Krishna R Kalari

Krishna R Kalari

UNVERIFIED PROFILE

Are you Krishna R Kalari?   Register this Author

Register author
Krishna R Kalari

Krishna R Kalari

Publications by authors named "Krishna R Kalari"

Are you Krishna R Kalari?   Register this Author

75Publications

1827Reads

26Profile Views

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.

Breast Cancer Res 2019 04 3;21(1):47. Epub 2019 Apr 3.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-019-1130-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448248PMC
April 2019

Cell-level somatic mutation detection from single-cell RNA-sequencing.

Bioinformatics 2019 Apr 26. Epub 2019 Apr 26.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btz288DOI Listing
April 2019

Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction.

Drug Metab Dispos 2018 09 6;46(9):1372-1381. Epub 2018 Jul 6.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (D.L., S.Q., B.R., L.W., R.M.W.) and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (K.R.K.), Mayo Clinic, Rochester, Minnesota

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.118.082164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090174PMC
September 2018

Your brain scan may be a reflection of your genes.

Brain 2018 09;141(9):2539-2541

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awy226DOI Listing
September 2018

Isoform-level gene expression patterns in single-cell RNA-sequencing data.

Bioinformatics 2018 07;34(14):2392-2400

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bty100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041805PMC
July 2018

HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data.

BMC Bioinformatics 2018 07 17;19(1):271. Epub 2018 Jul 17.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-018-2260-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050683PMC
July 2018

Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking.

Neuroscience 2018 03 11;373:159-168. Epub 2018 Jan 11.

Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.01.003DOI Listing
March 2018

Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-B Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune Response.

Mol Pharmacol 2017 08 14;92(2):175-184. Epub 2017 Jun 14.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (M.-F.H., L.W., R.M.W.), Division of Medical Oncology, Department of Oncology (J.N.I.), and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (K.R.K.), Mayo Clinic, Rochester, Minnesota; Department of Emergency Medicine, Vanderbilt Medical Center, Nashville, Tennessee (T.B.); Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts (P.E.G.); NCIC Clinical Trials Group, Kingston, Ontario Canada (L.E.S.); and RIKEN Center for Integrative Medical Science, Tsurumi-ku, Yokohama, Japan (T.M., M.K.)

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
Publisher Site
http://dx.doi.org/10.1124/mol.117.108340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508195PMC
August 2017

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance.

Genome Biol 2017 08 11;18(1):153. Epub 2017 Aug 11.

Department of Computer Science and Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 2122 Siebel Center, 201N. Goodwin Ave, Urbana, IL, 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-017-1282-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554409PMC
August 2017

Beta-Poisson model for single-cell RNA-seq data analyses.

Bioinformatics 2016 07 19;32(14):2128-35. Epub 2016 Apr 19.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btw202DOI Listing
July 2016

Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.

Mol Endocrinol 2016 Mar 11;30(3):382-98. Epub 2016 Feb 11.

Division of Clinical Pharmacology (M.-F.H., M.L., L.W., R.M.W.), Department of Molecular Pharmacology and Experimental Therapeutics, Division of Rheumatology (M.-F.H., T.B.), Department of Medicine, Division of Biomedical Statistics and Informatics (K.R.K.), Department of Health Sciences Research, and Division of Medical Oncology (M.P.G., J.N.I.), Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905; Division of Hematology/Oncology (P.E.G.), Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard University, Boston, Massachusetts 02114; National Cancer Institute of Canada Clinical Trials Group (L.E.S.), Kingston, Ontario, Canada K7L 3N6; and RIKEN Center for Integrative Medical Science (M.K.), Yokohama 230-0045, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2015-1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771694PMC
March 2016

BBBomics-Human Blood Brain Barrier Transcriptomics Hub.

Front Neurosci 2016 1;10:71. Epub 2016 Mar 1.

Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2016.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771746PMC
March 2016

Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial.

J Clin Oncol 2015 Mar 20;33(7):701-8. Epub 2015 Jan 20.

Edith A. Perez, E. Aubrey Thompson, Yan W. Asmann, and Xochiquetzal J. Geiger, Mayo Clinic, Jacksonville, FL; Karla V. Ballman, S. Keith Anderson, Krishna R. Kalari, Jeanette E. Eckel-Passow, Kathleen S. Tenner, Jin Jen, Beiyun Chen, Robert B. Jenkins, and Monica M. Reinholz, Mayo Clinic, Rochester, MN; Amylou C. Dueck, and Ann E. McCullough, Mayo Clinic, Scottsdale, AZ; Jian-Bing Fan, Illumina, San Diego, CA; George W. Sledge, Stanford School of Medicine, Palo Alto, CA; Eric P. Winer, Harvard Medical School, Boston, MA; and Julie R. Gralow, Seattle Cancer Care Alliance, Seattle, WA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.57.6298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334774PMC
March 2015

Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.

J Natl Cancer Inst 2014 Dec 8;107(2). Epub 2014 Dec 8.

Department of Oncology (MPG, MMA, JNI), Department of Health Sciences Research (VJS, KRK), and Department of Molecular Pharmacology and Experimental Therapeutics (MPG, SLS, MK, MMA), Mayo Clinic, Rochester, MN; Department of Genetics, University of North Carolina, Chapel Hill, NC (GOS, CMP); Center for Personalized Therapeutics, University of Chicago, Chicago, IL (YN, NJC, MJR); Foundation Medicine Inc., Cambridge, MA (JXS, PJS, VAM, JSR, RY); Novartis Pharmaceuticals Corporation, East Hanover, NJ (DC); Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY (JSR); Division of Hematology/Oncology, Vanderbilt University, Nashville, TN (HG); Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (AMGA, OB); Department Breast Cancer Susceptibility and Pharmacogenomics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, University Tuebingen, German Cancer Consortium (DKTK) and German Cancer Research (DKTK), Heidelberg, Germany (HB).Current affiliation of H. Gomez: Departamento de Medicina Oncologica, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/dju401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565524PMC
December 2014

Transcriptome-wide analysis of UTRs in non-small cell lung cancer reveals cancer-related genes with SNV-induced changes on RNA secondary structure and miRNA target sites.

PLoS One 2014 8;9(1):e82699. Epub 2014 Jan 8.

Center for non-coding RNA in Technology and Health, Section for Animal Genetics, Bioinformatics and Breeding, IKVH, University of Copenhagen, Frederiksberg, Denmark.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082699PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885406PMC
September 2014

Transcriptome analysis of garlic-induced hepatoprotection against alcoholic fatty liver.

J Agric Food Chem 2012 Nov 26;60(44):11104-19. Epub 2012 Oct 26.

Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf303800pDOI Listing
November 2012

A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines.

Nucleic Acids Res 2011 Aug 27;39(15):e100. Epub 2011 May 27.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkr362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159479PMC
August 2011

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.

J Cell Physiol 2011 Apr;226(4):879-87

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jcp.22463
Publisher Site
http://dx.doi.org/10.1002/jcp.22463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075823PMC
April 2011

Integrated analysis of gene expression, CpG island methylation, and gene copy number in breast cancer cells by deep sequencing.

PLoS One 2011 Feb 25;6(2):e17490. Epub 2011 Feb 25.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045451PMC
February 2011

Gemcitabine Cytotoxicity: Interaction of Efflux and Deamination.

J Drug Metab Toxicol 2011 Feb;2(107):1-10

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4172/2157-7609.1000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144579PMC
February 2011

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.

Drug Metab Dispos 2010 Dec 20;38(12):2329-38. Epub 2010 Sep 20.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.110.035220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993460PMC
December 2010

Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.

Genome Res 2010 Nov 5;20(11):1482-92. Epub 2010 Oct 5.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.107672.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963812PMC
November 2010

Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach.

BMC Genomics 2010 Jun 4;11:357. Epub 2010 Jun 4.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-11-357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894803PMC
June 2010

Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.

J Neurochem 2009 Sep 8;110(6):1806-17. Epub 2009 Jul 8.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic-Mayo Medical School, Rochester, Minnesota 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2009.06276.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838417PMC
September 2009

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

Cancer Cell 2009 Sep;16(3):259-66

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2009.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755578PMC
September 2009

Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.

J Clin Endocrinol Metab 2009 Aug 12;94(8):3072-84. Epub 2009 May 12.

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2008-2109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730876PMC
August 2009

Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics.

Pharmacogenet Genomics 2009 Aug;19(8):567-76

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32832c14b8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763634PMC
August 2009

A knowledge-based approach to predict intragenic deletions or duplications.

Bioinformatics 2008 Sep 21;24(18):1975-9. Epub 2008 Jul 21.

Department of Biomedical Engineering, Center for Bioinformatics and Computational Biology, University of Iowa, Iowa, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btn370DOI Listing
September 2008

Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics.

Clin Cancer Res 2008 Jun;14(11):3503-13

Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-07-5150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778274PMC
June 2008

First exons and introns--a survey of GC content and gene structure in the human genome.

In Silico Biol 2006 ;6(3):237-42

Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, IA 52242, USA.

View Article

Download full-text PDF

Source
February 2007