Kristen J Brennand

Kristen J Brennand

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Kristen J Brennand

Publications by authors named "Kristen J Brennand"

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Spatial genome exploration in the context of cognitive and neurological disease.

Curr Opin Neurobiol 2019 Dec 27;59:112-119. Epub 2019 Jun 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889018PMC
December 2019

Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs.

Neurobiol Dis 2019 Dec 2;132:104562. Epub 2019 Aug 2.

Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834907PMC
December 2019

CRISPR-based functional evaluation of schizophrenia risk variants.

Schizophr Res 2019 Jul 2. Epub 2019 Jul 2.

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.06.017DOI Listing
July 2019

Leveraging Human Induced Pluripotent Stem Cell-Based Models Provides Biological Context to Genome-wide Association Study Findings.

Biol Psychiatry 2019 04;85(7):532-533

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.021DOI Listing
April 2019

New considerations for hiPSC-based models of neuropsychiatric disorders.

Mol Psychiatry 2019 01 26;24(1):49-66. Epub 2018 Feb 26.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41380-018-0029-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109625PMC
January 2019

Type I interferon response impairs differentiation potential of pluripotent stem cells.

Proc Natl Acad Sci U S A 2019 01 3;116(4):1384-1393. Epub 2019 Jan 3.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1812449116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347712PMC
January 2019

GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.

Acta Neuropathol Commun 2018 12 21;6(1):144. Epub 2018 Dec 21.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1186/s40478-018-0642-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303945PMC
December 2018

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells.

Front Pediatr 2018 3;6:82. Epub 2018 Apr 3.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fped.2018.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891587PMC
April 2018

Mapping regulatory variants in hiPSC models.

Nat Genet 2018 01;50(1):1-2

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-017-0017-4DOI Listing
January 2018

The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening.

Front Cell Dev Biol 2017 19;5:117. Epub 2017 Dec 19.

Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fcell.2017.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742170PMC
December 2017

Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells.

Front Cell Neurosci 2017 23;11:360. Epub 2017 Nov 23.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, line>New York, NY, United States.

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http://dx.doi.org/10.3389/fncel.2017.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703699PMC
November 2017

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons.

Mol Neuropsychiatry 2017 Nov 20;3(2):73-84. Epub 2017 Jul 20.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1159/000477762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701275PMC
November 2017

Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells.

Stem Cell Investig 2017 16;4:91. Epub 2017 Nov 16.

Departments of Genetics and Genomics, Neuroscience, and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.21037/sci.2017.10.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723749PMC
November 2017

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.

Cell Stem Cell 2017 08 20;21(2):274-283.e5. Epub 2017 Jul 20.

Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173027
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http://dx.doi.org/10.1016/j.stem.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553280PMC
August 2017

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

Stem Cell Reports 2017 08 27;9(2):615-628. Epub 2017 Jul 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550013PMC
August 2017

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells.

Stem Cell Reports 2017 08 27;9(2):600-614. Epub 2017 Jul 27.

Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550034PMC
August 2017

Neural organoids for disease phenotyping, drug screening and developmental biology studies.

Neurochem Int 2017 Jun 12;106:85-93. Epub 2016 Oct 12.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389930PMC
June 2017

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis.

Stem Cell Reports 2017 03 16;8(3):519-528. Epub 2017 Feb 16.

Departments of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355568PMC
March 2017

What if it was easier to prevent schizophrenia than to treat it?

NPJ Schizophr 2017 13;3. Epub 2017 Feb 13.

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029 USA.

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http://www.nature.com/articles/s41537-017-0012-x
Publisher Site
http://dx.doi.org/10.1038/s41537-017-0012-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441527PMC
February 2017

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms.

Brain Res 2017 01 12;1655:283-293. Epub 2015 Nov 12.

Icahn School of Medicine at Mount Sinai, Department of Psychiatry, 1425 Madison Ave, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865445PMC
January 2017

Spatial genome organization and cognition.

Nat Rev Neurosci 2016 11 6;17(11):681-691. Epub 2016 Oct 6.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.

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http://dx.doi.org/10.1038/nrn.2016.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503467PMC
November 2016

Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons.

JAMA Psychiatry 2016 Nov;73(11):1180-1188

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York7Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.2575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437975PMC
November 2016

Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.

Methods 2016 05 25;101:113-24. Epub 2015 Nov 25.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860098PMC
May 2016

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms.

Brain Res 2017 01 12;1655:283-293. Epub 2015 Nov 12.

Icahn School of Medicine at Mount Sinai, Department of Psychiatry, 1425 Madison Ave, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865445PMC
January 2017

Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease.

Mol Psychiatry 2015 Jun 31;20(6):677-684. Epub 2015 Mar 31.

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, 9-20B New York, NY 10029, USA.

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http://dx.doi.org/10.1038/mp.2015.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440836PMC
June 2015

From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease.

Biomark Insights 2015 27;10(Suppl 1):31-41. Epub 2015 Apr 27.

Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.

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http://dx.doi.org/10.4137/BMI.S20066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444490PMC
June 2015

A guide to generating and using hiPSC derived NPCs for the study of neurological diseases.

J Vis Exp 2015 Feb 21(96):e52495. Epub 2015 Feb 21.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai; Department of Neuroscience, Icahn School of Medicine at Mount Sinai;

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http://dx.doi.org/10.3791/52495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354663PMC
February 2015

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.

Front Pharmacol 2014 2;5:252. Epub 2014 Dec 2.

Lilly Research Laboratories, Eli Lilly and Company Indianapolis, IN, USA.

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http://dx.doi.org/10.3389/fphar.2014.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251289PMC
December 2014

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Neural stem and progenitor cells in health and disease.

Wiley Interdiscip Rev Syst Biol Med 2013 Nov-Dec;5(6):701-15. Epub 2013 Sep 20.

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/wsbm.1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160040PMC
October 2014

Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells.

Biol Psychiatry 2014 Jun 15;75(12):936-44. Epub 2013 Nov 15.

Department of Psychiatry, John Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022707PMC
June 2014

Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.

Neuron 2014 May 10;82(3):560-72. Epub 2014 Apr 10.

Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051437PMC
May 2014

Inducing cellular aging: enabling neurodegeneration-in-a-dish.

Cell Stem Cell 2013 Dec;13(6):635-6

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908665PMC
December 2013

Modeling schizophrenia using induced pluripotent stem cell-derived and fibroblast-induced neurons.

Schizophr Bull 2013 Jan 19;39(1):4-10. Epub 2012 Nov 19.

Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA.

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http://dx.doi.org/10.1093/schbul/sbs127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523925PMC
January 2013

Modeling psychiatric disorders through reprogramming.

Dis Model Mech 2012 Jan 4;5(1):26-32. Epub 2011 Oct 4.

Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1242/dmm.008268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255540PMC
January 2012

Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia.

Stem Cells 2011 Dec;29(12):1915-22

Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/stem.762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381343PMC
December 2011

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

Hum Mol Genet 2011 Oct 9;20(R2):R109-15. Epub 2011 Aug 9.

Laboratory of Genetics (LOG-G), The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/hmg/ddr336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447776PMC
October 2011

Modelling schizophrenia using human induced pluripotent stem cells.

Nature 2011 May 13;473(7346):221-5. Epub 2011 Apr 13.

Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla California 92037, USA.

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http://dx.doi.org/10.1038/nature09915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392969PMC
May 2011