Kornelia Polyak

Kornelia Polyak

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Kornelia Polyak

Publications by authors named "Kornelia Polyak"

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Premenopausal Plasma Osteoprotegerin and Breast Cancer Risk: A Case-Control Analysis Nested within the Nurses' Health Study II.

Cancer Epidemiol Biomarkers Prev 2020 Jun 10;29(6):1264-1270. Epub 2020 Apr 10.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-19-1154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269832PMC
June 2020

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

Mol Cell 2020 Jun 15;78(6):1096-1113.e8. Epub 2020 May 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306005PMC
June 2020

Immune Escape during Breast Tumor Progression.

Cancer Immunol Res 2020 Apr;8(4):422-427

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138346PMC
April 2020

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance.

Cancer Cell 2020 Apr;37(4):471-484

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181408PMC
April 2020

Tumor Neoantigens: When Too Much of a Good Thing Is Bad.

Cancer Cell 2019 11;36(5):466-467

Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.009DOI Listing
November 2019

Metastasis as a systemic disease: molecular insights and clinical implications.

Biochim Biophys Acta Rev Cancer 2019 08 14;1872(1):89-102. Epub 2019 Jun 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America; Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2019.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692219PMC
August 2019

Intratumoral Heterogeneity: More Than Just Mutations.

Trends Cell Biol 2019 07 12;29(7):569-579. Epub 2019 Apr 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579620PMC
July 2019

Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment.

Cancer Discov 2019 02 24;9(2):176-198. Epub 2019 Jan 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-1177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387871PMC
February 2019

[Li-Fraumeni syndrome].

Orv Hetil 2019 Feb;160(6):228-234

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6720.

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http://dx.doi.org/10.1556/650.2019.31290DOI Listing
February 2019

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Cancer Cell 2018 12 21;34(6):939-953.e9. Epub 2018 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310147PMC
December 2018

Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

Mol Oncol 2018 11 21;12(11):1838-1855. Epub 2018 Sep 21.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway.

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http://doi.wiley.com/10.1002/1878-0261.12375
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http://dx.doi.org/10.1002/1878-0261.12375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210052PMC
November 2018

A confetti trail of tumour evolution.

Nat Cell Biol 2018 06;20(6):639-641

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0110-7DOI Listing
June 2018

Dissecting the mammary gland one cell at a time.

Nat Commun 2018 06 26;9(1):2473. Epub 2018 Jun 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 02215, MA, USA.

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http://dx.doi.org/10.1038/s41467-018-04905-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018702PMC
June 2018

BET Bromodomain Proteins as Cancer Therapeutic Targets.

Cold Spring Harb Symp Quant Biol 2016 6;81:123-129. Epub 2017 Jan 6.

Department of Medical Oncology, Dana-Farber Cancer Institute; Department of Medicine, Brigham and Women's Hospital; and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.030908DOI Listing
February 2018

Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk.

Cancer Res 2017 06 30;77(11):2800-2809. Epub 2017 Mar 30.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477484PMC
June 2017

Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer.

NPJ Breast Cancer 2016 26;2. Epub 2016 Oct 26.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/npjbcancer.2016.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243126PMC
October 2016

Intratumor Heterogeneity in Breast Cancer.

Adv Exp Med Biol 2016 ;882:169-89

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave. D740, 02215, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-319-22909-6_7DOI Listing
August 2016

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Mol Cell 2016 07 30;63(2):277-292. Epub 2016 Jun 30.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(16)30224-6
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http://dx.doi.org/10.1016/j.molcel.2016.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982517PMC
July 2016

The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women.

Cancer Res 2016 04 3;76(7):1926-34. Epub 2016 Mar 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873436PMC
April 2016

Combining miR-10b-Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer.

Cancer Res 2015 Oct 10;75(20):4407-15. Epub 2015 Sep 10.

Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-0888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609288PMC
October 2015

Tumorigenesis: it takes a village.

Nat Rev Cancer 2015 Aug 2;15(8):473-83. Epub 2015 Jul 2.

1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] BBS Program, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA. [4] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrc3971DOI Listing
August 2015

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

Cell Rep 2015 Jun 4;11(10):1549-63. Epub 2015 Jun 4.

Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; BBS Program, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; The Broad Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.011DOI Listing
June 2015

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer.

Cancer Res 2015 Apr 10;75(7):1516-26. Epub 2015 Feb 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Center for Functional Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2443DOI Listing
April 2015

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

Stem Cell Reports 2015 Feb 22;4(2):297-311. Epub 2015 Jan 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0038
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http://www.cell.com/cms/attachment/2025101614/2044763771/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400386
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http://dx.doi.org/10.1016/j.stemcr.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325231PMC
February 2015

Clonal evolution in cancer: a tale of twisted twines.

Cell Stem Cell 2015 Jan;16(1):11-2

Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.12.011DOI Listing
January 2015

MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis.

Cell Stem Cell 2014 Dec 16;15(6):762-74. Epub 2014 Oct 16.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.001DOI Listing
December 2014

BRCA1 haploinsufficiency for replication stress suppression in primary cells.

Nat Commun 2014 Nov 17;5:5496. Epub 2014 Nov 17.

1] Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/ncomms6496
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http://dx.doi.org/10.1038/ncomms6496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243249PMC
November 2014

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.

Nature 2014 Oct 30;514(7520):54-8. Epub 2014 Jul 30.

1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [4] BBS Program, Harvard Medical School, Boston, Massachusetts 02115, USA [5] Harvard Stem Cell Institute and the Broad Institute, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature13556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184961PMC
October 2014

Tumor heterogeneity: the Lernaean hydra of oncology?

Oncology (Williston Park) 2014 Sep;28(9):781-2, 784

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September 2014

Oncogene-like induction of cellular invasion from centrosome amplification.

Nature 2014 Jun 13;510(7503):167-71. Epub 2014 Apr 13.

1] Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061398PMC
June 2014

JARID1B is a luminal lineage-driving oncogene in breast cancer.

Cancer Cell 2014 Jun;25(6):762-77

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02141, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079039PMC
June 2014

Cancer: Clonal cooperation.

Nature 2014 Apr;508(7494):52-3

Department of Medical Oncology, Dana-Farber Cancer Institute, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/508052aDOI Listing
April 2014

Tumor heterogeneity confounds and illuminates: a case for Darwinian tumor evolution.

Authors:
Kornelia Polyak

Nat Med 2014 Apr;20(4):344-6

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3518DOI Listing
April 2014

Genetic and phenotypic diversity in breast tumor metastases.

Cancer Res 2014 Mar 21;74(5):1338-48. Epub 2014 Jan 21.

Authors' Affiliations: Departments of Medical Oncology and Biostatistics and Computational Biology, Dana-Farber Cancer Institute; Department of Medicine, Brigham and Women's Hospital; Department of Medicine, Harvard Medical School; Department of Biostatistics, Harvard School of Public Health, Boston; Departments of Physics and Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Harvard Stem Cell Institute, Cambridge, Massachusetts; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York; Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medical Oncology, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; Department of Pathology, MizMedi Hospital, Seoul, South Korea; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; and Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2357-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963810PMC
March 2014

Sorting out the FACS: a devil in the details.

Cell Rep 2014 Mar;6(5):779-81

Life Sciences Division, Lawrence Berkeley National Laboratory, Mailstop 977R225A, 1 Cyclotron Road, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.celrep.2014.02.021DOI Listing
March 2014

Targeting Akt3 signaling in triple-negative breast cancer.

Cancer Res 2014 Feb 12;74(3):964-73. Epub 2013 Dec 12.

Authors' Affiliations: Department of Pathology, Beth Israel Deaconess Medical Center; Department of Medicine, Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute; and Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946502PMC
February 2014

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.

Cell Rep 2014 Feb 23;6(3):514-27. Epub 2014 Jan 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.12.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928845PMC
February 2014

Deconvoluting complex tissues for expression quantitative trait locus-based analyses.

Philos Trans R Soc Lond B Biol Sci 2013 6;368(1620):20120363. Epub 2013 May 6.

Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1098/rstb.2012.0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682728PMC
December 2013

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

Cancer Cell 2013 Oct 3;24(4):450-65. Epub 2013 Oct 3.

UCSF/Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931310PMC
October 2013

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.

Cancer Cell 2013 Sep;24(3):365-78

Genetics Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822334PMC
September 2013

The expression of Psoriasin (S100A7) and CD24 is linked and related to the differentiation of mammary epithelial cells.

PLoS One 2012 27;7(12):e53119. Epub 2012 Dec 27.

Ingrid Asp Psoriasis Research Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531385PMC
June 2013

Tracking tumor resistance using 'liquid biopsies'.

Nat Med 2013 Jun;19(6):676-7

Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1038/nm.3233DOI Listing
June 2013

Cancer. Cancer cell phenotypes, in fifty shades of grey.

Science 2013 Feb;339(6119):528-9

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1234415
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http://dx.doi.org/10.1126/science.1234415DOI Listing
February 2013

Cellular heterogeneity and molecular evolution in cancer.

Annu Rev Pathol 2013 Jan 22;8:277-302. Epub 2012 Oct 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1146/annurev-pathol-020712-163923DOI Listing
January 2013

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Cancer Res 2012 Dec 27;72(24):6319-24. Epub 2012 Nov 27.

Research Department of Cancer Biology, University College London Cancer Institute, University College London, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-3658DOI Listing
December 2012

SnapShot: breast cancer.

Cancer Cell 2012 Oct;22(4):562-562.e1

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215 USA.

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http://dx.doi.org/10.1016/j.ccr.2012.06.021DOI Listing
October 2012

On using functional genetics to understand breast cancer biology.

Authors:
Kornelia Polyak

Cold Spring Harb Perspect Biol 2012 Jul 1;4(7):a013516. Epub 2012 Jul 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/cshperspect.a013516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385952PMC
July 2012

The challenges posed by cancer heterogeneity.

Nat Biotechnol 2012 Jul 10;30(7):604-10. Epub 2012 Jul 10.

Massachusetts Institute of Technology, Cambridge, Massachusetts, USA and Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2294DOI Listing
July 2012

The microenvironment in breast cancer progression: biology and implications for treatment.

Breast Cancer Res 2011 1;13(6):227. Epub 2011 Nov 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D740C, Boston, MA 02215, USA.

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http://dx.doi.org/10.1186/bcr2912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326543PMC
June 2012

Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.

Genes Chromosomes Cancer 2012 May 3;51(5):480-9. Epub 2012 Feb 3.

Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://doi.wiley.com/10.1002/gcc.21935
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http://dx.doi.org/10.1002/gcc.21935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302210PMC
May 2012

Intra-tumour heterogeneity: a looking glass for cancer?

Nat Rev Cancer 2012 Apr 19;12(5):323-34. Epub 2012 Apr 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston MA 02215, USA.

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http://dx.doi.org/10.1038/nrc3261DOI Listing
April 2012

On chromatin remodeling in mammary gland differentiation and breast tumorigenesis.

Authors:
Kornelia Polyak

Cold Spring Harb Perspect Biol 2012 Mar 1;4(3). Epub 2012 Mar 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282408PMC
March 2012

Altered antisense-to-sense transcript ratios in breast cancer.

Proc Natl Acad Sci U S A 2012 Feb 22;109(8):2820-4. Epub 2010 Nov 22.

Department of Medical Oncology, and Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286925PMC
February 2012

Progress in breast cancer research.

Proc Natl Acad Sci U S A 2012 Feb 13;109(8):2715-7. Epub 2012 Feb 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286956PMC
February 2012

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.

Proc Natl Acad Sci U S A 2012 Jan 16;109(1):221-6. Epub 2011 Dec 16.

Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252958PMC
January 2012

Heterogeneity in breast cancer.

Authors:
Kornelia Polyak

J Clin Invest 2011 Oct 3;121(10):3786-8. Epub 2011 Oct 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195489PMC
October 2011

Functional synergies yet distinct modulators affected by genetic alterations in common human cancers.

Cancer Res 2011 May 11;71(10):3471-81. Epub 2011 Mar 11.

Thomson Reuters, Healthcare & Life Science, St. Joseph, Michigan 49085, USA.

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May 2011

Targeting the missing links for cancer therapy.

Nat Med 2011 Mar;17(3):283-4

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March 2011

Molecular markers for the diagnosis and management of ductal carcinoma in situ.

Authors:
Kornelia Polyak

J Natl Cancer Inst Monogr 2010 ;2010(41):210-3

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St D740C, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/jncimonographs/lgq019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161056PMC
February 2011

Gene expression profiling of human breast tissue samples using SAGE-Seq.

Genome Res 2010 Dec 2;20(12):1730-9. Epub 2010 Nov 2.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989999PMC
December 2010

The origins and implications of intratumor heterogeneity.

Cancer Prev Res (Phila) 2010 Nov 19;3(11):1361-4. Epub 2010 Oct 19.

Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633425PMC
November 2010

Going small is the new big.

Authors:
Kornelia Polyak

Nat Methods 2010 Aug;7(8):597, 599-600

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August 2010