Kristopher T Kahle

Kristopher T Kahle

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Kristopher T Kahle

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99Publications

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Teaching NeuroImages: Unilateral focal segmental hyperhidrosis from spinal tumor progression.

Neurology 2019 Aug;93(7):e729-e730

From the Departments of Neurosurgery (C.S.H., A.J.K., K.T.K., M.L.D.) and Pediatrics (K.T.K., M.L.D.), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1212/WNL.0000000000007950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715508PMC
August 2019

Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development.

Dev Biol 2019 Aug 28. Epub 2019 Aug 28.

Department of Genetics, Harvard Medical School, Boston, MA, 02124, USA; Department of Orthopaedic Research, Boston Children's Hospital, Boston, MA, 02124, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606193029
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http://dx.doi.org/10.1016/j.ydbio.2019.08.016DOI Listing
August 2019

Teaching NeuroImages: Spinal subdural hematoma in pediatric nonaccidental trauma.

Neurology 2019 Jul;93(5):e522-e523

From the Department of Neurosurgery, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1212/WNL.0000000000007869DOI Listing
July 2019

Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus.

Trends Mol Med 2019 Jun 8;25(6):467-469. Epub 2019 Apr 8.

Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA; Yale-Rockefeller NIH Centers for Mendelian Genomics, Yale University, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.03.004DOI Listing
June 2019

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases.

Aging Dis 2019 Jun 1;10(3):626-636. Epub 2019 Jun 1.

1 Department of Neurology, The First Affiliate Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

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http://dx.doi.org/10.14336/AD.2018.0928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538211PMC
June 2019

EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease.

Trends Mol Med 2019 04 25;25(4):265-286. Epub 2019 Feb 25.

Department of Neurosurgery, Yale School of Medicine, New Haven CT, USA; Department of Pediatrics, Yale School of Medicine, New Haven CT, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456402PMC
April 2019

Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus.

Sci Rep 2019 Apr 17;9(1):6196. Epub 2019 Apr 17.

Pediatric Genomics Discovery Program, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1038/s41598-019-42549-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470164PMC
April 2019

Familial Trigeminal Neuralgia Cases Implicate Genetic Factors in Disease Pathogenesis.

JAMA Neurol 2019 Jan;76(1):9-10

Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2018.3322DOI Listing
January 2019

The Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure Hydrocephalus.

World Neurosurg 2018 Nov 4;119:e46-e52. Epub 2018 Jul 4.

Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.06.209DOI Listing
November 2018

Human Genetics and Molecular Mechanisms of Congenital Hydrocephalus.

World Neurosurg 2018 Nov 8;119:441-443. Epub 2018 Sep 8.

Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA; Department of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.wneu.2018.09.018DOI Listing
November 2018

9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus.

Cold Spring Harb Mol Case Stud 2018 10 1;4(5). Epub 2018 Oct 1.

Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1101/mcs.a003145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169828PMC
October 2018

De novo mutation in congenital scalp hemangioma.

Cold Spring Harb Mol Case Stud 2018 08 1;4(4). Epub 2018 Aug 1.

Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06519, USA.

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http://dx.doi.org/10.1101/mcs.a002998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071566PMC
August 2018

Non-syndromic single-suture craniosynostosis in triplets.

Childs Nerv Syst 2018 06 19;34(6):1241-1245. Epub 2018 Feb 19.

Department of Neurosurgery and Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s00381-018-3754-5DOI Listing
June 2018

A novel association of campomelic dysplasia and hydrocephalus with an unbalanced chromosomal translocation upstream of .

Cold Spring Harb Mol Case Stud 2018 06 1;4(3). Epub 2018 Jun 1.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1101/mcs.a002766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983176PMC
June 2018

Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib.

Pediatr Blood Cancer 2018 05 30;65(5):e26969. Epub 2018 Jan 30.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/pbc.26969
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http://dx.doi.org/10.1002/pbc.26969DOI Listing
May 2018

Multimodal treatment approach in a patient with multiple intracranial myxomatous aneurysms.

J Neurosurg Pediatr 2018 03 5;21(3):315-321. Epub 2018 Jan 5.

4Radiology, Boston Children's Hospital, Boston, Massachusetts; and.

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https://thejns.org/view/journals/j-neurosurg-pediatr/21/3/ar
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http://dx.doi.org/10.3171/2017.9.PEDS17288DOI Listing
March 2018

SOX2 immunity and tissue resident memory in children and young adults with glioma.

J Neurooncol 2017 Aug 15;134(1):41-53. Epub 2017 Jun 15.

Department of Pediatrics, Yale School of Medicine, 333 Cedar Street, LMP 2073, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s11060-017-2515-8DOI Listing
August 2017

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.

Expert Opin Ther Targets 2017 08 12;21(8):795-804. Epub 2017 Jul 12.

d Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology; and Centers for Mendelian Genomics , Yale School of Medicine , New Haven , CT , USA.

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http://dx.doi.org/10.1080/14728222.2017.1351949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081737PMC
August 2017

Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.

Trends Neurosci 2017 05 18;40(5):276-294. Epub 2017 Apr 18.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473173PMC
May 2017

The KCC3 cotransporter as a therapeutic target for peripheral neuropathy.

Expert Opin Ther Targets 2017 02 5;21(2):113-116. Epub 2017 Jan 5.

b Departments of Neurosurgery , Pediatrics and Cellular & Molecular Physiology; and Centers for Mendelian Genomics, Yale School of Medicine , New Haven , CT , USA.

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http://dx.doi.org/10.1080/14728222.2017.1275569DOI Listing
February 2017

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Cell Metab 2017 02;25(2):285-299

Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06477, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.01.007DOI Listing
February 2017

Mystery Case: Acute hydrocephalus caused by radiographically occult fourth ventricular outlet obstruction.

Neurology 2017 01;88(5):e36-e37

From the Departments of Neurosurgery (D.D., K.T.K.), Pediatrics (K.T.K.), and Cellular and Molecular Physiology (K.T.K.), Yale School of Medicine (M.H.), New Haven, CT.

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http://dx.doi.org/10.1212/WNL.0000000000003555DOI Listing
January 2017

The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.

Neuroscientist 2016 12 29;22(6):555-562. Epub 2016 Apr 29.

Division of Epilepsy and Clinical Electrophysiology, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/1073858416645087DOI Listing
December 2016

Digenic mutations of human paralogs in Dent's disease type 2 associated with Chiari I malformation.

Hum Genome Var 2016 8;3:16042. Epub 2016 Dec 8.

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/hgv.2016.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143364PMC
December 2016

Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database.

J Neurooncol 2016 10 16;130(1):133-140. Epub 2016 Jul 16.

Department of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s11060-016-2218-6DOI Listing
October 2016

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.

Sci Signal 2016 10 18;9(450):e3. Epub 2016 Oct 18.

Department of Cellular and Molecular Physiology and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/scisignal.aaj2227DOI Listing
October 2016

Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia.

J Psychiatr Res 2016 Jun 27;77:22-6. Epub 2016 Feb 27.

Department of Neurosurgery and Pediatrics, Interdepartmental Neuroscience Program, Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.02.016DOI Listing
June 2016

Hydrocephalus in children.

Lancet 2016 Feb 6;387(10020):788-99. Epub 2015 Aug 6.

Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(15)60694-8DOI Listing
February 2016

Treatment of Edema Associated With Intracerebral Hemorrhage.

Curr Treat Options Neurol 2016 Feb;18(2)

Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s11940-015-0392-zDOI Listing
February 2016

Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.

J Neurophysiol 2016 Jan 28;115(1):8-18. Epub 2015 Oct 28.

Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee

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http://jn.physiology.org/content/jn/early/2015/10/23/jn.0086
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http://jn.physiology.org/lookup/doi/10.1152/jn.00865.2015
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http://dx.doi.org/10.1152/jn.00865.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760510PMC
January 2016

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia.

Front Cell Neurosci 2015 12;9:386. Epub 2015 Oct 12.

Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School Boston, MA, USA ; Manton Center for Orphan Disease Research, Boston Children's Hospital Boston, MA, USA.

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http://dx.doi.org/10.3389/fncel.2015.00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600830PMC
November 2015

K-Cl cotransporters, cell volume homeostasis, and neurological disease.

Trends Mol Med 2015 Aug 1;21(8):513-23. Epub 2015 Jul 1.

Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2015.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834970PMC
August 2015

Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.

J Clin Neurosci 2015 Jul 10;22(7):1188-90. Epub 2015 Apr 10.

Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit Street, WACC 745, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jocn.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457609PMC
July 2015

Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.

Stroke 2015 Jul 11;46(7):1956-1965. Epub 2015 Jun 11.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, (G.B., H.Y., L.L., S.W., Y.S., D.S.); Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA (K.T.K.); Manton Center for Orphan Diseases, Harvard Medical School, MA (K.T.K.); Renal Division and Vascular Biology Center, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA (B.E.S., S.L.A); Division of Nephrology, Dept. of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (SS.Y., SH.L); Veterans Affairs Pittsburgh Health Care System, Geriatric Research, Educational and Clinical Center, Pittsburgh, PA (D.S).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643659PMC
http://dx.doi.org/10.1161/STROKEAHA.115.008939DOI Listing
July 2015

Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis.

Front Cell Neurosci 2015 9;9:255. Epub 2015 Jul 9.

Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Harvard University Boston, MA, USA ; Manton Center for Orphan Disease Research, Children's Hospital Boston, Harvard University Boston, MA, USA.

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http://dx.doi.org/10.3389/fncel.2015.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496573PMC
July 2015

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Sci Signal 2015 Jun 30;8(383):ra65. Epub 2015 Jun 30.

Institut de Neurobiologie de la Méditerranée (INMED), INSERM Unité 901, 13273 Marseille, France. Aix-Marseille Université, UMR 901, 13273 Marseille, France.

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http://dx.doi.org/10.1126/scisignal.aaa0354DOI Listing
June 2015

Progesterone in traumatic brain injury.

N Engl J Med 2015 04;372(18):1765-6

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http://dx.doi.org/10.1056/NEJMc1503138DOI Listing
April 2015

A novel method to study cerebrospinal fluid dynamics in rats.

J Neurosci Methods 2015 Feb 30;241:78-84. Epub 2014 Dec 30.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2014.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323871PMC
February 2015

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.

Glia 2015 Jan 26;63(1):23-36. Epub 2014 Jul 26.

Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1002/glia.22730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237714PMC
January 2015

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Sci Signal 2014 Jul 15;7(334):re3. Epub 2014 Jul 15.

Department of Neurosurgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02115, USA. Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2005365DOI Listing
July 2014

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures.

Epilepsia 2014 Jun 6;55(6):806-18. Epub 2014 May 6.

Department of Biosciences and Neuroscience Center, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/epi.12620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284054PMC
June 2014

Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury.

Spine J 2014 May 14;14(5):777-81. Epub 2013 Nov 14.

Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Box 8600 Clinical Science Center, 600 Highland Ave., Madison, WI 53792, USA; Waisman Center, 1500 Highland Ave, Madison, WI 53705, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15299430130122
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http://dx.doi.org/10.1016/j.spinee.2013.06.100DOI Listing
May 2014

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain.

JAMA Neurol 2014 May;71(5):640-5

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts7Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2014.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465580PMC
May 2014

Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2.

Front Cell Neurosci 2014 6;8:27. Epub 2014 Feb 6.

INSERM, Institut de Neurobiologie de la Méditerranée (INMED) Marseille, France ; Aix-Marseille Université, UMR901 Marseille, France.

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http://dx.doi.org/10.3389/fncel.2014.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915100PMC
April 2014

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

Biochem J 2014 Mar;458(3):559-73

*MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20131478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940040PMC
March 2014

Dysregulation of diverse ion transport pathways controlling cell volume homoestasis contribute to neuroglial cell injury following ischemic stroke.

Transl Stroke Res 2014 Feb 27;5(1):1-2. Epub 2014 Jan 27.

Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15217, USA,

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http://dx.doi.org/10.1007/s12975-014-0324-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913849PMC
February 2014

The incidence of complications in elective cranial neurosurgery associated with dural closure material.

J Neurosurg 2014 Jan 13;120(1):278-84. Epub 2013 Sep 13.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and.

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http://dx.doi.org/10.3171/2013.8.JNS13703DOI Listing
January 2014

Endoscopic burr hole evacuation of an acute subdural hematoma.

J Clin Neurosci 2013 Dec 17;20(12):1751-3. Epub 2013 Aug 17.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WHT 502, Boston, MA 02114-2698, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2013.02.019DOI Listing
December 2013

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2.

Trends Neurosci 2013 Dec 15;36(12):726-737. Epub 2013 Oct 15.

Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01662236130015
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http://dx.doi.org/10.1016/j.tins.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381966PMC
December 2013

Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.

Neurocrit Care 2013 Oct;19(2):222-31

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s12028-013-9824-3
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http://dx.doi.org/10.1007/s12028-013-9824-3DOI Listing
October 2013

The SLC12 family of electroneutral cation-coupled chloride cotransporters.

Mol Aspects Med 2013 Apr-Jun;34(2-3):288-98

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.

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http://dx.doi.org/10.1016/j.mam.2012.05.002DOI Listing
September 2013

Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport.

Front Neurol 2013 25;4:78. Epub 2013 Jun 25.

Division of Neurosurgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3389/fneur.2013.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691543PMC
June 2013

The DECRA trial and decompressive craniectomy in diffuse traumatic brain injury: is decompression really ineffective?

World Neurosurg 2013 Jan 14;79(1):80-1. Epub 2012 Nov 14.

Department of Neurosurgery, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.wneu.2012.11.014DOI Listing
January 2013

Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?

J Clin Neurosci 2013 Jan 29;20(1):30-1. Epub 2012 Nov 29.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.jocn.2012.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529838PMC
January 2013

The GABA excitatory/inhibitory shift in brain maturation and neurological disorders.

Neuroscientist 2012 Oct 30;18(5):467-86. Epub 2012 Apr 30.

INMED, INSERM unit 901 and Neurochlore, Marseille, France.

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http://dx.doi.org/10.1177/1073858412438697DOI Listing
October 2012

Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells.

Cell Physiol Biochem 2012 8;30(1):33-48. Epub 2012 Jun 8.

Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1159/000339047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603147PMC
October 2012

Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals.

PLoS One 2011 14;6(12):e29193. Epub 2011 Dec 14.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237608PMC
August 2012

The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury.

Eur Spine J 2012 Jun 14;21 Suppl 4:S492-4. Epub 2011 Dec 14.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s00586-011-2116-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369053PMC
June 2012

Endoscopic treatment of hydrocephalus.

Arch Neurol 2012 May;69(5):664

Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1001/archneurol.2011.1766DOI Listing
May 2012

Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss.

Neurologist 2012 May;18(3):159-70

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/NRL.0b013e318247bcd8DOI Listing
May 2012

Chordoma: current concepts, management, and future directions.

Lancet Oncol 2012 Feb;13(2):e69-76

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/S1470-2045(11)70337-0DOI Listing
February 2012

Diffuse central neurocytoma with craniospinal dissemination.

J Clin Neurosci 2012 Jan 15;19(1):163-6. Epub 2011 Nov 15.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jocn.2011.07.016DOI Listing
January 2012

Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques.

J Clin Neurosci 2012 Jan 21;19(1):92-4. Epub 2011 Nov 21.

Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.jocn.2011.08.001DOI Listing
January 2012

Novel treatment targets for cerebral edema.

Neurotherapeutics 2012 Jan;9(1):65-72

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://link.springer.com/10.1007/s13311-011-0087-4
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http://dx.doi.org/10.1007/s13311-011-0087-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271162PMC
January 2012

Deep brain stimulation for medically refractory life-threatening status dystonicus in children.

J Neurosurg Pediatr 2012 Jan;9(1):99-102

Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.3171/2011.10.PEDS11360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734533PMC
January 2012