Krista Huybrechts

Krista Huybrechts

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Krista Huybrechts

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Validation of algorithms to identify adverse perinatal outcomes in the Medicaid Analytic Extract database.

Pharmacoepidemiol Drug Saf 2020 Mar 2. Epub 2020 Mar 2.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/pds.4967DOI Listing
March 2020

Effectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study.

Ann Intern Med 2020 Mar 10. Epub 2020 Mar 10.

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (S.S., K.F.H., K.J.L., J.J.G.).

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http://dx.doi.org/10.7326/M19-2522DOI Listing
March 2020

Perinatal Outcomes Associated with Maternal Asthma and Its Severity and Control during Pregnancy.

J Allergy Clin Immunol Pract 2020 Jan 22. Epub 2020 Jan 22.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaip.2020.01.016DOI Listing
January 2020

Evaluating the Utility of Coarsened Exact Matching for Pharmacoepidemiology using Real and Simulated Claims Data.

Am J Epidemiol 2019 Dec 17. Epub 2019 Dec 17.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/aje/kwz268DOI Listing
December 2019

Using nationally representative survey data for external adjustment of unmeasured confounders: An example using the NHANES data.

Pharmacoepidemiol Drug Saf 2019 Dec 20. Epub 2019 Dec 20.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pds.4946DOI Listing
December 2019

Safety and Effectiveness of Dabigatran and Other Direct Oral Anticoagulants Compared With Warfarin in Patients With Atrial Fibrillation.

Clin Pharmacol Ther 2019 Dec 23. Epub 2019 Dec 23.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1753DOI Listing
December 2019

The Impact of Technology on the Diagnosis of Congenital Malformations.

Am J Epidemiol 2019 Nov;188(11):1892-1901

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1093/aje/kwz153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825822PMC
November 2019

Impact of State Laws Restricting Opioid Duration on Characteristics of New Opioid Prescriptions.

J Gen Intern Med 2019 Nov;34(11):2339-2341

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11606-019-05150-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848320PMC
November 2019

Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations.

JAMA 2019 Nov 15. Epub 2019 Nov 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2019.18587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865841PMC
November 2019

Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance.

Pharmacoepidemiol Drug Saf 2019 09 22;28(9):1211-1221. Epub 2019 Jul 22.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pds.4794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830505PMC
September 2019

Antipsychotic utilization patterns among patients with schizophrenic disorder: a cross-national analysis in four countries.

Eur J Clin Pharmacol 2019 Jul 1;75(7):1005-1015. Epub 2019 Mar 1.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.

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http://dx.doi.org/10.1007/s00228-019-02654-9DOI Listing
July 2019

Evaluating utilization patterns of oral anticoagulants in routine care.

J Thromb Haemost 2019 07 29;17(7):1033-1043. Epub 2019 May 29.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jth.14467DOI Listing
July 2019

Use of real-world evidence from healthcare utilization data to evaluate drug safety during pregnancy.

Pharmacoepidemiol Drug Saf 2019 07 10;28(7):906-922. Epub 2019 May 10.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pds.4789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823105PMC
July 2019

β-Blocker Use in Pregnancy and the Risk for Congenital Malformations.

Ann Intern Med 2019 06;170(12):909-910

University of New South Wales, Sydney, New South Wales, Australia (H.Z.).

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http://dx.doi.org/10.7326/L19-0157DOI Listing
June 2019

Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes.

J Clin Psychiatry 2019 Jun 18;80(4). Epub 2019 Jun 18.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.4088/JCP.18m12572DOI Listing
June 2019

Poorly Controlled Asthma During Pregnancy Remains Common in the United States.

J Allergy Clin Immunol Pract 2019 Nov - Dec;7(8):2672-2680.e10. Epub 2019 Jun 28.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.05.043DOI Listing
June 2019

Claims Data Studies of Direct Oral Anticoagulants Can Achieve Balance in Important Clinical Parameters Only Observable in Electronic Health Records.

Clin Pharmacol Ther 2019 04 11;105(4):979-993. Epub 2018 Nov 11.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422763PMC
April 2019

Sequential Monitoring of the Comparative Effectiveness and Safety of Dabigatran in Routine Care.

Circ Cardiovasc Qual Outcomes 2019 02;12(2):e005173

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (S.S., C.G., J.M.F., M.K., K.F.H.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005173DOI Listing
February 2019

Using prescription claims to detect aberrant behaviors with opioids: comparison and validation of 5 algorithms.

Pharmacoepidemiol Drug Saf 2019 01 24;28(1):62-69. Epub 2018 Apr 24.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1002/pds.4443
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http://dx.doi.org/10.1002/pds.4443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200661PMC
January 2019

Changes in Outpatient Use of Antibiotics by Adults in the United States, 2006-2015.

Drug Saf 2018 12;41(12):1333-1342

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Suite #3030, 1620 Tremont Street, Boston, MA, 02120, USA.

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http://dx.doi.org/10.1007/s40264-018-0697-4DOI Listing
December 2018

Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring.

JAMA 2018 12;320(23):2429-2437

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2018.18307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669077PMC
December 2018

Opioid dispensing patterns after oocyte retrieval.

Fertil Steril 2018 10;110(5):905-909

Department of Anesthesiology, Perioperative & Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183049
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http://dx.doi.org/10.1016/j.fertnstert.2018.06.023DOI Listing
October 2018

Implications of the Propensity Score Matching Paradox in Pharmacoepidemiology.

Am J Epidemiol 2018 09;187(9):1951-1961

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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https://academic.oup.com/aje/article/187/9/1951/4994700
Publisher Site
http://dx.doi.org/10.1093/aje/kwy078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118075PMC
September 2018

Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study.

Neurology 2018 08 6;91(6):e533-e542. Epub 2018 Jul 6.

From the Department of Epidemiology (A.P., J.M.C., S.H.-D.), Harvard T.H. Chan School of Public Health, Boston; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (E.P., K.F.H., R.J.D., H.M., B.T.B.), and Department of Anesthesiology, Perioperative and Pain Medicine (B.T.B.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Division of Maternal-Fetal Medicine (K.J.G.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000005944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105051PMC
August 2018

Frequency of Opioid Dispensing After Vaginal Delivery.

Obstet Gynecol 2018 08;132(2):459-465

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts; Science, Aetion Inc, New York, New York; and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000002741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060020PMC
August 2018

Opioid Overdose After Surgical Discharge.

JAMA 2018 Aug;320(5):502-504

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2018.6933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142985PMC
August 2018

Longitudinal Trends and Variation in Antipsychotic Use in Older Adults After Cardiac Surgery.

J Am Geriatr Soc 2018 08 19;66(8):1491-1498. Epub 2018 Aug 19.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.15418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217828PMC
August 2018

Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes.

Am J Psychiatry 2018 06 7;175(6):564-574. Epub 2018 May 7.

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston; the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston; the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston; and the Perinatal and Reproductive Psychiatry Program, Center for Women's Mental Health, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2018.17040393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988929PMC
June 2018

Patterns of opioid initiation at first visits for pain in United States primary care settings.

Pharmacoepidemiol Drug Saf 2018 05 2;27(5):495-503. Epub 2017 Oct 2.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/pds.4322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880749PMC
May 2018

Generalized boosted modeling to identify subgroups where effect of dabigatran versus warfarin may differ: An observational cohort study of patients with atrial fibrillation.

Pharmacoepidemiol Drug Saf 2018 04 30;27(4):383-390. Epub 2018 Jan 30.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/pds.4395DOI Listing
April 2018

Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.

BMJ 2018 03 28;360:k1218. Epub 2018 Mar 28.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA, 02120, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871903PMC
http://dx.doi.org/10.1136/bmj.k1218DOI Listing
March 2018

Variability in the Use of Protective Mechanical Ventilation During General Anesthesia.

Anesth Analg 2018 02;126(2):503-512

From the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1213/ANE.0000000000002343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696999PMC
February 2018

Topiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study.

Neurology 2018 01 27;90(4):e342-e351. Epub 2017 Dec 27.

From the Department of Epidemiology (S.H.-D., J.M.C.), Harvard T.H. Chan School of Public Health; Division of Pharmacoepidemiology and Pharmacoeconomics (K.F.H., R.J.D., H.M., B.T.B., E.P.), Department of Medicine, and Division of Epilepsy (P.B.P.), Brigham and Women's Hospital and Harvard Medical School; and Department of Anesthesiology, Critical Care, and Pain Medicine (B.T.B.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798655PMC
January 2018

Placental Complications Associated With Psychostimulant Use in Pregnancy.

Obstet Gynecol 2017 12;130(6):1192-1201

Department of Epidemiology, Harvard T.H. Chan School of Public Health, the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000002362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709205PMC
December 2017

Antipsychotic Medication Use Among Publicly Insured Pregnant Women in the United States.

Psychiatr Serv 2017 Nov 15;68(11):1112-1119. Epub 2017 Jun 15.

Dr. Park, Dr. Huybrechts, Dr. Bateman, Dr. Desai, Dr. Patorno, and Ms. Mogun are with the Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston. Dr. Park is also with the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, where Dr. Jacqueline Cohen and Dr. Hernandez-Diaz are affiliated. Dr. Bateman is also with the Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Dr. Lee Cohen is with the Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ps.201600408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665733PMC
November 2017

Evaluation of algorithms to identify delirium in administrative claims and drug utilization database.

Pharmacoepidemiol Drug Saf 2017 Aug 9;26(8):945-953. Epub 2017 May 9.

Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1002/pds.4226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583076PMC
August 2017

Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.

BMJ 2017 Aug 2;358:j3326. Epub 2017 Aug 2.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538591PMC
http://dx.doi.org/10.1136/bmj.j3326DOI Listing
August 2017

Lithium Use in Pregnancy and the Risk of Cardiac Malformations.

N Engl J Med 2017 08;377(9):893-894

Harvard T.H. Chan School of Public Health, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1708919DOI Listing
August 2017

Zidovudine use in pregnancy and congenital malformations.

AIDS 2017 07;31(12):1733-1743

aDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School bDepartment of Epidemiology cDepartment of Biostatistics, Harvard T.H. Chan School of Public Health dDepartment of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534355PMC
July 2017

Patterns of Opioid Prescription and Use After Cesarean Delivery.

Obstet Gynecol 2017 07;130(1):29-35

Department of Anesthesiology, Critical Care, and Pain Medicine and the Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, and the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; the Department of Anesthesiology, Columbia University Medical Center, New York, New York; the Division of Obstetric Anesthesiology and the Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Michigan Health System, Ann Arbor, Michigan; the Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, North Carolina; and the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California.

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http://dx.doi.org/10.1097/AOG.0000000000002093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600205PMC
July 2017

Benzodiazepines and risk of all cause mortality in adults: cohort study.

BMJ 2017 Jul 6;358:j2941. Epub 2017 Jul 6.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499256PMC
http://dx.doi.org/10.1136/bmj.j2941DOI Listing
July 2017

Adverse Events Associated with Antipsychotic Use in Hospitalized Older Adults After Cardiac Surgery.

J Am Geriatr Soc 2017 Jun 10;65(6):1229-1237. Epub 2017 Feb 10.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.14768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478449PMC
June 2017

The Potential Return on Public Investment in Detecting Adverse Drug Effects.

Med Care 2017 06;55(6):545-551

Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/MLR.0000000000000717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433260PMC
June 2017

Lithium Use in Pregnancy and the Risk of Cardiac Malformations.

N Engl J Med 2017 06;376(23):2245-2254

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (E.P., K.F.H., B.T.B., R.J.D., H.M.), and the Department of Anesthesiology, Perioperative and Pain Medicine (B.T.B.), Brigham and Women's Hospital and Harvard Medical School, the Department of Epidemiology, Harvard T.H. Chan School of Public Health (J.M.C., S.H.-D.), and the Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital (L.S.C.) - all in Boston.

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http://dx.doi.org/10.1056/NEJMoa1612222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667676PMC
June 2017

Pregabalin use early in pregnancy and the risk of major congenital malformations.

Neurology 2017 May 26;88(21):2020-2025. Epub 2017 Apr 26.

From the Division of Pharmacoepidemiology and Pharmacoeconomics (E.P., B.T.B., K.F.H., R.J.D., H.M.), Department of Medicine, and Division of Women's Health and Division of Epilepsy (P.B.P.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School; Department of Anesthesiology, Critical Care, and Pain Medicine (B.T.B.), Massachusetts General Hospital and Harvard Medical School; and Department of Epidemiology (S.C.M., J.M.C., A.P., S.H.-D.), Harvard T.H. Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000003959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440246PMC
May 2017

Clinical Outcomes of Concomitant Use of Warfarin and Selective Serotonin Reuptake Inhibitors: A Multidatabase Observational Cohort Study.

J Clin Psychopharmacol 2017 Apr;37(2):200-209

From the *Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; †Faculty of Pharmacy, National Yang-Ming University, Taipei, Taiwan; ‡Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and §Division of Pharmacy Practice and Science, College of Pharmacy, The Ohio State University, Columbus, OH.

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http://dx.doi.org/10.1097/JCP.0000000000000658DOI Listing
April 2017

A Propensity-score-based Fine Stratification Approach for Confounding Adjustment When Exposure Is Infrequent.

Epidemiology 2017 03;28(2):249-257

From the aDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA; bResearch Triangle Institute, Research Triangle Park, NC; cBoston University School of Public Health, Boston, MA; dDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and eDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1097/EDE.0000000000000595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497217PMC
March 2017

Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study.

BMJ 2017 Mar 6;356:j895. Epub 2017 Mar 6.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168035PMC
http://dx.doi.org/10.1136/bmj.j895DOI Listing
March 2017

Propensity Score Weighting Compared to Matching in a Study of Dabigatran and Warfarin.

Drug Saf 2017 02;40(2):169-181

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA.

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http://dx.doi.org/10.1007/s40264-016-0480-3DOI Listing
February 2017

Angiotensin-Converting Enzyme Inhibitors and the Risk of Congenital Malformations.

Obstet Gynecol 2017 01;129(1):174-184

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine and the Division of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital, Harvard Medical School, the Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; and the Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177460PMC
January 2017

Variation in Use of Blood Transfusion in Primary Total Hip and Knee Arthroplasties.

J Arthroplasty 2016 12 18;31(12):2757-2763.e2. Epub 2016 May 18.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.arth.2016.05.022DOI Listing
December 2016

Persistent opioid use following cesarean delivery: patterns and predictors among opioid-naïve women.

Am J Obstet Gynecol 2016 09 17;215(3):353.e1-353.e18. Epub 2016 Mar 17.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ajog.2016.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003640PMC
September 2016

Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations.

JAMA Psychiatry 2016 09;73(9):938-46

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts4Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.1520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321163PMC
September 2016

Variations in the Use of Perioperative Multimodal Analgesic Therapy.

Anesthesiology 2016 Apr;124(4):837-45

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts (K.S.L., E.P., K.F.H., J.L., B.T.B.); Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (K.S.L., B.T.B.); Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada (K.S.L.); and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.P.R).

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http://dx.doi.org/10.1097/ALN.0000000000001034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792695PMC
April 2016

Preterm birth and antidepressant medication use during pregnancy: a systematic review and meta-analysis.

PLoS One 2014 26;9(3):e92778. Epub 2014 Mar 26.

MetroWest Medical Center, Tufts University School of Medicine, Framingham, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966829PMC
December 2015

Safety and effectiveness of dabigatran and warfarin in routine care of patients with atrial fibrillation.

Thromb Haemost 2015 Nov 8;114(6):1277-89. Epub 2015 Oct 8.

John Seeger, PharmD, DrPH, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA, Tel.: +1 617 278 0335, Fax: +1 617 232 8602, E-mail:

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH15-06-0497
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http://dx.doi.org/10.1160/TH15-06-0497DOI Listing
November 2015

In Response.

Anesth Analg 2015 Nov;121(5):1397-8

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, Department of Anesthesia, Stanford University Medical Center, Stanford, California Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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https://insights.ovid.com/crossref?an=00000539-201511000-000
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http://dx.doi.org/10.1213/ANE.0000000000000847DOI Listing
November 2015

Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data.

Pharmacoepidemiol Drug Saf 2015 Sep 4;24(9):934-42. Epub 2015 Jun 4.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School.

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http://dx.doi.org/10.1002/pds.3798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822692PMC
September 2015

The Most Commonly Dispensed Prescription Medications Among Pregnant Women Enrolled in the U.S. Medicaid Program.

Obstet Gynecol 2015 Sep;126(3):465-73

Departments of Pediatrics and Family Medicine and Public Health and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California; and the Department of Epidemiology, Harvard School of Public Health, the Division of Pharmacoepidemiology & Pharmacoeconomics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://pdfs.journals.lww.com/greenjournal/2015/09000/The_Mos
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/AOG.0000000000000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651654PMC
September 2015

Maternal Antidepressant Use and Persistent Pulmonary Hypertension of the Newborn--Reply.

JAMA 2015 Sep 22-29;314(12):1294

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2015.10048DOI Listing
September 2015

Calcium Channel Blocker Exposure in Late Pregnancy and the Risk of Neonatal Seizures.

Obstet Gynecol 2015 Aug;126(2):271-8

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Division of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital and Harvard Medical School, the Departments of Anesthesiology, Critical Care, and Pain Medicine and Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000000908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526118PMC
August 2015

Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.

BMJ 2015 May 14;350:h2102. Epub 2015 May 14.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://www.bmj.com/cgi/doi/10.1136/bmj.h2102
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431352PMC
http://dx.doi.org/10.1136/bmj.h2102DOI Listing
May 2015

Evaluating possible confounding by prescriber in comparative effectiveness research.

Epidemiology 2015 Mar;26(2):238-41

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/EDE.0000000000000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347927PMC
March 2015

Antipsychotics and mortality: adjusting for mortality risk scores to address confounding by terminal illness.

J Am Geriatr Soc 2015 Mar 6;63(3):516-23. Epub 2015 Mar 6.

Department of Epidemiology, School of Public Health, Harvard University, Boston, Massachusetts; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, School of Medicine, Harvard University, Boston, Massachusetts.

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http://doi.wiley.com/10.1111/jgs.13326
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http://dx.doi.org/10.1111/jgs.13326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374043PMC
March 2015

Statins and congenital malformations: cohort study.

BMJ 2015 Mar 17;350:h1035. Epub 2015 Mar 17.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362473PMC
http://dx.doi.org/10.1136/bmj.h1035DOI Listing
March 2015

Prescription drug insurance coverage and patient health outcomes: a systematic review.

Am J Public Health 2015 Feb;105(2):e17-30

Aaron S. Kesselheim, Krista F. Huybrechts, Niteesh K. Choudhry, Lisa A. Fulchino, Danielle L. Isaman, and Mary K. Kowal are with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Troyen A. Brennan is with CVS Caremark, Woonsocket, RI.

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http://scholar.harvard.edu/files/nkc/files/2015_insurance_co
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http://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2014.3
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http://dx.doi.org/10.2105/AJPH.2014.302240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318289PMC
February 2015

Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011.

Anesth Analg 2014 Dec;119(6):1344-9

From the *Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; †Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; ‡Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and §Department of Anesthesia, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1213/ANE.0000000000000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321970PMC
December 2014

In Reply: Cho et al.

Obstet Gynecol 2014 Sep;124(3):638

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School and, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000000445DOI Listing
September 2014

Electronic medication packaging devices and medication adherence: a systematic review.

JAMA 2014 Sep;312(12):1237-47

Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2014.10059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209732PMC
September 2014

Instrumental variable applications using nursing home prescribing preferences in comparative effectiveness research.

Pharmacoepidemiol Drug Saf 2014 Aug 24;23(8):830-8. Epub 2014 Mar 24.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1002/pds.3611
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http://dx.doi.org/10.1002/pds.3611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116440PMC
August 2014

Validity of maternal and infant outcomes within nationwide Medicaid data.

Pharmacoepidemiol Drug Saf 2014 Jun 16;23(6):646-55. Epub 2014 Apr 16.

Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/pds.3627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205050PMC
June 2014

Antidepressant use in pregnancy and the risk of cardiac defects.

N Engl J Med 2014 Jun;370(25):2397-407

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (K.F.H., J.A., J.M.F., H.M., R.L., M.K., S.S.), the Department of Epidemiology, Harvard School of Public Health (K.P., S.H.-D.), the Center for Women's Mental Health, Massachusetts General Hospital (L.S.C.), and the Medical Genetics Unit, MassGeneral Hospital for Children (L.B.H.) - all in Boston; and Duke University School of Medicine, Durham, NC (S.S.).

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http://dx.doi.org/10.1056/NEJMoa1312828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062924PMC
June 2014

Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance beneficiaries in the United States.

Anesthesiology 2014 May;120(5):1216-24

From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (B.T.B.); Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (S.H.-D.); Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.P.R.); and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.D.S., M.D., M.A.F., K.F.H.).

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http://dx.doi.org/10.1097/ALN.0000000000000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999216PMC
May 2014

Increase in prescription opioid use during pregnancy among Medicaid-enrolled women.

Obstet Gynecol 2014 May;123(5):997-1002

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, the Department of Epidemiology, Harvard School of Public Health, and the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000000208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020039PMC
May 2014

National trends in antidepressant medication treatment among publicly insured pregnant women.

Gen Hosp Psychiatry 2013 May-Jun;35(3):265-71. Epub 2013 Jan 30.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

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http://dx.doi.org/10.1016/j.genhosppsych.2012.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077674PMC
December 2013

Methylergonovine maleate and the risk of myocardial ischemia and infarction.

Am J Obstet Gynecol 2013 Nov 11;209(5):459.e1-459.e13. Epub 2013 Jul 11.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ajog.2013.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103983PMC
November 2013

Development of a comorbidity index for use in obstetric patients.

Obstet Gynecol 2013 Nov;122(5):957-65

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, the Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan; and the Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1097/AOG.0b013e3182a603bbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829199PMC
November 2013

Antidepressant use and risk for preeclampsia.

Epidemiology 2013 Sep;24(5):682-91

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/EDE.0b013e31829e0aaaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159745PMC
September 2013

Estimation using all available covariate information versus a fixed look-back window for dichotomous covariates.

Pharmacoepidemiol Drug Saf 2013 May 22;22(5):542-50. Epub 2013 Mar 22.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

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http://dx.doi.org/10.1002/pds.3434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653131PMC
May 2013

Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population.

Hypertension 2012 Oct 10;60(4):913-20. Epub 2012 Sep 10.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.197095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501756PMC
October 2012

Bias in comparative effectiveness studies due to regional variation in medical practice intensity: a legitimate concern, or much ado about nothing?

Circ Cardiovasc Qual Outcomes 2012 Sep;5(5):e61-4

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.112.966
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http://dx.doi.org/10.1161/CIRCOUTCOMES.112.966093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519359PMC
September 2012