Kristina Schoonjans

Kristina Schoonjans

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Kristina Schoonjans

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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.

Diabetes 2020 Apr 10;69(4):614-623. Epub 2020 Feb 10.

Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.2337/db19-0764DOI Listing
April 2020

Identifying gene function and module connections by the integration of multispecies expression compendia.

Genome Res 2019 12 21;29(12):2034-2045. Epub 2019 Nov 21.

Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

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http://dx.doi.org/10.1101/gr.251983.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886503PMC
December 2019

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver.

Cells 2019 11 19;8(11). Epub 2019 Nov 19.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.3390/cells8111467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912679PMC
November 2019

The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility.

Cell Rep 2019 Aug;28(9):2443-2454.e4

Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.088DOI Listing
August 2019

NTCP deficiency in mice protects against obesity and hepatosteatosis.

JCI Insight 2019 Jun 25;5. Epub 2019 Jun 25.

Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1172/jci.insight.127197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675549PMC
June 2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

Am J Physiol Gastrointest Liver Physiol 2019 05 15;316(5):G574-G584. Epub 2019 Feb 15.

Novo Nordic Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/ajpgi.00010.2019
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http://dx.doi.org/10.1152/ajpgi.00010.2019DOI Listing
May 2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

Mol Cell 2019 02 11;73(4):775-787.e10. Epub 2019 Jan 11.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183100
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http://dx.doi.org/10.1016/j.molcel.2018.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396316PMC
February 2019

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Mol Metab 2018 05 17;11:84-95. Epub 2018 Mar 17.

Department of Biomedical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001409PMC
May 2018

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Cell Syst 2018 Jan 30;6(1):90-102.e4. Epub 2017 Nov 30.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.10.016DOI Listing
January 2018

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue.

Nat Commun 2018 01 16;9(1):245. Epub 2018 Jan 16.

Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41467-017-02068-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770450PMC
January 2018

The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation.

J Endocr Soc 2018 Jan 1;2(1):24-41. Epub 2017 Dec 1.

Centre de Recherche en Reproduction et Fertilité, Université de Montréal, St-Hyacinthe, Quebec J2S 2M2, Canada.

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http://dx.doi.org/10.1210/js.2017-00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779114PMC
January 2018

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Integr Biol (Camb) 2017 10;9(10):810-819

Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, EPFL-STI-IMT-LMIS2, Building BM, Station 17, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1039/c7ib00015dDOI Listing
October 2017

Megatrends in bile acid receptor research.

Hepatol Commun 2017 10 24;1(8):831-835. Epub 2017 Aug 24.

Icahn School of Medicine at Mount Sinai New York NY.

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http://dx.doi.org/10.1002/hep4.1085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678912PMC
October 2017

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells.

FASEB J 2017 09 9;31(9):3848-3857. Epub 2017 May 9.

Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland;

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http://dx.doi.org/10.1096/fj.201601365RDOI Listing
September 2017

Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection.

Biol Reprod 2017 Jun;96(6):1231-1243

Centre de recherche en reproduction et fertilité, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, Quebec, Canada.

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http://dx.doi.org/10.1093/biolre/iox045DOI Listing
June 2017

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice.

Liver Transpl 2017 01;23(1):63-74

Translational Medicine Research Center, Affiliated Jiangning Hospital and Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1002/lt.24628DOI Listing
January 2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.

J Hepatol 2017 01 20;66(1):132-141. Epub 2016 Sep 20.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.08.024DOI Listing
January 2017

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Science 2016 Jun 28;352(6292):1436-43. Epub 2016 Apr 28.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.aaf2693DOI Listing
June 2016

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Genes Dev 2016 06;30(11):1255-60

Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1101/gad.277483.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911925PMC
June 2016

Bile acid-FXRα pathways regulate male sexual maturation in mice.

Oncotarget 2016 Apr;7(15):19468-82

INSERM U 1103, Laboratoire GReD, Campus Universitaire des Cézeaux, TSA 60026, CS 60026, 63178 Aubière Cedex, France.

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http://dx.doi.org/10.18632/oncotarget.7153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991395PMC
April 2016

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology.

Trends Pharmacol Sci 2015 Dec 2;36(12):847-857. Epub 2015 Nov 2.

Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.08.002DOI Listing
December 2015

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice.

Hepatology 2015 Nov 22;62(5):1606-18. Epub 2015 Jul 22.

Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/hep.27907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618256PMC
November 2015

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.

Endocrinology 2015 Nov 17;156(11):3961-70. Epub 2015 Aug 17.

University of Cambridge (C.A.B., J.R., L.L.G., F.M.G., F.R.), Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences (R.E.K., J.J.H.), the Panum Institute, University of Copenhagen, Copenhagen, Denmark; and Institute of Bioengineering (K.S.), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.

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http://dx.doi.org/10.1210/en.2015-1321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606749PMC
November 2015

Molecular basis for the regulation of the nuclear receptor LRH-1.

Curr Opin Cell Biol 2015 Apr 15;33:26-34. Epub 2014 Nov 15.

Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, SV IBI GR-SCH, Station 15, CH-1015 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674140012
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http://dx.doi.org/10.1016/j.ceb.2014.10.007DOI Listing
April 2015

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis.

Nat Commun 2015 Apr 15;6:6801. Epub 2015 Apr 15.

1] UMR MD3, EA2405 Polarisation des Macrophages et Récepteurs Nucléaires dans les Pathologies Inflammatoires et Infectieuses, UPS, Toulouse 31400, France [2] Université de Toulouse, UMR 152, UPS, Toulouse 31400, France.

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http://dx.doi.org/10.1038/ncomms7801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410638PMC
April 2015

Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.

Endocrinology 2015 Feb 26;156(2):660-9. Epub 2014 Nov 26.

Inserm Unit 1103 (A.V., E.M., M.B., A.D.H., J.-P.S., S.B., F.C., J.-M.A.L., D.H.V.), Génétique Reproduction et Développement (GReD), Boîte Postale 80026; Clermont Université (A.V., E.M., M.B., A.D.H., J.-P.S., S.B., F.C., J.-M.A.L., D.H.V.), Université Blaise Pascal, GReD; and Centre National de la Recherche Scientifique (A.V., E.M., M.B., A.D.H., J.-P.S., S.B., F.C., J.-M.A.L., D.H.V.), Unité Mixte de recherche 6293, GReD, F-63170 Aubière Cedex, France; Centre de Recherche en Nutrition Humaine d'Auvergne (A.V., E.M., M.B., A.D.H., J.-P.S., S.B., F.C., J.-M.A.L., D.H.V.), F-63000 Clermont-Ferrand Cedex, France; and Institute of Bioengineering (K.S.), Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1210/en.2014-1418DOI Listing
February 2015

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Eur Heart J 2015 Jan 6;36(1):51-9. Epub 2014 Mar 6.

Cardiovascular Research, Institute of Physiology, University of Zurich and University Heart Center, Cardiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland Zurich Center of Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1093/eurheartj/ehu095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286317PMC
January 2015

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.

Expert Opin Ther Targets 2014 Dec 29;18(12):1367-76. Epub 2014 Sep 29.

INSERM U 1103, Génétique Reproduction et Développement (GReD) , BP 80026, F-63171 Aubière Cedex , France +33 4 73407415 ; +33 4 73407042 ;

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http://dx.doi.org/10.1517/14728222.2014.964209DOI Listing
December 2014

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.

Cell Metab 2014 Nov 4;20(5):856-869. Epub 2014 Sep 4.

Laboratory of Integrative and Systems Physiology, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.08.001DOI Listing
November 2014

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.

Cell Metab 2014 Oct 28;20(4):603-13. Epub 2014 Aug 28.

Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.07.023DOI Listing
October 2014

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.

Hepatology 2014 Sep;60(3):1054-65

INSERM U 1103, Génétique Reproduction et Développement (GReD), Aubière, France; Clermont Université, Université Blaise, Pascal, GReD, BP 80026, Aubière, France; CNRS, UMR 6293, GReD, Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, Clermont-Ferrand, France.

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http://dx.doi.org/10.1002/hep.27204DOI Listing
September 2014

Another Shp on the horizon for bile acids.

Cell Metab 2014 Aug;20(2):203-5

Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.07.019DOI Listing
August 2014

The orphan nuclear receptor Nr5a2 is essential for luteinization in the female mouse ovary.

Endocrinology 2014 May 19;155(5):1931-43. Epub 2014 Feb 19.

Centre de Recherche en Reproduction Animale (K.B., B.D.M.), Faculté de Médecine Vétérinaire, Université de Montréal, Saint Hyacinthe, Québec, Canada J2S 7C6; Gossen Consultancy (J.G.), 5345 BA Oss, The Netherlands; and Laboratory of Integrative and Systems Physiology (K.S.), École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1210/en.2013-1765DOI Listing
May 2014

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Gut 2014 Apr 18;63(4):647-55. Epub 2013 Apr 18.

Epithelial Carcinogenesis Group, Molecular Pathology Programme, CNIO-Spanish National Cancer Research Center, , Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2012-304381DOI Listing
April 2014

Hepatic glucose sensing and integrative pathways in the liver.

Cell Mol Life Sci 2014 Apr 7;71(8):1453-67. Epub 2013 Nov 7.

Department of Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-013-1505-zDOI Listing
April 2014

Vitamin D and energy homeostasis: of mice and men.

Nat Rev Endocrinol 2014 Feb 19;10(2):79-87. Epub 2013 Nov 19.

Clinical and Experimental Endocrinology, KU Leuven, O&NI Herestraat 49 - bus 902, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrendo.2013.226DOI Listing
February 2014

Probing the Binding Site of Bile Acids in TGR5.

ACS Med Chem Lett 2013 Dec 15;4(12):1158-62. Epub 2013 Oct 15.

Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia , 06123 Perugia, Italy ; TES Pharma S.r.l. , via Palmiro Togliatti 20, 06073 Corciano (Perugia), Italy.

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http://dx.doi.org/10.1021/ml400247kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027510PMC
December 2013

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

Hepatology 2013 Oct 19;58(4):1451-60. Epub 2013 Aug 19.

INSERM U.757, Université Paris Sud, Orsay, France; Université Paris Sud, Orsay, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1002/hep.26463DOI Listing
October 2013

The metabolic footprint of aging in mice.

Sci Rep 2011 31;1:134. Epub 2011 Oct 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fe´de´rale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/srep00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216615PMC
September 2013

Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network.

Mol Metab 2013 16;2(3):314-23. Epub 2013 Mar 16.

Swiss Federal Institute of Technology, ETH Zürich, Competence Centre for Systems Physiology (CC-SPMD), Institute of Food Nutrition and Health, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.

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http://dx.doi.org/10.1016/j.molmet.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773829PMC
September 2013

Metabolic characterization of a Sirt5 deficient mouse model.

Sci Rep 2013 Sep 30;3:2806. Epub 2013 Sep 30.

Laboratory of Integrative and Systems Physiology (LISP/NCEM), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/srep02806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786297PMC
September 2013

Liver receptor homolog-1 is essential for pregnancy.

Nat Med 2013 Aug 30;19(8):1061-6. Epub 2013 Jun 30.

Centre de recherche en reproduction animale, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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http://dx.doi.org/10.1038/nm.3192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983050PMC
August 2013

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.

Sci Rep 2012 30;2:430. Epub 2012 May 30.

Laboratory of Integrative and Systems Physiology-LISP, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/srep00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362799PMC
February 2013

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.

Cell 2012 Sep 30;150(6):1287-99. Epub 2012 Aug 30.

Laboratory of Integrative and Systems Physiology, School of Life Sciences, École Polytechnique Fédérale de Lausanne 1015, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2012.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604687PMC
September 2012

LRH-1-dependent glucose sensing determines intermediary metabolism in liver.

J Clin Invest 2012 Aug 9;122(8):2817-26. Epub 2012 Jul 9.

Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1172/JCI62368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408738PMC
August 2012

The bile acid membrane receptor TGR5: a valuable metabolic target.

Dig Dis 2011 17;29(1):37-44. Epub 2011 Jun 17.

Laboratory of Integrative and Systems Physiology at the Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1159/000324126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128138PMC
October 2011

Emerging actions of the nuclear receptor LRH-1 in the gut.

Biochim Biophys Acta 2011 Aug 29;1812(8):947-55. Epub 2010 Dec 29.

Laboratory of Integrative and Systems Physiology, EPFL SV IBI1 NCEM1, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.bbadis.2010.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617401PMC
August 2011

Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells.

Eur J Immunol 2011 Jul 6;41(7):1980-91. Epub 2011 Jun 6.

Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/eji.201041357DOI Listing
July 2011

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.

J Hepatol 2011 Jun 9;54(6):1263-72. Epub 2010 Dec 9.

Laboratory of Integrative and Systems Physiology (LISP), Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2010.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650458PMC
June 2011

Mitochondrial matrix calcium is an activating signal for hormone secretion.

Cell Metab 2011 May;13(5):601-11

Department of Cell Physiology and Metabolism, University of Geneva, University Medical Center, Switzerland.

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http://dx.doi.org/10.1016/j.cmet.2011.03.015DOI Listing
May 2011

Redefining the TGR5 triterpenoid binding pocket at the C-3 position.

ChemMedChem 2010 Dec;5(12):1983-8

UMR/CNRS, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1002/cmdc.201000329DOI Listing
December 2010

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.

FASEB J 2010 Nov 20;24(11):4613-26. Epub 2010 Jul 20.

Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1096/fj.10-162222DOI Listing
November 2010

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Cell Metab 2010 Oct;12(4):321-327

Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Integrative and Systems Physiology, Station 15, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2010.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642811PMC
October 2010

Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner.

FASEB J 2010 May 7;24(5):1340-6. Epub 2010 Jan 7.

Division of Experimental Pathology, Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1096/fj.09-140913DOI Listing
May 2010

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr.

Am J Physiol Gastrointest Liver Physiol 2010 Feb 8;298(2):G151-8. Epub 2009 Oct 8.

Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.

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http://dx.doi.org/10.1152/ajpgi.00336.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822506PMC
February 2010

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.

J Clin Invest 2009 Dec 2;119(12):3752-64. Epub 2009 Nov 2.

INSERM U895, Centre Méditerranéen de Médecine Moléculaire, Hôpital l'Archet 2, Nice, France.

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http://dx.doi.org/10.1172/JCI38521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786790PMC
December 2009

Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells.

FASEB J 2008 Dec 18;22(12):4117-25. Epub 2008 Aug 18.

Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1096/fj.08-114157DOI Listing
December 2008

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

Proc Natl Acad Sci U S A 2008 Nov 28;105(44):17187-92. Epub 2008 Oct 28.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, 67404 Illkirch, France.

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http://dx.doi.org/10.1073/pnas.0808207105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579399PMC
November 2008

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.

J Chem Inf Model 2008 Sep 13;48(9):1792-801. Epub 2008 Aug 13.

Dipartimento di Chimica e Tecnologia del Farmaco, Universita di Perugia, Via del Liceo 1, 06123 Perugia, Italy.

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http://dx.doi.org/10.1021/ci800196hDOI Listing
September 2008

Targeting bile-acid signalling for metabolic diseases.

Nat Rev Drug Discov 2008 Aug;7(8):678-93

Institute of Genetics and Molecular and Cellular Biology, 1 Rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/nrd2619DOI Listing
August 2008

Liver receptor homolog 1 is essential for ovulation.

Genes Dev 2008 Jul;22(14):1871-6

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France.

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http://dx.doi.org/10.1101/gad.472008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492734PMC
July 2008

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues.

J Lipid Res 2008 May 13;49(5):1024-33. Epub 2008 Feb 13.

Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, St. Hyacinthe, Quebec, Canada J2S 7C6.

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http://dx.doi.org/10.1194/jlr.M700554-JLR200DOI Listing
May 2008

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.

Chem Biol 2008 Apr;15(4):383-92

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département de Biologie et de Génomique Structurales, Université Louis Pasteur, Strasbourg F-67000, France.

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http://dx.doi.org/10.1016/j.chembiol.2008.03.016DOI Listing
April 2008

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.

J Med Chem 2008 Mar 29;51(6):1831-41. Epub 2008 Feb 29.

Institut de Genetique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/INSERM/ULP, Illkirch, France.

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http://dx.doi.org/10.1021/jm7015864DOI Listing
March 2008

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.

Thyroid 2008 Feb;18(2):167-74

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, Illkirch, France.

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http://dx.doi.org/10.1089/thy.2007.0255DOI Listing
February 2008

Sirtuins: the 'magnificent seven', function, metabolism and longevity.

Ann Med 2007 ;39(5):335-45

Institut de Génétique et de Biologie Moléculaire et Cellulaire de Strasbourg (IGBMC), INSERM/CNRS/ULP, Illkirch, France.

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http://dx.doi.org/10.1080/07853890701408194DOI Listing
December 2007