Kory J Lavine

Kory J Lavine

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Kory J Lavine

Publications by authors named "Kory J Lavine"

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New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity.

Annu Rev Physiol 2020 02 28;82:1-20. Epub 2019 Oct 28.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA; email:

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http://dx.doi.org/10.1146/annurev-physiol-021119-034412DOI Listing
February 2020

Role of donor macrophages after heart and lung transplantation.

Am J Transplant 2019 Dec 18. Epub 2019 Dec 18.

Department of Medicine, Washington University, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1111/ajt.15751DOI Listing
December 2019

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens.

J Vis Exp 2019 Dec 17(154). Epub 2019 Dec 17.

Department of Medicine, Washington University School of Medicine; Department of Immunology and Pathology, Washington University School of Medicine; Department of Developmental Biology, Washington University School of Medicine;

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http://dx.doi.org/10.3791/60015DOI Listing
December 2019

Macrophage Plasticity and Function in the Eye and Heart.

Trends Immunol 2019 Sep 15;40(9):825-841. Epub 2019 Aug 15.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719788PMC
September 2019

The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).

J Am Coll Cardiol 2018 10;72(18):2213-2230

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183830
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http://dx.doi.org/10.1016/j.jacc.2018.08.2149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209119PMC
October 2018

The human heart contains distinct macrophage subsets with divergent origins and functions.

Nat Med 2018 08 11;24(8):1234-1245. Epub 2018 Jun 11.

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1038/s41591-018-0059-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082687PMC
August 2018

Recognition of self-DNA drives cardiac inflammation: why broken hearts fail.

Nat Med 2017 12;23(12):1400-1401

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nm.4455DOI Listing
December 2017

A CD103 Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis.

Immunity 2017 11;47(5):974-989.e8

Toronto General Hospital Research Institute, University Health Network (UHN), Toronto ON, M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, M5S 1A1, Canada; Department of Immunology, University of Toronto, Toronto ON, M5S 1A1, Canada; Peter Munk Cardiac Centre, Toronto ON, M5G 1L7, Canada; Ted Rogers Centre for Heart Research, Toronto ON, M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.10.011DOI Listing
November 2017

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.

Immunity 2017 08;47(2):323-338.e6

Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; ICCE Institute, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578409PMC
August 2017

Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart.

JACC Basic Transl Sci 2017 08 28;2(4):477-483. Epub 2017 Aug 28.

Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, 63110 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628514PMC
http://dx.doi.org/10.1016/j.jacbts.2017.02.005DOI Listing
August 2017

Pediatric and adult dilated cardiomyopathy represent distinct pathological entities.

JCI Insight 2017 Jul 20;2(14). Epub 2017 Jul 20.

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/jci.insight.94382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518561PMC
July 2017

Skeletal muscle inflammation and atrophy in heart failure.

Heart Fail Rev 2017 03;22(2):179-189

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine St. Louis, 660 S. Euclid Ave, Campus Box 8086, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s10741-016-9593-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352459PMC
March 2017

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circ Res 2016 Sep 21;119(7):853-64. Epub 2016 Jul 21.

From the Center for Systems Biology, Department of Imaging (H.B.S., M.H., T.H., G.C., Y.S., Y.I., B.T., R.W., F.K.S., M.N.) and Cardiovascular Research Center (M.N.), Massachusetts General Hospital and Harvard Medical School, Boston; Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MS (K.J.L.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (M.B.M., P.L.); Department of Cardiology and Angiology I, Heart Center Freiburg University, Germany (T.H.); Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA (O.F.K., J.E.D., D.G.A.); David H. Koch Institute for Integrative Cancer Research (O.F.K., J.E.D., D.G.A.) and Department of Chemical Engineering (D.G.A.), Massachusetts Institute of Technology, Cambridge; Alnylam Pharmaceuticals, Cambridge, MA (A.B., K.F.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378496PMC
September 2016

Primitive Embryonic Macrophages are Required for Coronary Development and Maturation.

Circ Res 2016 05 23;118(10):1498-511. Epub 2016 Mar 23.

From the Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.L., K.J.L.); Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, United Kingdom (J.C., H.B., S.E.W.J.); Peter Munk Cardiac Centre, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada (S.E.); and Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO (K.J.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567774PMC
May 2016

Slicing Into Human Translational Cardiovascular Biology.

JACC Basic Transl Sci 2016 Apr 25;1(3):168-169. Epub 2016 Apr 25.

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.jacbts.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113352PMC
April 2016

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Cell Rep 2016 Jan 24;14(1):82-92. Epub 2015 Dec 24.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; ICCE Institute, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706805PMC
January 2016

Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo.

J Am Heart Assoc 2015 Jun 2;4(6):e001993. Epub 2015 Jun 2.

Division of Cardiology, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO (K.J.L., S.A.E., C.J.W., P.M.B., D.L.M.).

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http://dx.doi.org/10.1161/JAHA.115.001993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599537PMC
June 2015

Origin and functions of tissue macrophages.

Immunity 2014 Jul;41(1):21-35

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470379PMC
July 2014

Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart.

J Am Heart Assoc 2013 Sep 30;2(5):e000343. Epub 2013 Sep 30.

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1161/JAHA.113.000343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835243PMC
September 2013

Coronary collaterals predict improved survival and allograft function in patients with coronary allograft vasculopathy.

Circ Heart Fail 2013 Jul 24;6(4):773-84. Epub 2013 May 24.

Division of Cardiology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863089PMC
July 2013

Rethinking Phase II Clinical Trial Design in Heart Failure.

Clin Investig (Lond) 2013 Jan;3(1):57-68

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

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http://dx.doi.org/10.4155/cli.12.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204480PMC
January 2013

Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.

Circ Res 2009 Jan;104(2):159-69

Washington University School of Medicine, Department of Developmental Biology, St Louis, MO 63110, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.108.19123
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http://dx.doi.org/10.1161/CIRCRESAHA.108.191239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757940PMC
January 2009

Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.

Development 2008 Sep;135(18):3161-71

Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.019919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306353PMC
September 2008

Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.

J Clin Invest 2008 Jul;118(7):2404-14

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI34561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430494PMC
July 2008

Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.

Dev Dyn 2008 Mar;237(3):713-24

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://doi.wiley.com/10.1002/dvdy.21468
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http://dx.doi.org/10.1002/dvdy.21468DOI Listing
March 2008

Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center.

Trends Genet 2008 Jan 3;24(1):33-40. Epub 2007 Dec 3.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.tig.2007.10.007DOI Listing
January 2008

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.

Development 2007 Oct 19;134(20):3743-52. Epub 2007 Sep 19.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.004879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099314PMC
October 2007

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.

Dev Biol 2007 Jul 6;307(2):300-13. Epub 2007 May 6.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.04.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267922PMC
July 2007

Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization.

Trends Cardiovasc Med 2007 Apr;17(3):77-83

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.tcm.2007.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267919PMC
April 2007

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.

Dev Biol 2007 Feb 5;302(1):80-91. Epub 2006 Sep 5.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.08.071DOI Listing
February 2007

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

Genes Dev 2006 Jun;20(12):1651-66

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gad.1411406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482484PMC
June 2006

Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development.

Development 2006 Jan 24;133(1):173-80. Epub 2005 Nov 24.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.02175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065859PMC
January 2006

Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.

Dev Cell 2005 Jan;8(1):85-95

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.devcel.2004.12.002DOI Listing
January 2005