Krister Wennerberg

Krister Wennerberg

UNVERIFIED PROFILE

Are you Krister Wennerberg?   Register this Author

Register author
Krister Wennerberg

Krister Wennerberg

Publications by authors named "Krister Wennerberg"

Are you Krister Wennerberg?   Register this Author

97Publications

2028Reads

31Profile Views

ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors.

Authors:
Katja Kaipio Ping Chen Pia Roering Kaisa Huhtinen Piia Mikkonen Päivi Östling Laura Lehtinen Naziha Mansuri Taina Korpela Swapnil Potdar Johanna Hynninen Annika Auranen Seija Grénman Krister Wennerberg Sampsa Hautaniemi Olli Carpén

J Pathol 2020 Feb 3;250(2):159-169. Epub 2019 Dec 3.

Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/path.5356DOI Listing
February 2020

Atypical KRAS Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Authors:
G Aaron Hobbs Nicole M Baker Anne M Miermont Ryan D Thurman Mariaelena Pierobon Timothy H Tran Andrew O Anderson Andrew M Waters J Nathaniel Diehl Bjoern Papke Richard G Hodge Jennifer E Klomp Craig M Goodwin Jonathan M DeLiberty Junning Wang Raymond W S Ng Prson Gautam Kirsten L Bryant Dominic Esposito Sharon L Campbell Emanuel F Petricoin Dhirendra K Simanshu Andrew J Aguirre Brian M Wolpin Krister Wennerberg Udo Rudloff Adrienne D Cox Channing J Der

Cancer Discov 2020 Jan 24;10(1):104-123. Epub 2019 Oct 24.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/2159-8290.CD-19-1006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954322PMC
January 2020

A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening.

Authors:
Abhishekh Gupta Prson Gautam Krister Wennerberg Tero Aittokallio

Commun Biol 2020 Jan 23;3(1):42. Epub 2020 Jan 23.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s42003-020-0765-zDOI Listing
January 2020

Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer.

Authors:
Chiara Facciotto Julia Casado Laura Turunen Suvi-Katri Leivonen Manuela Tumiati Ville Rantanen Liisa Kauppi Rainer Lehtonen Sirpa Leppä Krister Wennerberg Sampsa Hautaniemi

Clin Epigenetics 2019 Dec 11;11(1):192. Epub 2019 Dec 11.

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, PO Box 63, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13148-019-0781-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907220PMC
December 2019

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment.

Authors:
Erlend Skaga Evgeny Kulesskiy Marit Brynjulvsen Cecilie J Sandberg Swapnil Potdar Iver A Langmoen Aki Laakso Emília Gaál-Paavola Markus Perola Krister Wennerberg Einar O Vik-Mo

Clin Transl Med 2019 Dec 30;8(1):33. Epub 2019 Dec 30.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s40169-019-0253-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937360PMC
December 2019

Human Tumor-Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing.

Authors:
Katja Tuomainen Ahmed Al-Samadi Swapnil Potdar Laura Turunen Minna Turunen Piia-Riitta Karhemo Paula Bergman Maija Risteli Pirjo Åström Riia Tiikkaja Reidar Grenman Krister Wennerberg Outi Monni Tuula Salo

Cancers (Basel) 2019 Dec 30;12(1). Epub 2019 Dec 30.

Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/cancers12010092DOI Listing
December 2019

Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.

Authors:
Balaguru Ravikumar Sanna Timonen Zaid Alam Elina Parri Krister Wennerberg Tero Aittokallio

Cell Chem Biol 2019 Nov 11;26(11):1608-1622.e6. Epub 2019 Sep 11.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00014, Finland; Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.chembiol.2019.08.007DOI Listing
November 2019

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.

Authors:
Manar Elmadani Suleiman Khan Olli Tenhunen Johanna Magga Tero Aittokallio Krister Wennerberg Risto Kerkelä

J Am Heart Assoc 2019 Nov 16;8(21):e013018. Epub 2019 Oct 16.

Research Unit of Biomedicine Department of Pharmacology and Toxicology University of Oulu Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1161/JAHA.119.013018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898841PMC
November 2019

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify -Mutant Lung Cancers.

Authors:
Sarang S Talwelkar Ashwini S Nagaraj Jennifer R Devlin Annabrita Hemmes Swapnil Potdar Elina A Kiss Pipsa Saharinen Kaisa Salmenkivi Mikko I Mäyränpää Krister Wennerberg Emmy W Verschuren

Mol Cancer Ther 2019 10 18;18(10):1863-1874. Epub 2019 Jul 18.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1535-7163.MCT-18-0573DOI Listing
October 2019

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types.

Authors:
Muntasir M Majumder Aino-Maija Leppä Monica Hellesøy Paul Dowling Alina Malyutina Reidun Kopperud Despina Bazou Emma Andersson Alun Parsons Jing Tang Olli Kallioniemi Satu Mustjoki Peter O'Gorman Krister Wennerberg Kimmo Porkka Bjørn T Gjertsen Caroline A Heckman

Haematologica 2019 Aug 22. Epub 2019 Aug 22.

Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3324/haematol.2019.217414DOI Listing
August 2019

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Authors:
Prson Gautam Alok Jaiswal Tero Aittokallio Hassan Al-Ali Krister Wennerberg

Cell Chem Biol 2019 Jul 2;26(7):970-979.e4. Epub 2019 May 2.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00290 Helsinki, Finland; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S24519456193010
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642004PMC
July 2019

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer.

Authors:
Jing Tang Prson Gautam Abhishekh Gupta Liye He Sanna Timonen Yevhen Akimov Wenyu Wang Agnieszka Szwajda Alok Jaiswal Denes Turei Bhagwan Yadav Matti Kankainen Jani Saarela Julio Saez-Rodriguez Krister Wennerberg Tero Aittokallio

NPJ Syst Biol Appl 2019 8;5:20. Epub 2019 Jul 8.

1Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41540-019-0098-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614366PMC
July 2019

Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer.

Authors:
Alok Jaiswal Bhagwan Yadav Krister Wennerberg Tero Aittokallio

Methods Mol Biol 2019 ;1888:205-217

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/978-1-4939-8891-4_12DOI Listing
June 2019

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma.

Authors:
Erlend Skaga Evgeny Kulesskiy Artem Fayzullin Cecilie J Sandberg Swapnil Potdar Aija Kyttälä Iver A Langmoen Aki Laakso Emília Gaál-Paavola Markus Perola Krister Wennerberg Einar O Vik-Mo

BMC Cancer 2019 Jun 25;19(1):628. Epub 2019 Jun 25.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.

View Article

Download full-text PDF

 Source
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5861-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593575PMC
June 2019

Anagrelide for Gastrointestinal Stromal Tumor.

Authors:
Olli-Pekka Pulkka Yemarshet K Gebreyohannes Agnieszka Wozniak John-Patrick Mpindi Olli Tynninen Katherine Icay Alejandra Cervera Salla Keskitalo Astrid Murumägi Evgeny Kulesskiy Maria Laaksonen Krister Wennerberg Markku Varjosalo Pirjo Laakkonen Rainer Lehtonen Sampsa Hautaniemi Olli Kallioniemi Patrick Schöffski Harri Sihto Heikki Joensuu

Clin Cancer Res 2019 03 7;25(5):1676-1687. Epub 2018 Dec 7.

Laboratory of Molecular Oncology, Research Programs Unit, Translational Cancer Biology, Department of Oncology, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-0815DOI Listing
March 2019

Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas.

Authors:
Bertha A Brodin Krister Wennerberg Elisabet Lidbrink Otte Brosjö Swapnil Potdar Jennifer N Wilson Limin Ma Lotte N Moens Asle Hesla Edvin Porovic Edvin Bernhardsson Antroula Papakonstantinou Henrik Bauer Panagiotis Tsagkozis Karin von Sivers Johan Wejde Päivi Östling Olli Kallioniemi Christina Linder Stragliotto

Br J Cancer 2019 02 12;120(4):435-443. Epub 2019 Feb 12.

Department of Breast cancer, Endocrine tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41416-018-0359-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462037PMC
February 2019

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

Authors:
Ralf Buettner Le Xuan Truong Nguyen Bijender Kumar Corey Morales Chao Liu Lisa S Chen Tea Pemovska Timothy W Synold Joycelynne Palmer Ryan Thompson Ling Li Dinh Hoa Hoang Bin Zhang Lucy Ghoda Claudia Kowolik Mika Kontro Calum Leitch Krister Wennerberg Xiaochun Yu Ching-Cheng Chen David Horne Varsha Gandhi Vinod Pullarkat Guido Marcucci Steven T Rosen

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Hematology Malignancies and Stem Cell Transplantation Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, California.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/jcp.28294
Publisher Site
http://dx.doi.org/10.1002/jcp.28294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697246PMC
February 2019

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing.

Authors:
Ziaurrehman Tanoli Zaid Alam Aleksandr Ianevski Krister Wennerberg Markus Vähä-Koskela Tero Aittokallio

Brief Bioinform 2018 Dec 18. Epub 2018 Dec 18.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bib/bby119DOI Listing
December 2018

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Authors:
Angelina V Vaseva Devon R Blake Thomas S K Gilbert Serina Ng Galen Hostetter Salma H Azam Irem Ozkan-Dagliyan Prson Gautam Kirsten L Bryant Kenneth H Pearce Laura E Herring Haiyong Han Lee M Graves Agnieszka K Witkiewicz Erik S Knudsen Chad V Pecot Naim Rashid Peter J Houghton Krister Wennerberg Adrienne D Cox Channing J Der

Cancer Cell 2018 11;34(5):807-822.e7

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

 Source
https://www.researchgate.net/publication/325458004_KRAS_Supp
Web Search
http://scholar.google.fi/citations?user=_42T_HMAAAAJ&hl=en
Web Search
https://www.journals.elsevier.com/cancer-cell/recent-article
Web Search
https://linkinghub.elsevier.com/retrieve/pii/S15356108183046
Publisher Site
http://dx.doi.org/10.1016/j.ccell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321749PMC
November 2018

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

Authors:
Liye He Evgeny Kulesskiy Jani Saarela Laura Turunen Krister Wennerberg Tero Aittokallio Jing Tang

Methods Mol Biol 2018 ;1711:351-398

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, PO Box 33, Helsinki, 00014, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/978-1-4939-7493-1_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383747PMC
October 2018

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.

Authors:
Matheus Dyczynski Yasmin Yu Magdalena Otrocka Santiago Parpal Tiago Braga Aine Brigette Henley Henric Zazzi Mikael Lerner Krister Wennerberg Jenny Viklund Jessica Martinsson Dan Grandér Angelo De Milito Katja Pokrovskaja Tamm

Cancer Lett 2018 10 25;435:32-43. Epub 2018 Jul 25.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.canlet.2018.07.028DOI Listing
October 2018

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma.

Authors:
Chirag Nepal Colm J O'Rourke Douglas V N P Oliveira Andrzej Taranta Steven Shema Prson Gautam Julien Calderaro Andrew Barbour Chiara Raggi Krister Wennerberg Xin W Wang Anja Lautem Lewis R Roberts Jesper B Andersen

Hepatology 2018 09 12;68(3):949-963. Epub 2018 Jun 12.

Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/hep.29764
Publisher Site
http://dx.doi.org/10.1002/hep.29764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599967PMC
September 2018

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy.

Authors:
Tatiana Lepikhova Piia-Riitta Karhemo Riku Louhimo Bhagwan Yadav Astrid Murumägi Evgeny Kulesskiy Mikko Kivento Harri Sihto Reidar Grénman Stina M Syrjänen Olli Kallioniemi Tero Aittokallio Krister Wennerberg Heikki Joensuu Outi Monni

Mol Cancer Ther 2018 09 3;17(9):2060-2071. Epub 2018 Jul 3.

Research Programs Unit, Genome-Scale Biology Program and Medicum, Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/1535-7163.MCT-17-0733DOI Listing
September 2018

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.

Authors:
Otto Kauko Caitlin M O'Connor Evgeny Kulesskiy Jaya Sangodkar Anna Aakula Sudeh Izadmehr Laxman Yetukuri Bhagwan Yadav Artur Padzik Teemu Daniel Laajala Pekka Haapaniemi Majid Momeny Taru Varila Michael Ohlmeyer Tero Aittokallio Krister Wennerberg Goutham Narla Jukka Westermarck

Sci Transl Med 2018 07;10(450)

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1126/scitranslmed.aaq1093DOI Listing
July 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Authors:
Liye He Jing Tang Emma I Andersson Sanna Timonen Steffen Koschmieder Krister Wennerberg Satu Mustjoki Tero Aittokallio

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-3644DOI Listing
May 2018

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.

Authors:
Mehreen Ali Suleiman A Khan Krister Wennerberg Tero Aittokallio

Bioinformatics 2018 04;34(8):1353-1362

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btx766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905617PMC
April 2018

Toward universal protein post-translational modification detection in high throughput format.

Authors:
Harri Härmä Natalia Tong-Ochoa Arjan J van Adrichem Ilian Jelesarov Krister Wennerberg Kari Kopra

Chem Commun (Camb) 2018 Mar;54(23):2910-2913

Materials Chemistry and Chemical Analysis, University of Turku, Turku, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1039/c7cc09575aDOI Listing
March 2018

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.

Authors:
Jing Tang Zia-Ur-Rehman Tanoli Balaguru Ravikumar Zaid Alam Anni Rebane Markus Vähä-Koskela Gopal Peddinti Arjan J van Adrichem Janica Wakkinen Alok Jaiswal Ella Karjalainen Prson Gautam Liye He Elina Parri Suleiman Khan Abhishekh Gupta Mehreen Ali Laxman Yetukuri Anna-Lena Gustavsson Brinton Seashore-Ludlow Anne Hersey Andrew R Leach John P Overington Gretchen Repasky Krister Wennerberg Tero Aittokallio

Cell Chem Biol 2018 02 21;25(2):224-229.e2. Epub 2017 Dec 21.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; Department of Mathematics and Statistics, University of Turku, 20014 Turku, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.chembiol.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814751PMC
February 2018

Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles.

Authors:
ZiaurRehman Tanoli Zaid Alam Markus Vähä-Koskela Balaguru Ravikumar Alina Malyutina Alok Jaiswal Jing Tang Krister Wennerberg Tero Aittokallio

Database (Oxford) 2018 01 1;2018:1-13. Epub 2018 Jan 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/database/bay083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146131PMC
January 2018

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.

Authors:
Mehmet Gönen Barbara A Weir Glenn S Cowley Francisca Vazquez Yuanfang Guan Alok Jaiswal Masayuki Karasuyama Vladislav Uzunangelov Tao Wang Aviad Tsherniak Sara Howell Daniel Marbach Bruce Hoff Thea C Norman Antti Airola Adrian Bivol Kerstin Bunte Daniel Carlin Sahil Chopra Alden Deran Kyle Ellrott Peddinti Gopalacharyulu Kiley Graim Samuel Kaski Suleiman A Khan Yulia Newton Sam Ng Tapio Pahikkala Evan Paull Artem Sokolov Hao Tang Jing Tang Krister Wennerberg Yang Xie Xiaowei Zhan Fan Zhu Tero Aittokallio Hiroshi Mamitsuka Joshua M Stuart Jesse S Boehm David E Root Guanghua Xiao Gustavo Stolovitzky William C Hahn Adam A Margolin

Cell Syst 2017 11 4;5(5):485-497.e3. Epub 2017 Oct 4.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA; Computational Biology Program, Oregon Health & Science University, Portland, OR, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cels.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814247PMC
November 2017

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling.

Authors:
Heikki Kuusanmäki Olli Dufva Elina Parri Arjan J van Adrichem Hanna Rajala Muntasir M Majumder Bhagwan Yadav Alun Parsons Wing C Chan Krister Wennerberg Satu Mustjoki Caroline A Heckman

Oncotarget 2017 Nov 31;8(57):97516-97527. Epub 2017 Oct 31.

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.22178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722580PMC
November 2017

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

Authors:
Riikka Karjalainen Tea Pemovska Mihaela Popa Minxia Liu Komal K Javarappa Muntasir M Majumder Bhagwan Yadav David Tamborero Jing Tang Dmitrii Bychkov Mika Kontro Alun Parsons Minna Suvela Mireia Mayoral Safont Kimmo Porkka Tero Aittokallio Olli Kallioniemi Emmet McCormack Bjørn T Gjertsen Krister Wennerberg Jonathan Knowles Caroline A Heckman

Blood 2017 08 15;130(6):789-802. Epub 2017 Jun 15.

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2016-02-699363DOI Listing
August 2017

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.

Authors:
Anna Cichonska Balaguru Ravikumar Elina Parri Sanna Timonen Tapio Pahikkala Antti Airola Krister Wennerberg Juho Rousu Tero Aittokallio

PLoS Comput Biol 2017 Aug 7;13(8):e1005678. Epub 2017 Aug 7.

Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.plos.org/10.1371/journal.pcbi.1005678
Publisher Site
http://dx.doi.org/10.1371/journal.pcbi.1005678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560747PMC
August 2017

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

Authors:
Pekka Kohonen Juuso A Parkkinen Egon L Willighagen Rebecca Ceder Krister Wennerberg Samuel Kaski Roland C Grafström

Nat Commun 2017 07 3;8:15932. Epub 2017 Jul 3.

Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, SE-17177 Stockholm, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms15932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500850PMC
July 2017

Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression.

Authors:
Muhammad Ammad-Ud-Din Suleiman A Khan Krister Wennerberg Tero Aittokallio

Bioinformatics 2017 Jul;33(14):i359-i368

Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
https://academic.oup.com/bioinformatics/article/33/14/i359/3
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btx266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870540PMC
July 2017

Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513].

Authors:
Bhagwan Yadav Krister Wennerberg Tero Aittokallio Jing Tang

Comput Struct Biotechnol J 2017;15:387. Epub 2017 Jul 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.csbj.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032504PMC
July 2017

Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells.

Authors:
Alok Jaiswal Gopal Peddinti Yevhen Akimov Krister Wennerberg Sergey Kuznetsov Jing Tang Tero Aittokallio

Genome Med 2017 06 1;9(1):51. Epub 2017 Jun 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13073-017-0440-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452371PMC
June 2017

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors.

Authors:
Paavo O Pietarinen Christopher A Eide Pilar Ayuda-Durán Swapnil Potdar Heikki Kuusanmäki Emma I Andersson John P Mpindi Tea Pemovska Mika Kontro Caroline A Heckman Olli Kallioniemi Krister Wennerberg Henrik Hjorth-Hansen Brian J Druker Jorrit M Enserink Jeffrey W Tyner Satu Mustjoki Kimmo Porkka

Oncotarget 2017 Apr;8(14):22606-22615

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.15146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410248PMC
April 2017

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

Authors:
Kari Kopra Arjan J van Adrichem Outi M H Salo-Ahen Juha Peltonen Krister Wennerberg Harri Härmä

Anal Chem 2017 04 29;89(8):4508-4516. Epub 2017 Mar 29.

Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1021/acs.analchem.6b04904DOI Listing
April 2017

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Authors:
Khalid Saeed Vesa Rahkama Samuli Eldfors Dmitry Bychkov John Patrick Mpindi Bhagwan Yadav Lassi Paavolainen Tero Aittokallio Caroline Heckman Krister Wennerberg Donna M Peehl Peter Horvath Tuomas Mirtti Antti Rannikko Olli Kallioniemi Päivi Östling Taija M Af Hällström

Eur Urol 2017 03 6;71(3):319-327. Epub 2016 May 6.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.eururo.2016.04.019DOI Listing
March 2017

Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells.

Authors:
Ulla-Maija Haltia Noora Andersson Bhagwan Yadav Anniina Färkkilä Evgeny Kulesskiy Matti Kankainen Jing Tang Ralf Bützow Annika Riska Arto Leminen Markku Heikinheimo Olli Kallioniemi Leila Unkila-Kallio Krister Wennerberg Tero Aittokallio Mikko Anttonen

Gynecol Oncol 2017 03 16;144(3):621-630. Epub 2017 Jan 16.

Clinical Chemistry and Hematology, University of Helsinki and HUSLAB, Helsinki University Hospital, PO Box 400, 00290 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ygyno.2016.12.016DOI Listing
March 2017

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in .

Authors:
Gregory Tombline Jonathan I Millen Bogdan Polevoda Matan Rapaport Bonnie Baxter Michael Van Meter Matthew Gilbertson Joe Madrey Gary A Piazza Lynn Rasmussen Krister Wennerberg E Lucile White John L Nitiss David S Goldfarb

Aging (Albany NY) 2017 01;9(1):68-97

Biology Department, University of Rochester, Rochester, NY 14627, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/aging.101114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310657PMC
January 2017

Cancer Cell Drug Response Transcriptomes in 3D.

Authors:
Krister Wennerberg

Cell Chem Biol 2016 11;23(11):1323-1324

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.chembiol.2016.11.002DOI Listing
November 2016

Consistency in drug response profiling.

Authors:
John Patrick Mpindi Bhagwan Yadav Päivi Östling Prson Gautam Disha Malani Astrid Murumägi Akira Hirasawa Sara Kangaspeska Krister Wennerberg Olli Kallioniemi Tero Aittokallio

Nature 2016 11;540(7631):E5-E6

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nature20171DOI Listing
November 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:
Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease.

Authors:
Dan Lindholm Dan D Pham Annunziata Cascone Ove Eriksson Krister Wennerberg Mart Saarma

Front Aging Neurosci 2016 26;8:254. Epub 2016 Oct 26.

Institute of Biotechnology, University of Helsinki Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fnagi.2016.00254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080529PMC
October 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Authors:
Solveig K Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O Falcao Christine Suver Bruce Hoff Venkat S K Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-Ud-Din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R Kramer Pekka Marttinen Aziz M Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P Tak Danielle Gerlag Tom W J Huizinga Fina Kurreeman Cornelia F Allaart S Louis Bridges Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M Mangravite

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

KIFC1 is a novel potential therapeutic target for breast cancer.

Authors:
Yonghe Li Wenyan Lu Dongquan Chen Rebecca J Boohaker Ling Zhai Indira Padmalayam Krister Wennerberg Bo Xu Wei Zhang

Cancer Biol Ther 2015 15;16(9):1316-22. Epub 2015 Jul 15.

a Drug Discovery Division; Southern Research Institute ; Birmingham , AL USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/15384047.2015.1070980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622065PMC
July 2016

Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells.

Authors:
Prson Gautam Leena Karhinen Agnieszka Szwajda Sawan Kumar Jha Bhagwan Yadav Tero Aittokallio Krister Wennerberg

Mol Cancer 2016 05 10;15(1):34. Epub 2016 May 10.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12943-016-0517-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862054PMC
May 2016

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

Authors:
Bhagwan Yadav Krister Wennerberg Tero Aittokallio Jing Tang

Comput Struct Biotechnol J 2015 25;13:504-13. Epub 2015 Sep 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.csbj.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759128PMC
March 2016

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

Authors:
Evgeny Kulesskiy Jani Saarela Laura Turunen Krister Wennerberg

J Lab Autom 2016 Feb 2;21(1):27-36. Epub 2015 Dec 2.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/2211068215618869DOI Listing
February 2016

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.

Authors:
Finny S Varghese Pasi Kaukinen Sabine Gläsker Maxim Bespalov Leena Hanski Krister Wennerberg Beate M Kümmerer Tero Ahola

Antiviral Res 2016 Feb 2;126:117-24. Epub 2016 Jan 2.

Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.antiviral.2015.12.012DOI Listing
February 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Authors:
Tikvah K Hayes Nicole F Neel Chaoxin Hu Prson Gautam Melissa Chenard Brian Long Meraj Aziz Michelle Kassner Kirsten L Bryant Mariaelena Pierobon Raoud Marayati Swapnil Kher Samuel D George Mai Xu Andrea Wang-Gillam Ahmed A Samatar Anirban Maitra Krister Wennerberg Emanuel F Petricoin Hongwei H Yin Barry Nelkin Adrienne D Cox Jen Jen Yeh Channing J Der

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data.

Authors:
John-Patrick Mpindi Potdar Swapnil Bychkov Dmitrii Saarela Jani Khalid Saeed Krister Wennerberg Tero Aittokallio Päivi Östling Olli Kallioniemi

Bioinformatics 2015 Dec 7;31(23):3815-21. Epub 2015 Aug 7.

University of Helsinki, Institute for Molecular Medicine, Tukholmankatu 8, FI-00290, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btv455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653387PMC
December 2015

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Authors:
Yuba Raj Pokharel Jani Saarela Agnieszka Szwajda Christian Rupp Anne Rokka Shibendra Lal Kumar Karna Kaisa Teittinen Garry Corthals Olli Kallioniemi Krister Wennerberg Tero Aittokallio Jukka Westermarck

Mol Cell Proteomics 2015 Dec 23;14(12):3274-83. Epub 2015 Oct 23.

From the ‡Institute for Molecular Medicine Finland FIMM, University of Helsinki, PO Box 20, FIN-00014 Helsinki, Finland; §Centre for Biotechnology, ¶Department of Pathology,University of Turku and Åbo Akademi, Turku, Finland, PO Box 123, FIN-20521 Turku, Finland.;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/mcp.M115.050773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762622PMC
December 2015

MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity.

Authors:
Arjan J van Adrichem Krister Wennerberg

FEBS Lett 2015 Dec 19;589(24 Pt B):3859-65. Epub 2015 Nov 19.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.febslet.2015.11.013DOI Listing
December 2015

Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening.

Authors:
Sarah J Duellman Wenhui Zhou Poncho Meisenheimer Gediminas Vidugiris James J Cali Prson Gautam Krister Wennerberg Jolanta Vidugiriene

Assay Drug Dev Technol 2015 Oct 18;13(8):456-65. Epub 2015 Sep 18.

1 Research and Development , Promega Corporation, Madison, Wisconsin.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1089/adt.2015.669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605357PMC
October 2015

From drug response profiling to target addiction scoring in cancer cell models.

Authors:
Bhagwan Yadav Peddinti Gopalacharyulu Tea Pemovska Suleiman A Khan Agnieszka Szwajda Jing Tang Krister Wennerberg Tero Aittokallio

Dis Model Mech 2015 Oct;8(10):1255-64

Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/dmm.021105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610238PMC
October 2015

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

Authors:
Arjan J van Adrichem Annika Fagerholm Laura Turunen Anna Lehto Jani Saarela Ari Koskinen Gretchen A Repasky Krister Wennerberg

Comb Chem High Throughput Screen 2015 ;18(1):3-17

Institute for Molecular Medicine Finland FIMM, Nordic EMBL Partnership for Molecular Medicine, Biomedicum Helsinki 2U, P.O. Box 20 (Tukholmankatu 8), FI- 00014, University of Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435052PMC
http://dx.doi.org/10.2174/1386207318666141205112730DOI Listing
September 2015

What is synergy? The Saariselkä agreement revisited.

Authors:
Jing Tang Krister Wennerberg Tero Aittokallio

Front Pharmacol 2015 1;6:181. Epub 2015 Sep 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://journal.frontiersin.org/article/10.3389/fphar.2015.00
Publisher Site
http://dx.doi.org/10.3389/fphar.2015.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555011PMC
September 2015

Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening.

Authors:
Jolanta Vidugiriene Donna Leippe Mary Sobol Gediminas Vidugiris Wenhui Zhou Poncho Meisenheimer Prson Gautam Krister Wennerberg James J Cali

Assay Drug Dev Technol 2014 Nov-Dec;12(9-10):514-26

1 Research and Development , Promega Corporation, Madison, Wisconsin.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1089/adt.2014.605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270152PMC
August 2015

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.

Authors:
Milla Kibble Niina Saarinen Jing Tang Krister Wennerberg Sari Mäkelä Tero Aittokallio

Nat Prod Rep 2015 Aug;32(8):1249-66

Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, 00014 University of Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1039/c5np00005jDOI Listing
August 2015

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

Authors:
Hassan Al-Ali Do-Hun Lee Matt C Danzi Houssam Nassif Prson Gautam Krister Wennerberg Bill Zuercher David H Drewry Jae K Lee Vance P Lemmon John L Bixby

ACS Chem Biol 2015 Aug 24;10(8):1939-51. Epub 2015 Jun 24.

○Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1021/acschembio.5b00289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899818PMC
August 2015

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

Authors:
Agnieszka Szwajda Prson Gautam Leena Karhinen Sawan Kumar Jha Jani Saarela Sushil Shakyawar Laura Turunen Bhagwan Yadav Jing Tang Krister Wennerberg Tero Aittokallio

Chem Biol 2015 Aug 23;22(8):1144-55. Epub 2015 Jul 23.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.chembiol.2015.06.021DOI Listing
August 2015

TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples.

Authors:
Liye He Krister Wennerberg Tero Aittokallio Jing Tang

Bioinformatics 2015 Jun 31;31(11):1866-8. Epub 2015 Jan 31.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Tukholmankatu 8, FI-00290, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://bioinformatics.oxfordjournals.org/content/early/2015/
Web Search
http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btv067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443685PMC
June 2015

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.

Authors:
Tea Pemovska Eric Johnson Mika Kontro Gretchen A Repasky Jeffrey Chen Peter Wells Ciarán N Cronin Michele McTigue Olli Kallioniemi Kimmo Porkka Brion W Murray Krister Wennerberg

Nature 2015 Mar 9;519(7541):102-5. Epub 2015 Feb 9.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://search.proquest.com/openview/7e9c80a48fbfe2e8d90feb1a
Web Search
http://dx.doi.org/10.1038/nature14119DOI Listing
March 2015

A community effort to assess and improve drug sensitivity prediction algorithms.

Authors:
James C Costello Laura M Heiser Elisabeth Georgii Mehmet Gönen Michael P Menden Nicholas J Wang Mukesh Bansal Muhammad Ammad-ud-din Petteri Hintsanen Suleiman A Khan John-Patrick Mpindi Olli Kallioniemi Antti Honkela Tero Aittokallio Krister Wennerberg James J Collins Dan Gallahan Dinah Singer Julio Saez-Rodriguez Samuel Kaski Joe W Gray Gustavo Stolovitzky

Nat Biotechnol 2014 Dec 1;32(12):1202-12. Epub 2014 Jun 1.

IBM T.J. Watson Research Center, IBM, Yorktown Heights, New York, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nbt.2877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547623PMC
December 2014

Antifungal application of nonantifungal drugs.

Authors:
Marios Stylianou Evgeny Kulesskiy José Pedro Lopes Margareta Granlund Krister Wennerberg Constantin F Urban

Antimicrob Agents Chemother 2014 25;58(2):1055-62. Epub 2013 Nov 25.

Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1128/AAC.01087-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910836PMC
September 2014

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Authors:
Suleiman A Khan Seppo Virtanen Olli P Kallioniemi Krister Wennerberg Antti Poso Samuel Kaski

Bioinformatics 2014 Sep;30(17):i497-504

Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btu456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147909PMC
September 2014

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization.

Authors:
Muhammad Ammad-ud-din Elisabeth Georgii Mehmet Gönen Tuomo Laitinen Olli Kallioniemi Krister Wennerberg Antti Poso Samuel Kaski

J Chem Inf Model 2014 Aug 6;54(8):2347-59. Epub 2014 Aug 6.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University , P.O. Box 15400, Espoo 00076, Finland.

View Article

Download full-text PDF

 Source
http://pubs.acs.org/doi/10.1021/ci500152b
Publisher Site
http://dx.doi.org/10.1021/ci500152bDOI Listing
August 2014

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.

Authors:
Colm Atkins Carrie W Evans Brian Nordin Matthew P Patricelli Robert Reynolds Krister Wennerberg James W Noah

J Biomol Screen 2014 Jul 24;19(6):936-46. Epub 2014 Jan 24.

Southern Research Institute, Birmingham, AL, USA University of Alabama at Birmingham, Birmingham, AL, USA

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/1087057113518068DOI Listing
July 2014

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies.

Authors:
Bhagwan Yadav Tea Pemovska Agnieszka Szwajda Evgeny Kulesskiy Mika Kontro Riikka Karjalainen Muntasir Mamun Majumder Disha Malani Astrid Murumägi Jonathan Knowles Kimmo Porkka Caroline Heckman Olli Kallioniemi Krister Wennerberg Tero Aittokallio

Sci Rep 2014 Jun 5;4:5193. Epub 2014 Jun 5.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep05193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046135PMC
June 2014

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine.

Authors:
Vilja Pietiainen Jani Saarela Carina von Schantz Laura Turunen Paivi Ostling Krister Wennerberg

Comb Chem High Throughput Screen 2014 May;17(4):377-86

Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2174/1386207317666140323195927DOI Listing
May 2014

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.

Authors:
Jing Tang Leena Karhinen Tao Xu Agnieszka Szwajda Bhagwan Yadav Krister Wennerberg Tero Aittokallio

PLoS Comput Biol 2013 12;9(9):e1003226. Epub 2013 Sep 12.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pcbi.1003226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772058PMC
April 2014

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.

Authors:
Jing Tang Agnieszka Szwajda Sushil Shakyawar Tao Xu Petteri Hintsanen Krister Wennerberg Tero Aittokallio

J Chem Inf Model 2014 Mar 21;54(3):735-43. Epub 2014 Feb 21.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki , Tukholmankatu 8, FI-00290, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1021/ci400709dDOI Listing
March 2014

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells.

Authors:
Hanna Antila Henri Autio Laura Turunen Kirsi Harju Päivi Tammela Krister Wennerberg Jari Yli-Kauhaluoma Henri J Huttunen Eero Castrén Tomi Rantamäki

J Neurosci Methods 2014 Jan 12;222:142-6. Epub 2013 Nov 12.

Neuroscience Center, P.O. Box 56, Viikinkaari 4, FI-00014 University of Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jneumeth.2013.11.001DOI Listing
January 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Authors:
Tea Pemovska Mika Kontro Bhagwan Yadav Henrik Edgren Samuli Eldfors Agnieszka Szwajda Henrikki Almusa Maxim M Bespalov Pekka Ellonen Erkki Elonen Bjørn T Gjertsen Riikka Karjalainen Evgeny Kulesskiy Sonja Lagström Anna Lehto Maija Lepistö Tuija Lundán Muntasir Mamun Majumder Jesus M Lopez Marti Pirkko Mattila Astrid Murumägi Satu Mustjoki Aino Palva Alun Parsons Tero Pirttinen Maria E Rämet Minna Suvela Laura Turunen Imre Västrik Maija Wolf Jonathan Knowles Tero Aittokallio Caroline A Heckman Kimmo Porkka Olli Kallioniemi Krister Wennerberg

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0350DOI Listing
December 2013

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

Authors:
Lisa M Wolfe Usha Veeraraghavan Susan Idicula-Thomas Stephan Schürer Krister Wennerberg Robert Reynolds Gurdyal S Besra Karen M Dobos

Mol Cell Proteomics 2013 Jun 5;12(6):1644-60. Epub 2013 Mar 5.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/mcp.M112.025635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675820PMC
June 2013

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

Authors:
Hanna L M Rajala Samuli Eldfors Heikki Kuusanmäki Arjan J van Adrichem Thomas Olson Sonja Lagström Emma I Andersson Andres Jerez Michael J Clemente Yiyi Yan Dan Zhang Andy Awwad Pekka Ellonen Olli Kallioniemi Krister Wennerberg Kimmo Porkka Jaroslaw P Maciejewski Thomas P Loughran Caroline Heckman Satu Mustjoki

Blood 2013 May 17;121(22):4541-50. Epub 2013 Apr 17.

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2012-12-474577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668487PMC
May 2013

Somatic STAT3 mutations in large granular lymphocytic leukemia.

Authors:
Hanna L M Koskela Samuli Eldfors Pekka Ellonen Arjan J van Adrichem Heikki Kuusanmäki Emma I Andersson Sonja Lagström Michael J Clemente Thomas Olson Sari E Jalkanen Muntasir Mamun Majumder Henrikki Almusa Henrik Edgren Maija Lepistö Pirkko Mattila Kathryn Guinta Pirjo Koistinen Taru Kuittinen Kati Penttinen Alun Parsons Jonathan Knowles Janna Saarela Krister Wennerberg Olli Kallioniemi Kimmo Porkka Thomas P Loughran Caroline A Heckman Jaroslaw P Maciejewski Satu Mustjoki

N Engl J Med 2012 May;366(20):1905-13

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1056/NEJMoa1114885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693860PMC
May 2012

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs.

Authors:
Suleiman A Khan Ali Faisal John Patrick Mpindi Juuso A Parkkinen Tuomo Kalliokoski Antti Poso Olli P Kallioniemi Krister Wennerberg Samuel Kaski

BMC Bioinformatics 2012 May 30;13:112. Epub 2012 May 30.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University, PO Box 15400, Espoo, 00076, Finland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2105-13-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532323PMC
May 2012

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.

Authors:
Marina S Manuvakhova Guyla G Johnson Misti C White Subramaniam Ananthan Melinda Sosa Clinton Maddox Sara McKellip Lynn Rasmussen Krister Wennerberg Judith V Hobrath E Lucile White Joseph A Maddry Maurizio Grimaldi

J Neurosci Res 2011 Jan;89(1):58-72

Laboratory of Neuropharmacology, Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/jnr.22526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280078PMC
January 2011

A high-throughput screen for chemical inhibitors of exocytic transport in yeast.

Authors:
Lisha Zhang N Miranda Nebane Krister Wennerberg Yujie Li Valerie Neubauer Judith V Hobrath Sara McKellip Lynn Rasmussen Nice Shindo Melinda Sosa Joseph A Maddry Subramaniam Ananthan Gary A Piazza E Lucile White Edina Harsay

Chembiochem 2010 Jun;11(9):1291-301

Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cbic.200900681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090732PMC
June 2010

MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.

Authors:
Katherine I Swenson-Fields Joshua C Sandquist Jessica Rossol-Allison Irene C Blat Krister Wennerberg Keith Burridge Anthony R Means

Mol Cell 2008 Oct;32(1):43-56

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molcel.2008.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603627PMC
October 2008

A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

Authors:
Adi D Dubash Krister Wennerberg Rafael García-Mata Marisa M Menold William T Arthur Keith Burridge

J Cell Sci 2007 Nov 30;120(Pt 22):3989-98. Epub 2007 Oct 30.

Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/jcs.003806DOI Listing
November 2007

Analysis of activated GAPs and GEFs in cell lysates.

Authors:
Rafael García-Mata Krister Wennerberg William T Arthur Nicole K Noren Shawn M Ellerbroek Keith Burridge

Methods Enzymol 2006 ;406:425-37

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S0076-6879(06)06031-9DOI Listing
March 2006

The Ras superfamily at a glance.

Authors:
Krister Wennerberg Kent L Rossman Channing J Der

J Cell Sci 2005 Mar;118(Pt 5):843-6

Cytoskeleton Inc., 1830 S. Acoma Street, Denver, CO 80223, USA.

View Article

Download full-text PDF

 Source
http://jcs.biologists.org/cgi/doi/10.1242/jcs.01660
Publisher Site
http://dx.doi.org/10.1242/jcs.01660DOI Listing
March 2005

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.

Authors:
Shawn M Ellerbroek Krister Wennerberg William T Arthur Jill M Dunty Dan R Bowman Kris A DeMali Channing Der Keith Burridge

Mol Biol Cell 2004 Jul 7;15(7):3309-19. Epub 2004 May 7.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1091/mbc.e04-02-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC452585PMC
July 2004

p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

Authors:
Julius Aitsebaomo Krister Wennerberg Channing J Der Chunlian Zhang Vishram Kedar Martin Moser Michelle L Kingsley-Kallesen Guo-Qing Zeng Cam Patterson

J Biol Chem 2004 Apr 14;279(17):17963-72. Epub 2004 Feb 14.

Carolina Cardiovascular Biology Center, the Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M311721200DOI Listing
April 2004

Rho-family GTPases: it's not only Rac and Rho (and I like it).

Authors:
Krister Wennerberg Channing J Der

J Cell Sci 2004 Mar;117(Pt 8):1301-12

Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/jcs.01118DOI Listing
March 2004

Rho and Rac take center stage.

Authors:
Keith Burridge Krister Wennerberg

Cell 2004 Jan;116(2):167-79

Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/s0092-8674(04)00003-0DOI Listing
January 2004

Integrin signaling to the actin cytoskeleton.

Authors:
Kris A DeMali Krister Wennerberg Keith Burridge

Curr Opin Cell Biol 2003 Oct;15(5):572-82

Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/s0955-0674(03)00109-1DOI Listing
October 2003

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.

Authors:
Krister Wennerberg Marie-Annick Forget Shawn M Ellerbroek William T Arthur Keith Burridge Jeffrey Settleman Channing J Der Steen H Hansen

Curr Biol 2003 Jul;13(13):1106-15

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/s0960-9822(03)00418-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918695PMC
July 2003

Serine phosphorylation negatively regulates RhoA in vivo.

Authors:
Shawn M Ellerbroek Krister Wennerberg Keith Burridge

J Biol Chem 2003 May 24;278(21):19023-31. Epub 2003 Mar 24.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599,USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M213066200DOI Listing
May 2003

RhoG signals in parallel with Rac1 and Cdc42.

Authors:
Krister Wennerberg Shawn M Ellerbroek Rong-Yu Liu Antoine E Karnoub Keith Burridge Channing J Der

J Biol Chem 2002 Dec 9;277(49):47810-7. Epub 2002 Oct 9.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M203816200DOI Listing
December 2002

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

Authors:
William T Arthur Shawn M Ellerbroek Channing J Der Keith Burridge Krister Wennerberg

J Biol Chem 2002 Nov 6;277(45):42964-72. Epub 2002 Sep 6.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M207401200DOI Listing
November 2002

Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1.

Authors:
Teet Velling Juha Risteli Krister Wennerberg Deane F Mosher Staffan Johansson

J Biol Chem 2002 Oct 26;277(40):37377-81. Epub 2002 Jul 26.

Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M206286200DOI Listing
October 2002