Publications by authors named "Krishnapriya Chinnaswamy"

21Publications

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.

J Med Chem 2020 07 24;63(13):7252-7267. Epub 2020 Jun 24.

Rogel Cancer Center, Departments of Internal Medicine and Pharmacology, Medical School, and Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.

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July 2020

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

J Med Chem 2019 12 5;62(24):11218-11231. Epub 2019 Dec 5.

School of Pharmaceutical Sciences and Institute of Drug Discovery & Development , Zhengzhou University , Zhengzhou 450001 , China.

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December 2019

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Cancer Cell 2019 11;36(5):498-511.e17

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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November 2019

Changing the Apoptosis Pathway through Evolutionary Protein Design.

J Mol Biol 2019 02 6;431(4):825-841. Epub 2019 Jan 6.

Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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February 2019

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

J Med Chem 2018 03 26;61(5):1934-1950. Epub 2018 Feb 26.

Institute of Translational Medicine , Zhejiang University School of Medicine , Hangzhou , Zhejiang 310029 , China.

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March 2018

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Angew Chem Int Ed Engl 2018 02 15;57(6):1601-1605. Epub 2018 Jan 15.

Comprehensive Cancer and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI, 48109, USA.

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February 2018

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

ACS Med Chem Lett 2016 Dec 13;7(12):1092-1096. Epub 2016 Sep 13.

Departments of Internal Medicine and Biological Chemistry and Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

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December 2016

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.

Nat Commun 2016 10 5;7:13084. Epub 2016 Oct 5.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90033, USA.

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October 2016

Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain.

PLoS One 2016 6;11(1):e0146522. Epub 2016 Jan 6.

Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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July 2016

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

J Med Chem 2015 Jun 16;58(12):4927-39. Epub 2015 Jun 16.

†Departments of Medicinal Chemistry, ‡Internal Medicine, §Pharmacology, and ∥Biological Chemistry, ⊥Life Sciences Institute, and #Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.

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June 2015

CSAR data set release 2012: ligands, affinities, complexes, and docking decoys.

J Chem Inf Model 2013 Aug 10;53(8):1842-52. Epub 2013 May 10.

Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109-1065, USA.

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August 2013

Effects of age and retinal degeneration on the expression of proprotein convertases in the visual cortex.

Brain Res 2010 Mar 23;1317:1-12. Epub 2009 Dec 23.

Psychology Department, University of Michigan-Flint, Flint, MI 48502, USA.

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March 2010