Kristen Pierce

A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans.

Authors:

Usha K Nivarthi Jesica Swanstrom Matthew J Delacruz Bhumi Patel Anna P Durbin Steve S Whitehead Beth D Kirkpatrick Kristen K Pierce Sean A Diehl Leah Katzelnick Ralph S Baric Aravinda M de Silva

Nat Commun 2021 02 17;12(1):1102. Epub 2021 Feb 17.

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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February 2021

Impact and costs of a hepatitis C virus screening programme for adults hospitalised at an academic medical centre.

Authors:

Timothy J Whitman Cindy D Noyes Andrew J Hale Devika Singh Stephen G DeVoe Allen B Repp Kristen K Pierce Louis B Polish Beth D Kirkpatrick Jean Dejace Lindsay M Smith Tim Lahey Christopher D Huston Laura J Catoe Prateek Ghatage Sean Bullis W Kemper Alston

BMJ Open Qual 2021 Feb;10(1)

Division of Infectious Diseases, Department of Medicine, The Robert Larner, MD College of Medicine at the University of Vermont, Burlington, Vermont, USA.

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February 2021

Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003.

Authors:

Huy A Tu Usha K Nivarthi Nancy R Graham Philip Eisenhauer Matthew J Delacruz Kristen K Pierce Stephen S Whitehead Jonathan E Boyson Jason W Botten Beth D Kirkpatrick Anna P Durbin Aravinda M deSilva Sean A Diehl

Cell Rep Med 2020 Dec 22;1(9):100155. Epub 2020 Dec 22.

Department of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.

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December 2020

Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity.

Authors:

Nancy R Graham Annalis N Whitaker Camilla A Strother Ashley K Miles Dore Grier Benjamin D McElvany Emily A Bruce Matthew E Poynter Kristen K Pierce Beth D Kirkpatrick Renee D Stapleton Gary An Eline van den Broek-Altenburg Jason W Botten Jessica W Crothers Sean A Diehl

Clin Transl Immunology 2020 7;9(10):e1189. Epub 2020 Oct 7.

Department of Microbiology and Molecular Genetics Larner College of Medicine, University of Vermont Burlington VT USA.

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October 2020

A Veterinarian From Vermont Presenting With a Painful Right Index Finger Following a Needlestick Injury That Occurred While Caring for a Dog.

Authors:

Prateek Ghatage Kristen K Pierce Christina Wojewoda Nicole Mendelson Jonathan Wilcock Robert Nesbit Christopher D Huston Timothy J Whitman

Clin Infect Dis 2020 Sep;71(6):1577-1579

Division of Infectious Diseases, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

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September 2020

Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex.

Authors:

Nancy R Graham Annalis N Whitaker Camilla A Strother Ashley K Miles Dore Grier Benjamin D McElvany Emily A Bruce Matthew E Poynter Kristen K Pierce Beth D Kirkpatrick Renee D Stapleton Gary An Jason W Botten Jessica W Crothers Sean A Diehl

medRxiv 2020 Jul 16. Epub 2020 Jul 16.

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July 2020

Safety of gemtuzumab ozogamicin as monotherapy or combination therapy in an expanded-access protocol for patients with relapsed or refractory acute myeloid leukemia.

Authors:

Eunice S Wang Richard Aplenc Deborah Chirnomas Michael Dugan Salman Fazal Swaminathan Iyer Tara L Lin Sucha Nand Kristen J Pierce Paul J Shami Jennifer J Vermette Camille N Abboud

Leuk Lymphoma 2020 08 20;61(8):1965-1973. Epub 2020 May 20.

Washington University Medical School, St. Louis, MO, USA.

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August 2020

Immunogenicity and Safety of a Tetravalent Recombinant Subunit Dengue Vaccine in Adults Previously Vaccinated with a Live Attenuated Tetravalent Dengue Vaccine: Results of a Phase-I Randomized Clinical Trial.

Authors:

Anna P Durbin Kristen K Pierce Beth D Kirkpatrick Palmtama Grier Beulah P Sabundayo Helen He Michele Sausser Amy Falk Russell Jason Martin Donna Hyatt Melissa Cook Jeffrey R Sachs Andrew Wen-Tseng Lee Liman Wang Beth-Ann Coller Stephen S Whitehead

Am J Trop Med Hyg 2020 08 7;103(2):855-863. Epub 2020 May 7.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

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August 2020

Rapid Induction and Maintenance of Virus-Specific CD8 T and CD4 T Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans.

Authors:

Nancy Graham Phil Eisenhauer Sean A Diehl Kristen K Pierce Stephen S Whitehead Anna P Durbin Beth D Kirkpatrick Alessandro Sette Daniela Weiskopf Jonathan E Boyson Jason W Botten

Front Immunol 2020 24;11:479. Epub 2020 Mar 24.

Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.

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March 2020

Corrigendum to ''Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model'' [EBioMedicine 41 (2019) 465-478].

Authors:

Usha K Nivarthi Huy A Tu Matthew J Delacruz Jesica Swanstrom Bhumi Patel Anna P Durbin Stephen S Whitehead Kristen K Pierce Beth D Kirkpatrick Ralph S Baric Ngan Nguyen Daniel E Emerling Aravinda M de Silva Sean A Diehl

EBioMedicine 2020 04 3;54:102708. Epub 2020 Apr 3.

Department of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA. Electronic address:

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April 2020

Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model.

Authors:

Usha K Nivarthi Huy A Tu Matthew J Delacruz Jesica Swanstrom Bhumi Patel Anna P Durbin Stephen S Whitehead Kristen K Pierce Beth D Kirkpatrick Ralph S Baric Ngan Nguyen Daniel E Emerling Aravinda M de Silva Sean A Diehl

EBioMedicine 2019 Mar 8;41:465-478. Epub 2019 Mar 8.

Department of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA. Electronic address:

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March 2019

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3.

Blood 2019 05 5;133(19):2013-2026. Epub 2019 Feb 5.

University of Utah Molecular Medicine Program, Salt Lake City, UT.

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May 2019

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.

Authors:

Zev A Wainberg Maria Alsina Heloisa P Soares Irene Braña Carolyn D Britten Gianluca Del Conte Patrick Ezeh Brett Houk Kenneth A Kern Stephen Leong Nuzhat Pathan Kristen J Pierce Lillian L Siu Jennifer Vermette Josep Tabernero

Target Oncol 2017 Dec;12(6):775-785

Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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December 2017

In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination.

Authors:

Stephen S Whitehead Anna P Durbin Kristen K Pierce Dan Elwood Benjamin D McElvany Ellen A Fraser Marya P Carmolli Cecilia M Tibery Noreen A Hynes Matthew Jo Janece M Lovchik Catherine J Larsson Elena A Doty Dorothy M Dickson Catherine J Luke Kanta Subbarao Sean A Diehl Beth D Kirkpatrick

PLoS Negl Trop Dis 2017 05 8;11(5):e0005584. Epub 2017 May 8.

Vaccine Testing Center, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States of America.

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May 2017

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

Authors:

Kristen K Pierce Stephen S Whitehead Beth D Kirkpatrick Palmtama L Grier Adrienne Jarvis Heather Kenney Marya P Carmolli Cynthia Reynolds Cecilia M Tibery Janece Lovchik Anna Janiak Catherine J Luke Anna P Durbin Alexander G Pletnev

J Infect Dis 2017 Jan 25;215(1):52-55. Epub 2016 Oct 25.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.

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January 2017

A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer.

Authors:

Josep María Del Campo Michael Birrer Craig Davis Keiichi Fujiwara Ashwin Gollerkeri Martin Gore Brett Houk Susie Lau Andres Poveda Antonio González-Martín Carolyn Muller Kei Muro Kristen Pierce Mie Suzuki Jennifer Vermette Amit Oza

Gynecol Oncol 2016 Jul 24;142(1):62-69. Epub 2016 Apr 24.

Princess Margaret Cancer Centre, 610 University Avenue, Toronto M5G 2M9, Canada. Electronic address:

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July 2016

The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model.

Authors:

Beth D Kirkpatrick Stephen S Whitehead Kristen K Pierce Cecilia M Tibery Palmtama L Grier Noreen A Hynes Catherine J Larsson Beulah P Sabundayo Kawsar R Talaat Anna Janiak Marya P Carmolli Catherine J Luke Sean A Diehl Anna P Durbin

Sci Transl Med 2016 Mar 16;8(330):330ra36. Epub 2016 Mar 16.

Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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March 2016

A 12-Month-Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response.

J Infect Dis 2016 Sep 16;214(6):832-5. Epub 2016 Feb 16.

Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland.

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September 2016

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.

Authors:

Suzanne F Jones Lillian L Siu Johanna C Bendell James M Cleary Albiruni R A Razak Jeffrey R Infante Shuchi S Pandya Philippe L Bedard Kristen J Pierce Brett Houk W Gregory Roberts S Martin Shreeve Geoffrey I Shapiro

Invest New Drugs 2015 10 4;33(5):1100-7. Epub 2015 Sep 4.

Dana-Farber Cancer Institute, Boston, MA, USA.

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October 2015

Robust and Balanced Immune Responses to All 4 Dengue Virus Serotypes Following Administration of a Single Dose of a Live Attenuated Tetravalent Dengue Vaccine to Healthy, Flavivirus-Naive Adults.

J Infect Dis 2015 Sep 22;212(5):702-10. Epub 2015 Mar 22.

National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland.

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September 2015

First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer.

Authors:

Geoffrey I Shapiro Katherine M Bell-McGuinn Julian R Molina Johanna Bendell James Spicer Eunice L Kwak Susan S Pandya Robert Millham Gary Borzillo Kristen J Pierce Lixin Han Brett E Houk Jorge D Gallo Maria Alsina Irene Braña Josep Tabernero

Clin Cancer Res 2015 04 4;21(8):1888-95. Epub 2015 Feb 4.

Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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April 2015

Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer.

Authors:

Carolyn D Britten Alex A Adjei Robert Millham Brett E Houk Gary Borzillo Kristen Pierce Zev A Wainberg Patricia M LoRusso

Invest New Drugs 2014 Jun 7;32(3):510-7. Epub 2014 Jan 7.

UCLA Medical Center, Los Angeles, CA, USA,

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June 2014

Lack of homologous protection against Campylobacter jejuni CG8421 in a human challenge model.

Authors:

Beth D Kirkpatrick Caroline E Lyon Chad K Porter Alex C Maue Patricia Guerry Kristen K Pierce Marya P Carmolli Mark S Riddle Catherine J Larsson Douglas Hawk Elizabeth A Dill A Fingar Frederic Poly Kelly A Fimlaid Fahmida Hoq David R Tribble

Clin Infect Dis 2013 Oct 9;57(8):1106-13. Epub 2013 Jul 9.

University of Vermont College of Medicine, Unit of Infectious Diseases and Vaccine Testing Center, Burlington, Vermont.

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October 2013

Vaccination of volunteers with low-dose, live-attenuated, dengue viruses leads to serotype-specific immunologic and virologic profiles.

Authors:

Janet C Lindow Anna P Durbin Stephen S Whitehead Kristen K Pierce Marya P Carmolli Beth D Kirkpatrick

Vaccine 2013 Jul 2;31(33):3347-52. Epub 2013 Jun 2.

University of Vermont College of Medicine, Vaccine Testing Center and Unit of Infectious Diseases, 95 Carrigan Drive, Stafford Hall 110, Burlington, VT, USA.

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July 2013

A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial.

Authors:

Anna P Durbin Beth D Kirkpatrick Kristen K Pierce Daniel Elwood Catherine J Larsson Janet C Lindow Cecilia Tibery Beulah P Sabundayo Donna Shaffer Kawsar R Talaat Noreen A Hynes Kimberli Wanionek Marya P Carmolli Catherine J Luke Brian R Murphy Kanta Subbarao Stephen S Whitehead

J Infect Dis 2013 Mar 17;207(6):957-65. Epub 2013 Jan 17.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Rm 217, Baltimore, MD 21205, USA.

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March 2013

Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.

Authors:

Jeffrey R Infante D Ross Camidge Linda R Mileshkin Eric X Chen Rodney J Hicks Danny Rischin Howard Fingert Kristen J Pierce Huiping Xu W Gregory Roberts S Martin Shreeve Howard A Burris Lillian L Siu

J Clin Oncol 2012 May 26;30(13):1527-33. Epub 2012 Mar 26.

Sarah Cannon Research Institute, Nashville, TN, USA.

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May 2012

Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours.

Authors:

Patrick Schöffski Suzanne F Jones Herlinde Dumez Jeffrey R Infante Elke Van Mieghem Camilla Fowst Paola Gerletti Huiping Xu John L Jakubczak Patricia A English Kristen J Pierce Howard A Burris

Eur J Cancer 2011 Oct 16;47(15):2256-64. Epub 2011 Aug 16.

Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium.

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October 2011

Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine.

Authors:

Anna P Durbin Beth D Kirkpatrick Kristen K Pierce Alexander C Schmidt Stephen S Whitehead

Vaccine 2011 Sep 21;29(42):7242-50. Epub 2011 Jul 21.

Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.

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September 2011

Recrudescent Campylobacter jejuni infection in an immunocompetent adult following experimental infection with a well-characterized organism.

Authors:

Shahida Baqar David R Tribble Marya Carmolli Katrin Sadigh Frederic Poly Chad Porter Catherine J Larsson Kristen K Pierce Patricia Guerry Michael Darsley Beth Kirkpatrick

Clin Vaccine Immunol 2010 Jan 18;17(1):80-6. Epub 2009 Nov 18.

University of Vermont College of Medicine, Unit of Infectious Diseases and Vaccine Testing Center, 110 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405, USA.

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January 2010

Campylobacter jejuni strain CG8421: a refined model for the study of Campylobacteriosis and evaluation of Campylobacter vaccines in human subjects.

Clin Infect Dis 2009 Nov;49(10):1512-9

Department of Enteric Diseases, Naval Medical Research Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

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November 2009

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