Publications by authors named "Kristine Pelton"

22Publications

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 08 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.

Prostate Cancer Prostatic Dis 2018 06 23;21(2):196-203. Epub 2018 May 23.

Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41391-018-0045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026483PMC
June 2018

Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

Neuro Oncol 2017 Jul;19(7):908-917

Department of Radiation Oncology, Department of Pathology, Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center (DF/BWCC), Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; Accelerate Brain Cancer Cure (ABC2), Washington, DC; Harvard Program in Therapeutic Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570228PMC
July 2017

Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.

Clin Cancer Res 2016 Mar 19;22(5):1185-96. Epub 2015 Oct 19.

Inserm, U 1127, Paris, France. CNRS, UMR 7225, Paris, France. Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Paris, France. Institut du Cerveau et de la Moëlle épinière, ICM, 47, Bd de l'Hôpital, Paris, France. AP-HP, Hôpital universitaire Pitié-Salpêtrière, Service de Neurologie 2-Mazarin, 47, Bd de l'Hôpital, Paris, France. AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neuropathologie R Escourolle, 47, Bd de l'Hôpital, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842012PMC
March 2016

Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo.

Am J Pathol 2014 Jul;184(7):2099-110

The Program in Vascular Biology, Boston Children's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ajpath.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076468PMC
July 2014

Cholesterol and prostate cancer.

Curr Opin Pharmacol 2012 Dec 21;12(6):751-9. Epub 2012 Jul 21.

The Urological Diseases Research Center, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coph.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515742PMC
December 2012

Hypercholesterolemia promotes an osteoporotic phenotype.

Am J Pathol 2012 Sep 4;181(3):928-36. Epub 2012 Jul 4.

Department of Orthopaedic Surgery, Children's Hospital Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432436PMC
September 2012

The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network.

PLoS One 2012 2;7(7):e39448. Epub 2012 Jul 2.

Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039448PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388073PMC
November 2012

Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors.

PLoS One 2012 18;7(1):e30062. Epub 2012 Jan 18.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261168PMC
July 2012

FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle.

Am J Pathol 2011 Dec 11;179(6):2977-89. Epub 2011 Oct 11.

Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260854PMC
December 2011

Prohibitin is a cholesterol-sensitive regulator of cell cycle transit.

J Cell Biochem 2010 Dec;111(5):1367-74

Department of Orthopaedic Surgery, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://doi.wiley.com/10.1002/jcb.22865
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http://dx.doi.org/10.1002/jcb.22865DOI Listing
December 2010

Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia.

J Urol 2010 Oct 21;184(4):1555-9. Epub 2010 Aug 21.

Department of Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.juro.2010.05.083DOI Listing
October 2010

Ezetimibe is an inhibitor of tumor angiogenesis.

Am J Pathol 2009 Mar 29;174(3):1017-26. Epub 2009 Jan 29.

Dept. of Orthopaedic Surgery, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2353/ajpath.2009.080551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665761PMC
March 2009