Publications by authors named "Kristen Whitworth"

10 Publications

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Data on the hemostasis in epistaxis with Topically Administered TXA Versus Topical Oxymetazoline Spray.

Data Brief 2020 Apr 13;29:105283. Epub 2020 Feb 13.

Lakeland Health, United States.

The use of tranexamic acid (TXA) has recently gained popularity as a treatment modality for epistaxis in the emergency department. Data are presented on the efficacy of the topical use of the intravenous formulation of TXA versus the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patient presenting to the emergency department with anterior epistaxis. The original article "Comparative Effectiveness of Topically Administered TXA Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis" [1] provides complete interpretation of the data. The dataset regarding these treatment modalities has clinical significance toward preventing an avoidable need for escalation of treatment that could potentially increase patient discomfort and prolong emergency department throughput time.
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http://dx.doi.org/10.1016/j.dib.2020.105283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047014PMC
April 2020

Reexpansion Pulmonary Edema.

J Am Osteopath Assoc 2020 Jan;120(1):49

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http://dx.doi.org/10.7556/jaoa.2020.011DOI Listing
January 2020

Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis.

J Emerg Med 2020 Feb 30;58(2):211-216. Epub 2019 Dec 30.

Lakeland Health Emergency Medicine Residency Program, Lakeland Health, Saint Joseph, Michigan.

Background: The use of tranexamic acid (TXA) has recently gained popularity as a treatment modality for epistaxis in the emergency department. Previous studies have compared topical TXA to nasal packing. However, topical TXA has not yet been compared with topical oxymetazoline in the treatment of epistaxis.

Objectives: This study compares the efficacy of the intravenous formulation of TXA applied topically vs. the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patients presenting to the emergency department with anterior epistaxis.

Methods: In this prospective study, patients presenting to the emergency department with the chief complaint of epistaxis, and meeting inclusion criteria, were allocated into 2 treatment groups; topical oxymetazoline vs. topical application of the intravenous preparation of TXA. Patients were assessed for time to hemostasis in the emergency department as well as the occurrence of rebleeding within the next 48 h after discharge.

Results: Hemostasis was achieved in 14 (78%) of the 18 patients in the TXA group compared with 7 (35%) of the 20 patients in the oxymetazoline group. While there were occurrences of rebleeding in the emergency department before discharge and at 48 h in both groups, 11 patients in the TXA group had no recurrence of bleeding compared with 5 in the oxymetazoline group.

Conclusion: This study demonstrated that the topical application of the intravenous preparation of TXA is more effective than topical oxymetazoline for achievement of hemostasis in anterior epistaxis. This has clinical significance toward preventing an avoidable need for escalation of treatment that could include applying nasal packing or cautery as well as preventing avoidable return emergency department visits. These outcomes would increase cost, potentially increase patient discomfort, and prolong emergency department throughput time.
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http://dx.doi.org/10.1016/j.jemermed.2019.11.038DOI Listing
February 2020

Nystagmus Associated with Carbamazepine Toxicity.

Clin Pract Cases Emerg Med 2017 Nov 18;1(4):441-442. Epub 2017 Oct 18.

Lakeland Health, Department of Emergency Medicine, Saint Joseph, Michigan.

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http://dx.doi.org/10.5811/cpcem.2017.6.34772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965243PMC
November 2017

Post-operative Appendix Specimen Retention Presenting as Small Bowel Obstruction.

Clin Pract Cases Emerg Med 2017 Nov 3;1(4):287-290. Epub 2017 Oct 3.

Lakeland Health, Department of Emergency Medicine, Saint Joseph, Michigan.

One rare complication of appendectomy is a retained appendicolith, which can become a focal point for infection presenting hours to years after surgery. We present a case in which a 50-year-old male presented to the emergency department with a small bowel obstruction one week post appendectomy. A diagnostic laparoscopy was performed, and a necrotic appendiceal specimen containing a staple line across the base as well as an appendicolith was removed. It is crucial to include rare surgical complications in our differentials, alongside the more common pathologies when approaching and treating patients with abdominal pain.
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http://dx.doi.org/10.5811/cpcem.2017.5.34078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965195PMC
November 2017

Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1.

Virology 2017 01 26;501:102-106. Epub 2016 Nov 26.

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

African swine fever is a highly contagious, often fatal disease of swine for which there is no vaccine or other curative treatment. The macrophage marker, CD163, is a putative receptor for African swine fever virus (ASFV). Pigs possessing a complete knockout of CD163 on macrophages were inoculated with Georgia 2007/1, a genotype 2 isolate. Knockout and wild type pen mates became infected and showed no differences in clinical signs, mortality, pathology or viremia. There was also no difference following in vitro infection of macrophages. The results do not rule out the possibility that other ASFV strains utilize CD163, but demonstrate that CD163 is not necessary for infection with the Georgia 2007/1 isolate. This work rules out a significant role for CD163 in ASFV infection and creates opportunities to focus on alternative receptors and entry mechanisms.
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http://dx.doi.org/10.1016/j.virol.2016.11.012DOI Listing
January 2017

Purpuric skin eruption in an illicit drug user: Levamisole-induced vasculitis.

Am J Emerg Med 2016 Jul 1;34(7):1321.e5-6. Epub 2015 Dec 1.

Lakeland Health Emergency Medicine Residency Program, Lakeland Health, Saint Joseph, MI 49085.

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http://dx.doi.org/10.1016/j.ajem.2015.11.055DOI Listing
July 2016