Kris A Steinbrecher

Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.

Authors:

Alexander A Boucher Leah Rosenfeldt Duaa Mureb Jessica Shafer Bal Krishan Sharma Adam Lane Rebecca R Crowther Melanie C McKell Jordan Whitt Theresa Alenghat Joseph Qualls Silvio Antoniak Nigel Mackman Matthew J Flick Kris A Steinbrecher Joseph S Palumbo

J Thromb Haemost 2020 01 11;18(1):91-103. Epub 2019 Oct 11.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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January 2020

NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8 T cells for tumor promotion.

Authors:

Liwen Li Lei Han Fan Sun Jingjiao Zhou Kim C Ohaegbulam Xudong Tang Xingxing Zang Kris A Steinbrecher Zhaoxia Qu Gutian Xiao

Oncoimmunology 2018;7(6):e1435250. Epub 2018 Feb 27.

Hillman Cancer Center, University of Pittsburgh Medical Centers, Pittsburgh, Pennsylvania, USA.

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February 2018

Enhanced survival following oral and systemic Salmonella enterica serovar Typhimurium infection in polymeric immunoglobulin receptor knockout mice.

Authors:

Kristina J Betz Elizabeth A Maier Surya Amarachintha David Wu Erik P Karmele Jeremy M Kinder Kris A Steinbrecher Monica M McNeal Deborah H Luzader Simon P Hogan Sean R Moore

PLoS One 2018 1;13(6):e0198434. Epub 2018 Jun 1.

Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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December 2018

Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.

Authors:

Surya Amarachintha Eleana Harmel-Laws Kris A Steinbrecher

Sci Rep 2018 01 24;8(1):1521. Epub 2018 Jan 24.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.

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January 2018

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Nat Med 2017 10;23(10):1241

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October 2017

Guanylate cyclase 2C agonism corrects CFTR mutants.

Authors:

Kavisha Arora Yunjie Huang Kyushik Mun Sunitha Yarlagadda Nambirajan Sundaram Marco M Kessler Gerhard Hannig Caroline B Kurtz Inmaculada Silos-Santiago Michael Helmrath Joseph J Palermo John P Clancy Kris A Steinbrecher Anjaparavanda P Naren

JCI Insight 2017 10 5;2(19). Epub 2017 Oct 5.

Division of Pulmonary Medicine, Department of Pediatrics, and.

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October 2017

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Nat Med 2017 Jul 12;23(7):829-838. Epub 2017 Jun 12.

Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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July 2017

Activation of TGF- activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease.

Authors:

Zhiwei Liu Fansheng Kong Jefferson E Vallance Eleana Harmel-Laws Surya Amarachintha Kris A Steinbrecher Michael J Rosen Sandip Bhattacharyya

Physiol Rep 2017 Apr;5(7)

Department of Pediatrics, Center for Prevention of Preterm Birth Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati Ohio

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April 2017

Myeloid-derived NF-κB negative regulation of PU.1 and c/EBP-β-driven pro-inflammatory cytokine production restrains LPS-induced shock.

Authors:

Simone Vanoni Yi-Ting Tsai Amanda Waddell Lisa Waggoner Jared Klarquist Senad Divanovic Kasper Hoebe Kris A Steinbrecher Simon P Hogan

Innate Immun 2017 02 8;23(2):175-187. Epub 2016 Dec 8.

1 Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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February 2017

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.

Authors:

Pauline T Ikpa Hein F B M Sleddens Kris A Steinbrecher Maikel P Peppelenbosch Hugo R de Jonge Ron Smits Marcel J C Bijvelds

Histochem Cell Biol 2016 Oct 31;146(4):445-55. Epub 2016 May 31.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

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October 2016

Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.

Authors:

Lijun Xin Tony T Jiang Vandana Chaturvedi Jeremy M Kinder James M Ertelt Jared H Rowe Kris A Steinbrecher Sing Sing Way

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10672-7. Epub 2014 Jul 7.

Divisions of Infectious Diseases and

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July 2014

Effect of guanylate cyclase-C activity on energy and glucose homeostasis.

Authors:

Denovan P Begg Kris A Steinbrecher Joram D Mul Adam P Chambers Rohit Kohli April Haller Mitchell B Cohen Stephen C Woods Randy J Seeley

Diabetes 2014 Nov 4;63(11):3798-804. Epub 2014 Jun 4.

Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH.

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November 2014

Thrombin drives tumorigenesis in colitis-associated colon cancer.

Authors:

Brian Turpin Whitney Miller Leah Rosenfeldt Keith Kombrinck Matthew J Flick Kris A Steinbrecher Eleana Harmel-Laws Eric S Mullins Maureen Shaw David P Witte Alexey Revenko Brett Monia Joseph S Palumbo

Cancer Res 2014 Jun 7;74(11):3020-3030. Epub 2014 Apr 7.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati OH, and ISIS Pharmaceuticals, Carlsbad CA.

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June 2014

Deletion of Fanca or Fancd2 dysregulates Treg in mice.

Authors:

Wei Du Ozlem Erden Andrew Wilson Jared M Sipple Jonathan Schick Parinda Mehta Kasiani C Myers Kris A Steinbrecher Stella M Davies Qishen Pang

Blood 2014 Mar 5;123(12):1938-47. Epub 2014 Feb 5.

Division of Experimental Hematology and Cancer Biology.

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March 2014

The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor.

Authors:

Kris A Steinbrecher

Curr Opin Gastroenterol 2014 Jan;30(1):1-6

Department of Pediatrics, University of Cincinnati College of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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January 2014

Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.

Authors:

Eleana Harmel-Laws Elizabeth A Mann Mitchell B Cohen Kris A Steinbrecher

PLoS One 2013 11;8(11):e79180. Epub 2013 Nov 11.

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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August 2014

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection.

Authors:

Shokrollah Elahi James M Ertelt Jeremy M Kinder Tony T Jiang Xuzhe Zhang Lijun Xin Vandana Chaturvedi Beverly S Strong Joseph E Qualls Kris A Steinbrecher Theodosia A Kalfa Aimen F Shaaban Sing Sing Way

Nature 2013 Dec 6;504(7478):158-62. Epub 2013 Nov 6.

Division of Infectious Diseases and Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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December 2013

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

Authors:

Isaac T W Harley Traci E Stankiewicz Daniel A Giles Samir Softic Leah M Flick Monica Cappelletti Rachel Sheridan Stavra A Xanthakos Kris A Steinbrecher R Balfour Sartor Rohit Kohli Christopher L Karp Senad Divanovic

Hepatology 2014 May 27;59(5):1830-9. Epub 2014 Mar 27.

Division of Cellular and Molecular Immunology, Cincinnati Children's Hospital Research Foundation, and the University of Cincinnati College of Medicine, Cincinnati, OH.

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May 2014

Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen.

Authors:

Elizabeth A Mann Eleana Harmel-Laws Mitchell B Cohen Kris A Steinbrecher

BMC Gastroenterol 2013 Sep 2;13:135. Epub 2013 Sep 2.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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September 2013

Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.

Authors:

Amanda Waddell Richard Ahrens Yi-Ting Tsai Joseph D Sherrill Lee A Denson Kris A Steinbrecher Simon P Hogan

J Immunol 2013 May 5;190(9):4773-85. Epub 2013 Apr 5.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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May 2013

Murine guanylate cyclase C regulates colonic injury and inflammation.

Authors:

Kris A Steinbrecher Eleana Harmel-Laws Monica P Garin-Laflam Elizabeth A Mann Lucas D Bezerra Simon P Hogan Mitchell B Cohen

J Immunol 2011 Jun 9;186(12):7205-14. Epub 2011 May 9.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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June 2011

Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.

Authors:

Xiaonan Han Elizabeth Mann Shila Gilbert Yanfang Guan Kris A Steinbrecher Marshall H Montrose Mitchell B Cohen

PLoS One 2011 Jan 31;6(1):e16139. Epub 2011 Jan 31.

Division of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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January 2011

Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.

Authors:

David Wu Richard Ahrens Heather Osterfeld Taeko K Noah Katherine Groschwitz Paul S Foster Kris A Steinbrecher Marc E Rothenberg Noah F Shroyer Klaus I Matthaei Fred D Finkelman Simon P Hogan

J Biol Chem 2011 Apr 8;286(15):13357-69. Epub 2011 Feb 8.

Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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April 2011

Transmembrane guanylate cyclase in intestinal pathophysiology.

Authors:

Kris A Steinbrecher Mitchell B Cohen

Curr Opin Gastroenterol 2011 Mar;27(2):139-45

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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March 2011

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

Authors:

Kris A Steinbrecher Netanel A Horowitz Elizabeth A Blevins Kelley A Barney Maureen A Shaw Eleana Harmel-Laws Fred D Finkelman Matthew J Flick Malinda D Pinkerton Kathryn E Talmage Keith W Kombrinck David P Witte Joseph S Palumbo

Cancer Res 2010 Apr 16;70(7):2634-43. Epub 2010 Mar 16.

Divisions of Gastroenterology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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April 2010

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.

Authors:

Kris A Steinbrecher Eleana Harmel-Laws Raquel Sitcheran Albert S Baldwin

J Immunol 2008 Feb;180(4):2588-99

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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February 2008

Molecular cloning and promoter analysis of downregulated in adenoma (DRA).

Authors:

Waddah A Alrefai Xiaoming Wen Wen Jiang Jonathan P Katz Kris A Steinbrecher Mitchell B Cohen Ifor R Williams Pradeep K Dudeja Gary D Wu

Am J Physiol Gastrointest Liver Physiol 2007 Nov 30;293(5):G923-34. Epub 2007 Aug 30.

University of Illinois at Chicago, Jesse Brown VA Medical Center, Medical Research Service, Chicago, IL 60612, USA.

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November 2007

Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line.

Authors:

Jeffrey A Rudolph Julia Pratt Reena Mourya Kris A Steinbrecher Mitchell B Cohen

Cell Signal 2007 Jun 21;19(6):1221-8. Epub 2007 Jan 21.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, 45229, United States.

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June 2007