Kumar V S Nemmani

Kumar V S Nemmani

UNVERIFIED PROFILE

Are you Kumar V S Nemmani?   Register this Author

Register author
Kumar V S Nemmani

Kumar V S Nemmani

Publications by authors named "Kumar V S Nemmani"

Are you Kumar V S Nemmani?   Register this Author

34Publications

595Reads

44Profile Views

Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes.

Med Mol Morphol 2019 Mar 29;52(1):36-43. Epub 2018 Jun 29.

Department of Pharmacology, Novel Drug Discovery and Development (NDDD), Lupin Limited (Research Park), 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra, 412115, India.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00795-018-0200-4
Publisher Site
http://dx.doi.org/10.1007/s00795-018-0200-4DOI Listing
March 2019

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders.

Expert Opin Ther Targets 2018 07 22;22(7):615-628. Epub 2018 Jun 22.

a Department of Pharmacology, Novel Drug Discovery and Development , Lupin Limited , Pune , India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14728222.2018.1487952DOI Listing
July 2018

Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models.

Eur J Drug Metab Pharmacokinet 2018 Jun;43(3):331-346

Department of Pharmacology, Lupin Limited (Research Park), Pune, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13318-017-0454-6DOI Listing
June 2018

Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-AlaGIP in rat model of Huntington's disease.

Eur J Pharmacol 2018 Jun 22;828:31-41. Epub 2018 Mar 22.

Department of Pharmacology, Novel Drug Discovery and Development, Lupin Limited, Lupin Research Park, Survey No. 46A/47A, Village Nande, Taluka Mulshi, Pune 412115, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2018.03.034DOI Listing
June 2018

Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet.

Biochem Biophys Res Commun 2018 01 5;495(2):1608-1613. Epub 2017 Dec 5.

Lupin Limited (Research Park), Department of Pharmacology, Novel Drug Discovery and Development (NDDD), 46A/47A, Village Nande, Mulshi, Pune, 412 115, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2017.12.004DOI Listing
January 2018

Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice.

Eur J Drug Metab Pharmacokinet 2017 Oct;42(5):835-847

Department of Pharmacology, Lupin Limited (Research Park), Pune, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13318-017-0402-5DOI Listing
October 2017

Effect of D-AlaGIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice.

Eur J Pharmacol 2017 Jun 31;804:38-45. Epub 2017 Mar 31.

Department of Pharmacology, Novel Drug Discovery and Development, Lupin Limited (Research Park), Pune 412115, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2017.03.059DOI Listing
June 2017

APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice.

Eur J Pharmacol 2017 Apr 6;801:35-45. Epub 2017 Mar 6.

Lupin Limited (Research Park), Department of Pharmacology, Novel Drug Discovery and Development (NDDD), 46A/47A, Village Nande, Mulshi, Pune 412115, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2017.02.043DOI Listing
April 2017

Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen.

Bioorg Med Chem Lett 2014 Dec 5;24(24):5587-5592. Epub 2014 Nov 5.

Medicinal Chemistry Division, Piramal Life Sciences, Piramal Enterprises Limited, 1-Nirlon Complex, Goregaon East, Mumbai 400063, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.10.096DOI Listing
December 2014

Lead optimization of isocytosine-derived xanthine oxidase inhibitors.

Bioorg Med Chem Lett 2013 Feb 29;23(3):834-8. Epub 2012 Nov 29.

Department of Medicinal Chemistry, Piramal Healthcare Limited, Goregaon (E), Mumbai 400 063, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2012.11.057DOI Listing
February 2013

Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat.

Inflammopharmacology 2010 Aug 21;18(4):157-68. Epub 2010 May 21.

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-010-0043-7DOI Listing
August 2010

Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents.

Expert Opin Investig Drugs 2010 Apr;19(4):489-512

Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon (E), Mumbai - 400 063, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543781003640169DOI Listing
April 2010

NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs.

Bioorg Med Chem Lett 2009 Sep 3;19(18):5297-301. Epub 2009 Aug 3.

Pharmacology Department, Piramal Life Sciences Limited, Nirlon Complex, Goregaon East, Mumbai 400 063, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.07.142DOI Listing
September 2009

Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.

Bioorg Med Chem Lett 2009 Jun 18;19(11):2949-52. Epub 2009 Apr 18.

Department of Medicinal Chemistry, Piramal Life Sciences, 1-Nirlon Complex, Goregaon (E), Mumbai, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.04.055DOI Listing
June 2009

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes.

Expert Opin Ther Pat 2009 Feb;19(2):237-64

Department of Medicinal Chemistry & Pharmacology, Piramal Life Sciences Limited, Goregaon, Mumbai, India.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.1517/1354377080266571
Publisher Site
http://dx.doi.org/10.1517/13543770802665717DOI Listing
February 2009

Region-specific changes of calcium/calmodulin-dependent protein kinase IV in the mouse brain following chronic morphine treatment.

Neuroreport 2005 Jun;16(9):879-82

Department of Psychology and Centre for Research on Pain, McGill University, 1205 Dr Penfield Avenue, Montréal, Canada, Que. H3A 1B1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00001756-200506210-00001DOI Listing
June 2005

The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific.

Pharmacol Biochem Behav 2005 May 12;81(1):131-8. Epub 2005 Apr 12.

Department of Psychology, Furman University, 3300 Poinsett Highway, Greenville, SC 29613, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2005.03.001DOI Listing
May 2005

Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.

Pain 2004 Jun;109(3):274-83

Department of Psychology and Centre for Research on Pain, McGill University, 1205 Dr Penfield Ave., Montreal, QC, Canada H3A 1B1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pain.2004.01.035DOI Listing
June 2004

Protective effect of a polyherbal formulation (Immu-21) against cyclophosphamide-induced mutagenicity in mice.

Phytother Res 2003 Apr;17(4):306-10

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S A S Nagar, Punjab 160 062, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ptr.1125DOI Listing
April 2003

Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice.

Life Sci 2003 Jan;72(7):759-68

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Phase-X, S. A. S., Nagar-160 062 (Pb), India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0024-3205(02)02333-0DOI Listing
January 2003

Ginseng total saponin potentiates acute U-50,488H-induced analgesia and inhibits tolerance to U-50,488H-induced analgesia in mice.

Pharmacol Biochem Behav 2002 May;72(1-2):1-6

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Phase-X, Sector 67, SAS Nagar, Mohali 160 062 Pb, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0091-3057(02)00720-7DOI Listing
May 2002

Role of Ca2+ channels on the hypothermic response produced by activation of kappa-opioid receptors.

Pharmacol Biochem Behav 2002 May;72(1-2):93-9

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Phase-X, Sector 67, S.A.S. Nagar Mohali-160 062, Punjab, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0091-3057(01)00726-2DOI Listing
May 2002

Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.

Life Sci 2002 Mar;70(15):1727-40

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Nagar, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0024-3205(02)01496-0DOI Listing
March 2002

Cell proliferation and natural killer cell activity by polyherbal formulation, Immu-21 in mice.

Indian J Exp Biol 2002 Mar;40(3):282-7

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S. A. S. Nagar 160 062, India.

View Article

Download full-text PDF

Source
March 2002