Publications by authors named "Kristina Althoff"

21Publications

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.

Authors:
Lena Quambusch Ina Landel Laura Depta Jörn Weisner Niklas Uhlenbrock Matthias P Müller Franziska Glanemann Kristina Althoff Jens T Siveke Daniel Rauh

Angew Chem Int Ed Engl 2019 12 8;58(52):18823-18829. Epub 2019 Nov 8.

Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

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December 2019

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.

Authors:
Youjia Han Sven Lindner Yi Bei Heathcliff Dorado Garcia Natalie Timme Kristina Althoff Andrea Odersky Alexander Schramm Andrej Lissat Annette Künkele Hedwig E Deubzer Angelika Eggert Johannes H Schulte Anton G Henssen

Cancer Lett 2019 03 4;445:24-33. Epub 2019 Jan 4.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany; German Consortium for Translational Cancer Research (DKTK), Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:

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March 2019

ALK positively regulates MYCN activity through repression of HBP1 expression.

Authors:
Shana Claeys Geertrui Denecker Kaat Durinck Bieke Decaesteker Liselot M Mus Siebe Loontiens Suzanne Vanhauwaert Kristina Althoff Caroline Wigerup Daniel Bexell Emmy Dolman Kai-Oliver Henrich Lea Wehrmann Ellen M Westerhout Jean-Baptiste Demoulin Candy Kumps Tom Van Maerken Genevieve Laureys Christophe Van Neste Bram De Wilde Olivier De Wever Frank Westermann Rogier Versteeg Jan J Molenaar Sven Påhlman Johannes H Schulte Katleen De Preter Frank Speleman

Oncogene 2019 04 11;38(15):2690-2705. Epub 2018 Dec 11.

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

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April 2019

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.

Authors:
Phyllis F Cheung Florian Neff Christian Neander Anna Bazarna Konstantinos Savvatakis Sven-Thorsten Liffers Kristina Althoff Chang-Lung Lee Everett J Moding David G Kirsch Dieter Saur Alexandr V Bazhin Marija Trajkovic-Arsic Mathias F Heikenwalder Jens T Siveke

Cancer Res 2018 09 29;78(17):4997-5010. Epub 2018 May 29.

Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.

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September 2018

The mutational landscape of , and driven murine neuroblastoma mimics human disease.

Authors:
Bram De Wilde Anneleen Beckers Sven Lindner Althoff Kristina Katleen De Preter Pauline Depuydt Pieter Mestdagh Tom Sante Steve Lefever Falk Hertwig Zhiyu Peng Le-Ming Shi Sangkyun Lee Elien Vandermarliere Lennart Martens Björn Menten Alexander Schramm Matthias Fischer Johannes Schulte Jo Vandesompele Frank Speleman

Oncotarget 2018 Feb 22;9(9):8334-8349. Epub 2017 Dec 22.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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February 2018

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.

Authors:
Julian P Layer Marie T Kronmüller Thomas Quast Debby van den Boorn-Konijnenberg Maike Effern Daniel Hinze Kristina Althoff Alexander Schramm Frank Westermann Martin Peifer Gunther Hartmann Thomas Tüting Waldemar Kolanus Matthias Fischer Johannes Schulte Michael Hölzel

Oncoimmunology 2017;6(6):e1320626. Epub 2017 Apr 28.

Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.

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April 2017

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.

Authors:
Aline Gottlieb Kristina Althoff Laura Grunewald Theresa Thor Andrea Odersky Marc Schulte Hedwig E Deubzer Lukas Heukamp Angelika Eggert Alexander Schramm Johannes H Schulte Annette Künkele

Oncotarget 2017 Apr;8(17):27882-27891

Department of Pediatric Oncology, Hematology and SCT, Charité, 13353 Berlin, Germany.

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April 2017

MYCN-mediated murine cancer models.

Authors:
Kristina Althoff Alexander Schramm

Aging (Albany NY) 2017 Apr;9(4):1084-1085

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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April 2017

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.

Authors:
Kristian W Pajtler Natalie Sadowski Sandra Ackermann Kristina Althoff Kerstin Schönbeck Katharina Batzke Simon Schäfers Andrea Odersky Lukas Heukamp Kathy Astrahantseff Annette Künkele Hedwig E Deubzer Alexander Schramm Annika Sprüssel Theresa Thor Sven Lindner Angelika Eggert Matthias Fischer Johannes H Schulte

Oncotarget 2017 Jan;8(4):6730-6741

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.

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January 2017

Targeting tachykinin receptors in neuroblastoma.

Authors:
Anton G Henssen Andrea Odersky Annabell Szymansky Marleen Seiler Kristina Althoff Anneleen Beckers Frank Speleman Simon Schäfers Katleen De Preter Kathy Astrahanseff Joachim Struck Alexander Schramm Angelika Eggert Andreas Bergmann Johannes H Schulte

Oncotarget 2017 Jan;8(1):430-443

Department of Pediatric Oncology/Hematology, Charité- Universitätsmedizin Berlin, Germany.

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January 2017

Towards diagnostic application of non-coding RNAs in neuroblastoma.

Authors:
Kristina Althoff Johannes H Schulte Alexander Schramm

Expert Rev Mol Diagn 2016 12 15;16(12):1307-1313. Epub 2016 Nov 15.

a Department of Pediatric Oncology and Hematology , University Children's Hospital Essen , Essen , Germany.

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December 2016

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells.

Authors:
Kathrin Fielitz Kristina Althoff Katleen De Preter Julie Nonnekens Jasmin Ohli Sandra Elges Wolfgang Hartmann Günter Klöppel Thomas Knösel Marc Schulte Ludger Klein-Hitpass Daniela Beisser Henning Reis Annette Eyking Elke Cario Johannes H Schulte Alexander Schramm Ulrich Schüller

Oncotarget 2016 11;7(46):74415-74426

Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany.

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November 2016

Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.

Authors:
Melanie Schwermer Sabine Dreesmann Angelika Eggert Kristina Althoff Laura Steenpass Alexander Schramm Johannes H Schulte Petra Temming

Clin Exp Ophthalmol 2017 Apr 10;45(3):288-296. Epub 2016 Nov 10.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.

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April 2017

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.

Authors:
Johannes Fabian Desirée Opitz Kristina Althoff Marco Lodrini Barbara Hero Ruth Volland Anneleen Beckers Katleen de Preter Anneleen Decock Nitin Patil Mohammed Abba Annette Kopp-Schneider Kathy Astrahantseff Jasmin Wünschel Sebastian Pfeil Maria Ercu Annette Künkele Jamie Hu Theresa Thole Leonille Schweizer Gunhild Mechtersheimer Daniel Carter Belamy B Cheung Odilia Popanda Andreas von Deimling Jan Koster Rogier Versteeg Manfred Schwab Glenn M Marshall Frank Speleman Ulrike Erb Margot Zoeller Heike Allgayer Thorsten Simon Matthias Fischer Andreas E Kulozik Angelika Eggert Olaf Witt Johannes H Schulte Hedwig E Deubzer

Oncotarget 2016 10;7(41):66344-66359

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), INF, Heidelberg, Germany.

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October 2016

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Authors:
Anton Henssen Kristina Althoff Andrea Odersky Anneleen Beckers Richard Koche Frank Speleman Simon Schäfers Emma Bell Maike Nortmeyer Frank Westermann Katleen De Preter Alexandra Florin Lukas Heukamp Annika Spruessel Kathy Astrahanseff Sven Lindner Natalie Sadowski Alexander Schramm Lucile Astorgues-Xerri Maria E Riveiro Angelika Eggert Esteban Cvitkovic Johannes H Schulte

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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May 2016

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma.

Authors:
Anneleen Beckers Gert Van Peer Daniel R Carter Moritz Gartlgruber Carl Herrmann Saurabh Agarwal Hetty H Helsmoortel Kristina Althoff Jan J Molenaar Belamy B Cheung Johannes H Schulte Yves Benoit Jason M Shohet Frank Westermann Glenn M Marshall Jo Vandesompele Katleen De Preter Frank Speleman

Cancer Lett 2015 Sep 26;366(1):123-32. Epub 2015 Jun 26.

Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

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September 2015

Mutational dynamics between primary and relapse neuroblastomas.

Authors:
Alexander Schramm Johannes Köster Yassen Assenov Kristina Althoff Martin Peifer Ellen Mahlow Andrea Odersky Daniela Beisser Corinna Ernst Anton G Henssen Harald Stephan Christopher Schröder Lukas Heukamp Anne Engesser Yvonne Kahlert Jessica Theissen Barbara Hero Frederik Roels Janine Altmüller Peter Nürnberg Kathy Astrahantseff Christian Gloeckner Katleen De Preter Christoph Plass Sangkyun Lee Holger N Lode Kai-Oliver Henrich Moritz Gartlgruber Frank Speleman Peter Schmezer Frank Westermann Sven Rahmann Matthias Fischer Angelika Eggert Johannes H Schulte

Nat Genet 2015 Aug 29;47(8):872-7. Epub 2015 Jun 29.

1] Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany. [2] Pediatric Oncology and Hematology, Charité University Medicine, Berlin, Germany. [3] German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.

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August 2015

MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation.

Authors:
Anneleen Beckers Gert Van Peer Daniel R Carter Evelien Mets Kristina Althoff Belamy B Cheung Johannes H Schulte Pieter Mestdagh Jo Vandesompele Glenn M Marshall Katleen De Preter Frank Speleman

Oncotarget 2015 Mar;6(7):5204-16

Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium.

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March 2015

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Authors:
Kristina Althoff Sven Lindner Andrea Odersky Pieter Mestdagh Anneleen Beckers Sarah Karczewski Jan J Molenaar Anna Bohrer Shirley Knauer Frank Speleman Matthias Epple Diana Kozlova Sena Yoon Kwanghee Baek Jo Vandesompele Angelika Eggert Alexander Schramm Johannes H Schulte

Int J Cancer 2015 Mar 5;136(6):1308-20. Epub 2014 Aug 5.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.

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March 2015

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.

Authors:
Anton Henssen Theresa Thor Andrea Odersky Lukas Heukamp Nicolai El-Hindy Anneleen Beckers Frank Speleman Kristina Althoff Simon Schäfers Alexander Schramm Ulrich Sure Gudrun Fleischhack Angelika Eggert Johannes H Schulte

Oncotarget 2013 Nov;4(11):2080-95

Istituto Superiore di Sanità, Rome, Italy.

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November 2013

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

Authors:
Kristina Althoff Anneleen Beckers Andrea Odersky Pieter Mestdagh Johannes Köster Isabella M Bray Kenneth Bryan Jo Vandesompele Frank Speleman Raymond L Stallings Alexander Schramm Angelika Eggert Annika Sprüssel Johannes H Schulte

Int J Cancer 2013 Sep 7;133(5):1064-73. Epub 2013 Mar 7.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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September 2013