Publications by authors named "Kristopher M Kahlig"

25Publications

Eleclazine exhibits enhanced selectivity for long QT syndrome type 3-associated late Na current.

Heart Rhythm 2018 02 7;15(2):277-286. Epub 2017 Oct 7.

Department of Biology, Gilead Sciences, Inc., Fermont, California. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2017.09.028DOI Listing
February 2018

Early somatic mosaicism is a rare cause of long-QT syndrome.

Proc Natl Acad Sci U S A 2016 10 28;113(41):11555-11560. Epub 2016 Sep 28.

Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1607187113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068256PMC
October 2016

Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects.

Diabetes 2014 Oct 8;63(10):3545-56. Epub 2014 May 8.

Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Inc., Fremont, CA.

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http://dx.doi.org/10.2337/db13-1562DOI Listing
October 2014

Febrile temperatures unmask biophysical defects in Nav1.1 epilepsy mutations supportive of seizure initiation.

J Gen Physiol 2013 Dec;142(6):641-53

Department of Medical Genetics, Division of Biomedical Genetics, and 2 Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, 3508 AB Utrecht, Netherlands.

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http://dx.doi.org/10.1085/jgp.201311042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840920PMC
December 2013

Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.

Mol Pharmacol 2014 Jan 7;85(1):162-74. Epub 2013 Nov 7.

Department of Biology (Cardiovascular Therapeutic Area), Gilead Sciences, Inc., Foster City and Fremont, California (K.M.K., R.H., L.L., L.B., S.R.); Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (A.L.G.).

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http://dx.doi.org/10.1124/mol.113.088492DOI Listing
January 2014

Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression.

J Biol Chem 2012 Dec 19;287(50):42001-8. Epub 2012 Oct 19.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M112.421883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516746PMC
December 2012

Nav 1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome.

Eur J Neurosci 2011 Oct 22;34(8):1268-75. Epub 2011 Aug 22.

Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07826.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195841PMC
October 2011

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.

Epilepsia 2011 May 31;52(5):1000-9. Epub 2011 Mar 31.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0275, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2011.03040.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093448PMC
May 2011

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.

Channels (Austin) 2011 Mar-Apr;5(2):161-72. Epub 2011 Mar 1.

Department of Biology,Gilead Sciences, Palo Alto, CA, USA.

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http://dx.doi.org/10.4161/chan.5.2.14851DOI Listing
July 2011

Multiplexed transposon-mediated stable gene transfer in human cells.

Proc Natl Acad Sci U S A 2010 Jan 6;107(4):1343-8. Epub 2010 Jan 6.

Department of Medicine, Vanderbilt University, Nashville, TN 37235, USA.

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http://dx.doi.org/10.1073/pnas.0910383107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824351PMC
January 2010

Propranolol blocks cardiac and neuronal voltage-gated sodium channels.

Front Pharmacol 2010 31;1:144. Epub 2010 Dec 31.

Department of Medicine, Vanderbilt University School of Medicine Nashville, TN, USA.

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http://dx.doi.org/10.3389/fphar.2010.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153018PMC
November 2011

Divergent sodium channel defects in familial hemiplegic migraine.

Proc Natl Acad Sci U S A 2008 Jul 9;105(28):9799-804. Epub 2008 Jul 9.

Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37240, USA.

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http://dx.doi.org/10.1073/pnas.0711717105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474506PMC
July 2008

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures.

Epilepsia 2008 Sep 21;49(9):1535-45. Epub 2008 Apr 21.

Department of Pharmacology, Division of GeneticMedicine, Vanderbilt University, Nashville, Tennessee 37232-0275, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2008.01619.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647030PMC
September 2008

Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation.

J Neurosci 2006 Oct;26(43):10958-66

Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0275, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3378-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674674PMC
October 2006

Nonfunctional SCN1A is common in severe myoclonic epilepsy of infancy.

Epilepsia 2006 Oct;47(10):1636-42

Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0275, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2006.00643.xDOI Listing
October 2006

Regulation of dopamine transporter trafficking by intracellular amphetamine.

Mol Pharmacol 2006 Aug 9;70(2):542-8. Epub 2006 May 9.

Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University, 465 21st Ave. South, Nashville, TN 37232-8548, USA.

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http://dx.doi.org/10.1124/mol.106.023952DOI Listing
August 2006

Amphetamine induces dopamine efflux through a dopamine transporter channel.

Proc Natl Acad Sci U S A 2005 Mar 22;102(9):3495-500. Epub 2005 Feb 22.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 465 21st Avenue South, Nashville, TN 37232-8548, USA.

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http://dx.doi.org/10.1073/pnas.0407737102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549289PMC
March 2005

Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier.

J Biol Chem 2004 Mar 29;279(10):8966-75. Epub 2003 Dec 29.

Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232-8548, USA.

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http://dx.doi.org/10.1074/jbc.M303976200DOI Listing
March 2004

Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine.

Eur J Pharmacol 2003 Oct;479(1-3):153-8

Center for Molecular Neuroscience, Department of Molecular Physiology and Biophysics, Vanderbilt University, 465 21st Ave South, Nashville, TN 37232-8548, USA.

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http://dx.doi.org/10.1016/j.ejphar.2003.08.065DOI Listing
October 2003

A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.

J Neurosci 2003 Mar;23(5):1697-709

Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8548, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741950PMC
March 2003

PI 3-kinase regulation of dopamine uptake.

J Neurochem 2002 May;81(4):859-69

Department of Pharmacology, MC 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00892.xDOI Listing
May 2002