Kristy A Brown

Kristy A Brown

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Kristy A Brown

Kristy A Brown

Publications by authors named "Kristy A Brown"

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Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.

J Steroid Biochem Mol Biol 2019 May 6;189:161-170. Epub 2019 Mar 6.

Department of Medicine, Weill Cornell Medicine, New York, USA; Graduate School of Medical Sciences, Weill Cornell Medicine, New York, USA; Department of Physiology, Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502693PMC
May 2019

The benefits of adding metformin to tamoxifen to protect the endometrium-A randomized placebo-controlled trial.

Clin Endocrinol (Oxf) 2018 11 9;89(5):605-612. Epub 2018 Sep 9.

Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/cen.13830DOI Listing
November 2018

IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue.

FASEB J 2018 06 23;32(6):3361-3370. Epub 2018 Jan 23.

Functional Foods Forum, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1096/fj.201700938RRRDOI Listing
June 2018

Obesity and breast cancer - Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue.

Mol Cell Endocrinol 2018 05 15;466:15-30. Epub 2017 Sep 15.

Metabolism & Cancer Laboratory, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Physiology, Monash University, Clayton, VIC, Australia; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.09.014DOI Listing
May 2018

Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells.

J Steroid Biochem Mol Biol 2017 06 14;170:49-53. Epub 2016 Jul 14.

Metabolism and Cancer Laboratory, Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Physiology, Monash University, Clayton, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.07.005DOI Listing
June 2017

Editorial.

J Steroid Biochem Mol Biol 2017 06;170

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http://dx.doi.org/10.1016/j.jsbmb.2017.04.014DOI Listing
June 2017

The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer.

Breast Cancer Res Treat 2017 01 15;161(2):213-227. Epub 2016 Nov 15.

Department of Anatomical Pathology and Surgery, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1007/s10549-016-4050-2DOI Listing
January 2017

Ghrelin and Breast Cancer: Emerging Roles in Obesity, Estrogen Regulation, and Cancer.

Front Oncol 2016 9;6:265. Epub 2017 Jan 9.

Metabolism and Cancer Laboratory, Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, Australia; Department of Physiology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fonc.2016.00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220482PMC
January 2017

Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer.

Curr Opin Pharmacol 2016 12 19;31:90-96. Epub 2016 Nov 19.

Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2016.11.003DOI Listing
December 2016

Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

J Biol Chem 2016 07 1;291(31):16011-23. Epub 2016 Jun 1.

From the Department of Medicine, Weill Cornell Medical College, New York, New York 10065.

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http://dx.doi.org/10.1074/jbc.M115.698902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965552PMC
July 2016

p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis.

Cancer Res 2015 Dec 16;75(23):5001-7. Epub 2015 Nov 16.

Metabolism and Cancer Laboratory, Centres for Cancer Research and Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia. Department of Physiology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0563DOI Listing
December 2015

Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer.

J Steroid Biochem Mol Biol 2015 Sep 21;153:35-44. Epub 2015 Jul 21.

Metabolism & Cancer Laboratory, Centre for Cancer Research, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia; Department of Physiology, Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.07.008DOI Listing
September 2015

Obesity-Associated Inflammatory Cytokines and Prostaglandin E2 Stimulate Glucose Transporter mRNA Expression and Glucose Uptake in Primary Human Adipose Stromal Cells.

J Interferon Cytokine Res 2015 Aug 3;35(8):600-5. Epub 2015 Apr 3.

1 Metabolism & Cancer Laboratory, Centre for Cancer Research, MIMR-PHI Institute of Medical Research , Victoria, Australia .

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http://dx.doi.org/10.1089/jir.2014.0194DOI Listing
August 2015

Estrogens, obesity, inflammation, and breast cancer-what is the link?

Semin Reprod Med 2015 May 2;33(3):208-12. Epub 2015 Jun 2.

MIMR-PHI Centre for Medical Research, Monash Medical Centre, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1055/s-0035-1552581DOI Listing
May 2015

Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer.

Cancer Res 2015 Feb 29;75(4):645-55. Epub 2015 Jan 29.

Metabolism and Cancer Laboratory, Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Clayton, Victoria, Australia. Department of Physiology, Monash University, Clayton, Victoria, Australia.

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http://cancerres.aacrjournals.org/content/75/4/645.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2164DOI Listing
February 2015

Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism.

Breast Cancer Res Treat 2014 Aug 24;147(1):193-201. Epub 2014 Jul 24.

Metabolism & Cancer Laboratory, MIMR-PHI Institute of Medical Research, Clayton, VIC, 3168, Australia.

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http://dx.doi.org/10.1007/s10549-014-3060-1DOI Listing
August 2014

Impact of obesity on mammary gland inflammation and local estrogen production.

Authors:
Kristy A Brown

J Mammary Gland Biol Neoplasia 2014 Jul 17;19(2):183-9. Epub 2014 Jun 17.

Metabolism & Cancer Laboratory, MIMR-PHI Institute of Medical Research, Clayton, VIC, Australia,

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http://dx.doi.org/10.1007/s10911-014-9321-0DOI Listing
July 2014

Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β.

Endocrinology 2014 May 24;155(5):1606-17. Epub 2014 Feb 24.

Cancer Drug Discovery Laboratory (K.A.L., M.J.Y., Z.Z., R.S.C., A.L.C., C.D.C.) and Metabolism and Cancer Laboratory (K.A.B.), Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia; Environmental and Biotechnology Centre (K.A.L.), Swinburne University, Hawthorn, Victoria 3122, Australia; and Department of Biochemistry and Molecular Biology (C.D.C.), Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1210/en.2013-1948DOI Listing
May 2014

Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression.

J Clin Endocrinol Metab 2013 Dec 24;98(12):E2013-21. Epub 2013 Sep 24.

MD, Department of Molecular Endocrinology, National Research Institute for Child Health and Development, 2-10-1 Ohkura, Setagaya, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1210/jc.2013-2520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399493PMC
December 2013

Obesity and breast cancer: role of inflammation and aromatase.

J Mol Endocrinol 2013 Dec 26;51(3):T51-9. Epub 2013 Nov 26.

Metabolism and Cancer Laboratory, Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia Departments ofBiochemistry and Molecular Biology Physiology, Monash University, Clayton, Victoria 3168, Australia.

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https://jme.bioscientifica.com/view/journals/jme/51/3/T51.xm
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http://dx.doi.org/10.1530/JME-13-0217DOI Listing
December 2013

CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes.

Horm Cancer 2013 Aug 13;4(4):233-41. Epub 2013 Apr 13.

Metabolism and Cancer Laboratory, Prince Henry's Institute, Block E level 4, 246 Clayton Rd, Clayton, P.O. Box 5152, Melbourne, VIC, 3168, Australia.

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http://dx.doi.org/10.1007/s12672-013-0142-1DOI Listing
August 2013

Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism.

Mol Endocrinol 2013 May 21;27(5):715-25. Epub 2013 Mar 21.

Prince Henry's Institute of Medical Research-Monash Medical Centre, Block E, Level 4246 Clayton Road, PO Box 5152, Clayton, Victoria-3168, Australia.

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http://dx.doi.org/10.1210/me.2013-1011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416759PMC
May 2013

Endocrine-related cancers and the role of AMPK.

Mol Cell Endocrinol 2013 Feb 16;366(2):170-9. Epub 2012 Jul 16.

Metabolism and Cancer Laboratory, Prince Henry's Institute, Clayton 3168, Australia.

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http://dx.doi.org/10.1016/j.mce.2012.06.016DOI Listing
February 2013

Obesity and breast cancer: mechanisms and therapeutic implications.

Front Biosci (Elite Ed) 2012 Jun 1;4:2515-24. Epub 2012 Jun 1.

Metabolism and Cancer Laboratory, Prince Henry's Institute, Clayton, Australia, 3168.

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June 2012

LKB1 expression is inhibited by estradiol-17β in MCF-7 cells.

J Steroid Biochem Mol Biol 2011 Nov 12;127(3-5):439-43. Epub 2011 Jun 12.

Prince Henry's Institute, Block E Level 4, Monash Medical Centre, 246 Clayton Road, Clayton, Melbourne, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.jsbmb.2011.06.005DOI Listing
November 2011

Promoter-specific effects of metformin on aromatase transcript expression.

Steroids 2011 Jul 15;76(8):768-71. Epub 2011 Mar 15.

Prince Henry's Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/j.steroids.2011.02.041DOI Listing
July 2011

Teasing out the role of aromatase in the healthy and diseased testis.

Spermatogenesis 2011 Jul 1;1(3):240-249. Epub 2011 Jul 1.

Prince Henry's Institute of Medical Research; Clayton, VIC Australia.

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http://dx.doi.org/10.4161/spmg.1.3.18037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271666PMC
July 2011

Obesity, aromatase and breast cancer.

Expert Rev Endocrinol Metab 2011 May;6(3):383-395

a Prince Henry's Institute of Medical Research, and the Departments of Biochemistry and Physiology, Monash University, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1586/eem.11.35DOI Listing
May 2011

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase.

Breast Cancer Res Treat 2010 Sep 19;123(2):591-6. Epub 2010 Mar 19.

Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, VIC, 3168, Australia.

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http://link.springer.com/10.1007/s10549-010-0834-y
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http://dx.doi.org/10.1007/s10549-010-0834-yDOI Listing
September 2010

Progress in aromatase research and identification of key future directions.

J Steroid Biochem Mol Biol 2010 Feb 22;118(4-5):311-5. Epub 2009 Sep 22.

Academic Department of Biochemistry, Royal Marsden Hospital, London SW3 6JJ, United Kingdom.

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http://dx.doi.org/10.1016/j.jsbmb.2009.09.005DOI Listing
February 2010

Obesity and breast cancer: progress to understanding the relationship.

Cancer Res 2010 Jan 22;70(1):4-7. Epub 2009 Dec 22.

Prince Henry's Institute, Monash Medical Centre, Department of Physiology, Monash University, Clayton, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2257DOI Listing
January 2010

Characterisation of aromatase expression in the human adipocyte cell line SGBS.

Breast Cancer Res Treat 2008 Dec 5;112(3):429-35. Epub 2008 Jan 5.

Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1007/s10549-007-9883-2DOI Listing
December 2008

Molecular cloning of equine 17beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo.

J Mol Endocrinol 2007 Feb;38(1-2):67-78

Faculté de Médecine Vétérinaire, Centre de Recherche en Reproduction Animale, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1677/jme.1.02097DOI Listing
February 2007

Gonadotropin-dependent regulation of bovine pituitary adenylate cyclase-activating polypeptide in ovarian follicles prior to ovulation.

Reproduction 2007 Feb;133(2):441-53

Centre de recherche en reproduction animale et Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1530/REP-06-0188DOI Listing
February 2007

Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo.

J Steroid Biochem Mol Biol 2007 Jan 16;103(1):10-9. Epub 2006 Oct 16.

Centre de recherche en reproduction animale et Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1016/j.jsbmb.2006.07.005DOI Listing
January 2007

Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation.

J Mol Endocrinol 2006 Oct;37(2):239-50

Centre de recherche en reproduction animale et Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1677/jme.1.02078DOI Listing
October 2006

Human chorionic gonadotropin-dependent up-regulation of genes responsible for estrogen sulfoconjugation and export in granulosa cells of luteinizing preovulatory follicles.

Endocrinology 2006 Sep 8;147(9):4222-33. Epub 2006 Jun 8.

Centre de Recherche en Reproduction Animale and Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1210/en.2006-0420DOI Listing
September 2006

Molecular characterization of equine P-selectin (CD62P) and its regulation in ovarian follicles during the ovulatory process.

Biol Reprod 2005 Mar 24;72(3):736-44. Epub 2004 Nov 24.

Centre de recherche en reproduction animale and Département de biomédecine vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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http://dx.doi.org/10.1095/biolreprod.104.034710DOI Listing
March 2005

Cyclooxygenase-2 and its role in ovulation: a 2004 account.

Hum Reprod Update 2004 Sep-Oct;10(5):373-85. Epub 2004 Jun 17.

Centre de recherche en reproduction animale and Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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http://dx.doi.org/10.1093/humupd/dmh032DOI Listing
February 2005

Human chorionic gonadotropin-dependent regulation of 17beta-hydroxysteroid dehydrogenase type 4 in preovulatory follicles and its potential role in follicular luteinization.

Endocrinology 2004 Apr 15;145(4):1906-15. Epub 2004 Jan 15.

Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada J2S 7C6.

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http://dx.doi.org/10.1210/en.2003-1715DOI Listing
April 2004

Expression of key prostaglandin synthases in equine endometrium during late diestrus and early pregnancy.

Biol Reprod 2004 Feb 15;70(2):391-9. Epub 2003 Oct 15.

Centre de Recherche en Reproduction Animale, Faculté de Médecine, Université de Montréal, Canada.

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http://dx.doi.org/10.1095/biolreprod.103.020800DOI Listing
February 2004