Kristopher W Krausz

Kristopher W Krausz

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Kristopher W Krausz

Kristopher W Krausz

Publications by authors named "Kristopher W Krausz"

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Withaferin A Improves Nonalcoholic Steatohepatitis in Mice.

J Pharmacol Exp Ther 2019 Nov 16;371(2):360-374. Epub 2019 Aug 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.)

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http://dx.doi.org/10.1124/jpet.119.256792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800446PMC
November 2019

Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Oct 10;1864(10):1396-1411. Epub 2019 Jun 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 2089, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.05.014DOI Listing
October 2019

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Gastroenterology 2019 09 30;157(3):744-759.e4. Epub 2019 May 30.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194097
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http://dx.doi.org/10.1053/j.gastro.2019.05.057DOI Listing
September 2019

The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells.

Chem Biol Interact 2018 Dec 17;296:45-56. Epub 2018 Sep 17.

College of Pharmacy, Jinan University, Guangzhou, 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.

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http://dx.doi.org/10.1016/j.cbi.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628920PMC
December 2018

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Nat Med 2018 12 5;24(12):1919-1929. Epub 2018 Nov 5.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

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http://www.nature.com/articles/s41591-018-0222-4
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http://dx.doi.org/10.1038/s41591-018-0222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479226PMC
December 2018

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatol Commun 2018 Dec 1;2(12):1567-1582. Epub 2018 Oct 1.

Laboratory of Metabolism National Cancer Institute, National Institutes of Health Bethesda MD.

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http://dx.doi.org/10.1002/hep4.1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287584PMC
December 2018

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

J Lipid Res 2018 11 29;59(11):2140-2152. Epub 2018 Aug 29.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://www.jlr.org/lookup/doi/10.1194/jlr.M088419
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http://dx.doi.org/10.1194/jlr.M088419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210912PMC
November 2018

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Hepatology 2018 10 21;68(4):1574-1588. Epub 2018 May 21.

Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH.

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http://dx.doi.org/10.1002/hep.29857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111007PMC
October 2018

Metabolic alterations in triptolide-induced acute hepatotoxicity.

Biomed Chromatogr 2018 Oct 4;32(10):e4299. Epub 2018 Jul 4.

National Cancer Institute, National Institutes of Health, Laboratory of Metabolism, Center for Cancer Research, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/bmc.4299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150827PMC
October 2018

Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation.

Drug Metab Dispos 2018 09 29;46(9):1310-1319. Epub 2018 Jun 29.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (Ti. Y., H.W., L.C., G.W., H.H.); and Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health National Cancer Institute, Bethesda, Maryland (Ti. Y., Q.W., S.T., To.Y., G.L., K.W.K., F.J.G.)

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http://dx.doi.org/10.1124/dmd.118.082008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081736PMC
September 2018

Structure-Activity Relationships of the Main Bioactive Constituents of on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Drug Metab Dispos 2018 07 24;46(7):1030-1040. Epub 2018 Apr 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Yo.Z., Ti.Y., D.S. C.X., To.Y., K.W.K., F.J.G.); State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China (Yo.Z., Yi.Z., L.Z., X.Y.); Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon (W.H.B.); and College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (D.S.)

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http://dx.doi.org/10.1124/dmd.117.080176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003592PMC
July 2018

Inverse association of vitamin D levels with lung cancer mediated by genetic variation.

Cancer Med 2018 06 3;7(6):2764-2775. Epub 2018 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892.

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http://dx.doi.org/10.1002/cam4.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010700PMC
June 2018

Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

J Gastroenterol Hepatol 2018 May 19;33(5):1138-1145. Epub 2018 Feb 19.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jgh.14046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334298PMC
May 2018

Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro.

Drug Metab Dispos 2018 04 23;46(4):336-345. Epub 2018 Jan 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.X., X.G., D.S., Y.Z., K.W.K., F.J.G.); and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, People's Republic of China (X.G., X.Q.)

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http://dx.doi.org/10.1124/dmd.117.079723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829541PMC
April 2018

Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides.

Food Funct 2018 Mar 10;9(3):1410-1423. Epub 2018 Jan 10.

College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, P. R. China and Guangzhou Research and Creativity Biotechnology Co. Ltd, Guangzhou, 510663, P. R. China.

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http://dx.doi.org/10.1039/c7fo01298eDOI Listing
March 2018

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Mol Metab 2018 03 2;9:217-219. Epub 2018 Feb 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870094PMC
March 2018

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Mol Metab 2018 01 6;7:80-89. Epub 2017 Nov 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784329PMC
January 2018

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Biochim Biophys Acta Mol Basis Dis 2017 12 24;1863(12):3170-3182. Epub 2017 Aug 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675002PMC
December 2017

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Cell Metab 2017 Oct 14;26(4):672-685.e4. Epub 2017 Sep 14.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131173050
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http://dx.doi.org/10.1016/j.cmet.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668683PMC
October 2017

Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.

PLoS One 2017 16;12(5):e0177953. Epub 2017 May 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433781PMC
September 2017

Orthogonal Comparison of GC-MS and H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Anal Chem 2017 08 12;89(15):7900-7906. Epub 2017 Jul 12.

Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334302PMC
August 2017

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

Toxicology 2017 07 24;386:133-142. Epub 2017 May 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594256PMC
July 2017

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.

J Biol Chem 2017 06 6;292(26):11055-11069. Epub 2017 May 6.

From the Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio 44272 and

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http://dx.doi.org/10.1074/jbc.M117.784322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491788PMC
June 2017

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

Arch Toxicol 2017 May 16;91(5):2235-2244. Epub 2016 Nov 16.

Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00204-016-1877-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331015PMC
May 2017

Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

Radiat Res 2017 05 9;187(5):612-629. Epub 2017 Mar 9.

a   Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://www.bioone.org/doi/10.1667/RR14592.1
Publisher Site
http://dx.doi.org/10.1667/RR14592.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539505PMC
May 2017

An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

Diabetes 2017 03 8;66(3):613-626. Epub 2016 Nov 8.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.2337/db16-0663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319721PMC
March 2017

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

J Lipid Res 2016 12 16;57(12):2130-2137. Epub 2016 Sep 16.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1194/jlr.M071183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321228PMC
December 2016

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.

Biochem Pharmacol 2016 Nov 26;119:93-104. Epub 2016 Aug 26.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061623PMC
http://dx.doi.org/10.1016/j.bcp.2016.08.021DOI Listing
November 2016

Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

Environ Sci Technol 2016 09 5;50(17):9652-60. Epub 2016 Aug 5.

School of Public Health, Fudan University , Shanghai 200032, PR China.

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http://dx.doi.org/10.1021/acs.est.6b02113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169518PMC
September 2016

Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.

Cancer Epidemiol Biomarkers Prev 2016 06 24;25(6):978-86. Epub 2016 Mar 24.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891298PMC
June 2016

Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.

Anal Bioanal Chem 2016 Jun 13;408(16):4267-73. Epub 2016 Apr 13.

School of Pharmaceutical Sciences, Sun Yat-sen University, 132# Waihuandong Rd, University City of Guangzhou, Guangzhou, 510006, China.

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http://dx.doi.org/10.1007/s00216-016-9525-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300981PMC
June 2016

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

Drug Metab Dispos 2016 May 10;44(5):720-31. Epub 2016 Mar 10.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China (Ti.Y., H.W., M.Z., Yi.C., X.C., J.Z., Yu.C., F.L., Y.W., G.W., H.H.); Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Ti.Y., To.Y., K.W.K., C.X., C.N.B., F.J.G.)

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http://dx.doi.org/10.1124/dmd.116.069419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851304PMC
May 2016

Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cancer Res 2016 Mar 15;76(6):1569-77. Epub 2016 Feb 15.

Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794383PMC
March 2016

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Nat Commun 2015 Dec 15;6:10166. Epub 2015 Dec 15.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms10166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682112PMC
December 2015

Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.

Metabolomics 2015 Oct 20;11(5):1082-1094. Epub 2014 Dec 20.

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC ; Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC.

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http://dx.doi.org/10.1007/s11306-014-0765-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635442PMC
October 2015

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.

Cancer Prev Res (Phila) 2015 Sep 11;8(9):786-95. Epub 2015 Jun 11.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584416PMC
September 2015

Metabolic mapping of A3 adenosine receptor agonist MRS5980.

Biochem Pharmacol 2015 Sep 23;97(2):215-23. Epub 2015 Jul 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581425PMC
September 2015

Maternal bile acid transporter deficiency promotes neonatal demise.

Nat Commun 2015 Sep 29;6:8186. Epub 2015 Sep 29.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/ncomms9186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598356PMC
September 2015

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.

Biochim Biophys Acta 2015 Jul 28;1852(7):1242-52. Epub 2015 Feb 28.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433820PMC
July 2015

Modulation of colon cancer by nutmeg.

J Proteome Res 2015 Apr 10;14(4):1937-46. Epub 2015 Mar 10.

†Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/pr5013152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334305PMC
April 2015

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Biochim Biophys Acta 2015 Jan 4;1851(1):19-29. Epub 2014 May 4.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219936PMC
January 2015

Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.

PLoS One 2014 2;9(1):e84583. Epub 2014 Jan 2.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084583PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879345PMC
November 2014

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.

Biochim Biophys Acta 2014 Nov 29;1841(11):1596-607. Epub 2014 Aug 29.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188754PMC
November 2014

Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.

J Lipid Res 2014 Nov 5;55(11):2309-19. Epub 2014 Sep 5.

Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1194/jlr.M050682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617133PMC
November 2014

Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.

Chem Biol Interact 2014 Nov 27;223:80-6. Epub 2014 Sep 27.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cbi.2014.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376644PMC
November 2014

N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.

Carcinogenesis 2014 Oct 12;35(10):2264-72. Epub 2014 Aug 12.

Department of Pharmaceutical Sciences, SUNY-Buffalo, Buffalo, NY 14214, USA, Department of Biochemistry & Molecular Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA and

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http://dx.doi.org/10.1093/carcin/bgu174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178474PMC
October 2014

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Am J Physiol Gastrointest Liver Physiol 2014 Sep 17;307(5):G564-73. Epub 2014 Jul 17.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and

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http://dx.doi.org/10.1152/ajpgi.00153.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154119PMC
September 2014

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.

Nat Commun 2014 Sep 3;5:4573. Epub 2014 Sep 3.

State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 21009, China.

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http://dx.doi.org/10.1038/ncomms5573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164778PMC
September 2014

Metabolic profiling of praziquantel enantiomers.

Biochem Pharmacol 2014 Jul 10;90(2):166-78. Epub 2014 May 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168258PMC
July 2014

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.

Cancer Res 2014 Jun 15;74(12):3259-70. Epub 2014 Apr 15.

Authors' Affiliations: Laboratory of Molecular Immunogenomics, Genomic and Immunity Section, NIAMS/NIH; Laboratories of Human Carcinogenesis, and Metabolism, National Cancer Institute, NIH, Bethesda, Maryland; Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis; Metabolomics Core Facility; Nuclear Magnetic Resonance Spectroscopy, The Pennsylvania State University, University Park, Pennsylvania; Ohio State University Comprehensive Cancer Center, Columbus, Ohio; and Department of Clinical Research, University of Bern, Bern, Switzerland

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100625PMC
June 2014

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.

Gastroenterology 2014 May 15;146(5):1313-24. Epub 2014 Jan 15.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992178PMC
May 2014

Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity.

J Proteome Res 2014 May 10;13(5):2679-87. Epub 2014 Apr 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://pubs.acs.org/doi/10.1021/pr500145n
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http://dx.doi.org/10.1021/pr500145nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018097PMC
May 2014

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract.

Br J Pharmacol 2014 Apr;171(7):1735-46

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/bph.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966752PMC
April 2014

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.

J Lipid Res 2014 Mar 16;55(3):455-65. Epub 2013 Dec 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1194/jlr.M044420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934730PMC
March 2014

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Arch Toxicol 2013 Nov 11;87(11):1975-1987. Epub 2013 Apr 11.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00204-013-1053-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338077PMC
November 2013

Potential role of CYP2D6 in the central nervous system.

Xenobiotica 2013 Nov 25;43(11):973-84. Epub 2013 Apr 25.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA .

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http://dx.doi.org/10.3109/00498254.2013.791410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750078PMC
November 2013

Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model.

Metabolites 2013 Aug 7;3(3):658-72. Epub 2013 Aug 7.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/metabo3030658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901288PMC
August 2013

Metabolomics reveals that tumor xenografts induce liver dysfunction.

Mol Cell Proteomics 2013 Aug 1;12(8):2126-35. Epub 2013 May 1.

Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/mcp.M113.028324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734574PMC
August 2013

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Chem Res Toxicol 2013 Jul 7;26(7):1088-96. Epub 2013 Jun 7.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334300PMC
July 2013

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

J Clin Invest 2013 Jul 10;123(7):2921-34. Epub 2013 Jun 10.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1172/JCI66353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696551PMC
July 2013

Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells.

Anal Bioanal Chem 2013 Jun 19;405(15):5279-89. Epub 2013 Apr 19.

School of Pharmaceutical Sciences, Sun Yat-sen University, 132# Waihuandong Road, Guangzhou University City, Guangzhou 510006, China.

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http://dx.doi.org/10.1007/s00216-013-6927-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678261PMC
June 2013

Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.

PLoS Genet 2012 29;8(11):e1003053. Epub 2012 Nov 29.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510057PMC
May 2013

Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair.

J Proteome Res 2013 May 24;12(5):2269-81. Epub 2013 Apr 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/pr400161kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678303PMC
May 2013

Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.

J Proteome Res 2013 Mar 31;12(3):1369-76. Epub 2013 Jan 31.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/pr301023xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594779PMC
March 2013

Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.

Drug Metab Dispos 2013 Feb 16;41(2):406-13. Epub 2012 Nov 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.048009
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http://dx.doi.org/10.1124/dmd.112.048009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558860PMC
February 2013

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity.

Evid Based Complement Alternat Med 2013 4;2013:985257. Epub 2013 Feb 4.

School of Pharmaceutical Sciences, Sun Yat-sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575671PMC
February 2013

Implication of intestinal VDR deficiency in inflammatory bowel disease.

Biochim Biophys Acta 2013 Jan 2;1830(1):2118-28. Epub 2012 Oct 2.

National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.bbagen.2012.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508150PMC
January 2013

CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.

Toxicol Appl Pharmacol 2013 Jan 8;266(2):245-53. Epub 2012 Nov 8.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.taap.2012.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661416PMC
January 2013

TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.

J Lipid Res 2012 Dec 3;53(12):2698-707. Epub 2012 Oct 3.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1194/jlr.M031773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494264PMC
December 2012

Metabolic map and bioactivation of the anti-tumour drug noscapine.

Br J Pharmacol 2012 Nov;167(6):1271-86

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2012.02067.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504993PMC
November 2012

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.

Cell Metab 2012 Nov;16(5):634-44

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496181PMC
November 2012

Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.

Toxicol Sci 2012 Oct 12;129(2):456-68. Epub 2012 Jul 12.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1093/toxsci/kfs211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491956PMC
October 2012

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

J Lipid Res 2012 Aug 4;53(8):1625-35. Epub 2012 Jun 4.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1194/jlr.M027433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540854PMC
August 2012

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.

Hepatology 2012 Jul 6;56(1):118-29. Epub 2012 Jun 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/hep.25630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371056PMC
July 2012

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

Hepatology 2012 Jul 6;56(1):281-90. Epub 2012 Jun 6.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

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http://doi.wiley.com/10.1002/hep.25645
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http://dx.doi.org/10.1002/hep.25645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378765PMC
July 2012

Metabolomics reveals the metabolic map of procainamide in humans and mice.

Biochem Pharmacol 2012 May 24;83(10):1435-44. Epub 2012 Feb 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bcp.2012.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665348PMC
May 2012

Expression and regulation of human fetal-specific CYP3A7 in mice.

Endocrinology 2012 Mar 17;153(3):1453-63. Epub 2012 Jan 17.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281537PMC
March 2012

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.

Cancer Res 2011 Nov 7;71(21):6590-600. Epub 2011 Sep 7.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206149PMC
November 2011

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model.

J Proteome Res 2011 Sep 28;10(9):4120-33. Epub 2011 Jul 28.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/pr200310sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170755PMC
September 2011

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus.

J Biol Chem 2011 Jun 12;286(22):19511-22. Epub 2011 Apr 12.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M111.221739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103330PMC
June 2011

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Biochem Pharmacol 2011 Apr 12;81(8):1043-53. Epub 2011 Feb 12.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521100082
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http://dx.doi.org/10.1016/j.bcp.2011.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309239PMC
April 2011

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats.

Radiat Res 2011 Apr 10;175(4):473-84. Epub 2011 Feb 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1667/RR2437.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089756PMC
April 2011

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.

Hepatology 2011 Apr;53(4):1282-93

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/hep.24193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077083PMC
April 2011

Pregnane X receptor-mediated induction of Cyp3a by black cohosh.

Xenobiotica 2011 Feb 27;41(2):112-23. Epub 2010 Oct 27.

Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.

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http://dx.doi.org/10.3109/00498254.2010.527021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019262PMC
February 2011