Kum Kum Khanna

Kum Kum Khanna

UNVERIFIED PROFILE

Are you Kum Kum Khanna?   Register this Author

Register author
Kum Kum Khanna

Kum Kum Khanna

Publications by authors named "Kum Kum Khanna"

Are you Kum Kum Khanna?   Register this Author

100Publications

2866Reads

8Profile Views

First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.

J Cell Sci 2019 Sep 26;132(18). Epub 2019 Sep 26.

The Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, The University of Queensland, Herston 4029, QLD, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.233379DOI Listing
September 2019

Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.

Redox Biol 2019 Aug 28;28:101310. Epub 2019 Aug 28.

School of Environment and Science, Griffith University, Nathan, QLD, 4111, Australia; Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, 4111, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2019.101310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742860PMC
August 2019

Mechanisms of Genomic Instability in Breast Cancer.

Trends Mol Med 2019 Jul 8;25(7):595-611. Epub 2019 May 8.

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2019.04.004DOI Listing
July 2019

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival.

Cancers (Basel) 2019 Jul 29;11(8). Epub 2019 Jul 29.

Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, 38320 La Laguna, Tenerife, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11081073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721324PMC
July 2019

MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells.

Oncogene 2019 Jun 10;38(26):5239-5249. Epub 2019 Apr 10.

School of Pharmacy, University of Queensland, Brisbane, QLD, 4102, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-019-0789-3DOI Listing
June 2019

A Comprehensive Review on Current Advances in Peptide Drug Development and Design.

Int J Mol Sci 2019 May 14;20(10). Epub 2019 May 14.

Radiation Biology Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan.

View Article

Download full-text PDF

Source
https://www.mdpi.com/1422-0067/20/10/2383
Publisher Site
http://dx.doi.org/10.3390/ijms20102383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566176PMC
May 2019

Patterns of Genomic Instability in Breast Cancer.

Trends Pharmacol Sci 2019 03 6;40(3):198-211. Epub 2019 Feb 6.

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01656147193001
Publisher Site
http://dx.doi.org/10.1016/j.tips.2019.01.005DOI Listing
March 2019

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8 T-cells infiltration in triple-negative breast cancer.

J Exp Clin Cancer Res 2019 Feb 18;38(1):85. Epub 2019 Feb 18.

Signal Transduction laboratory, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13046-019-1075-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379987PMC
February 2019

Mitotic slippage: an old tale with a new twist.

Cell Cycle 2019 01 2;18(1):7-15. Epub 2019 Jan 2.

a QIMR Berghofer Medical Research Institute , Herston , QLD , Australia.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15384101.2018.1
Publisher Site
http://dx.doi.org/10.1080/15384101.2018.1559557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343733PMC
January 2019

RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination.

Ann Transl Med 2018 Dec;6(Suppl 2):S122

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2018.12.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330604PMC
December 2018

Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy.

Cancer Sci 2018 Nov 20;109(11):3383-3392. Epub 2018 Oct 20.

Health Research Institute, Faculty of ESTeM, University of Canberra, Canberra, ACT, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215877PMC
November 2018

Serendipity, luck and hard work.

Authors:
Kum Kum Khanna

Nat Cell Biol 2018 Sep;20(9):1004

Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41556-018-0170-8DOI Listing
September 2018

The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking.

Int J Biochem Cell Biol 2018 06 13;99:28-37. Epub 2018 Mar 13.

QIMR Berghofer Medical Research Institute, 300 Herston Rd., Herston, 4006, Brisbane, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2018.03.002DOI Listing
June 2018

Identification of ATM-Interacting Proteins by Co-immunoprecipitation and Glutathione-S-Transferase (GST) Pull-Down Assays.

Methods Mol Biol 2017 ;1599:163-181

QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6955-5_13DOI Listing
February 2018

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 10 27;550(7677):548. Epub 2017 Sep 27.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature24026DOI Listing
October 2017

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Bioorg Med Chem Lett 2017 07 15;27(14):3096-3100. Epub 2017 May 15.

Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2017.05.039DOI Listing
July 2017

DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair.

J Biol Chem 2017 06 17;292(26):10779-10790. Epub 2017 May 17.

From the Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.772475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491765PMC
June 2017

Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 03 15;543(7643):65-71. Epub 2017 Feb 15.

University of Melbourne Centre for Cancer Research, University of Melbourne, Melbourne, 3010, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature21063DOI Listing
March 2017

The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells.

Sci Rep 2017 01 4;7:39873. Epub 2017 Jan 4.

Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep39873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209724PMC
January 2017

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Authors:
Kate Lawrenson Siddhartha Kar Karen McCue Karoline Kuchenbaeker Kyriaki Michailidou Jonathan Tyrer Jonathan Beesley Susan J Ramus Qiyuan Li Melissa K Delgado Janet M Lee Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Banu K Arun Brita Arver Elisa V Bandera Monica Barile Rosa B Barkardottir Daniel Barrowdale Matthias W Beckmann Javier Benitez Andrew Berchuck Maria Bisogna Line Bjorge Carl Blomqvist William Blot Natalia Bogdanova Anders Bojesen Stig E Bojesen Manjeet K Bolla Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Fiona Bruinsma Joan Brunet Shaik Ahmad Buhari Barbara Burwinkel Ralf Butzow Saundra S Buys Qiuyin Cai Trinidad Caldes Ian Campbell Rikki Canniotto Jenny Chang-Claude Jocelyne Chiquette Ji-Yeob Choi Kathleen B M Claes Linda S Cook Angela Cox Daniel W Cramer Simon S Cross Cezary Cybulski Kamila Czene Mary B Daly Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Joe Dennis Peter Devilee Orland Diez Jennifer A Doherty Susan M Domchek Cecilia M Dorfling Thilo Dörk Martine Dumont Hans Ehrencrona Bent Ejlertsen Steve Ellis Christoph Engel Eunjung Lee D Gareth Evans Peter A Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Henrik Flyger Lenka Foretova Florentia Fostira William D Foulkes Brooke L Fridley Eitan Friedman Debra Frost Gaetana Gambino Patricia A Ganz Judy Garber Montserrat García-Closas Aleksandra Gentry-Maharaj Maya Ghoussaini Graham G Giles Rosalind Glasspool Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Ellen L Goode Marc T Goodman Mark H Greene Jacek Gronwald Pascal Guénel Christopher A Haiman Per Hall Emily Hallberg Ute Hamann Thomas V O Hansen Patricia A Harrington Mikael Hartman Norhashimah Hassan Sue Healey Florian Heitz Josef Herzog Estrid Høgdall Claus K Høgdall Frans B L Hogervorst Antoinette Hollestelle John L Hopper Peter J Hulick Tomasz Huzarski Evgeny N Imyanitov Claudine Isaacs Hidemi Ito Anna Jakubowska Ramunas Janavicius Allan Jensen Esther M John Nichola Johnson Maria Kabisch Daehee Kang Miroslav Kapuscinski Beth Y Karlan Sofia Khan Lambertus A Kiemeney Susanne Kruger Kjaer Julia A Knight Irene Konstantopoulou Veli-Matti Kosma Vessela Kristensen Jolanta Kupryjanczyk Ava Kwong Miguel de la Hoya Yael Laitman Diether Lambrechts Nhu Le Kim De Leeneer Jenny Lester Douglas A Levine Jingmei Li Annika Lindblom Jirong Long Artitaya Lophatananon Jennifer T Loud Karen Lu Jan Lubinski Arto Mannermaa Siranoush Manoukian Loic Le Marchand Sara Margolin Frederik Marme Leon F A G Massuger Keitaro Matsuo Sylvie Mazoyer Lesley McGuffog Catriona McLean Iain McNeish Alfons Meindl Usha Menon Arjen R Mensenkamp Roger L Milne Marco Montagna Kirsten B Moysich Kenneth Muir Anna Marie Mulligan Katherine L Nathanson Roberta B Ness Susan L Neuhausen Heli Nevanlinna Silje Nord Robert L Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I Olopade Janet E Olson Curtis Olswold David O'Malley Irene Orlow Nick Orr Ana Osorio Sue Kyung Park Celeste L Pearce Tanja Pejovic Paolo Peterlongo Georg Pfeiler Catherine M Phelan Elizabeth M Poole Katri Pylkäs Paolo Radice Johanna Rantala Muhammad Usman Rashid Gad Rennert Valerie Rhenius Kerstin Rhiem Harvey A Risch Gus Rodriguez Mary Anne Rossing Anja Rudolph Helga B Salvesen Suleeporn Sangrajrang Elinor J Sawyer Joellen M Schildkraut Marjanka K Schmidt Rita K Schmutzler Thomas A Sellers Caroline Seynaeve Mitul Shah Chen-Yang Shen Xiao-Ou Shu Weiva Sieh Christian F Singer Olga M Sinilnikova Susan Slager Honglin Song Penny Soucy Melissa C Southey Marie Stenmark-Askmalm Dominique Stoppa-Lyonnet Christian Sutter Anthony Swerdlow Sandrine Tchatchou Manuel R Teixeira Soo H Teo Kathryn L Terry Mary Beth Terry Mads Thomassen Maria Grazia Tibiletti Laima Tihomirova Silvia Tognazzo Amanda Ewart Toland Ian Tomlinson Diana Torres Thérèse Truong Chiu-Chen Tseng Nadine Tung Shelley S Tworoger Celine Vachon Ans M W van den Ouweland Helena C van Doorn Elizabeth J van Rensburg Laura J Van't Veer Adriaan Vanderstichele Ignace Vergote Joseph Vijai Qin Wang Shan Wang-Gohrke Jeffrey N Weitzel Nicolas Wentzensen Alice S Whittemore Hans Wildiers Robert Winqvist Anna H Wu Drakoulis Yannoukakos Sook-Yee Yoon Jyh-Cherng Yu Wei Zheng Ying Zheng Kum Kum Khanna Jacques Simard Alvaro N Monteiro Juliet D French Fergus J Couch Matthew L Freedman Douglas F Easton Alison M Dunning Paul D Pharoah Stacey L Edwards Georgia Chenevix-Trench Antonis C Antoniou Simon A Gayther

Nat Commun 2016 09 7;7:12675. Epub 2016 Sep 7.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms12675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023955PMC
September 2016

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer.

Sci Rep 2016 Sep 26;6:34000. Epub 2016 Sep 26.

The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036051PMC
http://dx.doi.org/10.1038/srep34000DOI Listing
September 2016

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis.

Cancer Res 2016 08 24;76(15):4372-82. Epub 2016 May 24.

Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. School of Medicine, The University of Queensland, Herston, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-0544DOI Listing
August 2016

Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach.

Mol Biosyst 2016 Mar;12(3):963-72

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5mb00655dDOI Listing
March 2016

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

Oncotarget 2016 Feb;7(6):6353-68

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.7047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872719PMC
February 2016

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.

Mol Oncol 2016 Jan 26;10(1):179-93. Epub 2015 Sep 26.

University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, QLD 4102, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1016/j.molonc.2015.09.007
Publisher Site
http://dx.doi.org/10.1016/j.molonc.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528935PMC
January 2016

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease.

Trends Pharmacol Sci 2015 Dec 1;36(12):822-846. Epub 2015 Nov 1.

Signal Transduction Laboratory, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia; School of Natural Sciences, Griffith University, Nathan, QLD 411, Australia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01656147150017
Publisher Site
http://dx.doi.org/10.1016/j.tips.2015.08.009DOI Listing
December 2015

Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.

Mol Cancer Ther 2015 Oct 20;14(10):2321-31. Epub 2015 Aug 20.

Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-15-0374DOI Listing
October 2015

Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.

FASEB J 2015 Aug 27;29(8):3326-34. Epub 2015 Apr 27.

*Signal Transduction Laboratory, Translational Leukaemia Research, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia; Institut National De La Recherche Agronomique, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Équipes de Recherche Labellisées Centre National de la Recherche Scientifique 3559, Saclay Plant Sciences, Versailles, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.14-269944DOI Listing
August 2015

Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish.

FASEB J 2015 May 9;29(5):1999-2009. Epub 2015 Feb 9.

*Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Vascular Biology and Development Laboratory, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia; Zebrafish Developmental Genetics Laboratory, Monash University, Clayton, Victoria, Australia; and Cancer Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.14-265090
Publisher Site
http://dx.doi.org/10.1096/fj.14-265090DOI Listing
May 2015

The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin.

Cell Rep 2015 Apr 26;11(1):149-63. Epub 2015 Mar 26.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 Centre National de la Recherche Scientifique (CNRS), UdS, INSERM U964, BP 10142, 67404 Illkirch Cedex, Strasbourg, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.03.005DOI Listing
April 2015

MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments.

Oncoscience 2015 20;2(2):99-101. Epub 2015 Feb 20.

QIMR Berghofer Medical Research Institute, Herston QLD, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381702PMC
http://dx.doi.org/10.18632/oncoscience.135DOI Listing
April 2015

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Cancer Res 2015 Mar 14;75(5):858-69. Epub 2015 Jan 14.

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, Texas. Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-2289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351820PMC
March 2015

The Integrator complex controls the termination of transcription at diverse classes of gene targets.

Cell Res 2015 Mar 13;25(3):288-305. Epub 2015 Feb 13.

1] Department of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA [2] Howard Hughes Medical Institute, 522 First Avenue New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2015.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349240PMC
March 2015

Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51.

Cancer Treat Rev 2015 Jan 1;41(1):35-45. Epub 2014 Nov 1.

Signal Transduction Laboratory, QIMR Berghofer, Herston Rd, Herston, QLD 4006, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctrv.2014.10.006DOI Listing
January 2015

Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma.

Cancer Res 2014 Dec 28;74(24):7298-308. Epub 2014 Oct 28.

Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. School of Medicine, University of Queensland, Herston, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-1339DOI Listing
December 2014

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Nucleic Acids Res 2014 Jun 20;42(10):6326-36. Epub 2014 Apr 20.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, 4102, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gku276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041449PMC
June 2014

SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.

J Biol Chem 2014 Jun 14;289(26):18514-25. Epub 2014 May 14.

Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.559930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140253PMC
June 2014

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma.

Clin Cancer Res 2014 Jun 16;20(12):3187-97. Epub 2014 May 16.

Authors' Affiliations: Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Herston; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research; St Vincent's Clinical School, Faculty of Medicine, University of NSW; Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, New South Wales; Australian Pancreatic Cancer Genome Initiative, for the full list of contributors see http://www.pancreaticcancer.net.au/apgi/collaborators; Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and Centre for Cancer Biology, SA Pathology; School of Medicine, University of Adelaide, Adelaide, Australia; and Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United KingdomAuthors' Affiliations: Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Herston; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland; The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research; St Vincent's Clinical School, Faculty of Medicine, University of NSW; Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, New South Wales; Australian Pancreatic Cancer Genome Initiative, for the full list of contributors see http://www.pancreaticcancer.net.au/apgi/collaborators; Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and Centre for Cancer Biology, SA Pathology; School of Medicine, University of Adelaide, Adelaide, Australia; and Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/content/early/2014/05/
Web Search
http://clincancerres.aacrjournals.org/content/early/2014/05/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-14-0048DOI Listing
June 2014

Rad51 supports triple negative breast cancer metastasis.

Oncotarget 2014 May;5(10):3261-72

QIMR Berghofer Medical Research Institute, Signal Transduction Laboratory, Herston Rd, Herston QLD 4006, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102808PMC
http://dx.doi.org/10.18632/oncotarget.1923DOI Listing
May 2014

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

Nat Commun 2014 Apr 7;5:3561. Epub 2014 Apr 7.

Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC7, 214E, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041212PMC
April 2014

Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells.

Free Radic Biol Med 2014 Feb 22;67:265-77. Epub 2013 Nov 22.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2013.11.001DOI Listing
February 2014

Tumor protein D52 represents a negative regulator of ATM protein levels.

Cell Cycle 2013 Sep 21;12(18):3083-97. Epub 2013 Aug 21.

Molecular Oncology Laboratory; Children's Cancer Research Unit; Kids Research Institute; The Children's Hospital at Westmead; Sydney, NSW Australia; The University of Sydney Discipline of Paediatrics and Child Health; The Children's Hospital at Westmead; Sydney, NSW Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.26146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875682PMC
September 2013

Mouse models uncap novel roles of SSBs.

Cell Res 2013 Jun 7;23(6):744-5. Epub 2013 May 7.

Queensland Institute of Medical Research, Herston, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2013.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674395PMC
June 2013

Peptidyl-prolyl isomerization for cytokinetic abscission: fold and cut.

Cell Cycle 2012 May 1;11(9):1754. Epub 2012 May 1.

University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.20313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372396PMC
May 2012

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

DNA Repair (Amst) 2012 Apr 11;11(4):441-8. Epub 2012 Feb 11.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2012.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319278PMC
April 2012

ATM protein kinase: the linchpin of cellular defenses to stress.

Cell Mol Life Sci 2011 Sep 2;68(18):2977-3006. Epub 2011 May 2.

Institute of Molecular Biology and Biotechnology, The University of Lahore, 1 Km Raiwind Road, Thokar Niaz Baig, Lahore, Pakistan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-011-0683-9DOI Listing
September 2011

Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.

Breast Cancer Res Treat 2011 Aug 28;129(1):255-63. Epub 2011 Apr 28.

Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-011-1539-6DOI Listing
August 2011

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons.

Mol Neurodegener 2011 Jul 5;6:47. Epub 2011 Jul 5.

Department of Alzheimer's Disease Research, Research Institute, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8511, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-6-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145572PMC
July 2011

Breast cancer stem cells: treatment resistance and therapeutic opportunities.

Carcinogenesis 2011 May 10;32(5):650-8. Epub 2011 Feb 10.

Signal Transduction Lab, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgr028DOI Listing
May 2011

BRCA1 A‐complex fine tunes repair functions of BRCA1.

Aging (Albany NY) 2011 May;3(5):461-3

Queensland Institute of Medical Research, Signal Transduction Laboratory, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156597PMC
http://dx.doi.org/10.18632/aging.100334DOI Listing
May 2011

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.

Dis Model Mech 2010 Nov-Dec;3(11-12):752-62. Epub 2010 Sep 27.

Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467-8601, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.004689DOI Listing
February 2011

Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges.

Hum Pathol 2011 Feb 24;42(2):153-65. Epub 2010 Nov 24.

Molecular & Cellular Pathology, The University of Queensland, UQ Centre for Clinical Research, Herston, 4029 Brisbane, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2010.07.008DOI Listing
February 2011

ATM mediated phosphorylation of CHD4 contributes to genome maintenance.

Genome Integr 2011 Jan 10;2(1). Epub 2011 Jan 10.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

View Article

Download full-text PDF

Source
http://genomeintegrity.biomedcentral.com/articles/10.1186/20
Publisher Site
http://dx.doi.org/10.1186/2041-9414-2-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035021PMC
January 2011

SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.

Antioxid Redox Signal 2010 Apr;12(7):797-808

Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2009.2913DOI Listing
April 2010

Selenium and selenoproteins in health and disease.

Antioxid Redox Signal 2010 Apr;12(7):793-5

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2009.2973DOI Listing
April 2010

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Nucleic Acids Res 2010 Apr 17;38(6):1821-31. Epub 2009 Dec 17.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847229PMC
April 2010

MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.

Genes Cancer 2010 Mar;1(3):239-250

Model Organism Division, Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

View Article

Download full-text PDF

Source
http://gan.sagepub.com/lookup/doi/10.1177/1947601910368059
Publisher Site
http://dx.doi.org/10.1177/1947601910368059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943399PMC
March 2010

Cep55 stabilization is required for normal execution of cytokinesis.

Cell Cycle 2009 Nov 10;8(22):3742-9. Epub 2009 Nov 10.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/cc.8.22.10047
Publisher Site
http://dx.doi.org/10.4161/cc.8.22.10047DOI Listing
November 2009

INTS3 controls the hSSB1-mediated DNA damage response.

J Cell Biol 2009 Oct 28;187(1):25-32. Epub 2009 Sep 28.

Howard Hughes Medical Institute, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.200907026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762097PMC
October 2009

Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

Clin Cancer Res 2009 Oct 6;15(20):6314-20. Epub 2009 Oct 6.

Signal Transduction Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-0096DOI Listing
October 2009

The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.

Cancer Res 2009 Aug 28;69(16):6651-9. Epub 2009 Jul 28.

Queensland Institute of Medical Research, Brisbane, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-0825DOI Listing
August 2009