Publications by authors named "Kristine Vanijcharoenkarn"

6 Publications

  • Page 1 of 1

Immediate reactions following the first dose of the SARS-CoV2 mRNA vaccines do not preclude second dose administration.

Clin Infect Dis 2021 May 14. Epub 2021 May 14.

Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

Addressing COVID19 vaccine hesitancy and minimizing potential vaccine contraindications are critical to combat the ongoing pandemic. We describe a practical approach to immediate adverse events after the first dose of the SARS-CoV2 mRNA vaccines, focusing on allergic reactions with respect to their diagnosis and management.
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http://dx.doi.org/10.1093/cid/ciab448DOI Listing
May 2021

Approach to Perioperative Anaphylaxis in 2020: Updates in Diagnosis and Management.

Curr Allergy Asthma Rep 2021 01 6;21(1). Epub 2021 Jan 6.

Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA, USA.

Purpose Of Review: The goal of the paper is to review the epidemiology, pathogenesis, diagnosis, and manifestations of perioperative anaphylaxis (POA). We seek to review the most common culprits of POA and different diagnostic modalities for evaluation.

Recent Findings: Specific IgE testing has a limited role in POA evaluation due to lack of widespread availability and low sensitivity. Basophil activation testing is complementary to skin tests and can assist NMBA sensitivity diagnosis in complex cases. In the past years, there has been an exponential increase in suspected teicoplanin allergic reactions in the European Union. Chlorhexidine is also being increasingly implicated as a culprit in POA. Multiple classes of perioperative medications cause POA. Diagnostic modalities available include skin testing with nonirritating concentrations, basophil activation tests, specific IgE, and drug provocation testing. An accurate record and critical analysis of perioperative events is more important than isolated test results. Future studies evaluating the pathophysiology of these reactions and other therapeutic strategies, such as targeting the MRGPRX2 receptor, are needed.
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http://dx.doi.org/10.1007/s11882-020-00980-yDOI Listing
January 2021

The spectrum of allergic ocular diseases.

Ann Allergy Asthma Immunol 2021 03 1;126(3):240-254. Epub 2020 Dec 1.

Allergy and Immunology, Nova Southeastern University, Davie, Florida.

Objective: The purpose of this article is to review the pathophysiologic mechanisms, differential diagnosis, evaluation, and treatment of the various manifestations of ocular allergy, with an especial focus on immunoglobulin E (IgE)-mediated disease.

Data Sources: A PubMed search was performed to include articles, using the search terms ocular allergy and allergic conjunctivitis.

Study Selections: Recent and relevant human studies in the English language pertaining to our topic of study were selected. Animal studies pertaining to pathophysiology of ocular allergy were also reviewed. We focused on clinical trials, practice guidelines, reviews, and systematic reviews. In addition, case reports were reviewed if they described rare clinical presentations, disease mechanisms, or novel therapies.

Results: Ocular allergy encompasses both IgE- and non-IgE-mediated disease, and the clinical severity may range from mild to sight-threatening inflammation. A comprehensive treatment regimen including education, lifestyle measures, topical therapies, and even systemic interventions may be necessary for the effective management of ocular allergies, tailored according to symptom severity.

Conclusion: Ocular allergy is frequently encountered by allergists and eye-care specialists, and despite progressively increasing incidence, it often remains underdiagnosed and, hence, untreated.
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http://dx.doi.org/10.1016/j.anai.2020.11.016DOI Listing
March 2021

The Role of Mast Cells in Aspirin-Exacerbated Respiratory Disease (AERD) Pathogenesis: Implications for Future Therapeutics.

J Asthma Allergy 2020 12;13:463-470. Epub 2020 Oct 12.

Department of Otolaryngology - Head & Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.

Mast cells (MC) have recently been demonstrated to play an integral role in the pathogenesis of aspirin-exacerbated respiratory disease (AERD). When activated, MCs release pre-formed granules of many pro-inflammatory mediators, including histamine, serotonin, and various chemokines and cytokines including tumor necrosis factor (TNF)-α, interferon ɣ (IFN ɣ), macrophage inhibitory factor, transforming growth factor, interleukin (IL) 1, 3-6, 9, 10, 13 and 16. These mediators promote inflammation in AERD by recruiting or activating a network of cells involved in acute and chronic inflammatory pathways, such as endothelial, epithelial, stromal, and other immune cells. Several studies have implicated multifactorial pathways for MC activation in AERD beyond classical IgE mediated mechanisms. The elucidation of these complex networks therefore represents important targets for innovative patient therapeutics. This review summarizes classic and alternative pathways of MC activation in AERD with a special focus in relation to new and emerging treatment strategies.
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http://dx.doi.org/10.2147/JAA.S237463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569245PMC
October 2020

Epidemiology and risk factors for asthma.

Respir Med 2019 03 31;149:16-22. Epub 2019 Jan 31.

Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University, USA.

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http://dx.doi.org/10.1016/j.rmed.2019.01.014DOI Listing
March 2019

Exogenous progesterone hypersensitivity associated with recurrent pregnancy loss.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1412-1413. Epub 2018 Jan 12.

Cornell Center for Reproductive Medicine, New York, NY.

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http://dx.doi.org/10.1016/j.jaip.2017.11.041DOI Listing
November 2019