Publications by authors named "Kristin Technau-Hafsi"

29 Publications

  • Page 1 of 1

Case Report: Blurred Vision and Eruptive Nevi - Bilateral Diffuse Uveal Melanocytic Proliferation With Mucocutaneous Involvement in a Lung Cancer Patient.

Front Oncol 2021 13;11:658407. Epub 2021 Apr 13.

Eye Center, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

We describe a case of a 65-year old patient presenting with unusual mucocutaneous melanocytic proliferations of a Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) imitating a multifocal melanoma in situ, which improved dramatically after plasmapheresis. The patient first presented at the dermatology department due to rapidly evolving brown and black macules on the glans penis. Further skin involvement of the perineal and perianal region, mamillae and oral mucosa was stated. Histology from a penile biopsy was compatible with a melanoma in situ. Due to the distribution pattern and elevated serum tumor marker S100B, metastatic melanoma was considered. Staging examinations using PET-CT scan however, revealed a lung tumor, later confirmed as a Non-small-cell lung cancer (NSCLC). Primary radio chemotherapy was initiated to treat NSCLC. Shortly after initiation of radio chemotherapy the patient developed massive vision impairment and a NSCLC-associated BDUMP was diagnosed which led to the correct classification of melanocytic skin lesions as mucocutaneous BDUMP manifestation. Plasmapheresis was started resulting in a rapid improvement of vision starting ten days after the first plasmapheresis. In contrast skin manifestations started to disappear with a marked delay 4 months after the last plasmapheresis cycle. This case highlights the importance of memorizing multiple rapidly progressing melanocytic skin and/or mucous membrane spots together with visual impairment as a possible paraneoplastic BDUMP that needs a fundamentally different therapeutic approach compared to multifocal melanoma in situ. What is already known about this topic? Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) is a paraneoplastic syndrome with melanocytic uveal proliferation leading to vision impairment. Extraocular manifestation is rare, mainly affect the subepidermal compartment and is hard to treat. Plasmapheresis has been shown to be an effective treatment mainly for vision improvement in some but not all cases. What does this study add? Our BDUMP case with widespread skin and mucosal involvement initially mimicked a multifocal melanoma and showed an excellent treatment response to plasmapheresis. Improvement of mucocutaneous lesions has not been documented well in the literature so far. We show a more than one year lasting follow up still underlining the beneficial effect of plasmapheresis in this case. In-vitro data supports the hypothesis that plasma exchange eliminates a "Cultured melanocyte elongation and proliferation (CMEP)" factor out of patient blood leading to decreased melanocyte proliferation shown numerically in-vitro and clinically in-vivo. Our case clearly indicates that before establishing a definite diagnosis and therapy in patients with rapidly evolving melanocytic skin and/or mucosal lesions BDUMP mimicking multifocal melanoma should be considered making a thorough diagnostic workup mandatory.
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http://dx.doi.org/10.3389/fonc.2021.658407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076566PMC
April 2021

Für dermatologische Notfallpatienten benötigte Ressourcen: Eine zwölfmonatige prospektive Datenerhebung aus Deutschland.

J Dtsch Dermatol Ges 2019 Oct;17(10):1018-1028

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Deutschland.

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http://dx.doi.org/10.1111/ddg.13922_gDOI Listing
October 2019

Esophageal lichen planus: towards diagnosis of an underdiagnosed disease.

Scand J Gastroenterol 2019 Oct 14;54(10):1189-1198. Epub 2019 Oct 14.

Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Although lichen planus (LP) is a common skin disorder, the prevalence of esophageal involvement (ELP) and its clinical manifestations are poorly defined. We aimed to establish diagnostic criteria and characterize disease outcomes of ELP. Clinical, endoscopic, histological, and immunofluorescence data from consecutive patients with known LP between 2013 and 2018 were analyzed. We established endoscopic (denudation and tearing of the mucosa, hyperkeratosis and trachealization) and histological criteria (mucosal detachment, T-lymphocytic infiltrate, intraepithelial apoptosis, dyskeratosis, and fibrinogen deposits along the basement membrane) to grade disease severity. Endoscopic findings were correlated with clinical symptoms. Response to medical therapy was monitored. Fifty-two consecutive patients (median age 59.5 years) were analyzed. According to our grading system, 16 patients were considered as severe and 18 as mild ELP. Dysphagia was the only symptom which differentiated patients with severe (14/16) or mild ELP (8/18) from patients without ELP (1/18). Concomitant oral and genital involvement of LP was associated with the presence of ELP, while oral involvement alone was not. Follow-up of 14/16 patients with severe EPL for at least one year revealed that most of these patients responded to topical corticosteroids (budesonide:  = 9/10 or fluticasone  = 2/2). Three budesonide patients experienced a resolution of symptomatic esophageal stenosis. Esophageal involvement of LP is frequent, but may be asymptomatic. ELP can be diagnosed using the diagnostic criteria proposed here. Dysphagia and combined oral and genital manifestation are associated with ELP. Therapy with topical corticosteroids appears to be a prudent therapeutic approach for ELP.
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http://dx.doi.org/10.1080/00365521.2019.1674375DOI Listing
October 2019

[Granulomatous rosacea in a lung transplant recipient : A possible therapy option in a unique group of patients].

Hautarzt 2020 Feb;71(2):134-138

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Rosacea, a frequent chronic inflammatory disease of the adnexal structures, is associated with an increased number of demodex mites. In patients with immunosuppression, it can present in fulminant progressions like granulomatous rosacea. In this specific subgroup of patients, treatment is not only complicated by aggressive occurrences, but is also limited by possible drug interactions with immunosuppressive drugs. We present a case of a 66-year-old lung transplant recipient, who was successfully treated with oral metronidazole and ivermectin cream.
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http://dx.doi.org/10.1007/s00105-019-04479-0DOI Listing
February 2020

Resources spent on dermatological emergency patients: A twelve-month prospective data collection from Germany.

J Dtsch Dermatol Ges 2019 10 3;17(10):1018-1026. Epub 2019 Sep 3.

Department for Dermatology and Venerology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Background And Objectives: Rising numbers of patients consulting emergency units are associated with an increased demand for material and personnel. In order to better quantify these resources, we performed an analysis of diagnostic procedures, treatment types, and the quantity and educational level of staff involved in emergency consultations.

Patients And Methods: The study was conducted as a prospective single-center survey over twelve months in the dermatology unit of a Germany university hospital. 3155 consultations were included by consecutive sampling.

Results: Diagnostic tests (e.g. microbiological swab, blood testing, punch biopsy) were performed in 29 % of all consultations. Physicians prescribed treatment in 70 % of cases, with steroids and antihistamines being the most frequent topical and systemic treatment, respectively. Each patient was seen by at least one physician and a nurse, and in 25 % of cases an additional physician was involved. Less than thirty minutes was required for the consultation in the vast majority of cases. On average, emergency consultations required two hours per day of the treating physician's time, not including the time of other involved staff such as nurses and laboratory technicians.

Conclusions: This study demonstrates the extent of resources involved in the treatment of dermatological emergency consultations.
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http://dx.doi.org/10.1111/ddg.13922DOI Listing
October 2019

Patientencharakteristika der dermatologischen Notfallambulanz an einer Universitätsklinik in Deutschland.

J Dtsch Dermatol Ges 2018 Dec;16(12):1451-1458

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg und Medizinische Fakultät, Universität Freiburg, Deutschland.

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http://dx.doi.org/10.1111/ddg.13689_gDOI Listing
December 2018

Dermatological conditions presenting to the emergency dermatological unit of a university hospital in Germany.

J Dtsch Dermatol Ges 2018 Dec 12;16(12):1451-1456. Epub 2018 Nov 12.

Department of Dermatology and Venerology, Medical Center - University of Freiburg and Medical Faculty, University of Freiburg, Germany.

Background And Objectives: Recently, there have been increasing numbers of patients consulting emergency units in all medical disciplines. Our aim was to analyze the demographics, referral mode, symptoms, localization of lesions, prior treatment, diagnoses and hospitalization rate of dermatological patients.

Patient And Methods: The study was conducted as a prospective single center survey over six months in the dermatology unit of a university hospital in Germany. 1552 consultations were included with consecutive sampling.

Results: The study cohort had a mean age of 41 years and included 53 % females. Nearly half of the patients lived less than 10 kilometers from the study center. 72 % of patients referred themselves. The main symptoms were itching and occurrence of a rash; these symptoms had been present for more than a week on average. A general manifestation was present on the skin in most cases. 55 % of patients were seen by a dermatologist or a general practitioner before the consultation. Prior treatment had been received in 49 % of cases. Eight percent of patients were hospitalized. Eczema was the most common diagnosis, followed by urticaria and scabies.

Conclusions: This study confirms that a considerable number of patients present with non-urgent diagnoses. Careful prescreening and sensitization of the population may be necessary to reverse this trend.
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http://dx.doi.org/10.1111/ddg.13689DOI Listing
December 2018

Eosinophilic dermatosis of hematologic malignancy: Correlation of molecular characteristics of skin lesions and extracutaneous manifestations of hematologic malignancy.

J Cutan Pathol 2019 Mar 17;46(3):175-181. Epub 2018 Dec 17.

Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Skin diseases are frequent in patients with chronic lymphocytic leukemia (CLL) and other hematological neoplasias. Eosinophilic dermatosis (ED) of hematologic malignancy has long been considered a nonspecific cutaneous reaction pattern. Recently neoplastic cells have been shown to be present in ED, thus challenging the classification as a nonspecific dermatosis.

Methods: We report five patients with ED in association with CLL. We further investigated the presence of neoplastic B-cells in the skin infiltrate by immunohistochemistry and immunoglobulin heavy chain rearrangement and compared these to extracutaneous manifestations of CLL.

Results: The phenotype of the lymphocytic infiltrate was predominately CD3+ (range: 60%-90%). CD20+ and CD79a+ lymphocytes were less frequent, accounting for up to 15% (range: absent - 15%). CD23+ lymphocytes represented up to 20% (range: absent - 20%) of the infiltrate. The analysis of the immunoglobulin heavy chain rearrangement in the skin specimens showed clonal rearrangements in 4/5 patients and in three of these four patients clones were identical to extracutaneous CLL manifestations.

Conclusion: Our data show that neoplastic B-cells are very frequently found in ED when systematically evaluated. This findings support the hypothesis that leukemic cells play a pathogenetic role in ED of hematologic malignancy.
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http://dx.doi.org/10.1111/cup.13389DOI Listing
March 2019

Rezidivierende ulzeronekrotische Plaques und Knoten mit spontaner Remission.

J Dtsch Dermatol Ges 2018 Sep;16(9):1155-1158

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität, Freiburg, Germany.

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http://dx.doi.org/10.1111/ddg.13626_gDOI Listing
September 2018

Recurrent ulceronecrotic plaques and nodules with spontaneous remission.

J Dtsch Dermatol Ges 2018 Sep 9;16(9):1155-1158. Epub 2018 Aug 9.

Department of Dermatology and Venereology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany.

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http://dx.doi.org/10.1111/ddg.13626DOI Listing
September 2018

BRAF V600E Mutations in Nevi and Melanocytic Tumors of Uncertain Malignant Potential.

J Invest Dermatol 2018 11 12;138(11):2489-2491. Epub 2018 Jul 12.

Institute for Surgical Pathology, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.04.035DOI Listing
November 2018

Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival.

J Invest Dermatol 2018 03 18;138(3):679-687. Epub 2017 Oct 18.

Department of Dermatology and Venereology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany. Electronic address:

The enzyme indoleamine 2,3-dioxygenase (IDO) is emerging as a facilitator of cancer development through its effects on cancer-associated inflammation. Recent studies report a significant improvement of the response rates in melanoma patients to PD-1 antibodies when IDO inhibitors were added to the regimen. Data on IDO expression in primary human melanomas are, however, incomplete and conflicting. Here, we show that the level of IDO expression in primary human melanoma cells significantly correlates with Breslow thickness (P = 0.003), the presence of tumor-infiltrating lymphocytes (P = 0.029), and the intensity of the peritumoral inflammatory infiltrate (P = 0.001). The expression of IDO in melanoma cells predicted independently of Breslow thickness and tumor stage (P = 0.04). We further show that CD11c dendritic cells and CD68 macrophages in the microenvironment of melanomas express IDO. The level of IDO expression in antigen-presenting cells correlated positively to peritumoral inflammation (P = 0.001) but not to tumor-infiltrating lymphocytes. Significant negative correlation with progression-free survival was found for patients for whom antigen-presenting cells were very strongly IDO positive. These results suggest that IDO induction within melanoma cells may directly reflect tumor progression, whereas IDO in antigen-presenting cells may determine immune surveillance with impact on local and systemic tolerance.
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http://dx.doi.org/10.1016/j.jid.2017.09.036DOI Listing
March 2018

Malignant PEComa.

J Cutan Pathol 2018 01 22;45(1):84-89. Epub 2017 Nov 22.

Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany.

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http://dx.doi.org/10.1111/cup.13061DOI Listing
January 2018

Papulopustulose des Gesichts und des Capillitiums.

J Dtsch Dermatol Ges 2017 Jul;15(7):755-757

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs--Universität Freiburg, Deutschland.

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http://dx.doi.org/10.1111/ddg.13265_gDOI Listing
July 2017

Papulopustular lesions of the face and scalp.

J Dtsch Dermatol Ges 2017 Jul 14;15(7):755-757. Epub 2017 Jun 14.

Department of Dermatology and Venereology, Medical Center - University of Freiburg, Faculty of Medicine, University Freiburg, Germany.

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http://dx.doi.org/10.1111/ddg.13265DOI Listing
July 2017

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression.

Oncotarget 2017 Jun;8(26):42901-42916

Department of Hematology and Oncology, University Medical Center, Faculty of Medicine, Freiburg, Germany.

Novel targeted and immunotherapeutic approaches have revolutionized the treatment of metastatic melanoma. A better understanding of the melanoma-microenvironment, in particular the interaction of cells with extracellular matrix molecules, may help to further improve these new therapeutic strategies.We observed that the extracellular matrix molecule biglycan (Bgn) was expressed in certain human melanoma cells and primary fibroblasts when evaluated by microarray-based gene expression analysis. Bgn expression in the melanoma tissues correlated with low overall-survival and low progression-free-survival in patients. To understand the functional role of Bgn we used gene-targeted mice lacking functional Bgn. Here we observed that melanoma growth, metastasis-formation and tumor-related death were reduced in Bgn-/- mice compared to Bgn+/+ mice. In vitro invasion of melanoma cells into organotypic-matrices derived from Bgn-/- fibroblasts was reduced compared to melanoma invasion into Bgn-proficient matrices. Tissue stiffness as determined by atomic-force-microscopy was reduced in Bgn-/- matrices. Isolation of melanoma cells and fibroblasts from the stiffer Bgn+/+ matrices revealed an increase in integrin-β1 expression compared to the Bgn-/- fibroblast matrices. Overexpression of integrin-β1 in B16-melanoma cells abolished the survival benefit seen in Bgn-/- mice. Consistent with the studies performed in mice, the abundance of Bgn-expression in human melanoma samples positively correlated with the expression of integrin-β1, which is in agreement with results from the organotypic invasion-assay and the in vivo mouse studies.This study describes a novel role for Bgn-related tissue stiffness in the melanoma-microenvironment via regulation of integrin-β1 expression by melanoma cells in both mice and humans.
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http://dx.doi.org/10.18632/oncotarget.17160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522114PMC
June 2017

Verkrustete Papulopusteln, Plaques und Ulzerationen.

J Dtsch Dermatol Ges 2017 Jan;15(1):104-107

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg im Breisgau.

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http://dx.doi.org/10.1111/ddg.13087_gDOI Listing
January 2017

Crusted papulopustular lesions, plaques and ulcers.

J Dtsch Dermatol Ges 2017 Jan 30;15(1):101-104. Epub 2016 Dec 30.

Department of Dermatology, University Medical Center, Freiburg im Breisgau, Germany.

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http://dx.doi.org/10.1111/ddg.13087DOI Listing
January 2017

Esophageal involvement is frequent in lichen planus: study in 32 patients with suggestion of clinicopathologic diagnostic criteria and therapeutic implications.

Eur J Gastroenterol Hepatol 2016 Dec;28(12):1374-1382

Departments of aDermatology bInternal Medicine, Gastroenterology, Hepatology, Endocrinology and Infectiology cInternal Medicine, Institute for Exercise and Occupational Medicine dInstitute of Pathology, Medical Center, Faculty of Medicine, University of Freiburg eDepartment of Medicine, RKK St. Josef's Hospital, Freiburg, Germany fSkin & Cancer Foundation Inc., Carlton gDepartment of Dermatology, Royal Melbourne Hospital, Parkville hDepartment of Dermatology, Box Hill Hospital-Monash University, Eastern Health Clinical School, Box Hill, Victoria, Australia.

Objective: Lichen planus (LP) is a classic skin disease that can involve the skin, hair, and nails, as well as the oral and genital mucosa. Histopathology is characterized by a T-lymphocytic, lichenoid, and interface dermatitis. Multiple case reports and small case series have shown that LP can involve the esophagus. However, the diagnostic criteria, incidence, and best treatment options remain uncertain. This study aimed to refine the diagnostic criteria, estimate prevalence, and present an outlook on treatment options to prevent long-term sequelae.

Patients And Methods: Thirty-two consecutive patients with LP of the skin, hair, nails, oral mucosa, and/or genital mucosa underwent a comprehensive clinicopathologic assessment. Esophagogastroduodenoscopy was performed, and biopsies were evaluated histologically, immunohistochemically, and by direct immunofluorescence. Patients diagnosed with esophageal lichen planus (ELP) were followed up prospectively where possible.

Results: In total, 20 of 32 patients had ELP. Ten of these 20 patients were classified as having proven ELP, with clear-cut endoscopically visible lesions; the other 10 were classified as having probable ELP. Eight of 10 patients with proven ELP were started on new or additional therapy because of esophageal findings. Treatment with a topical budesonide formulation or systemic corticosteroids was successful in most patients with proven ELP and reversed functional esophageal stenosis.

Conclusion: ELP can be found in more than 50% of patients with proven mucocutaneous LP when clinical and pathologic findings are correlated carefully. Topical or systemic corticosteroids are the first-line therapy for ELP. Timely medical therapy seems to prevent scarring stenosis of the esophagus.
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http://dx.doi.org/10.1097/MEG.0000000000000732DOI Listing
December 2016

Successful Management of Calciphylaxis in a Kidney Transplant Patient: Case Report.

Transplant Direct 2016 Apr 17;2(4):e70. Epub 2016 Mar 17.

Renal Division, University Medical Center Freiburg, Freiburg, Germany.

Unlabelled: Calciphylaxis is a rare and often fatal condition mostly associated with end-stage renal disease. The pathophysiology remains elusive and treatment options are scarce. We present a rare case of severe calciphylaxis after kidney transplantation in a patient with persistent hyperparathyroidism.

Case Description: A 78-year-old man with a history of end-stage renal disease developed edema and ulcerations on both lower limbs 14 months after kidney transplantation while receiving an mammalian target of rapamycin inhibitor to manage polyoma virus-associated nephropathy. Skin biopsies taken from the ulcerations confirmed calciphylaxis. A multimodal treatment regimen combining medical (calcium-free phosphate binders, cinacalcet, paricalcitol, sodium thiosulfate, antibiotic treatment) and surgical treatments (debridement and autologous skin transplantation) ultimately resulted in successful wound healing.

Discussion: We describe a case of severe calciphylaxis in a nonuremic patient after kidney transplantation. Rapid diagnosis by skin biopsy and an aggressive multimodal therapy regimen followed by long-term oral sodium thiosulfate treatment were crucial factors for a favorable outcome.
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http://dx.doi.org/10.1097/TXD.0000000000000582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946510PMC
April 2016

Multilocular Facial Necrosis in a Young Boy: A Quiz.

Acta Derm Venereol 2017 02;97(2):299-301

Department of Dermatology and Venerology, University Medical Centre, Hauptstraße 7, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.2340/00015555-2499DOI Listing
February 2017

Palmoplantar keratodermas: clinical and genetic aspects.

J Dtsch Dermatol Ges 2016 Feb;14(2):123-39; quiz 140

Department of Dermatology, University of Freiburg Medical Center, Freiburg, Germany.

Palmoplantar keratodermas comprise a diverse group of acquired and hereditary disorders marked by excessive thickening of the epidermis of palms and soles. Early onset and positive family history suggest a genetic cause. While hereditary forms of palmoplantar keratoderma (PPK) may represent the sole or dominant clinical feature, they may also be associated with other ectodermal defects or extracutaneous manifestations. In recent years, much progress has been made in deciphering the genetic basis of PPK, which has led to the emergence of new disorders and syndromes. The elucidation of disease mechanisms has opened new avenues for specific therapies, increasingly sparking interest in this field. Given the high heterogeneity with respect to clinical features, genetic defects, and disease mechanisms, the classification of PPK is based on various criteria. These include extent of disease manifestations, morphology of palmoplantar skin involvement, inheritance patterns, and molecular pathogenesis. Though not always feasible, the clinical distinction of various PPK entities is based on fine-tuned criteria or clues. Remarkably, apparently distinct disorders have been shown to be allelic, as they are caused by mutations in the same gene. By contrast, similar clinical pictures may result from mutations in different genes. Because of this complexity, mutation analysis is required to determine the precise type of PPK. The best-defined entities are described in this review.
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http://dx.doi.org/10.1111/ddg.12930DOI Listing
February 2016

"Silver man" argyria of the skin after ingestion of a colloidal silver solution.

J Dtsch Dermatol Ges 2015 Oct;13(10):1030-2

Department of Dermatology and Venereology, University Hospital Freiburg, Germany.

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http://dx.doi.org/10.1111/ddg.12502DOI Listing
October 2015

[Silver man" argyria of the skin after ingestion of a colloidal silver solution].

J Dtsch Dermatol Ges 2015 Oct;13(10):1030-2

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg.

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http://dx.doi.org/10.1111/ddg.80_12502DOI Listing
October 2015

Bullous Delayed Pressure Urticaria Responding to Omalizumab.

Acta Derm Venereol 2016 Mar;96(3):416-7

Allergy Research Group, Department of Dermatology, Medical Center - University of Freiburg, Hauptstrasse 7, DE-79104, Freiburg, Germany.

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http://dx.doi.org/10.2340/00015555-2224DOI Listing
March 2016

Vegetating plaques in a patient with a seizure disorder.

J Dtsch Dermatol Ges 2015 Jun;13(6):585-6

Department of Dermatology, Medical Center - University of Freiburg, Germany.

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http://dx.doi.org/10.1111/ddg.12631DOI Listing
June 2015

Pruritic intertriginous vesiculopustular eruption.

J Dtsch Dermatol Ges 2014 Sep 1;12(9):827-30. Epub 2014 Aug 1.

Department of Dermatology, Medical Center - University of Freiburg.

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http://dx.doi.org/10.1111/ddg.12329DOI Listing
September 2014

Overlap of IgA pemphigus and linear IgA dermatosis in a patient with ulcerative colitis: a mere coincidence?

Acta Derm Venereol 2014 Mar;94(2):228-30

Departments of Dermatology and Gastroenterology, University of Freiburg Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.2340/00015555-1658DOI Listing
March 2014
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