Publications by authors named "Konrad Sandhoff"

100Publications

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease.

Int J Mol Sci 2020 Apr 7;21(7). Epub 2020 Apr 7.

Membrane Biology and Lipid Biochemistry Unit, LIMES Institute, University of Bonn, 53121 Bonn, Germany.

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April 2020

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Int J Mol Sci 2019 Nov 21;20(23). Epub 2019 Nov 21.

Experimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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November 2019

Emerging mechanisms of drug-induced phospholipidosis.

Biol Chem 2019 12;401(1):31-46

LIMES Institut, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2019

Lysosomal Glycosphingolipid Storage Diseases.

Annu Rev Biochem 2019 06;88:461-485

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Universität Bonn, D-53121 Bonn, Germany; email: ,

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June 2019

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.

Mol Genet Metab 2019 Sep - Oct;128(1-2):75-83. Epub 2019 May 4.

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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April 2020

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.

J Lipid Res 2019 06 15;60(6):1099-1111. Epub 2019 Apr 15.

Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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June 2019

Ganglioside Metabolism and Its Inherited Diseases.

Methods Mol Biol 2018 ;1804:97-141

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2019

Emerging concepts of ganglioside metabolism.

FEBS Lett 2018 12 16;592(23):3835-3864. Epub 2018 Jun 16.

LIMES Institute, University of Bonn, Germany.

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December 2018

Ganglioside Metabolism in Health and Disease.

Prog Mol Biol Transl Sci 2018 28;156:1-62. Epub 2018 Mar 28.

Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Electronic address:

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February 2019

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Cell Rep 2018 01 28;22(4):967-978. Epub 2018 Jan 28.

LIMES-Institute, Unit Development, Genetics and Molecular Physiology, Department for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany. Electronic address:

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January 2018

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient mutants.

Mol Biol Cell 2018 02 27;29(4):396-407. Epub 2017 Dec 27.

Department of Molecular Developmental Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany

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February 2018

Characterization of mutants as a model for lysosomal sphingolipid storage diseases.

Dis Model Mech 2017 06 7;10(6):737-750. Epub 2017 Apr 7.

LIMES-Institute, Program Unit Development & Genetics, Laboratory for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany

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June 2017

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

J Lipid Res 2017 03 26;58(3):563-577. Epub 2017 Jan 26.

Life and Medical Sciences (LIMES) Institut, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany

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March 2017

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism.

Authors:
Konrad Sandhoff

Biochimie 2016 Nov 5;130:146-151. Epub 2016 May 5.

University of Bonn, LIMES Institute, c/o Kekulé-Institute, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. Electronic address:

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November 2016

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer.

J Lipid Res 2015 Oct 11;56(10):1861-79. Epub 2015 Aug 11.

Life & Medical Sciences (LIMES) Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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October 2015

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

J Lipid Res 2015 Sep 14;56(9):1747-61. Epub 2015 Jul 14.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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September 2015

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification.

J Lipid Res 2014 Dec 22;55(12):2692-704. Epub 2014 Oct 22.

Life & Medical Sciences, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53115 Bonn, Germany.

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December 2014

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

J Lipid Res 2014 Dec 22;55(12):2606-19. Epub 2014 Oct 22.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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December 2014

Labeled chemical biology tools for investigating sphingolipid metabolism, trafficking and interaction with lipids and proteins.

Biochim Biophys Acta 2014 Aug 28;1841(8):1161-73. Epub 2013 Dec 28.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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August 2014

Metabolic and cellular bases of sphingolipidoses.

Authors:
Konrad Sandhoff

Biochem Soc Trans 2013 Dec;41(6):1562-8

*Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute (LIMES), c/o Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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December 2013

CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells.

J Neurosci 2013 Nov;33(46):18065-79

Departments of Internal Medicine, Molecular Physiology and Biophysics, Neurology, and Molecular and Cell Biology Program, University of Iowa, Iowa City, Iowa 52242, and Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, University of Bonn, D-53121 Bonn, Germany.

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November 2013

Sphingolipids and lysosomal pathologies.

Biochim Biophys Acta 2014 May 31;1841(5):799-810. Epub 2013 Oct 31.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53115 Bonn, Germany. Electronic address:

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May 2014

Cancer: Killing from the inside.

Nature 2013 Oct 2;502(7471):312-3. Epub 2013 Oct 2.

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October 2013

Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus.

Mech Ageing Dev 2013 Sep 13;134(9):391-9. Epub 2013 Aug 13.

Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.

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September 2013

The role of sphingolipid metabolism in cutaneous permeability barrier formation.

Biochim Biophys Acta 2014 Mar 15;1841(3):441-52. Epub 2013 Aug 15.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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March 2014

Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis.

J Neurosci 2013 Jun;33(25):10195-208

LIMES, Kekulé-Institut, 53121 Bonn, Germany.

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June 2013

My journey into the world of sphingolipids and sphingolipidoses.

Authors:
Konrad Sandhoff

Proc Jpn Acad Ser B Phys Biol Sci 2012 ;88(10):554-82

LIMES c/o Kekulé-Institut, University of Bonn, Bonn, Germany

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October 2013

Nrf2 links epidermal barrier function with antioxidant defense.

EMBO Mol Med 2012 May 2;4(5):364-79. Epub 2012 Mar 2.

Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland.

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May 2012

Mass spectrometric analysis of neutral sphingolipids: methods, applications, and limitations.

Biochim Biophys Acta 2011 Nov 27;1811(11):854-60. Epub 2011 Jun 27.

University of Bonn, Gerhard-Domagk, Bonn, Germany.

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November 2011

Lysosomal lipid storage diseases.

Cold Spring Harb Perspect Biol 2011 Jun 1;3(6). Epub 2011 Jun 1.

Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, University of Bonn, Germany.

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June 2011

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids.

J Neurochem 2011 Mar 7;116(5):702-7. Epub 2011 Jan 7.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2011

Biological function of the cellular lipid BMP-BMP as a key activator for cholesterol sorting and membrane digestion.

Neurochem Res 2011 Sep 7;36(9):1594-600. Epub 2010 Dec 7.

LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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September 2011

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.

J Cell Sci 2010 Jul 22;123(Pt 14):2502-11. Epub 2010 Jun 22.

European Molecular Biology Laboratory, Postfach 102209, 69117 Heidelberg, Germany.

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July 2010

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.

J Lipid Res 2010 Jul 23;51(7):1747-60. Epub 2010 Feb 23.

Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute (LIMES), Bonn, Germany.

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July 2010

Lysosomal degradation of membrane lipids.

FEBS Lett 2010 May 16;584(9):1700-12. Epub 2009 Oct 16.

LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany.

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May 2010

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.

EMBO J 2009 Dec 15;28(23):3706-16. Epub 2009 Oct 15.

LIMES-Institute, Program Unit Development, Genetics & Molecular Physiology, Laboratory for Molecular Developmental Biology, University of Bonn, Bonn, Germany.

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December 2009

Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.

J Biol Chem 2009 Nov 30;284(48):33549-60. Epub 2009 Sep 30.

Institute of Genetics, Division of Molecular Genetics, University of Bonn, Römerstrasse 164, 53117 Bonn, Germany.

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November 2009

Normal phase liquid chromatography coupled to quadrupole time of flight atmospheric pressure chemical ionization mass spectrometry for separation, detection and mass spectrometric profiling of neutral sphingolipids and cholesterol.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Oct 14;877(27):2976-82. Epub 2009 Jul 14.

LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk Str. 1, D-53121 Bonn, Germany.

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October 2009

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

J Biol Chem 2009 Apr 18;284(14):9372-81. Epub 2009 Feb 18.

Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-University, 53115 Bonn, Germany.

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April 2009

Direct observation of the nanoscale dynamics of membrane lipids in a living cell.

Nature 2009 Feb 21;457(7233):1159-62. Epub 2008 Dec 21.

Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

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February 2009

Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation.

Biochim Biophys Acta 2009 Apr 1;1793(4):674-83. Epub 2008 Nov 1.

LIMES Program Unit Membrane Biology and Lipid Biochemistry, Laboratory of Lipid Biochemistry, Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Germany.

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April 2009

Hexosaminidase assays.

Glycoconj J 2009 Nov;26(8):945-52

LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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November 2009

Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.

Structure 2008 May;16(5):809-17

Institut für Chemie und Biochemie, Kristallographie, Freie Universität Berlin, Takustr. 6, 14195 Berlin, Germany.

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May 2008

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Hum Mol Genet 2008 May 4;17(10):1465-81. Epub 2008 Feb 4.

Department of Neurology, J.W. Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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May 2008

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.

J Biol Chem 2008 Feb 26;283(5):2622-30. Epub 2007 Nov 26.

Département de Pharmacologie & de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, Switzerland.

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February 2008

Overexpression and mass spectrometry analysis of mature human acid ceramidase.

Biol Chem 2007 Dec;388(12):1333-43

LIMES Membrane Biology and Lipid Biochemistry Unit, University Bonn, c/o Kekulé-Institute, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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December 2007

Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides.

Eur J Cell Biol 2007 Dec 21;86(11-12):657-73. Epub 2007 Aug 21.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2007

Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity.

FEBS J 2007 Jul 11;274(13):3405-20. Epub 2007 Jun 11.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Germany.

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July 2007

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein.

Biol Chem 2007 Jun;388(6):617-26

LIMES Membrane Biology and Lipid Biochemistry Unit, University of Bonn, c/o Kekulé Institute, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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June 2007

Separation and mass spectrometric characterization of covalently bound skin ceramides using LC/APCI-MS and Nano-ESI-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jun 24;852(1-2):562-70. Epub 2007 Feb 24.

LIMES-Life and Medical Sciences Bonn, Program Unit Membrane and Lipid Biochemistry, Laboratory of Biology & Lipid Biochemistry, Friedrichs-Wilhelm-University, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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June 2007

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.

Nat Cell Biol 2007 Apr 11;9(4):461-9. Epub 2007 Mar 11.

Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany.

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April 2007

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

Proc Natl Acad Sci U S A 2007 Jan 21;104(1):359-64. Epub 2006 Dec 21.

Institut für Biochemie, OE 4310, and Institut für Toxikologie, OE 5340, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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January 2007

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

J Biol Chem 2007 Feb 4;282(5):3083-94. Epub 2006 Dec 4.

Department of Cellular und Molecular Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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February 2007

Sphingolipid metabolism diseases.

Biochim Biophys Acta 2006 Dec 14;1758(12):2057-79. Epub 2006 Jun 14.

Kekulé-Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2006

Characterization of human saposins by NMR spectroscopy.

Biochemistry 2006 Apr;45(16):5206-16

Department Chemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

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April 2006

Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Feb 27;62(Pt 2):117-20. Epub 2006 Jan 27.

Institut für Chemie und Biochemie/Kristallographie, Freie Universität Berlin, Germany.

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February 2006

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

Immunity 2006 Jan;24(1):105-17

Department of Immunology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany.

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January 2006

Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.

Genesis 2005 Dec;43(4):175-80

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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December 2005

Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense.

J Biol Chem 2005 Dec 17;280(50):41125-8. Epub 2005 Oct 17.

Kekulé-Institut für Organische Chemie und Biochemie, D-53121 Bonn, Germany.

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December 2005

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.

Annu Rev Cell Dev Biol 2005 ;21:81-103

Kekulé-Institut für Organische Chemie und Biochemie der Universität, 53121 Bonn, Germany.

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January 2006

Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system.

Glycobiology 2005 Dec 3;15(12):1302-11. Epub 2005 Aug 3.

Kekulé-Institute für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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December 2005

The epidermal barrier function is dependent on the serine protease CAP1/Prss8.

J Cell Biol 2005 Aug;170(3):487-96

Département de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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August 2005

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.

J Biol Chem 2005 Jul 27;280(30):28110-7. Epub 2005 May 27.

Department of Neurology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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July 2005

Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.

Asian J Androl 2005 Jun;7(2):147-58

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 4-17, New Orleans, LA 70112, USA.

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June 2005

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.

J Biol Chem 2005 May 17;280(20):20148-53. Epub 2005 Mar 17.

Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, 84132, USA.

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May 2005

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.

Proc Natl Acad Sci U S A 2005 Feb 14;102(8):2725-30. Epub 2005 Feb 14.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2005

Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation.

Eur J Cell Biol 2004 Dec;83(11-12):747-59

Institut für Physiologische Chemie, Universität Bonn, Bonn, Germany.

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December 2004

Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism.

Eur J Cell Biol 2004 Dec;83(11-12):667-79

Kekulé Institut für Organische Chemie und Biochemie der Universität Bonn, Bonn, Germany.

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December 2004

Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase.

Biol Chem 2004 Dec;385(12):1193-5

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2004

Site-specific cleavage--a model system for the identification of lipid-modified glutamate residues in proteins.

Chembiochem 2005 Jan;6(1):178-85

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk Strasse 1, 53121 Bonn, Germany.

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January 2005

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine.

FEBS Lett 2004 Feb;559(1-3):96-8

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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February 2004

Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation.

Eur J Biochem 2004 Feb;271(3):614-27

Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, D-53121 Bonn, Germany.

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February 2004

Saposin C is required for lipid presentation by human CD1b.

Nat Immunol 2004 Feb 11;5(2):169-74. Epub 2004 Jan 11.

Max-Planck-Institute for Infection Biology, Department of Immunology, Schumannstrasse 21-22, D-10117 Berlin, Germany.

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February 2004

Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay.

Methods Enzymol 2003 ;363:476-89

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

Interaction of the GM2 activator protein with sulfated and sialylated glycosphingolipids.

Methods Enzymol 2003 ;363:207-22

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

RNA interference: analyzing the function of glycoproteins and glycosylating proteins in mammalian cells.

Methods Enzymol 2003 ;363:173-90

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase.

Biol Chem 2003 Sep;384(9):1293-8

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strassel, D-53121 Bonn, Germany.

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September 2003