Krister Wennerberg

Krister Wennerberg

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Krister Wennerberg

Publications by authors named "Krister Wennerberg"

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A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening.

Commun Biol 2020 Jan 23;3(1):42. Epub 2020 Jan 23.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s42003-020-0765-zDOI Listing
January 2020

Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer.

Clin Epigenetics 2019 Dec 11;11(1):192. Epub 2019 Dec 11.

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, PO Box 63, Helsinki, Finland.

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http://dx.doi.org/10.1186/s13148-019-0781-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907220PMC
December 2019

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment.

Clin Transl Med 2019 Dec 30;8(1):33. Epub 2019 Dec 30.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway.

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http://dx.doi.org/10.1186/s40169-019-0253-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937360PMC
December 2019

Human Tumor-Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing.

Cancers (Basel) 2019 Dec 30;12(1). Epub 2019 Dec 30.

Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.3390/cancers12010092DOI Listing
December 2019

Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.

Cell Chem Biol 2019 Nov 11;26(11):1608-1622.e6. Epub 2019 Sep 11.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00014, Finland; Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.08.007DOI Listing
November 2019

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.

J Am Heart Assoc 2019 Nov 16;8(21):e013018. Epub 2019 Oct 16.

Research Unit of Biomedicine Department of Pharmacology and Toxicology University of Oulu Finland.

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http://dx.doi.org/10.1161/JAHA.119.013018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898841PMC
November 2019

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify -Mutant Lung Cancers.

Mol Cancer Ther 2019 10 18;18(10):1863-1874. Epub 2019 Jul 18.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0573DOI Listing
October 2019

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Cell Chem Biol 2019 Jul 2;26(7):970-979.e4. Epub 2019 May 2.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00290 Helsinki, Finland; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193010
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http://dx.doi.org/10.1016/j.chembiol.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642004PMC
July 2019

Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer.

Methods Mol Biol 2019 ;1888:205-217

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-4939-8891-4_12DOI Listing
June 2019

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma.

BMC Cancer 2019 Jun 25;19(1):628. Epub 2019 Jun 25.

Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424, Oslo, Norway.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5861-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593575PMC
June 2019

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing.

Brief Bioinform 2018 Dec 18. Epub 2018 Dec 18.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/bib/bby119DOI Listing
December 2018

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Cancer Cell 2018 11;34(5):807-822.e7

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://www.researchgate.net/publication/325458004_KRAS_Supp
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http://scholar.google.fi/citations?user=_42T_HMAAAAJ&hl=en
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https://www.journals.elsevier.com/cancer-cell/recent-article
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https://linkinghub.elsevier.com/retrieve/pii/S15356108183046
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http://dx.doi.org/10.1016/j.ccell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321749PMC
November 2018

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

Methods Mol Biol 2018 ;1711:351-398

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, PO Box 33, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1007/978-1-4939-7493-1_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383747PMC
October 2018

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy.

Mol Cancer Ther 2018 09 3;17(9):2060-2071. Epub 2018 Jul 3.

Research Programs Unit, Genome-Scale Biology Program and Medicum, Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0733DOI Listing
September 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3644DOI Listing
May 2018

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.

Bioinformatics 2018 04;34(8):1353-1362

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btx766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905617PMC
April 2018

Toward universal protein post-translational modification detection in high throughput format.

Chem Commun (Camb) 2018 Mar;54(23):2910-2913

Materials Chemistry and Chemical Analysis, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1039/c7cc09575aDOI Listing
March 2018

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

Nat Commun 2017 07 3;8:15932. Epub 2017 Jul 3.

Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1038/ncomms15932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500850PMC
July 2017

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

Anal Chem 2017 04 29;89(8):4508-4516. Epub 2017 Mar 29.

Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1021/acs.analchem.6b04904DOI Listing
April 2017

Cancer Cell Drug Response Transcriptomes in 3D.

Cell Chem Biol 2016 11;23(11):1323-1324

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.11.002DOI Listing
November 2016

Consistency in drug response profiling.

Nature 2016 11;540(7631):E5-E6

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature20171DOI Listing
November 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease.

Front Aging Neurosci 2016 26;8:254. Epub 2016 Oct 26.

Institute of Biotechnology, University of Helsinki Helsinki, Finland.

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http://dx.doi.org/10.3389/fnagi.2016.00254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080529PMC
October 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

KIFC1 is a novel potential therapeutic target for breast cancer.

Cancer Biol Ther 2015 15;16(9):1316-22. Epub 2015 Jul 15.

a Drug Discovery Division; Southern Research Institute ; Birmingham , AL USA.

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http://dx.doi.org/10.1080/15384047.2015.1070980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622065PMC
July 2016

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

Comput Struct Biotechnol J 2015 25;13:504-13. Epub 2015 Sep 25.

Institute for Molecular Medicine Finland (FIMM), FI-00014, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.csbj.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759128PMC
March 2016

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

J Lab Autom 2016 Feb 2;21(1):27-36. Epub 2015 Dec 2.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

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http://dx.doi.org/10.1177/2211068215618869DOI Listing
February 2016

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.

Antiviral Res 2016 Feb 2;126:117-24. Epub 2016 Jan 2.

Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.12.012DOI Listing
February 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Mol Cell Proteomics 2015 Dec 23;14(12):3274-83. Epub 2015 Oct 23.

From the ‡Institute for Molecular Medicine Finland FIMM, University of Helsinki, PO Box 20, FIN-00014 Helsinki, Finland; §Centre for Biotechnology, ¶Department of Pathology,University of Turku and Åbo Akademi, Turku, Finland, PO Box 123, FIN-20521 Turku, Finland.;

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http://dx.doi.org/10.1074/mcp.M115.050773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762622PMC
December 2015

MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity.

FEBS Lett 2015 Dec 19;589(24 Pt B):3859-65. Epub 2015 Nov 19.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.febslet.2015.11.013DOI Listing
December 2015

Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening.

Assay Drug Dev Technol 2015 Oct 18;13(8):456-65. Epub 2015 Sep 18.

1 Research and Development , Promega Corporation, Madison, Wisconsin.

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http://dx.doi.org/10.1089/adt.2015.669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605357PMC
October 2015

From drug response profiling to target addiction scoring in cancer cell models.

Dis Model Mech 2015 Oct;8(10):1255-64

Institute for Molecular Medicine Finland (FIMM), Nordic EMBL Partnership for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland

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http://dx.doi.org/10.1242/dmm.021105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610238PMC
October 2015

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

Comb Chem High Throughput Screen 2015 ;18(1):3-17

Institute for Molecular Medicine Finland FIMM, Nordic EMBL Partnership for Molecular Medicine, Biomedicum Helsinki 2U, P.O. Box 20 (Tukholmankatu 8), FI- 00014, University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435052PMC
http://dx.doi.org/10.2174/1386207318666141205112730DOI Listing
September 2015

What is synergy? The Saariselkä agreement revisited.

Front Pharmacol 2015 1;6:181. Epub 2015 Sep 1.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki Helsinki, Finland.

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http://journal.frontiersin.org/article/10.3389/fphar.2015.00
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http://dx.doi.org/10.3389/fphar.2015.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555011PMC
September 2015

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.

Nat Prod Rep 2015 Aug;32(8):1249-66

Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1039/c5np00005jDOI Listing
August 2015

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

ACS Chem Biol 2015 Aug 24;10(8):1939-51. Epub 2015 Jun 24.

○Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acschembio.5b00289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899818PMC
August 2015

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

Chem Biol 2015 Aug 23;22(8):1144-55. Epub 2015 Jul 23.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.06.021DOI Listing
August 2015

Antifungal application of nonantifungal drugs.

Antimicrob Agents Chemother 2014 25;58(2):1055-62. Epub 2013 Nov 25.

Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1128/AAC.01087-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910836PMC
September 2014

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Bioinformatics 2014 Sep;30(17):i497-504

Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, 00076 Espoo, Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio and Department of Computer Science, Helsinki Institute for Information Technology HIIT, University Of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btu456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147909PMC
September 2014

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization.

J Chem Inf Model 2014 Aug 6;54(8):2347-59. Epub 2014 Aug 6.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University , P.O. Box 15400, Espoo 00076, Finland.

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http://pubs.acs.org/doi/10.1021/ci500152b
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http://dx.doi.org/10.1021/ci500152bDOI Listing
August 2014

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.

J Biomol Screen 2014 Jul 24;19(6):936-46. Epub 2014 Jan 24.

Southern Research Institute, Birmingham, AL, USA University of Alabama at Birmingham, Birmingham, AL, USA

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http://dx.doi.org/10.1177/1087057113518068DOI Listing
July 2014

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine.

Comb Chem High Throughput Screen 2014 May;17(4):377-86

Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.

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http://dx.doi.org/10.2174/1386207317666140323195927DOI Listing
May 2014

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.

PLoS Comput Biol 2013 12;9(9):e1003226. Epub 2013 Sep 12.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pcbi.1003226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772058PMC
April 2014

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.

J Chem Inf Model 2014 Mar 21;54(3):735-43. Epub 2014 Feb 21.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki , Tukholmankatu 8, FI-00290, Helsinki, Finland.

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http://dx.doi.org/10.1021/ci400709dDOI Listing
March 2014

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells.

J Neurosci Methods 2014 Jan 12;222:142-6. Epub 2013 Nov 12.

Neuroscience Center, P.O. Box 56, Viikinkaari 4, FI-00014 University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2013.11.001DOI Listing
January 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0350DOI Listing
December 2013

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

Mol Cell Proteomics 2013 Jun 5;12(6):1644-60. Epub 2013 Mar 5.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1074/mcp.M112.025635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675820PMC
June 2013

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs.

BMC Bioinformatics 2012 May 30;13:112. Epub 2012 May 30.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University, PO Box 15400, Espoo, 00076, Finland.

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http://dx.doi.org/10.1186/1471-2105-13-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532323PMC
May 2012

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.

J Neurosci Res 2011 Jan;89(1):58-72

Laboratory of Neuropharmacology, Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA.

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http://dx.doi.org/10.1002/jnr.22526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280078PMC
January 2011

MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.

Mol Cell 2008 Oct;32(1):43-56

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603627PMC
October 2008

A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

J Cell Sci 2007 Nov 30;120(Pt 22):3989-98. Epub 2007 Oct 30.

Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA.

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http://dx.doi.org/10.1242/jcs.003806DOI Listing
November 2007

Analysis of activated GAPs and GEFs in cell lysates.

Methods Enzymol 2006 ;406:425-37

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)06031-9DOI Listing
March 2006

The Ras superfamily at a glance.

J Cell Sci 2005 Mar;118(Pt 5):843-6

Cytoskeleton Inc., 1830 S. Acoma Street, Denver, CO 80223, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.01660
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http://dx.doi.org/10.1242/jcs.01660DOI Listing
March 2005

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.

Mol Biol Cell 2004 Jul 7;15(7):3309-19. Epub 2004 May 7.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1091/mbc.e04-02-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC452585PMC
July 2004

p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

J Biol Chem 2004 Apr 14;279(17):17963-72. Epub 2004 Feb 14.

Carolina Cardiovascular Biology Center, the Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M311721200DOI Listing
April 2004

Rho-family GTPases: it's not only Rac and Rho (and I like it).

J Cell Sci 2004 Mar;117(Pt 8):1301-12

Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1242/jcs.01118DOI Listing
March 2004

Rho and Rac take center stage.

Cell 2004 Jan;116(2):167-79

Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00003-0DOI Listing
January 2004

Integrin signaling to the actin cytoskeleton.

Curr Opin Cell Biol 2003 Oct;15(5):572-82

Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s0955-0674(03)00109-1DOI Listing
October 2003

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.

Curr Biol 2003 Jul;13(13):1106-15

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s0960-9822(03)00418-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918695PMC
July 2003

Serine phosphorylation negatively regulates RhoA in vivo.

J Biol Chem 2003 May 24;278(21):19023-31. Epub 2003 Mar 24.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599,USA.

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http://dx.doi.org/10.1074/jbc.M213066200DOI Listing
May 2003

RhoG signals in parallel with Rac1 and Cdc42.

J Biol Chem 2002 Dec 9;277(49):47810-7. Epub 2002 Oct 9.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1074/jbc.M203816200DOI Listing
December 2002

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

J Biol Chem 2002 Nov 6;277(45):42964-72. Epub 2002 Sep 6.

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M207401200DOI Listing
November 2002

Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1.

J Biol Chem 2002 Oct 26;277(40):37377-81. Epub 2002 Jul 26.

Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden.

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http://dx.doi.org/10.1074/jbc.M206286200DOI Listing
October 2002