Publications by authors named "Krister Wennerberg"

100Publications

Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia.

Cancer Cell 2020 Dec;38(6):776-778

Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark. Electronic address:

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December 2020

Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition.

Leukemia 2020 12 10;34(12):3186-3196. Epub 2020 Jul 10.

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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December 2020

Immunogenomic Landscape of Hematological Malignancies.

Cancer Cell 2020 Sep 9;38(3):380-399.e13. Epub 2020 Jul 9.

Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center (HUH CCC), 00029 Helsinki, Finland; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki (UH), 00029 Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. Electronic address:

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September 2020

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Cell Rep 2020 06;31(11):107764

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Charité Universitätsmedizin Berlin, Institute of Pathology, Laboratory of Molecular Tumor Pathology and Systems Biology, 10117 Berlin, Germany. Electronic address:

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June 2020

Prediction of drug combination effects with a minimal set of experiments.

Nat Mach Intell 2019 Dec 9;1(12):568-577. Epub 2019 Dec 9.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

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December 2019

Identification of novel regulators of STAT3 activity.

PLoS One 2020 31;15(3):e0230819. Epub 2020 Mar 31.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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June 2020

Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics.

Mol Syst Biol 2020 03;16(3):e9195

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

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March 2020

Exploration of databases and methods supporting drug repurposing: a comprehensive survey.

Brief Bioinform 2020 Feb 14. Epub 2020 Feb 14.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.

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February 2020

A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening.

Commun Biol 2020 01 23;3(1):42. Epub 2020 Jan 23.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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January 2020

Human Tumor-Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing.

Cancers (Basel) 2019 Dec 30;12(1). Epub 2019 Dec 30.

Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

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December 2019

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment.

Clin Transl Med 2019 Dec 30;8(1):33. Epub 2019 Dec 30.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway.

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December 2019

Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer.

Clin Epigenetics 2019 12 11;11(1):192. Epub 2019 Dec 11.

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, PO Box 63, Helsinki, Finland.

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December 2019

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.

J Am Heart Assoc 2019 11 16;8(21):e013018. Epub 2019 Oct 16.

Research Unit of Biomedicine Department of Pharmacology and Toxicology University of Oulu Finland.

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November 2019

Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.

Cell Chem Biol 2019 Nov 11;26(11):1608-1622.e6. Epub 2019 Sep 11.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00014, Finland; Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland. Electronic address:

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November 2019

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma.

BMC Cancer 2019 Jun 25;19(1):628. Epub 2019 Jun 25.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.

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June 2019

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Cell Chem Biol 2019 07 2;26(7):970-979.e4. Epub 2019 May 2.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00290 Helsinki, Finland; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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July 2019

Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer.

Methods Mol Biol 2019 ;1888:205-217

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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June 2019

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Cancer Cell 2018 11;34(5):807-822.e7

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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November 2018

Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513].

Comput Struct Biotechnol J 2017;15:387. Epub 2017 Jul 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

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July 2017

Toward universal protein post-translational modification detection in high throughput format.

Chem Commun (Camb) 2018 Mar;54(23):2910-2913

Materials Chemistry and Chemical Analysis, University of Turku, Turku, Finland.

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March 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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May 2018

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

Methods Mol Biol 2018 ;1711:351-398

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, PO Box 33, Helsinki, 00014, Finland.

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October 2018

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma.

Hepatology 2018 09 12;68(3):949-963. Epub 2018 Jun 12.

Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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September 2018

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.

Bioinformatics 2018 04;34(8):1353-1362

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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April 2018

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.

PLoS Comput Biol 2017 Aug 7;13(8):e1005678. Epub 2017 Aug 7.

Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.

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August 2017

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

Nat Commun 2017 07 3;8:15932. Epub 2017 Jul 3.

Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, SE-17177 Stockholm, Sweden.

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July 2017

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

Anal Chem 2017 04 29;89(8):4508-4516. Epub 2017 Mar 29.

Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland.

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April 2017

Consistency in drug response profiling.

Nature 2016 11;540(7631):E5-E6

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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November 2016

Cancer Cell Drug Response Transcriptomes in 3D.

Cell Chem Biol 2016 11;23(11):1323-1324

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland. Electronic address:

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November 2016

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease.

Front Aging Neurosci 2016 26;8:254. Epub 2016 Oct 26.

Institute of Biotechnology, University of Helsinki Helsinki, Finland.

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October 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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October 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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August 2016

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.

Antiviral Res 2016 Feb 2;126:117-24. Epub 2016 Jan 2.

Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland. Electronic address:

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February 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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January 2016

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

J Lab Autom 2016 Feb 2;21(1):27-36. Epub 2015 Dec 2.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

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February 2016

MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity.

FEBS Lett 2015 Dec 19;589(24 Pt B):3859-65. Epub 2015 Nov 19.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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December 2015

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Mol Cell Proteomics 2015 Dec 23;14(12):3274-83. Epub 2015 Oct 23.

From the ‡Institute for Molecular Medicine Finland FIMM, University of Helsinki, PO Box 20, FIN-00014 Helsinki, Finland; §Centre for Biotechnology, ¶Department of Pathology,University of Turku and Åbo Akademi, Turku, Finland, PO Box 123, FIN-20521 Turku, Finland.;

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December 2015

From drug response profiling to target addiction scoring in cancer cell models.

Dis Model Mech 2015 Oct;8(10):1255-64

Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland

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October 2015

What is synergy? The Saariselkä agreement revisited.

Front Pharmacol 2015 1;6:181. Epub 2015 Sep 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki Helsinki, Finland.

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September 2015

Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening.

Assay Drug Dev Technol 2015 Oct 18;13(8):456-65. Epub 2015 Sep 18.

1 Research and Development , Promega Corporation, Madison, Wisconsin.

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October 2015

KIFC1 is a novel potential therapeutic target for breast cancer.

Cancer Biol Ther 2015 15;16(9):1316-22. Epub 2015 Jul 15.

a Drug Discovery Division; Southern Research Institute ; Birmingham , AL USA.

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July 2016

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

ACS Chem Biol 2015 Aug 24;10(8):1939-51. Epub 2015 Jun 24.

○Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States.

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August 2015

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.

Nat Prod Rep 2015 Aug;32(8):1249-66

Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, 00014 University of Helsinki, Finland.

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August 2015

TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples.

Bioinformatics 2015 Jun 31;31(11):1866-8. Epub 2015 Jan 31.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Tukholmankatu 8, FI-00290, Helsinki, Finland.

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June 2015

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

Comput Struct Biotechnol J 2015 25;13:504-13. Epub 2015 Sep 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

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March 2016

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

Comb Chem High Throughput Screen 2015 ;18(1):3-17

Institute for Molecular Medicine Finland FIMM, Nordic EMBL Partnership for Molecular Medicine, Biomedicum Helsinki 2U, P.O. Box 20 (Tukholmankatu 8), FI- 00014, University of Helsinki, Finland.

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September 2015

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Bioinformatics 2014 Sep;30(17):i497-504

Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland.

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September 2014

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization.

J Chem Inf Model 2014 Aug 6;54(8):2347-59. Epub 2014 Aug 6.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University , P.O. Box 15400, Espoo 00076, Finland.

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August 2014

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine.

Comb Chem High Throughput Screen 2014 May;17(4):377-86

Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.

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May 2014

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.

J Chem Inf Model 2014 Mar 21;54(3):735-43. Epub 2014 Feb 21.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki , Tukholmankatu 8, FI-00290, Helsinki, Finland.

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March 2014

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.

J Biomol Screen 2014 Jul 24;19(6):936-46. Epub 2014 Jan 24.

Southern Research Institute, Birmingham, AL, USA University of Alabama at Birmingham, Birmingham, AL, USA

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July 2014

Antifungal application of nonantifungal drugs.

Antimicrob Agents Chemother 2014 25;58(2):1055-62. Epub 2013 Nov 25.

Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

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September 2014

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells.

J Neurosci Methods 2014 Jan 12;222:142-6. Epub 2013 Nov 12.

Neuroscience Center, P.O. Box 56, Viikinkaari 4, FI-00014 University of Helsinki, Finland. Electronic address:

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January 2014

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.

PLoS Comput Biol 2013 12;9(9):e1003226. Epub 2013 Sep 12.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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April 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

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December 2013

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

Mol Cell Proteomics 2013 Jun 5;12(6):1644-60. Epub 2013 Mar 5.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

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June 2013

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs.

BMC Bioinformatics 2012 May 30;13:112. Epub 2012 May 30.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University, PO Box 15400, Espoo, 00076, Finland.

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May 2012

MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.

Mol Cell 2008 Oct;32(1):43-56

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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October 2008

A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

J Cell Sci 2007 Nov 30;120(Pt 22):3989-98. Epub 2007 Oct 30.

Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA.

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November 2007

Analysis of activated GAPs and GEFs in cell lysates.

Methods Enzymol 2006 ;406:425-37

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

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March 2006