Mr. Sovannarith Korm, PhD - Boston University School of Medicine/Pharmacology and Experimental Therapeutics - Postdoctoral associate

Mr. Sovannarith Korm

PhD

Boston University School of Medicine/Pharmacology and Experimental Therapeutics

Postdoctoral associate

Boston, MASSACHUSETTS | United States

Main Specialties: Hematology & Oncology

Additional Specialties: Cancer metabolism

ORCID logohttps://orcid.org/0000-0003-2211-2946


Top Author

Mr. Sovannarith Korm, PhD - Boston University School of Medicine/Pharmacology and Experimental Therapeutics - Postdoctoral associate

Mr. Sovannarith Korm

PhD

Introduction

Co-First Author*

1. Han S.H. *, KORM S. *, Han Y.G. *, Choi S.Y. *, Kim S.H., Chung H.J., Park K., Kim J.Y., Myung K., Lee J.Y., Kim H., Kim D.W. GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia. Autophagy, 2019 Mar 30:1-15.

2. Chung H.J. *, KORM S. *, Lee S.I. *, Phorl S., Noh S.H., Han M.A., Naskar R., Kim H.T., Lee J.Y. RAP80 binds p32 to preserve the functional integrity of mitochondria. Biochem Biophys Res Commun, 2017 Oct 21;492(3):441-446.

3. Park S.Y*, KORM S. *, Chung H.J, Choi S.J., Jang J.J., Cho S.H., Lim, Y.T., Kim H.T, Lee J.Y. RAP80 regulates epithelial mesenchymal transition related with metastasis and malignancy of cancer. Cancer Sci. 2016 Mar;107(3):267-73.

4. KORM S. *, Jeong, H.C*, Kim O.S, Park, J.R., Cho H., Kim Y.M., Chin Y.W. and Cha, H.J. ?-mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway. RSC Adv. 2015; 5: 34752-34760

5. Kim, J.J. *, KORM, S. *, Kim, W.S., Kim, O.S., Lee, J.S., Min, H.G., Chin, Y.W., and Cha, H.J. () Nobiletin suppresses MMP-9 expression through modulation of p38 MAPK activity in human dermal fibroblasts. Biol Pharm Bull. 2014; 37(1):158-63.

Contributing Author

1. Jung S., Han M., KORM S., Lee S.I.; Noh S., Phorl S., Naskar R., Lee K.S., Kim G.H., Choi Y.J., Lee J.Y. HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression. Biochem Biophys Res Commun. 2018 Sep 3;503(1):285-290.

2. Park S.Y., Phorl S., Jung S., KORM S., Lee S.I., Noh S., Han M., Naskar R., Kim J.Y., Choi Y.J., Lee J.Y. HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation. Biochem Biophys Res Commun, 2017 Dec 9;494(1-2):51-56.

3. Seth A., Lee H., Cho M.Y., Park C.S., KORM S., Lee J.Y., Choi I.P., Lim Y.T., and Hong K.S. Combining vasculature disrupting agent and toll-like receptor 7/8 agonist for cancer therapy. Oncotarget, 2017 Jan 17; 8(3): 5371–5381.

Primary Affiliation: Boston University School of Medicine/Pharmacology and Experimental Therapeutics - Boston, MASSACHUSETTS , United States

Specialties:

Additional Specialties:


View Mr. Sovannarith Korm’s Resume / CV

Education

Mar 2015 - Feb 2019
Graduate School of Analytical Science and Technology, Chungnam National University
PhD
Basic Science
Mar 2013 - Feb 2015
Sogang University
Master
Life Science
Jul 2012 - Aug 2012
Department of Biotechnology, Mahidol University Faculty of Science
Young Scientist researcher
Isolation of antibiotic property from Cambodian medical plants
Sep 2008 - Jun 2012
Department of Biology, Royal University of Phnom Penh
Bachelor
General Biology

Experience

Mar 2019 - Mar 2019
Boston University School of Medicine
Postdoctoral associate
Pharmacology and Experimental Therapeutics

Publications

8Publications

78Reads

5Profile Views

8PubMed Central Citations

GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.

Autophagy 2019 12 30;15(12):2076-2090. Epub 2019 Mar 30.

Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.

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http://dx.doi.org/10.1080/15548627.2019.1596492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844495PMC
December 2019
9 Reads
11.753 Impact Factor

HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression.

Biochem Biophys Res Commun 2018 09 14;503(1):285-290. Epub 2018 Jun 14.

Graduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, 305-764, Republic of Korea; Division of Scientific Instrumentation, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon, 34133, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.06.016DOI Listing
September 2018
27 Reads
2.300 Impact Factor

Combining vasculature disrupting agent and Toll-like receptor 7/8 agonist for cancer therapy.

Oncotarget 2017 Jan;8(3):5371-5381

Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Republic of Korea.

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http://dx.doi.org/10.18632/oncotarget.14260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354915PMC
January 2017
16 Reads
2 Citations
6.360 Impact Factor

RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer.

Cancer Sci 2016 Mar 10;107(3):267-73. Epub 2016 Feb 10.

Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.12877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814264PMC
March 2016
8 Reads
3 Citations

α-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway

RSC Adv., 2015,5, 34752-34760

RSC Advance

α-Mangostin (α-MG), one of the active substances in Garcinia mangostana, has been shown to exhibit anti-cancer effects in various cancer cell types. α-MG treatment induces G1 arrest in cancer cell models through the induction of cyclin-dependent kinase inhibitors (CDKIs) and the subsequent loss of CDK activity. However, outside its role in the p53-p21CIP1 axis, the precise molecular mechanisms underlying the effect of α-MG on cell cycle arrest remain unclear. In this study, we observed that α-MG inhibits the proliferation of HCT116 cells in a dose-dependent manner. Interestingly, although the loss of p53 rescued the α-MG effect on cell cycle arrest, in agreement with previous reports, p21Cip1 expression was only marginally delayed in the absence of p53 after α-MG treatment. Instead, we found that the activation of p38 mitogen activated protein kinase (MAPK) and the subsequent downregulation of Bmi-1 also contributed to the induction of p16Ink4a, which is responsible for G1 arrest upon α-MG treatment. These findings indicate that α-MG exerts cytostatic effects on colon cancer cells by inducing G1 arrest via the p38MAPK-p16INK4a axis.

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April 2015
4 Reads

Nobiletin suppresses MMP-9 expression through modulation of p38 MAPK activity in human dermal fibrobalsts.

Biol Pharm Bull 2014 ;37(1):158-63

Department of Life Science, College of Natural Science, Sogang University.

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http://dx.doi.org/10.1248/bpb.b13-00534DOI Listing
August 2014
18 Reads
3 Citations
1.780 Impact Factor