yet the influence of kinetic diameters of VOCs on their adsorption by KAC remains unclear. Here, we investigated the dynamic adsorption of VOCs with various kinetic diameters on a prepared KAC with high surface area of 3100 m/g, pore volume of 2.08 cm/g and average pore width (D) of 2.68 nm. Adsorption affinity was negatively correlated with size difference (D-σ), indicating that pore width of adsorbent should close to σ to obtain a strong interaction between VOCs and adsorbents. Amounts adsorbed were positively correlated with σ at low relative pressures (p/p < 0.01), and negatively correlated with σ at high relative pressures (p/p > 0.044). The above results suggest that larger molecules with higher affinities are preferentially adsorbed at low relative pressures, amounts adsorbed of smaller molecules are larger than that of bigger molecules at high relative pressures. This study provided new insights into adsorption mechanisms mediated by σ and the development of next generation adsorbents for efficient removal of VOCs.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127355DOI Listing
September 2021

Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.

Environ Res 2021 Oct 7:112163. Epub 2021 Oct 7.

Herbert Wertheim School of Public Health, University of California-San Diego, La Jolla, CA, USA. Electronic address:

Background: Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Because of this, AChE is considered a physiological marker of organophosphate exposure in agricultural settings. However, limited research exists on the associations between urinary organophosphate metabolites and AChE activity in children.

Methods: This study included 526 participants from 2 exams (April and July-October 2016) of ages 12-17 years living in agricultural communities in Ecuador. AChE activity was measured at both examinations, and organophosphate metabolites, including para-nitrophenol (PNP), 3,5,6-trichloro-2-pyridinol (TCPy), and malathion dicarboxylic acid (MDA) were measured in urine collected in July-October. We used generalized estimating equation generalized linear model (GEEGLM), adjusting for hemoglobin, creatinine, and other demographic and anthropometric covariates, to estimate associations of urinary metabolite concentrations with AChE activity (July-October) and AChE % change between April and July-October.

Results: The mean (SD) of AChE and AChE % change (April vs July-October) were 3.67 U/mL (0.54) and -2.5 % (15.4 %), respectively. AChE activity was inversely associated with PNP concentration, whereas AChE % change was inversely associated with PNP and MDA. There was evidence of a threshold: difference was only significant above the 80th percentile of PNP concentration (AChE difference per SD increase of metabolite = -0.12 U/mL [95 %CI: 0.20, -0.04]). Likewise, associations with AChE % change were significant only above the 80th percentile of TCPy (AChE % change per SD increase of metabolite = -1.38 % [95 %CI: 2.43 %, -0.32 %]) and PNP -2.47 % [95 %CI: 4.45 %, -0.50 %]). PNP concentration at ≥80th percentile was associated with elevated ORs for low AChE activity of 2.9 (95 % CI: 1.5, 5.7) and for AChE inhibition of ≤ -10 % of 3.7 (95 % CI: 1.4, 9.8).

Conclusions: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. These findings bring attention to the value of using multiple constructs of pesticide exposure in epidemiologic studies.
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http://dx.doi.org/10.1016/j.envres.2021.112163DOI Listing
October 2021

Stimulus-Specific Expression, Selective Generation and Novel Function of Grass Carp () IL-12 Isoforms: New Insights Into the Heterodimeric Cytokines in Teleosts.

Front Immunol 2021 16;12:734535. Epub 2021 Sep 16.

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Interleukin-12 (IL-12) is a heterodimeric cytokine composed of a p35 subunit specific to IL-12 and a p40 subunit shared with IL-23. In this study, we unveiled the existence of two paralogues in grass carp (named and ). Notably, and displayed distinct inducible expression patterns, as poly I:C merely induced the gene expression of but not , while recombinant grass carp interferon-gamma (rgcIfn-γ) only enhanced the transcription of but not . Moreover, the signaling mechanisms responsible for the inducible expression of and mRNA were elucidated. Because of the existence of three grass carp genes ( and ) and two paralogues, six gcIl-12 isoforms were predicted by 3D modeling. Results showed that gcp40a and gcp40b but not gcp40c had the potential for forming heterodimers with both gcp35 paralogues the disulfide bonds. Non-reducing electrophoresis experiments further disclosed that only gcp40b but not gcp40a or gcp40c could form heterodimers with gcp35 to produce secretory heterodimeric gcp35a/gcp40b (gcIl-12AB) and gcp35b/gcp40b (gcIl-12BB), which prompted us to prepare their recombinant proteins. These two recombinant proteins exhibited their extensive regulation on Ifn-γ production in various immune cells. Intriguingly, both gcIl-12 isoforms significantly enhanced the transcription of and in lymphocytes, and their regulation on expression was mediated by Stat3/Rorγt signaling, supporting the potential of gcIl-12 isoforms for inducing Th17-like responses. Additionally, stimulatory effects of gcIl-12 isoforms on and expression were attenuated by gcTgf-β1 suppressing the activation of Stat3 signaling, implying that their signaling could be manipulated. In brief, our works provide new insights into the inducible expression pattern, heterodimeric generation and functional novelty of Il-12 isoforms in teleosts.
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http://dx.doi.org/10.3389/fimmu.2021.734535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481787PMC
September 2021

Education, APOE ɛ4, and Cognition in Individuals with Subjective Cognitive Decline with Worry in the SILCODE Study.

Curr Alzheimer Res 2021 Sep 30. Epub 2021 Sep 30.

National Clinical Research Center for Geriatric Disease, Beijing, China.

Background: Education could offer a protective effect on cognition in individuals with Subjective Cognitive Decline (SCD), which is considered to be the early stage of Alzheimer's Dis- ease (AD). However, the effect of education on cognition in SCD individuals with SCD-plus fea- tures is not clear.

Objective: The aim of the study was to explore the effect of education on cognition in SCD individ- uals with SCD-plus features.

Methods: A total of 234 individuals with SCD were included from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Cognition was assessed across 4 domains (memory, executive, lan- guage, and general cognitive functions). Multiple linear regression models were constructed to ex- amine the effect of education on cognitive scores in individuals without worry (n=91) and with wor- ry (n=143). Furthermore, we assessed differences in effects between APOE ε4 noncarriers and APOE ε4 carriers in both groups.

Results: Multiple linear regression analysis showed a positive effect of education on memory, ex- ecutive, and language cognition in individuals without worry and all cognitive domains in individu- als with worry. Furthermore, we found a positive effect of education on executive cognition in APOE ε4 noncarriers without worry and language and general cognition in APOE ε4 carriers with- out worry. Meanwhile, education had a positive effect on all cognitive domains in APOE ε4 noncar- riers with worry and executive, language, and general cognition in APOE ε4 carriers with worry.

Conclusion: This study indicates that education has the potential to delay or reduce cognitive dec- line in SCD individuals with SCD-plus features.
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http://dx.doi.org/10.2174/1567205018666211001105425DOI Listing
September 2021

Preparation and Research of Monolayer WS FETs Encapsulated by h-BN Material.

Micromachines (Basel) 2021 Aug 24;12(9). Epub 2021 Aug 24.

Key Laboratory for Wide-Band Gap Semiconductor Materials and Devices of Education, The School of Microelectronics, Xidian University, Xi'an 710071, China.

Functional devices that use vertical van der Waals (vdWs) heterostructure material can effectively combine the properties of single component materials, and the strong interlayer coupling effect can change their electronic and optical properties. According to our research, WS/h-BN vertical vdWs heterostructure material can be synthesized by chemical vapor deposition (CVD) and wet transfer methods. Monolayer WS material and WS/h-BN vertical vdWs heterostructure material can be tested and characterized using XPS, SEM, EDS, AFM and Raman spectroscopy, which can prove the existence of corresponding materials. When the thickness of the material decreases, the Coulomb scattering amongst two-dimensional (2D) layered materials increases. This is because both the shielding effect and the distance between the channel and the interface layer decrease. FET devices are then fabricated on WS/h-BN vdWs heterostructure material by the electron beam lithography and evaporation processes. The effects of vdWs epitaxy on electrical transmission when WS/h-BN vdWs heterostructure material is formed are explored. Finally, the related electrical performance of FET devices is tested and analyzed. Our experimental research provides guidance for the use of electronic devices with vdWs heterostructure material.
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http://dx.doi.org/10.3390/mi12091006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464811PMC
August 2021

VIAE-Net: An End-to-End Altitude Estimation through Monocular Vision and Inertial Feature Fusion Neural Networks for UAV Autonomous Landing.

Sensors (Basel) 2021 Sep 20;21(18). Epub 2021 Sep 20.

Sichuan Tengden Technology Co., Ltd., Chengdu 610037, China.

Altitude estimation is one of the fundamental tasks of unmanned aerial vehicle (UAV) automatic navigation, where it aims to accurately and robustly estimate the relative altitude between the UAV and specific areas. However, most methods rely on auxiliary signal reception or expensive equipment, which are not always available, or applicable owing to signal interference, cost or power-consuming limitations in real application scenarios. In addition, fixed-wing UAVs have more complex kinematic models than vertical take-off and landing UAVs. Therefore, an altitude estimation method which can be robustly applied in a GPS denied environment for fixed-wing UAVs must be considered. In this paper, we present a method for high-precision altitude estimation that combines the vision information from a monocular camera and poses information from the inertial measurement unit (IMU) through a novel end-to-end deep neural network architecture. Our method has numerous advantages over existing approaches. First, we utilize the visual-inertial information and physics-based reasoning to build an ideal altitude model that provides general applicability and data efficiency for neural network learning. A further advantage is that we have designed a novel feature fusion module to simplify the tedious manual calibration and synchronization of the camera and IMU, which are required for the standard visual or visual-inertial methods to obtain the data association for altitude estimation modeling. Finally, the proposed method was evaluated, and validated using real flight data obtained during a fixed-wing UAV landing phase. The results show the average estimation error of our method is less than 3% of the actual altitude, which vastly improves the altitude estimation accuracy compared to other visual and visual-inertial based methods.
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http://dx.doi.org/10.3390/s21186302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472930PMC
September 2021

Efficacy and safety of traditional Chinese medicine injections in the treatment of chronic obstructive pulmonary disease: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27324

Chongqing Three Gorges Medical College, Chongqing, China.

Background: Chronic obstructive pulmonary disease (COPD) is a widespread, heterogeneous disease characterized by chronic inflammation of the airway and the gradual blockage of air flow due to bronchial obstruction. At present, a large number of traditional Chinese medicine injections (TCMIs) has been applied in the clinical treatment of COPD. However, there is insufficient evidence of evidence-based medicine of the interaction between them. Therefore, the purpose of this study is through the network meta-analysis to evaluate the efficacy and safety of the different TCMIs treatment of COPD, offering reference and evidence for clinical application.

Methods: We will search 7 databases for randomized controlled trials of TCMI for the COPD, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chinese Scientific Journals Database, and Wan-fang databases, from the date of the establishment of each database to October 31, 2021. The network meta-analysis will be implemented through Aggregate Data Drug Information System 1.16.8 and Stata 13.0 software. Pulmonary function included forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC will be the primary outcomes, FEV1 as a percentage of the estimated value (FEV1%pred), maximal voluntary ventilation (MVV), MVV as a percentage of the estimated value (MVV%pred), 6 minutes walking distance, The St. George's Respiratory Questionnaire score, and safety/adverse event will be evaluated as secondary outcomes. Mean differences or odds ratios will be used for statistical analysis. We will ensure the reliability of the results through node-split model and heterogeneity analysis. In addition, methodological quality will be evaluated based on the Cochrane Collaboration's tool, and the quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development and Evaluation system.

Results: This study will provide reliable evidence for the clinical selection of TCMI in the treatment of COPD.

Conclusion: The results of this study will evaluate the efficacy and safety of TCMI in the treatment of COPD, and provide decision-making references for future clinical and scientific research.
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http://dx.doi.org/10.1097/MD.0000000000027324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462615PMC
September 2021

The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing.

J Ethnopharmacol 2022 Jan 20;282:114662. Epub 2021 Sep 20.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, No.88 Changling Road, Xiqing District, Tianjin, 300193, China. Electronic address:

Ethnopharmacological Relevance: The diabetic wound is one of the common chronic complications of diabetes, which seriously affects patients' quality of life and even causes disability and death. Traditional Chinese medicine (TCM) is a unique and precious resource in China, which has a good curative effect and safety. At present, it has been found that Chinese herbal compounds and effective active ingredients can effectively promote diabetic wound healing, and its mechanism needs to be further studied. Signaling pathways are involved in the pathogenesis and progression of diabetic wounds, which is one of the main targets for the pathologic mechanism of diabetic wounds and the pharmacological research of therapeutic drugs.

Aim Of The Review: This study has been carried out to reveal the classical signaling pathways and potential targets by the action of TCM on diabetic wound healing and provides evidence for its clinical efficacy.

Materials And Methods: "diabetic wound", "diabetic foot ulcer", "traditional Chinese medicine", "natural plant" and "medicinal plant", were selected as the main keywords, and various online search engines, such as PubMed, Web of Science, CNKI and other publication resources, were used for searching literature.

Results: The results showed that TCM could regulate the signaling pathways to promote diabetic wound healing, such as Wnt, Nrf2/ARE, MAPK, PI3K/Akt, NF-κB, Notch, TGF-β/Smad, HIF-1α/VEGF, which maintaining inflammatory interaction balance, inhibiting oxidative stress and regulating abnormal glucose metabolism.

Conclusion: The effect of TCM on diabetic wound healing was reflected in multiple levels and multiple pathways. It is envisaged to carry out further research from precision-targeted therapy, provide ideas for screening the core target of TCM in treating diabetic wounds and create modern innovative drugs based on this target.
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http://dx.doi.org/10.1016/j.jep.2021.114662DOI Listing
January 2022

Photosynthetic physiological response of water-saving and drought-resistant rice to severe drought under wetting-drying alternation irrigation.

Physiol Plant 2021 Sep 22. Epub 2021 Sep 22.

Agricultural College, Anhui Agricultural University, Hefei, Anhui, China.

Water-saving and drought-resistant rice (WDR) is widely grown in central China in recent years. However, studies have not explored the interaction effect of WDR and irrigation regimes on drought-resistance capacities under severe drought at sensitive growth periods. A pot experiment was conducted using a WDR cultivar Hanyou73 (HY73) and traditional high-yielding and drought-sensitive cultivar Huiliangyou 898 (HLY898). Three irrigation regimes, including flooding irrigation (W1), mild wetting-drying alternation irrigation (W2), and severe wetting-drying alternation irrigation (W3), were applied before heading. At heading, severe drought with -50 KPa soil water potential was established for all treatments and cultivars. The findings showed that cultivar HY73 under W2 treatment had the highest yield, 1000-grain yield, filled grain, relative water content, and photosynthesis potential compared with the other combinations. The higher net photosynthetic rate (P ) was attributed to larger mesophyll conductance (g ) in drought for cultivar HY73 under W2 treatment compared with that for cultivar HLY898 and the other water treatments. Enhanced photo-respiration rate may be an important photoprotection mechanism for achieving high P for cultivar HY73 coupled with W2 treatment than for other combinations in drought. The relative expression level of OsPIP1;1 gene was significantly down-regulated during drought in all cultivars and water regimes. But OsPIP1;2, OsPIP2;3, OsTIP2;2, and OsTIP3;1 genes were upregulated to alleviate the significant decrease in g and g under drought. These results suggest that WDR and mild wetting-drying alternation irrigation (W2) have significant interaction effects in improving photosynthetic production potential by maintaining higher g under severe drought.
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http://dx.doi.org/10.1111/ppl.13568DOI Listing
September 2021

Tissue-specific differentiation of CD8 resident memory T cells.

Trends Immunol 2021 10 13;42(10):876-890. Epub 2021 Sep 13.

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia. Electronic address:

CD8 tissue-resident memory T (T) cells play crucial roles in defense against infections and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice and humans, they exist in all nonlymphoid organs and share key characteristics across all tissues, including downregulation of tissue egress and lymph node homing pathways. However, recent studies demonstrate considerable heterogeneity across T cells lodged in different tissues - linked to the activity of tissue-specific molecules, including chemokines, cytokines, and transcription factors. Current work indicates that transforming growth factor (TGF)-β plays a major role in generating T heterogeneity at phenotypic and functional levels. Here, we review common and unique features of T cells in different tissues and discuss putative strategies aimed at harnessing T cells for site-specific protection against infectious and malignant diseases.
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http://dx.doi.org/10.1016/j.it.2021.08.002DOI Listing
October 2021

Content-Noise Complementary Learning for Medical Image Denoising.

IEEE Trans Med Imaging 2021 Sep 16;PP. Epub 2021 Sep 16.

Medical imaging denoising faces great challenges, yet is in great demand. With its distinctive characteristics, medical imaging denoising in the image domain requires innovative deep learning strategies. In this study, we propose a simple yet effective strategy, the content-noise complementary learning (CNCL) strategy, in which two deep learning predictors are used to learn the respective content and noise of the image dataset complementarily. A medical image denoising pipeline based on the CNCL strategy is presented, and is implemented as a generative adversarial network, where various representative networks (including U-Net, DnCNN, and SRDenseNet) are investigated as the predictors. The performance of these implemented models has been validated on medical imaging datasets including CT, MR, and PET. The results show that this strategy outperforms state-of-the-art denoising algorithms in terms of visual quality and quantitative metrics, and the strategy demonstrates a robust generalization capability. These findings validate that this simple yet effective strategy demonstrates promising potential for medical image denoising tasks, which could exert a clinical impact in the future. Code is available at: https://github.com/gengmufeng/CNCL-denoising.
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http://dx.doi.org/10.1109/TMI.2021.3113365DOI Listing
September 2021

Accurate Identification and Early Diagnosis of Osteosarcoma through CRISPR-Cas12a-Based Average Telomerase Activity Detection.

ACS Synth Biol 2021 09 8;10(9):2409-2416. Epub 2021 Sep 8.

Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province 150081, China.

Sensitive and reliable analysis of telomerase activity is important for clinical diagnosis, therapy, and prognosis of osteosarcoma. Telomerase activity is a complicated concept including both the amount of active telomerases and the length of the telomerases extension product. Still, few of the strategies formerly proposed distinguish the two aspects of telomerase activity. Herein, we propose a novel CRISPR-Cas12a-based fluorescent sensing platform that can output signals of both the amounts of telomerase and length of telomerase extension products with the assistance of an elegantly designed stem-loop probe and CRISPR-Cas12a system. On this basis, we induced a novel index, average telomerase activity, for accurate cancer reporting. Through systematic laboratory and clinical experiments, we have demonstrated that average telomerase activity can accurately distinguish cancer cells and has the potential for osteosarcoma staging.
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http://dx.doi.org/10.1021/acssynbio.1c00389DOI Listing
September 2021

13C-Urea Breath Test for the Diagnosis of Infection in Patients after Partial Gastrectomy: A Systematic Review and Meta-Analysis.

J Invest Surg 2021 Sep 7:1-10. Epub 2021 Sep 7.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: The C-urea breath test (C-UBT) is a kind of safe, noninvasive, and reliable measure for () infection diagnosis in patients with complete stomach. Nevertheless, the test has not indicated fully precision in people who have had a gastrectomy. So, we made the use of a systematic review of plentiful published resources and research and meta-analysis. There are prominent research achievements regarding of utilizing C-UBT for infection patients diagnosis with the residual stomach.

Method: We searched publications available on Cochrane, PubMed, and Embase databases, and on the web of science. The last search was performed in May 2021. The basis model for this meta-analysis was fixed-effect through Metadisc Beta 1.4 software (Universidad Complutense, Madrid, Spain). When measuring the precision of C-urea breath test, we utilized the ratio analysis such as Ratio of diagnostic odds ratio (DOR) and its corresponding 95% confidence interval (95%CI).

Results: Ten associated researches were analyzed with a total of 1065 patients. In general, the sensitivity of included studies ranged from 0.40 to 1.00 (I = 81.2%), whereas the specificity ranged from 0.59 to 1.00 (I = 90.1%). The pooled sensitivity, specificity were 0.83 (95% CI, 0.79-0.86;  < 0.001), 0.79 (95% CI, 0.76-0.83;  < 0.001) respectively. The accuracy ranged from 71 to 99. The positive predictive values ranged from 45 to 100. The negative predictive values ranged from 53 to 100. The combined DOR was 36.02 (95%CI 15.65-82.92; I = 65.8%;  = 0.0018). The corresponding AUC for the SROC curve was 0.92 and the Q value was 0.85.

Conclusion: In conclusion, the outcomes of meta-analysis indicate that during the period of patients' diagnosis in infection, who undergoes partial gastrectomy, has high accuracy.
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http://dx.doi.org/10.1080/08941939.2021.1972185DOI Listing
September 2021

Iron-carbon material enhanced electrokinetic remediation of PCBs-contaminated soil.

Environ Pollut 2021 Dec 1;290:118100. Epub 2021 Sep 1.

Department of Environmental Science, Zhejiang University, Hangzhou, 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Zhejiang University, Hangzhou, 310058, China. Electronic address:

The high toxicity and persistence of polychlorinated biphenyls (PCBs) in the environment demands the development of effective remediation for PCBs-contaminated soils. In this study, electrokinetic (EK) remediation integrated with iron-carbon material (Fe/C) was established and used to remediate PCB28 (1 mg kg) contaminated soil under a voltage gradient of 1 V cm. Effects of Fe/C dosage, soil type, and remediation time were investigated. The operational condition was optimized as 4 g kg Fe/C, yellow soil, and 14 d-remediation, achieving PCB28 removal efficiency of 58.6 ± 8.8% and energy utilization efficiency of 146.5. Introduction of EK-Fe/C did not significantly affect soil properties except for slight soil moisture content increase and total Fe content loss. Soil electrical conductivity exhibited an increasing trend from anode to cathode attributed to EK-induced electromigration and electroosmosis. EK accelerated the corrosion and consumption of reactive Fe/FeC in Fe/C by generating acid condition. Fe/C in turn effectively prevented EK-induced soil acidification and maintained soil neutral to weak alkaline condition. A synergistic effect between EK and Fe/C was revealed by the order of PCB28 removal efficiency-EK-Fe/C (58.6 ± 8.8%) > EK (37.7 ± 1.6%) > Fe/C (6.8 ± 5.0%). This could be primarily attributed to EK and Fe/C enhanced Fenton reaction, where EK promoted Fe/C dissolution and HO generation. In addition to oxidation by Fenton reaction generated ·OH, EK-mediated electrochemical oxidation, Fe/C-induced reduction and migration of Fe/C adsorbed PCBs were all significant contributors to PCB28 removal in the EK-Fe/C system. These findings suggest that the combination of EK and Fe/C is a promising technology for remediation of organics-contaminated soil.
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http://dx.doi.org/10.1016/j.envpol.2021.118100DOI Listing
December 2021

Elevated Plasma Fractalkine Level Is Associated with the Severity of Hemorrhagic Fever with Renal Syndrome in Humans.

Viral Immunol 2021 Sep 31;34(7):491-499. Epub 2021 Aug 31.

Department of Immunology, The Fourth Military Medical University, Xi'an, China.

Hantaan virus infection may cause severe lethal hemorrhagic fever with renal syndrome (HFRS) in humans. The chemokine fractalkine (CX3CL1) acts as a proinflammatory cytokine, and it is elevated in several infectious diseases. However, little is known about the contributions of CX3CL1 to HFRS pathogenesis. Present study detected plasma CX3CL1 levels and expression of the receptor CX3CR1 in HFRS patients and discussed the possible effects of CX3CL1 on pathogenesis of HFRS. Plasma CX3CL1 in acute phase and Critical/Severe groups of HFRS patients were significantly increased compared to that in normal controls ( < 0.001 and  < 0.01, respectively). High plasma CX3CL1 was negatively correlated with platelet count ( = -0.5844,  < 0.0001) and positively correlated with blood urea nitrogen ( = 0.3668,  = 0.0039), creatinine ( = 0.42,  = 0.0008), and white blood cells ( = 0.2646,  = 0.0411). Expression of CX3CR1 on nonclassical and intermediate monocytes was also increased in the acute phase ( < 0.01 for both the cells) and Critical/Severe groups ( < 0.05 and  < 0.01, respectively) of HFRS patients compared to that in normal controls. Taken together, elevation of plasma CX3CL1 in HFRS patients and expression of CX3CR1 on nonclassical and intermediate monocyte subsets might provide new insights into the potential role of CX3CL1/CX3CR1 in pathogenesis of HFRS.
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http://dx.doi.org/10.1089/vim.2020.0244DOI Listing
September 2021

A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.

Semin Cell Dev Biol 2021 Aug 27. Epub 2021 Aug 27.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA; Johns Hopkins Schizophrenia Center, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Olfactory dysfunction is often the earliest indicator of disease in a range of neurological and psychiatric disorders. One tempting working hypothesis is that pathological changes in the peripheral olfactory system where the body is exposed to many adverse environmental stressors may have a causal role for the brain alteration. Whether and how the peripheral pathology spreads to more central brain regions may be effectively studied in rodent models, and there is successful precedence in experimental models for Parkinson's disease. It is of interest to study whether a similar mechanism may underlie the pathology of psychiatric illnesses, such as schizophrenia. However, direct comparison between rodent models and humans includes challenges under light of comparative neuroanatomy and experimental methodologies used in these two distinct species. We believe that neuroimaging modality that has been the main methodology of human brain studies may be a useful viewpoint to address and fill the knowledge gap between rodents and humans in this scientific question. Accordingly, in the present review article, we focus on brain imaging studies associated with olfaction in healthy humans and patients with neurological and psychiatric disorders, and if available those in rodents. We organize this review article at three levels: 1) olfactory bulb (OB) and peripheral structures of the olfactory system, 2) primary olfactory cortical and subcortical regions, and 3) associated higher-order cortical regions. This research area is still underdeveloped, and we acknowledge that further validation with independent cohorts may be needed for many studies presented here, in particular those with human subjects. Nevertheless, whether and how peripheral olfactory disturbance impacts brain function is becoming even a hotter topic in the ongoing COVID-19 pandemic, given the risk of long-term changes of mental status associated with olfactory infection of SARS-CoV-2. Together, in this review article, we introduce this underdeveloped but important research area focusing on its implications in neurological and psychiatric disorders, with several pioneered publications.
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http://dx.doi.org/10.1016/j.semcdb.2021.08.009DOI Listing
August 2021

Differential and Prognostic Significance of HOXB7 in Gliomas.

Front Cell Dev Biol 2021 11;9:697086. Epub 2021 Aug 11.

Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Diffuse glioma is the most common primary tumor of the central nervous system. The prognosis of the individual tumor is heavily dependent on its grade and subtype. Homeobox B7 (HOXB7), a member of the homeobox family, is abnormally overexpressed in a variety of tumors. However, its function in glioma is unclear. In this study, HOXB7 mRNA and protein expression levels were analyzed in 401 gliomas from the CGGA RNA-seq database (325 cases) and our hospital (76 cases). HOXB7 expression, at both mRNA and protein levels, were upregulated in glioblastoma (GBM) and isocitrate dehydrogenase 1 () wild-type glioma tissues. Kaplan-Meier with log-rank test showed that patients with high HOXB7 expression had a poor prognosis ( < 0.0001). Moreover, HOXB7 protein was deleted in 90.9% (20/22) of oligodendrogliomas and 13.0% (3/23) of astrocytomas. The sensitivity and specificity of HOXB7 protein deletion in oligodendroglioma were 90.9% (20/22) and 87.0% (20/23), respectively. To verify the reliability of using HOXB7 in differentiating oligodendroglioma, we used 1p/19q fluorescence hybridization (FISH) testing as a positive control. The Cohen's kappa coefficient of HOXB7 immunohistochemistry staining and 1p/19q FISH testing was 0.778 (95% CI: 0.594-0.962, < 0.001). In conclusion, HOXB7 is an independent predictor of poor prognosis in all grade gliomas. Additionally, HOXB7 is also a highly sensitive and specific indicator to differentiate oligodendroglioma from astrocytoma.
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http://dx.doi.org/10.3389/fcell.2021.697086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385304PMC
August 2021

Low-Power OR Logic Ferroelectric In-Situ Transistor Based on a CuInPS/MoS Van Der Waals Heterojunction.

Nanomaterials (Basel) 2021 Jul 31;11(8). Epub 2021 Jul 31.

Key Laboratory for Wide-Band Gap Semiconductor Materials and Devices of Education, The School of Microelectronics, Xidian University, Xi'an 710071, China.

Due to the limitations of thermodynamics, the Boltzmann distribution of electrons hinders the further reduction of the power consumption of field-effect transistors. However, with the emergence of ferroelectric materials, this problem is expected to be solved. Herein, we demonstrate an OR logic ferroelectric in-situ transistor based on a CIPS/MoS Van der Waals heterojunction. Utilizing the electric field amplification of ferroelectric materials, the CIPS/MoS vdW ferroelectric transistor offers an average subthreshold swing (SS) of 52 mV/dec over three orders of magnitude, and a minimum SS of 40 mV/dec, which breaks the Boltzmann limit at room temperature. The dual-gated ferroelectric in-situ transistor exhibits excellent OR logic operation with a supply voltage of less than 1 V. The results indicate that the CIPS/MoS vdW ferroelectric transistor has great potential in ultra-low-power applications due to its in-situ construction, steep-slope subthreshold swing and low supply voltage.
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http://dx.doi.org/10.3390/nano11081971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400550PMC
July 2021

Risk factors for new ischemic cerebral lesions after carotid artery stenting: A systematic review and meta-analysis.

Ann Vasc Surg 2021 Aug 23. Epub 2021 Aug 23.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; China International Neuroscience Institute (China-INI), Beijing, China; Department of Interventional Neuroradiology, Capital Medical University, Beijing, China. Electronic address:

Background: New ischemic cerebral lesions (NICL) are commonly occur after carotid artery stenting (CAS) with an incidence rate ranging from 18-58% and are detected by diffusion-weighted imaging-magnetic resonance imaging (DWI-MRI). Numerous studies have reported that NICL could increase the risk of future cerebrovascular events and cognitive impairment. This systematic review and meta-analysis aimed to identify risk factors for NICL after CAS.

Methods: Relevant literature reporting risk factors for NICL after CAS were searched. Randomized controlled trials, case-control studies, or cohort studies were included in accordance with the pre-specified eligibility criteria. The risk of bias was assessed using the Cochrane Collaboration criteria and the quality of evidence was assessed with the corresponding scale. Data were analyzed using the RevMan V. 5.3 analysis software.

Results: The final analyses included a total of 21 studies and 1907 participants, including 764 NICL-positives and 1143 NICL-negatives. Determinants for NICL-positivity were age (mean deviation (MD): 2.60; 95% confidence interval (CI): [1.53-3.68]), symptomatic carotid lesions (odds ratio (OR): 1.77; 95% CI: [1.39-2.25]) and smoking (OR: 0.74; 95% CI: [0.58-0.94]). For symptomatic patients, risk factors for NICL-positive included diabetes mellitus (OR: 1.76; 95% CI: [1.09-2.82]), but smoking (OR: 0.54; 95% CI: [0.31-0.93]) was a protective factor. Risk factors for centers with high NICL incidence were age (MD: 2.05; 95% CI: [0.93-3.17]) and symptomatic carotid lesions (OR: 1.77; 95% CI: [1.29-2.45]).

Conclusions: Older age and symptomatic carotid lesions are associated with an increased risk of post-CAS NICL whereas smoking is associated with a decreased risk. Risk factors for NICL in symptomatic patients is diabetes mellitus, while those for patients at centers with high incidence are age and symptomatic carotid lesions. Systematic review registration: CRD42019121129.
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http://dx.doi.org/10.1016/j.avsg.2021.05.031DOI Listing
August 2021

Nano-Zoo Interfacial Interaction as a Design Principle for Hybrid Soil Remediation Technology.

ACS Nano 2021 09 23;15(9):14954-14964. Epub 2021 Aug 23.

Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.

Using nanotechnology to remediate contaminated agricultural soil is promising but faces notable technical and economic challenges. Importantly, widely distributed soil invertebrates can potentially act as natural mobile facilitators for nanoscale remediation of contaminated soil. Herein, we have drawn inspiration from nano-bio interaction and established a hybrid remediation framework using nanoscale zerovalent iron (nZVI) and nematodes for organochlorine-contaminated soil. Approximately 80% pentachlorophenol (PCP, initially 50 mg/kg) was synergistically degraded by nZVI and nematodes within 3 days. Mechanistically, exposure to nZVI stimulated the synthesis of reductive biomolecules (including collagen, glutathione, and l-cysteine) which acted as a bioreductive barrier and significantly mitigated the toxicity of PCP. At the microinterface, collagen distributed in the epidermis chelated nZVI; subsequently, l-cysteine and glutathione strongly accelerated nZVI-induced PCP dechlorination by facilitating the reductive dissolution of nZVI oxide shell and electron transfer from Fe core to PCP. On the basis of the interfacial interaction, an optimized soil remediation approach composed of nZVI, nematodes, and l-cysteine was established, demonstrating a 2.1-fold increase in removal efficiency with only 48.5% nZVI consumption compared with the nZVI treatment alone. This work provides a heuristic model for developing cost-efficient remediation technologies with the synergistic force of functional materials and indigenous biota, which may be widely applicable to a range of environmental contamination scenarios.
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http://dx.doi.org/10.1021/acsnano.1c05180DOI Listing
September 2021

Severe hypoglycemia and finger clubbing in a patient with a BRCA1 mutation in a solitary fibrous tumor: a case report.

Ann Transl Med 2021 Jul;9(13):1093

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Solitary fibrous tumors (SFTs) are rare tumors that stem from mesenchymal cells of submesothelial tissues belonging to the pleura. They can occur in many places such as the spinal canal, intracranial, neck, kidney, liver, pelvis, limbs and other places, most commonly in the chest and abdomen. Pleural SFTs are one of the most common types, and are common in middle-aged people. Pleural SFTs can have an insidious expression, such that the illness can progress for years before diagnosis. SFTs can induce paraneoplastic syndromes, such as reactive hypoglycemia [Doege-Potter syndrome (DPS)] or hypertrophic osteoarthropathy [Pierre-Marie-Bamberger syndrome (PMBS)]. In this article, we report a case study of a 51-year-old man with pleural SFTs. Preoperative imaging examinations, including chest X-ray, computed tomography (CT), and magnetic resonance imaging (MRI), showed a huge mass in the right thoracic cavity, compressing surrounding tissues and organs and may invade other tissues. In addition, he suffers from severe hypoglycemia and finger clubbing, and has successfully undergone a complete resection, and now attends regular follow-up appointments. The paraneoplastic syndromes have resolved, and no recurrence has been found. Importantly, we used next-generation sequencing (NGS) to explore the molecular characteristics of the patient's pathological tissue at the DNA level and mRNA level, and found that breast cancer gene 1 (BRAC1) mutations may be an important pathogenic factor.
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http://dx.doi.org/10.21037/atm-21-914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339833PMC
July 2021

Safety and Efficacy of Laparoscopic Versus Open Gastrectomy in Patients With Advanced Gastric Cancer Following Neoadjuvant Chemotherapy: A Meta-Analysis.

Front Oncol 2021 6;11:704244. Epub 2021 Aug 6.

Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

Background: Given the expanding clinical applications of laparoscopic surgery and neoadjuvant chemotherapy in advanced gastric cancer treatment, there is an emerging need to summarize the few evidences that evaluated the safety and efficacy of laparoscopic versus open gastrectomy in patients with advanced gastric cancer (AGC) following neoadjuvant chemotherapy (NAC).

Methods: From January 1 to 2, 2021, we searched Ovid Embase, PubMed, Cochrane central register Trials (Ovid), and web of science to find relevant studies published in English, and two authors independently performed literature screening, quality assessment of the included studies, data extraction, and data analysis. This study was registered with PROSPERO (CRD42021228845).

Results: The initial search retrieved 1567 articles, and 6 studies were finally included in the meta-analysis review, which comprised 2 randomized control trials and 4 observational studies involving 288 laparoscopic gastrectomy (LG) and 416 open gastrectomy (OG) AGC patients treated with NAC. For intraoperative conditions, R0 resection rate, blood transfusion, intraoperative blood loss, number of lymph nodes dissected, proximal margin, and distal margin were comparable between LG group and open OG group. For postoperative short-term clinical outcomes, LG has significantly less postoperative complications (OR = 0.65, 95%CI: 0.42-1.00, p = 0.05) and shorter postoperative time to first aerofluxus (WMD = -0.57d, 95%CI: -0.89-0.25, p = 0.0004) than OG, and anastomotic leakage, pulmonary infection, pleural effusion, surgical site infection, thrombosis, intestinal obstruction, peritoneal effusion or abscess formation, postoperative time to first defecation, postoperative time to first liquid diet, and postoperative length of stay were comparable between the two groups. For postoperative survival outcomes, there were no significant differences in disease-free survival (DFS) and overall survival (OS) between the two groups.

Conclusion: The available evidences indicated that LG is an effective and feasible technology for the treatment of AGC patients treated with NAC, and LG patients have much less postoperative complications and faster bowel function recovery than OG patients.

Systematic Review Registration: PROSPERO database (identifier, CRD42021228845).
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http://dx.doi.org/10.3389/fonc.2021.704244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377369PMC
August 2021

Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model.

Med Sci Monit 2021 Aug 17;27:e932545. Epub 2021 Aug 17.

Department of Oromaxillofacial - Head and Neck Surgery, Tianjin Stomatological Hospital, Tianjin, China (mainland).

BACKGROUND The type of traumatic temporomandibular joint (TMJ) ankylosis depends on the degree of severity of TMJ trauma. Here, we performed comprehensive differential molecular profiling between TMJ fibrous and bony ankylosis. MATERIAL AND METHODS Six sheep were used and a bilateral different degree of TMJ trauma was performed to induce fibrous ankylosis in one side and bony ankylosis in the other side. The ankylosed calluses were harvested at days 14 and 28 postoperatively and analyzed by Affymetrix OviGene-1_0-ST microarrays. DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). The DEGs were also typed into protein-protein interaction (PPI) networks to get the interaction data. Ten DEGs, including 7 hub genes from PPI analysis, were confirmed by real-time PCR. RESULTS We found 90 and 323 DEGs at least 2-fold at days 14 and 28, respectively. At day 14, bony ankylosis showed upregulated DEGs, such as TLR8, SYK, NFKBIA, PTPRC, CD86, ITGAM, and ITGAL, indicating a stronger immune and inflammatory response and cell adhesion, while genes associated with anti-adhesion (PRG4) and inhibition of osteoblast differentiation (SFRP1) had higher expression in fibrous ankylosis. At day 28, bony ankylosis showed increased biological process related to new bone formation, while fibrous ankylosis was characterized by a prolonged immune and inflammatory reaction. CONCLUSIONS This study provides a differential gene expression profile between TMJ fibrous and bony ankylosis. Further study of these key genes may provide new ideas for future treatment of TMJ bony ankylosis.
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http://dx.doi.org/10.12659/MSM.932545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379999PMC
August 2021
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