Publications by authors named "Kumar Nilesh"

131 Publications

Fluid based visual prognostication in Type 3 macular neovascularization (MNV)- FLIP-3 Study.

Retina 2021 Jul 9. Epub 2021 Jul 9.

Department of Vitreoretina, Lotus Eye Hospital and Institute, Coimbatore, TN, India Singapore National Eye Center, Singapore Department of Ophthalmology, Bellvitge University Hospital, Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona Spain Ophthalmology Department, Gazi University School of Medicine, Besevler, Ankara, Turkey Division of Ophthalmology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Israel Department of Ophthalmology; University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy.

Purpose: To analyze the effect of fluid on visual acuity in cases of Type 3 macular neovascularization (MNV).

Methods: This multi-centric, retrospective cohort study included eyes with treatment-naïve Type 3 MNV. Analysis of fluid in different compartments was performed. Group A included eyes with isolated intraretinal fluid (IRF), while Group B included eyes with IRF in conjunction with sub retinal fluid (SRF) and/or sub retinal pigment epithelial fluid (Sub-RPEF).

Results: Eyes in Group A (31, 55.3%) had better BCVA of 20/50 snellen equivalent (0.42 ± 0.31 logMAR) at baseline and 20/50 snellen equivalent (0.40 ±0.28 logMAR) at complete resolution compared to Group B with visual acuity of 20/80 snellen equivalent (0.64 ± 0.35 logMAR) (p= 0.0181) at baseline and 20/100 snellen equivalent (0.70 ± 0.40 logMAR) (p= 0.0021) at complete resolution. Subfoveal atrophy was more in Group B (82.6% 19/23) at complete resolution in comparison to Group A ((16/31, 51.6%). Eyes in Group B needed more anti-VEGF injections (10.3±9.0) for complete resolution compared to Group A (5.7±4.8).

Conclusion: IRF might be associated with good visual acuity in Type 3 MNV in contrast to other forms of n-AMD. Furthermore, IRF in isolation might need fewer injections and could probably be associated with less subfoveal atrophy.
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http://dx.doi.org/10.1097/IAE.0000000000003261DOI Listing
July 2021

Dynamic Regulatory Event Mining by iDREM in Large-Scale Multi-omics Datasets During Biotic and Abiotic Stress in Plants.

Methods Mol Biol 2021 ;2328:191-202

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

The system-wide complexity of genome regulation encoding the organism phenotypic diversity is well understood. However, a major challenge persists about the appropriate method to describe the systematic dynamic genome regulation event utilizing enormous multi-omics datasets. Here, we describe Interactive Dynamic Regulatory Events Miner (iDREM) which reconstructs gene-regulatory networks from temporal transcriptome, proteome, and epigenome datasets during stress to envisage "master" regulators by simulating cascades of temporal transcription-regulatory and interactome events. The iDREM is a Java-based software that integrates static and time-series transcriptomics and proteomics datasets, transcription factor (TF)-target interactions, microRNA (miRNA)-target interaction, and protein-protein interactions to reconstruct temporal regulatory network and identify significant regulators in an unsupervised manner. The hidden Markov model detects specialized manipulated pathways as well as genes to recognize statistically significant regulators (TFs/miRNAs) that diverge in temporal activity. This method can be translated to any biotic or abiotic stress in plants and animals to predict the master regulators from condition-specific multi-omics datasets including host-pathogen interactions for comprehensive understanding of manipulated biological pathways.
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http://dx.doi.org/10.1007/978-1-0716-1534-8_12DOI Listing
January 2021

Inference of Gene Regulatory Network from Single-Cell Transcriptomic Data Using pySCENIC.

Methods Mol Biol 2021 ;2328:171-182

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

With the advent of recent next-generation sequencing (NGS) technologies in genomics, transcriptomics, and epigenomics, profiling single-cell sequencing became possible. The single-cell RNA sequencing (scRNA-seq) is widely used to characterize diverse cell populations and ascertain cell type-specific regulatory mechanisms. The gene regulatory network (GRN) mainly consists of genes and their regulators-transcription factors (TF). Here, we describe the lightning-fast Python implementation of the SCENIC (Single-Cell reEgulatory Network Inference and Clustering) pipeline called pySCENIC. Using single-cell RNA-seq data, it maps TFs onto gene regulatory networks and integrates various cell types to infer cell-specific GRNs. There are two fast and efficient GRN inference algorithms, GRNBoost2 and GENIE3, optionally available with pySCENIC. The pipeline has three steps: (1) identification of potential TF targets based on co-expression; (2) TF-motif enrichment analysis to identify the direct targets (regulons); and (3) scoring the activity of regulons (or other gene sets) on single cell types.
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http://dx.doi.org/10.1007/978-1-0716-1534-8_10DOI Listing
January 2021

Faricimab: Two in the Bush Is Proving Better than One in the Hand?

Ocul Immunol Inflamm 2021 Jul 9:1-3. Epub 2021 Jul 9.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1080/09273948.2021.1931350DOI Listing
July 2021

Ranibizumab Biosimilar (Razumab) vs Innovator Ranibizumab (Lucentis) in neovascular age-related macular degeneration (n-AMD)- efficacy and safety (BIRA study).

Eye (Lond) 2021 Jun 22. Epub 2021 Jun 22.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1038/s41433-021-01616-9DOI Listing
June 2021

Network biology to uncover functional and structural properties of the plant immune system.

Curr Opin Plant Biol 2021 Jun 5;62:102057. Epub 2021 Jun 5.

Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL, 35294, USA. Electronic address:

In the last two decades, advances in network science have facilitated the discovery of important systems' entities in diverse biological networks. This graph-based technique has revealed numerous emergent properties of a system that enable us to understand several complex biological processes including plant immune systems. With the accumulation of multiomics data sets, the comprehensive understanding of plant-pathogen interactions can be achieved through the analyses and efficacious integration of multidimensional qualitative and quantitative relationships among the components of hosts and their microbes. This review highlights comparative network topology analyses in plant-pathogen co-expression networks and interactomes, outlines dynamic network modeling for cell-specific immune regulatory networks, and discusses the new frontiers of single-cell sequencing as well as multiomics data integration that are necessary for unraveling the intricacies of plant immune systems.
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http://dx.doi.org/10.1016/j.pbi.2021.102057DOI Listing
June 2021

Biosimilar Ranibizumab (SB11) vs Reference Ranibizumab-Diving Deeper for Safety and Efficacy.

JAMA Ophthalmol 2021 Jun;139(6):677-679

Department of Vitreoretina, Lotus Eye Hospital and Institute, Coimbatore, India.

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http://dx.doi.org/10.1001/jamaophthalmol.2021.1037DOI Listing
June 2021

Terms non-exudative and non-neovascular: awaiting entry at the doors of AMD reclassification.

Graefes Arch Clin Exp Ophthalmol 2021 06 21;259(6):1381-1383. Epub 2021 Mar 21.

Center for Public Health, Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1007/s00417-021-05164-6DOI Listing
June 2021

Re: Kunimoto et al.: Efficacy and safety of abicipar in neovascular age-related macular degeneration: 52-week results of phase 3 randomized controlled study (Ophthalmology. 2020:127:1331-1334).

Ophthalmology 2021 Jun 27;128(6):e30. Epub 2021 Feb 27.

Department of Vitreoretina, Lotus Eye Hospital and Institute, Coimbatore, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.ophtha.2021.01.025DOI Listing
June 2021

Understanding the Mechanisms of Fluid Development in Age-Related Macular Degeneration.

Ophthalmol Retina 2021 02;5(2):105-107

Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.oret.2020.09.016DOI Listing
February 2021

Large impacted foreign body in maxillofacial region: an occupational hazard.

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Surgery, Krishna Institute of Medical Sciences Deemed University, Karad, India.

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http://dx.doi.org/10.1136/bcr-2020-239400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845726PMC
January 2021

Molecular pathology associated with altered synaptic transcriptome in the dorsolateral prefrontal cortex of depressed subjects.

Transl Psychiatry 2021 01 22;11(1):73. Epub 2021 Jan 22.

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Disrupted synaptic plasticity is the hallmark of major depressive disorder (MDD), with accompanying changes at the molecular and cellular levels. Often, the maladaptive molecular changes at the synapse are the result of global transcriptional reprogramming dictated by activity-dependent synaptic modulation. Thus far, no study has directly studied the transcriptome-wide expression changes locally at the synapse in MDD brain. Here, we have examined altered synaptic transcriptomics and their functional relevance in MDD with a focus on the dorsolateral prefrontal cortex (dlPFC). RNA was isolated from total fraction and purified synaptosomes of dlPFC from well-matched 15 non-psychiatric controls and 15 MDD subjects. Transcriptomic changes in synaptic and total fractions were detected by next-generation RNA-sequencing (NGS) and analyzed independently. The ratio of synaptic/total fraction was estimated to evaluate a shift in gene expression ratio in MDD subjects. Bioinformatics and network analyses were used to determine the biological relevance of transcriptomic changes in both total and synaptic fractions based on gene-gene network, gene ontology (GO), and pathway prediction algorithms. A total of 14,005 genes were detected in total fraction. A total of 104 genes were differentially regulated (73 upregulated and 31 downregulated) in MDD group based on 1.3-fold change threshold and p < 0.05 criteria. In synaptosomes, out of 13,236 detectable genes, 234 were upregulated and 60 were downregulated (>1.3-fold, p < 0.05). Several of these altered genes were validated independently by a quantitative polymerase chain reaction (qPCR). GO revealed an association with immune system processes and cell death. Moreover, a cluster of genes belonged to the nervous system development, and psychological disorders were discovered using gene-gene network analysis. The ratio of synaptic/total fraction showed a shift in expression of 119 genes in MDD subjects, which were primarily associated with neuroinflammation, interleukin signaling, and cell death. Our results suggest not only large-scale gene expression changes in synaptosomes, but also a shift in the expression of genes from total to synaptic fractions of dlPFC of MDD subjects with their potential role in immunomodulation and cell death. Our findings provide new insights into the understanding of transcriptomic regulation at the synapse and their possible role in MDD pathogenesis.
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http://dx.doi.org/10.1038/s41398-020-01159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822869PMC
January 2021

Management of unilateral idiopathic masseter muscle hypertrophy with botulinum toxin type A.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Oral & Maxillofacial Surgery, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.

Masseter hypertrophy (MH) is an uncommon disorder which can cause both aesthetic and functional problems. The most common aetiological factors associated with MH are habit of chewing gum, clenching and/or bruxism. The treatment of MH includes conservative management as well as surgical resection of the enlarged muscle and/or bone. Injection of botulinum toxin type A is a relatively new and minimally invasive method for management of masseter muscle hypertrophy, which offers many advantages over conventional surgical management. This paper reports a case of unilateral MH of unknown origin which was treated with injection of botulinum toxin type A, resulting in satisfactory reduction in the volume of muscle and improvement of facial aesthetics.
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http://dx.doi.org/10.1136/bcr-2020-239056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813317PMC
January 2021

Retrieval of foreign body from maxillary sinus through extraction socket.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Oral & Maxillofacial Surgery, Krishna Institute of Medical Sciences Deemed University, Karad, India

Dry socket or alveolar osteitis is one of the most common complication following tooth extraction. Patients usually reports of pain, which typically starts on third or fourth postoperative day and responds to simple irrigation and placement of zinc oxide eugenol (ZOE) pack, which provides an obtundent effect. The pack should be loosely kept in the extraction socket and should be changed periodically to allow healing. This report presents a case of retrieval of foreign body, which actually was a ZOE pack from maxillary sinus, 6 months after the patient underwent extraction of upper left maxillary first molar.
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http://dx.doi.org/10.1136/bcr-2020-238665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813383PMC
January 2021

Unusual presentation of mucormycosis mimicking a localised sino-orbital pathology.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

OMFS, Pravara Rural Dental College, Ahmednagar, Maharashtra, India.

Mucormycosis is an aggressive and deadly fungal infection, which is invariably associated with an immunocompromised patient. Mucormycosis in the head and neck region presents as skeletal necrosis, with or without soft tissue involvement. Early identification and treatment with combination of surgical debridement and parenteral antifungal therapy is critical for a favourable outcome. This paper reports an unusual presentation of mucormycosis, mimicking a localised sino-orbital pathology involving the infraorbital subcutaneous tissue and the maxillary sinus, in a 35 years old immunocompetent man. Despite aggressive antifungal therapy and surgical management, the course of disease was fatal, reiterating the high mortality associated with mucormycosis.
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http://dx.doi.org/10.1136/bcr-2020-239199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802651PMC
January 2021

Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.

Rev Med Virol 2020 Dec 31:e2204. Epub 2020 Dec 31.

Department of Innate Immunity, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions of various innate and adaptive immune cells and promotes immune-homeostasis. Importantly, it augments the interferon-based innate immune response to RNA viruses decreasing RNA virus replication. Several clinical trials report decreased mortality in measles and Ebola with vitamin A supplementation.During the Covid-19 pandemic interventions such as convalescent plasma, antivirals, monoclonal antibodies and immunomodulator drugs have been tried but most of them are difficult to implement in resource-limited settings. The current review explores the possibility of mega dose vitamin A as an affordable adjunct therapy for Covid-19 illness with minimal reversible side effects. Insight is provided into the effect of vitamin A on ACE-2 expression in the respiratory tract and its association with the prognosis of Covid-19 patients. Vitamin A supplementation may aid the generation of protective immune response to Covid-19 vaccines. An overview of the dosage and safety profile of vitamin A is presented along with recommended doses for prophylactic/therapeutic use in randomised controlled trials in Covid-19 patients.
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http://dx.doi.org/10.1002/rmv.2204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883262PMC
December 2020

Central ossifying fibroma of mandible.

BMJ Case Rep 2020 Dec 28;13(12). Epub 2020 Dec 28.

Department of Radiodiagnosis, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.
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http://dx.doi.org/10.1136/bcr-2020-239286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772295PMC
December 2020

Large oral focal mucinosis involving the left hemimandible.

BMJ Case Rep 2020 Dec 15;13(12). Epub 2020 Dec 15.

Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.

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http://dx.doi.org/10.1136/bcr-2020-235591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745335PMC
December 2020

Avascular necrosis of mandibular condyle: a case against extracorporeal fixation of condylar fracture.

Authors:
Kumar Nilesh

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

Oral & Maxillofacial Surgery, Krishna Institute of Medical Sciences Deemed University, Karad, India

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http://dx.doi.org/10.1136/bcr-2020-239737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737047PMC
December 2020

Biosimilars for Retinal Diseases: An Update.

Am J Ophthalmol 2021 04 9;224:36-42. Epub 2020 Dec 9.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Purpose: To review the biosimilars of anti-vascular endothelial growth factor agents for retinal diseases and provide an update about their development.

Design: Literature review.

Methods: A comprehensive literature review was performed for scientific articles, clinical trials, and press releases for the development of biosimilars in ophthalmology.

Results: To date, Razumab (Intas Pharmaceuticals Ltd, Ahmedabad, GJ, India) is the only approved biosimilar for ophthalmic use, but the landscape will rapidly change in the future with multiple biosimilar candidates, which are currently in phase 3 trials, showing promising early results.

Conclusion: Biosimilars hold the potential to reduce the financial burden of the highly efficacious biologic therapy in retinal pathologies. However, the off-label bevacizumab may differentiate the success of biosimilars in different geographic regions.
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http://dx.doi.org/10.1016/j.ajo.2020.11.017DOI Listing
April 2021

Utility of nested polymerase chain reaction for fungus in detecting clinically suspected patients of invasive fungal infections and its clinical correlation and comparison with fungal culture.

J Family Med Prim Care 2020 Sep 30;9(9):4992-4997. Epub 2020 Sep 30.

Department of General Medicine, IMS, BHU, Varanasi, Uttar Pradesh, India.

Aims And Objectives: The aim and objective of this study is to detect invasive fungal infections (IFIs) early and with more sensitivity by the nested polymerase chain reaction (PCR) for fungus as compared to fungal culture in clinically suspected patients and also explore its correlation in reference to age, duration of symptoms, immunocompromised status, and other risk factors predisposing to IFIs.

Materials And Methods: In this cross-sectional study, 50 suspected patients admitted in medical acute care unit/intensive care unit (ACU/ICU) of Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, India, comprised the study. All cases were selected based on the predefined inclusion and exclusion criteria. A detailed history, clinical examination, and all required investigations were done in all suspected patients. Blood samples were taken for nested-PCR for fungus and culture. Nested PCR was performed on extracted DNA form samples collected from all participants under the study.

Results: Our study comprised of 50 suspected immunocompromised patients of IFIs. Among the participants under the study, the most common risk factor was diabetes mellitus (28% cases). Nearly two-thirds (60%) of the cases were 50 years or more. Around 70% of the cases had a history of illness more than 2 weeks. Nested PCR for fungus came out to be positive in 21/50 patients (42%); however, fungal culture was positive in none. Among the admitted patient in ACU/ICU, 75% were neutropenic.

Conclusions: IFIs are more common in immunocompromised individuals, patients with comorbidities, long history of symptoms, and elderly population. Nested PCR for fungus has a high sensitivity (as compared to the fungal culture), and also they are rapid in giving the results. Thus, nested PCR for fungus can be used in a cost-effective manner for the early and reliable diagnosis of clinically suspected IFIs.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_775_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652180PMC
September 2020

Zenker's diverticulum: a rare clinical condition with unusual oral manifestation.

BMJ Case Rep 2020 Oct 31;13(10). Epub 2020 Oct 31.

Oral and Maxillofacial Surgery, Krishna Institute of Medical Sciences Deemed University, Karad, India

Oral mucosa exhibit clinical manifestations of a variety of systemic conditions and can serve as an indicator of overall health of an individual. Various systemic conditions like autoimmune, endocrine and haematological disorders can present with oral mucosal lesions, which can serve as an important diagnostic feature. These oral lesions can vary from oral ulceration, bleeding gums, xerostomia, chronic glossitis, to erosion and sensitivity of teeth. It is important that a clinician must be aware of the oral presentations of systemic conditions, so that timely diagnosis can be made and the necessary treatment is executed. This paper presents an unusual case of severe oral mucosal ulcerations and dysphagia in an elderly patient diagnosed with Zenker's diverticulum. Patient was relieved of all oral symptoms once the underlying gastrointestinal tract pathology was diagnosed and surgically corrected.
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http://dx.doi.org/10.1136/bcr-2020-239248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783602PMC
October 2020

Brolucizumab-related retinal vasculitis: emerging disconnect between clinical trials and real world.

Eye (Lond) 2021 05 20;35(5):1292-1294. Epub 2020 Oct 20.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1038/s41433-020-01227-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182886PMC
May 2021

Reconstruction of acquired lip defects: Ten-year experience at a tertiary care center.

J Oral Biol Craniofac Res 2020 Oct-Dec;10(4):698-704. Epub 2020 Sep 30.

Dept. of Oral & Maxillofacial Surgery, Sardar Patel Dental College, Luckhnow, Uttar Pradesh, India.

Aim: The purpose of this paper is to describe different acquired conditions necessitating lip reconstruction and present our ten-years' experience in managing the same at a tertiary care hospital.

Materials And Methods: Data of patients undergoing reconstruction of acquired lip defects from January 2009 to December 2019 were analyzed for demographic details, etiology, extent of defect, reconstruction option used, outcome and complications.

Results: 89 patients underwent lip reconstruction after excision of malignant tumors (81%), vascular malformations (12%) and traumatic injuries (7%). Mucosal and cutaneous lip defects were seen in 8 (9%) and 3 (3%) patients respectively, which were treated by primary closure, local advancement flap and tongue flap. Full thickness defects involving less than 1/3rd of lip (36%) and involving up to 2/3rd of lip (33%) were treated by primary closure, Abbe, Abbe Estlander flap and Karapenzic, Bernard Webster & peri-alar crescentic flaps respectively. Sub-total lip defects were repaired using distant and free vascularized flaps. All the localized cutaneous/mucosal defect repair healed uneventfully. Complications associated full thickness defect reconstruction included reduced stoma, flap necrosis and hypertrophic scar.

Conclusions: Repair of localized cutaneous/mucosal defects of lip are simple with no significant documented complication. However, full thickness tissue loss necessities careful surgical planning. The choice of surgical technique depends on the extent of lip length lost. While Karapandzic flap was most commonly utilized to reconstruct lip defect involving up to 2/3rd of the lip, radial forearm flap was a choice in managing subtotal lip tissue loss.
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http://dx.doi.org/10.1016/j.jobcr.2020.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548440PMC
September 2020
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