Publications by authors named "Konrad Sandhoff"

100Publications

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease.

Authors:
Bernadette Breiden Konrad Sandhoff

Int J Mol Sci 2020 Apr 7;21(7). Epub 2020 Apr 7.

Membrane Biology and Lipid Biochemistry Unit, LIMES Institute, University of Bonn, 53121 Bonn, Germany.

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April 2020

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Authors:
Nesli-Ece Sen Aleksandar Arsovic David Meierhofer Susanne Brodesser Carola Oberschmidt Júlia Canet-Pons Zeynep-Ece Kaya Melanie-Vanessa Halbach Suzana Gispert Konrad Sandhoff Georg Auburger

Int J Mol Sci 2019 Nov 21;20(23). Epub 2019 Nov 21.

Experimental Neurology, Building 89, Goethe University Medical Faculty, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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November 2019

Emerging mechanisms of drug-induced phospholipidosis.

Authors:
Bernadette Breiden Konrad Sandhoff

Biol Chem 2019 12;401(1):31-46

LIMES Institut, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2019

Lysosomal Glycosphingolipid Storage Diseases.

Authors:
Bernadette Breiden Konrad Sandhoff

Annu Rev Biochem 2019 06;88:461-485

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Universität Bonn, D-53121 Bonn, Germany; email: ,

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June 2019

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.

Authors:
Susi Anheuser Bernadette Breiden Konrad Sandhoff

Mol Genet Metab 2019 Sep - Oct;128(1-2):75-83. Epub 2019 May 4.

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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April 2020

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.

Authors:
Susi Anheuser Bernadette Breiden Konrad Sandhoff

J Lipid Res 2019 06 15;60(6):1099-1111. Epub 2019 Apr 15.

Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

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June 2019

Ganglioside Metabolism and Its Inherited Diseases.

Authors:
Bernadette Breiden Konrad Sandhoff

Methods Mol Biol 2018 ;1804:97-141

LIMES Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2019

Emerging concepts of ganglioside metabolism.

Authors:
Roger Sandhoff Konrad Sandhoff

FEBS Lett 2018 12 16;592(23):3835-3864. Epub 2018 Jun 16.

LIMES Institute, University of Bonn, Germany.

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December 2018

Ganglioside Metabolism in Health and Disease.

Authors:
Roger Sandhoff Heike Schulze Konrad Sandhoff

Prog Mol Biol Transl Sci 2018 28;156:1-62. Epub 2018 Mar 28.

Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Electronic address:

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February 2019

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Authors:
Andreas Bickert Paul Kern Martina van Uelft Stefanie Herresthal Thomas Ulas Katharina Gutbrod Bernadette Breiden Joachim Degen Konrad Sandhoff Joachim L Schultze Peter Dörmann Dieter Hartmann Reinhard Bauer Klaus Willecke

Biochim Biophys Acta Mol Cell Biol Lipids 2018 07 10;1863(7):734-749. Epub 2018 Apr 10.

Molecular Genetics, Life and Medical Sciences Institute, University of Bonn, Germany. Electronic address:

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July 2018

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Authors:
Mariangela Sociale Anna-Lena Wulf Bernadette Breiden Kathrin Klee Melanie Thielisch Franka Eckardt Julia Sellin Margret H Bülow Sinah Löbbert Nadine Weinstock André Voelzmann Joachim Schultze Konrad Sandhoff Reinhard Bauer

Cell Rep 2018 01 28;22(4):967-978. Epub 2018 Jan 28.

LIMES-Institute, Unit Development, Genetics and Molecular Physiology, Department for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany. Electronic address:

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January 2018

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient mutants.

Authors:
Margret H Bülow Christian Wingen Deniz Senyilmaz Dominic Gosejacob Mariangela Sociale Reinhard Bauer Heike Schulze Konrad Sandhoff Aurelio A Teleman Michael Hoch Julia Sellin

Mol Biol Cell 2018 02 27;29(4):396-407. Epub 2017 Dec 27.

Department of Molecular Developmental Biology, Life & Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany

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February 2018

Characterization of mutants as a model for lysosomal sphingolipid storage diseases.

Authors:
Julia Sellin Heike Schulze Marie Paradis Dominic Gosejacob Cyrus Papan Andrej Shevchenko Olympia Ekaterina Psathaki Achim Paululat Melanie Thielisch Konrad Sandhoff Michael Hoch

Dis Model Mech 2017 06 7;10(6):737-750. Epub 2017 Apr 7.

LIMES-Institute, Program Unit Development & Genetics, Laboratory for Molecular Developmental Biology, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany

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June 2017

Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.

Authors:
Christopher G F Graf Christian Schulz Marina Schmälzlein Christian Heinlein Manuel Mönnich Lukas Perkams Markus Püttner Irene Boos Markus Hessefort Jose Nelson Lombana Sanchez Michael Weyand Clemens Steegborn Bernadette Breiden Kerstin Ross Günter Schwarzmann Konrad Sandhoff Carlo Unverzagt

Angew Chem Int Ed Engl 2017 05 5;56(19):5252-5257. Epub 2017 Apr 5.

Bioorg. Chemie, Gebäude NWI, Universität Bayreuth, 95440, Bayreuth, Germany.

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May 2017

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

Authors:
Sophie Schonauer Heinz G Körschen Anke Penno Andreas Rennhack Bernadette Breiden Konrad Sandhoff Katharina Gutbrod Peter Dörmann Diana N Raju Per Haberkant Mathias J Gerl Britta Brügger Hila Zigdon Ayelet Vardi Anthony H Futerman Christoph Thiele Dagmar Wachten

J Biol Chem 2017 04 3;292(15):6177-6189. Epub 2017 Mar 3.

From the Minerva Max Planck Research Group, Molecular Physiology, and

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April 2017

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

Authors:
Misbaudeen Abdul-Hammed Bernadette Breiden Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2017 03 26;58(3):563-577. Epub 2017 Jan 26.

Life and Medical Sciences (LIMES) Institut, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany

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March 2017

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism.

Authors:
Konrad Sandhoff

Biochimie 2016 Nov 5;130:146-151. Epub 2016 May 5.

University of Bonn, LIMES Institute, c/o Kekulé-Institute, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. Electronic address:

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November 2016

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer.

Authors:
Günter Schwarzmann Bernadette Breiden Konrad Sandhoff

J Lipid Res 2015 Oct 11;56(10):1861-79. Epub 2015 Aug 11.

Life & Medical Sciences (LIMES) Institute, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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October 2015

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

Authors:
Susi Anheuser Bernadette Breiden Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2015 Sep 14;56(9):1747-61. Epub 2015 Jul 14.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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September 2015

Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics.

Authors:
Diana Raju Sophie Schonauer Hussein Hamzeh Kevin C Flynn Frank Bradke Katharina Vom Dorp Peter Dörmann Yildiz Yildiz Christian Trötschel Ansgar Poetsch Bernadette Breiden Konrad Sandhoff Heinz G Körschen Dagmar Wachten

PLoS Genet 2015 Mar 24;11(3):e1005063. Epub 2015 Mar 24.

Minerva Research Group-Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany.

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March 2015

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification.

Authors:
Martin Gantner Günter Schwarzmann Konrad Sandhoff Thomas Kolter

J Lipid Res 2014 Dec 22;55(12):2692-704. Epub 2014 Oct 22.

Life & Medical Sciences, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53115 Bonn, Germany.

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December 2014

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

Authors:
Vincent O Oninla Bernadette Breiden Jonathan O Babalola Konrad Sandhoff

J Lipid Res 2014 Dec 22;55(12):2606-19. Epub 2014 Oct 22.

LIMES Institute, Membrane Biology and Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, D-53121 Bonn, Germany.

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December 2014

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice.

Authors:
Matthias Schäfer Ann-Helen Willrodt Svitlana Kurinna Andrea S Link Hany Farwanah Alexandra Geusau Florian Gruber Olivier Sorg Aaron J Huebner Dennis R Roop Konrad Sandhoff Jean-Hilaire Saurat Erwin Tschachler Marlon R Schneider Lutz Langbein Wilhelm Bloch Hans-Dietmar Beer Sabine Werner

EMBO Mol Med 2014 04 6;6(4):442-57. Epub 2014 Feb 6.

Department of Biology, Institute of Molecular Health Sciences, ETH Zurich Zurich, Switzerland.

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April 2014

Labeled chemical biology tools for investigating sphingolipid metabolism, trafficking and interaction with lipids and proteins.

Authors:
Günter Schwarzmann Christoph Arenz Konrad Sandhoff

Biochim Biophys Acta 2014 Aug 28;1841(8):1161-73. Epub 2013 Dec 28.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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August 2014

Metabolic and cellular bases of sphingolipidoses.

Authors:
Konrad Sandhoff

Biochem Soc Trans 2013 Dec;41(6):1562-8

*Membrane Biology and Lipid Biochemistry Unit, Life and Medical Sciences Institute (LIMES), c/o Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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December 2013

CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells.

Authors:
Luis Tecedor Colleen S Stein Mark L Schultz Hany Farwanah Konrad Sandhoff Beverly L Davidson

J Neurosci 2013 Nov;33(46):18065-79

Departments of Internal Medicine, Molecular Physiology and Biophysics, Neurology, and Molecular and Cell Biology Program, University of Iowa, Iowa City, Iowa 52242, and Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, University of Bonn, D-53121 Bonn, Germany.

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November 2013

Sphingolipids and lysosomal pathologies.

Authors:
Heike Schulze Konrad Sandhoff

Biochim Biophys Acta 2014 May 31;1841(5):799-810. Epub 2013 Oct 31.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53115 Bonn, Germany. Electronic address:

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May 2014

Cancer: Killing from the inside.

Authors:
Paul Saftig Konrad Sandhoff

Nature 2013 Oct 2;502(7471):312-3. Epub 2013 Oct 2.

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October 2013

Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease.

Authors:
Yildiz Yildiz Per Hoffmann Stefan Vom Dahl Bernadette Breiden Roger Sandhoff Claus Niederau Mia Horwitz Stefan Karlsson Mirella Filocamo Deborah Elstein Michael Beck Konrad Sandhoff Eugen Mengel Maria C Gonzalez Markus M Nöthen Ellen Sidransky Ari Zimran Manuel Mattheisen

Orphanet J Rare Dis 2013 Sep 26;8:151. Epub 2013 Sep 26.

Department of Internal Medicine I, University Clinic of Bonn, Bonn, Germany.

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September 2013

Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus.

Authors:
Anastasia Piyanova Onder Albayram Carlo Alberto Rossi Hany Farwanah Kerstin Michel Pierluigi Nicotera Konrad Sandhoff Andras Bilkei-Gorzo

Mech Ageing Dev 2013 Sep 13;134(9):391-9. Epub 2013 Aug 13.

Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.

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September 2013

The role of sphingolipid metabolism in cutaneous permeability barrier formation.

Authors:
Bernadette Breiden Konrad Sandhoff

Biochim Biophys Acta 2014 Mar 15;1841(3):441-52. Epub 2013 Aug 15.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. Electronic address:

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March 2014

Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis.

Authors:
Konrad Sandhoff Klaus Harzer

J Neurosci 2013 Jun;33(25):10195-208

LIMES, Kekulé-Institut, 53121 Bonn, Germany.

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June 2013

My journey into the world of sphingolipids and sphingolipidoses.

Authors:
Konrad Sandhoff

Proc Jpn Acad Ser B Phys Biol Sci 2012 ;88(10):554-82

LIMES c/o Kekulé-Institut, University of Bonn, Bonn, Germany

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October 2013

Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes.

Authors:
Christina Ginkel Dieter Hartmann Katharina vom Dorp Armin Zlomuzica Hany Farwanah Matthias Eckhardt Roger Sandhoff Joachim Degen Mariona Rabionet Ekrem Dere Peter Dörmann Konrad Sandhoff Klaus Willecke

J Biol Chem 2012 Dec 16;287(50):41888-902. Epub 2012 Oct 16.

Molecular Genetics, University of Bonn, 53115 Bonn, Germany.

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December 2012

Nrf2 links epidermal barrier function with antioxidant defense.

Authors:
Matthias Schäfer Hany Farwanah Ann-Helen Willrodt Aaron J Huebner Konrad Sandhoff Dennis Roop Daniel Hohl Wilhelm Bloch Sabine Werner

EMBO Mol Med 2012 May 2;4(5):364-79. Epub 2012 Mar 2.

Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland.

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May 2012

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.

Authors:
Dagmar Fehrenschild Uwe Galli Bernadette Breiden Wilhelm Bloch Peter Schettina Susanne Brodesser Christian Michels Christian Günschmann Konrad Sandhoff Carien M Niessen Catherin Niemann

J Invest Dermatol 2012 Feb 22;132(2):337-45. Epub 2011 Sep 22.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

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February 2012

Mass spectrometric analysis of neutral sphingolipids: methods, applications, and limitations.

Authors:
Hany Farwanah Thomas Kolter Konrad Sandhoff

Biochim Biophys Acta 2011 Nov 27;1811(11):854-60. Epub 2011 Jun 27.

University of Bonn, Gerhard-Domagk, Bonn, Germany.

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November 2011

Lysosomal lipid storage diseases.

Authors:
Heike Schulze Konrad Sandhoff

Cold Spring Harb Perspect Biol 2011 Jun 1;3(6). Epub 2011 Jun 1.

Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, University of Bonn, Germany.

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June 2011

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

Authors:
Irfan Y Tamboli Heike Hampel Nguyen T Tien Karen Tolksdorf Bernadette Breiden Paul M Mathews Paul Saftig Konrad Sandhoff Jochen Walter

J Neurosci 2011 Feb;31(5):1837-49

Department of Neurology, University of Bonn, 53127 Bonn, Germany.

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February 2011

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.

Authors:
Simona Frateschi Eric Camerer Giovanna Crisante Sarah Rieser Mathieu Membrez Roch-Philippe Charles Friedrich Beermann Jean-Christophe Stehle Bernadette Breiden Konrad Sandhoff Samuel Rotman Marek Haftek Anne Wilson Stephan Ryser Martin Steinhoff Shaun R Coughlin Edith Hummler

Nat Commun 2011 Jan;2:161

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne 1005, Switzerland.

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January 2011

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids.

Authors:
Hichem D Gallala Bernadette Breiden Konrad Sandhoff

J Neurochem 2011 Mar 7;116(5):702-7. Epub 2011 Jan 7.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.

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March 2011

Biological function of the cellular lipid BMP-BMP as a key activator for cholesterol sorting and membrane digestion.

Authors:
Hichem D Gallala Konrad Sandhoff

Neurochem Res 2011 Sep 7;36(9):1594-600. Epub 2010 Dec 7.

LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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September 2011

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.

Authors:
Anna Wähe Bahram Kasmapour Christoph Schmaderer David Liebl Konrad Sandhoff Anders Nykjaer Gareth Griffiths Maximiliano G Gutierrez

J Cell Sci 2010 Jul 22;123(Pt 14):2502-11. Epub 2010 Jun 22.

European Molecular Biology Laboratory, Postfach 102209, 69117 Heidelberg, Germany.

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July 2010

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.

Authors:
Misbaudeen Abdul-Hammed Bernadette Breiden Matthew A Adebayo Jonathan O Babalola Günter Schwarzmann Konrad Sandhoff

J Lipid Res 2010 Jul 23;51(7):1747-60. Epub 2010 Feb 23.

Membrane Biology and Biochemistry Unit, Life and Medical Sciences Institute (LIMES), Bonn, Germany.

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July 2010

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

Authors:
Thomas Kirkegaard Anke G Roth Nikolaj H T Petersen Ajay K Mahalka Ole Dines Olsen Irina Moilanen Alicja Zylicz Jens Knudsen Konrad Sandhoff Christoph Arenz Paavo K J Kinnunen Jesper Nylandsted Marja Jäättelä

Nature 2010 Jan;463(7280):549-53

Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

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January 2010

Role for LAMP-2 in endosomal cholesterol transport.

Authors:
Alexander Schneede Christine K Schmidt Maarit Hölttä-Vuori Jörg Heeren Marion Willenborg Judith Blanz Mykola Domanskyy Bernadette Breiden Susanne Brodesser Jobst Landgrebe Konrad Sandhoff Elina Ikonen Paul Saftig Eeva-Liisa Eskelinen

J Cell Mol Med 2011 Feb;15(2):280-95

Institute of Biochemistry, University of Kiel, Kiel, Germany.

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February 2011

Lysosomal degradation of membrane lipids.

Authors:
Thomas Kolter Konrad Sandhoff

FEBS Lett 2010 May 16;584(9):1700-12. Epub 2009 Oct 16.

LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany.

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May 2010

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.

Authors:
Reinhard Bauer André Voelzmann Bernadette Breiden Ute Schepers Hany Farwanah Ines Hahn Franka Eckardt Konrad Sandhoff Michael Hoch

EMBO J 2009 Dec 15;28(23):3706-16. Epub 2009 Oct 15.

LIMES-Institute, Program Unit Development, Genetics & Molecular Physiology, Laboratory for Molecular Developmental Biology, University of Bonn, Bonn, Germany.

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December 2009

Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.

Authors:
Silke Imgrund Dieter Hartmann Hany Farwanah Matthias Eckhardt Roger Sandhoff Joachim Degen Volkmar Gieselmann Konrad Sandhoff Klaus Willecke

J Biol Chem 2009 Nov 30;284(48):33549-60. Epub 2009 Sep 30.

Institute of Genetics, Division of Molecular Genetics, University of Bonn, Römerstrasse 164, 53117 Bonn, Germany.

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November 2009

Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.

Authors:
Christian Bach Sabine Gilch Romina Rost Alex D Greenwood Marion Horsch Glaucia N M Hajj Susanne Brodesser Axel Facius Sandra Schädler Konrad Sandhoff Johannes Beckers Christine Leib-Mösch Hermann M Schätzl Ina Vorberg

J Biol Chem 2009 Nov 11;284(45):31260-9. Epub 2009 Sep 11.

Institute of Virology, Technische Universität München, Trogerstrasse 30, 81675 Munich, Germany.

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November 2009

Normal phase liquid chromatography coupled to quadrupole time of flight atmospheric pressure chemical ionization mass spectrometry for separation, detection and mass spectrometric profiling of neutral sphingolipids and cholesterol.

Authors:
Hany Farwanah Jennifer Wirtz Thomas Kolter Klaus Raith Reinhard H H Neubert Konrad Sandhoff

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Oct 14;877(27):2976-82. Epub 2009 Jul 14.

LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk Str. 1, D-53121 Bonn, Germany.

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October 2009

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

Authors:
Ulrich Matzner Bernadette Breiden Günter Schwarzmann Afshin Yaghootfam Arvan L Fluharty Andrej Hasilik Konrad Sandhoff Volkmar Gieselmann

J Biol Chem 2009 Apr 18;284(14):9372-81. Epub 2009 Feb 18.

Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-University, 53115 Bonn, Germany.

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April 2009

Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology.

Authors:
Sabata Martino Ilaria di Girolamo Chiara Cavazzin Roberto Tiribuzi Rossella Galli Anna Rivaroli Manuela Valsecchi Konrad Sandhoff Sandro Sonnino Angelo Vescovi Angela Gritti Aldo Orlacchio

J Neurochem 2009 Apr 20;109(1):135-47. Epub 2009 Feb 20.

Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università di Perugia, Perugia, Italy.

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April 2009

Direct observation of the nanoscale dynamics of membrane lipids in a living cell.

Authors:
Christian Eggeling Christian Ringemann Rebecca Medda Günter Schwarzmann Konrad Sandhoff Svetlana Polyakova Vladimir N Belov Birka Hein Claas von Middendorff Andreas Schönle Stefan W Hell

Nature 2009 Feb 21;457(7233):1159-62. Epub 2008 Dec 21.

Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

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February 2009

Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation.

Authors:
Heike Schulze Thomas Kolter Konrad Sandhoff

Biochim Biophys Acta 2009 Apr 1;1793(4):674-83. Epub 2008 Nov 1.

LIMES Program Unit Membrane Biology and Lipid Biochemistry, Laboratory of Lipid Biochemistry, Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Germany.

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April 2009

Hexosaminidase assays.

Authors:
Michaela Wendeler Konrad Sandhoff

Glycoconj J 2009 Nov;26(8):945-52

LIMES, Membrane Biology and Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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November 2009

Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.

Authors:
Maxim Rossmann Robert Schultz-Heienbrok Joachim Behlke Natascha Remmel Claudia Alings Konrad Sandhoff Wolfram Saenger Timm Maier

Structure 2008 May;16(5):809-17

Institut für Chemie und Biochemie, Kristallographie, Freie Universität Berlin, Takustr. 6, 14195 Berlin, Germany.

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May 2008

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Authors:
Isabel Lastres-Becker Susanne Brodesser Dieter Lütjohann Mekhman Azizov Jana Buchmann Edith Hintermann Konrad Sandhoff Annette Schürmann Joachim Nowock Georg Auburger

Hum Mol Genet 2008 May 4;17(10):1465-81. Epub 2008 Feb 4.

Department of Neurology, J.W. Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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May 2008

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.

Authors:
Roch-Philippe Charles Marjorie Guitard Céline Leyvraz Bernadette Breiden Marek Haftek Zofia Haftek-Terreau Jean-Christophe Stehle Konrad Sandhoff Edith Hummler

J Biol Chem 2008 Feb 26;283(5):2622-30. Epub 2007 Nov 26.

Département de Pharmacologie & de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, Switzerland.

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February 2008

Overexpression and mass spectrometry analysis of mature human acid ceramidase.

Authors:
Heike Schulze Ute Schepers Konrad Sandhoff

Biol Chem 2007 Dec;388(12):1333-43

LIMES Membrane Biology and Lipid Biochemistry Unit, University Bonn, c/o Kekulé-Institute, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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December 2007

Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides.

Authors:
Bernadette Breiden Hichem Gallala Thomas Doering Konrad Sandhoff

Eur J Cell Biol 2007 Dec 21;86(11-12):657-73. Epub 2007 Aug 21.

LIMES, Membrane Biology & Lipid Biochemistry Unit, Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2007

Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity.

Authors:
Natascha Remmel Silvia Locatelli-Hoops Bernadette Breiden Guenter Schwarzmann Konrad Sandhoff

FEBS J 2007 Jul 11;274(13):3405-20. Epub 2007 Jun 11.

LIMES, Membrane Biology & Lipid Biochemistry Unit, c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Germany.

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July 2007

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein.

Authors:
Jonathan O Babalola Michaela Wendeler Bernadette Breiden Christoph Arenz Guenter Schwarzmann Silvia Locatelli-Hoops Konrad Sandhoff

Biol Chem 2007 Jun;388(6):617-26

LIMES Membrane Biology and Lipid Biochemistry Unit, University of Bonn, c/o Kekulé Institute, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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June 2007

Separation and mass spectrometric characterization of covalently bound skin ceramides using LC/APCI-MS and Nano-ESI-MS/MS.

Authors:
Hany Farwanah Barbara Pierstorff Christian E H Schmelzer Klaus Raith Reinhard H H Neubert Thomas Kolter Konrad Sandhoff

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jun 24;852(1-2):562-70. Epub 2007 Feb 24.

LIMES-Life and Medical Sciences Bonn, Program Unit Membrane and Lipid Biochemistry, Laboratory of Biology & Lipid Biochemistry, Friedrichs-Wilhelm-University, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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June 2007

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.

Authors:
Ralph Gareus Marion Huth Bernadette Breiden Arianna Nenci Nora Rösch Ingo Haase Wilhelm Bloch Konrad Sandhoff Manolis Pasparakis

Nat Cell Biol 2007 Apr 11;9(4):461-9. Epub 2007 Mar 11.

Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany.

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April 2007

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

Authors:
Andreas Rummel Timo Eichner Tanja Weil Tino Karnath Aleksandrs Gutcaits Stefan Mahrhold Konrad Sandhoff Richard L Proia K Ravi Acharya Hans Bigalke Thomas Binz

Proc Natl Acad Sci U S A 2007 Jan 21;104(1):359-64. Epub 2006 Dec 21.

Institut für Biochemie, OE 4310, and Institut für Toxikologie, OE 5340, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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January 2007

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

Authors:
Richard Jennemann Roger Sandhoff Lutz Langbein Sylvia Kaden Ulrike Rothermel Hichem Gallala Konrad Sandhoff Herbert Wiegandt Hermann-Josef Gröne

J Biol Chem 2007 Feb 4;282(5):3083-94. Epub 2006 Dec 4.

Department of Cellular und Molecular Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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February 2007

Saposin A mobilizes lipids from low cholesterol and high bis(monoacylglycerol)phosphate-containing membranes: patient variant Saposin A lacks lipid extraction capacity.

Authors:
Silvia Locatelli-Hoops Natascha Remmel Ralf Klingenstein Bernadette Breiden Maksim Rossocha Maike Schoeniger Christine Koenigs Wolfram Saenger Konrad Sandhoff

J Biol Chem 2006 Oct 12;281(43):32451-60. Epub 2006 Aug 12.

Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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October 2006

Sphingolipid metabolism diseases.

Authors:
Thomas Kolter Konrad Sandhoff

Biochim Biophys Acta 2006 Dec 14;1758(12):2057-79. Epub 2006 Jun 14.

Kekulé-Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2006

Characterization of human saposins by NMR spectroscopy.

Authors:
Michael John Michaela Wendeler Markus Heller Konrad Sandhoff Horst Kessler

Biochemistry 2006 Apr;45(16):5206-16

Department Chemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

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April 2006

Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris.

Authors:
Robert Schultz-Heienbrok Natascha Remmel R Klingenstein Maksim Rossocha Konrad Sandhoff Wolfram Saenger Timm Maier

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Feb 27;62(Pt 2):117-20. Epub 2006 Jan 27.

Institut für Chemie und Biochemie/Kristallographie, Freie Universität Berlin, Germany.

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February 2006

The enzyme-binding region of human GM2-activator protein.

Authors:
Michaela Wendeler Norbert Werth Timm Maier Guenter Schwarzmann Thomas Kolter Maike Schoeniger Daniel Hoffmann Thorsten Lemm Wolfram Saenger Konrad Sandhoff

FEBS J 2006 Mar;273(5):982-91

Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Germany.

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March 2006

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

Authors:
Florian Winau Stephan Weber Subash Sad Juana de Diego Silvia Locatelli Hoops Bernadette Breiden Konrad Sandhoff Volker Brinkmann Stefan H E Kaufmann Ulrich E Schaible

Immunity 2006 Jan;24(1):105-17

Department of Immunology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany.

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January 2006

Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.

Authors:
Tadashi Yamashita Maria Laura Allende Danielle N Kalkofen Norbert Werth Konrad Sandhoff Richard L Proia

Genesis 2005 Dec;43(4):175-80

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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December 2005

Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense.

Authors:
Thomas Kolter Florian Winau Ulrich E Schaible Matthias Leippe Konrad Sandhoff

J Biol Chem 2005 Dec 17;280(50):41125-8. Epub 2005 Oct 17.

Kekulé-Institut für Organische Chemie und Biochemie, D-53121 Bonn, Germany.

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December 2005

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.

Authors:
Thomas Kolter Konrad Sandhoff

Annu Rev Cell Dev Biol 2005 ;21:81-103

Kekulé-Institut für Organische Chemie und Biochemie der Universität, 53121 Bonn, Germany.

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January 2006

Amplification and overexpression of prosaposin in prostate cancer.

Authors:
Shahriar Koochekpour Yu-Jun Zhuang Rameen Beroukhim Chia-Ling Hsieh Matthias D Hofer Haiyen E Zhau Masao Hiraiwa Daniel Y Pattan Joy L Ware Ronald B Luftig Konrad Sandhoff Charles L Sawyers Kenneth J Pienta Mark A Rubin Robert L Vessella William R Sellers Oliver Sartor

Genes Chromosomes Cancer 2005 Dec;44(4):351-64

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

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December 2005

Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system.

Authors:
Günter Schwarzmann Michaela Wendeler Konrad Sandhoff

Glycobiology 2005 Dec 3;15(12):1302-11. Epub 2005 Aug 3.

Kekulé-Institute für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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December 2005

A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A.

Authors:
Andrew J Norris Julian P Whitelegge Arman Yaghoubian Jean-Rene Alattia Gilbert G Privé Tatsushi Toyokuni Hubert Sun Mai N Brooks Luigi Panza Pamela Matto Federica Compostella Natascha Remmel Ralf Klingenstein Konrad Sandhoff Claire Fluharty Arvan Fluharty Kym F Faull

J Lipid Res 2005 Oct 1;46(10):2254-64. Epub 2005 Aug 1.

Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA.

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October 2005

The epidermal barrier function is dependent on the serine protease CAP1/Prss8.

Authors:
Céline Leyvraz Roch-Philippe Charles Isabelle Rubera Marjorie Guitard Samuel Rotman Bernadette Breiden Konrad Sandhoff Edith Hummler

J Cell Biol 2005 Aug;170(3):487-96

Département de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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August 2005

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.

Authors:
Irfan Y Tamboli Kai Prager Esther Barth Michael Heneka Konrad Sandhoff Jochen Walter

J Biol Chem 2005 Jul 27;280(30):28110-7. Epub 2005 May 27.

Department of Neurology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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July 2005

Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.

Authors:
Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff Ardalan Minokadeh David Y Patten

Asian J Androl 2005 Jun;7(2):147-58

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 4-17, New Orleans, LA 70112, USA.

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June 2005

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.

Authors:
Jose Antonio Chavez William L Holland Julia Bär Konrad Sandhoff Scott A Summers

J Biol Chem 2005 May 17;280(20):20148-53. Epub 2005 Mar 17.

Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, 84132, USA.

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May 2005

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.

Authors:
Tadashi Yamashita Yun-Ping Wu Roger Sandhoff Norbert Werth Hiroki Mizukami Jessica M Ellis Jeffrey L Dupree Rudolf Geyer Konrad Sandhoff Richard L Proia

Proc Natl Acad Sci U S A 2005 Feb 14;102(8):2725-30. Epub 2005 Feb 14.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2005

Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation.

Authors:
Julia Reichelt Bernadette Breiden Konrad Sandhoff Thomas M Magin

Eur J Cell Biol 2004 Dec;83(11-12):747-59

Institut für Physiologische Chemie, Universität Bonn, Bonn, Germany.

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December 2004

Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism.

Authors:
Hichem Gallala Oliver Macheleidt Thomas Doering Volker Schreiner Konrad Sandhoff

Eur J Cell Biol 2004 Dec;83(11-12):667-79

Kekulé Institut für Organische Chemie und Biochemie der Universität Bonn, Bonn, Germany.

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December 2004

Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase.

Authors:
Melanie Kölzer Klaus Ferlinz Oliver Bartelsen Silvia Locatelli Hoops Florian Lang Konrad Sandhoff

Biol Chem 2004 Dec;385(12):1193-5

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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December 2004

Site-specific cleavage--a model system for the identification of lipid-modified glutamate residues in proteins.

Authors:
Peter Sawatzki Ingo Damm Barbara Pierstorff Heike Hupfer Konrad Sandhoff Thomas Kolter

Chembiochem 2005 Jan;6(1):178-85

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk Strasse 1, 53121 Bonn, Germany.

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January 2005

Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells.

Authors:
Shahriar Koochekpour Oliver Sartor Tae-Jin Lee Arthur Zieske David Y Patten Masao Hiraiwa Konrad Sandhoff Natascha Remmel Ardalan Minokadeh

Prostate 2004 Oct;61(2):114-23

Department of Microbiology, Immunology, and Parasitology, Louisiana State University-Health Sciences Center, New Orleans, Louisiana, USA.

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October 2004

Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation.

Authors:
Madanan Madathiparambil Gopalakrishnan Hans-Wilhelm Grosch Silvia Locatelli-Hoops Norbert Werth Eva Smolenová Michael Nettersheim Konrad Sandhoff Andrej Hasilik

Biochem J 2004 Nov;383(Pt. 3):507-15

Institute of Physiological Chemistry, Philipps-University Marburg, Karl-von-Frisch-Strasse 1, 35033 Marburg, Germany.

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November 2004

Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease.

Authors:
Rosaria Buccoliero Jacques Bodennec Gerhild Van Echten-Deckert Konrad Sandhoff Anthony H Futerman

J Neurochem 2004 Jul;90(1):80-8

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

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July 2004

Severe subacute GM2 gangliosidosis caused by an apparently silent HEXA mutation (V324V) that results in aberrant splicing and reduced HEXA mRNA.

Authors:
Brandy A Wicklow Jennifer L Ivanovich Margot M Plews Timothy J Salo Michael J Noetzel Gregg T Lueder Luca Cartegni Michael M Kaback Konrad Sandhoff Robert D Steiner Barbara L Triggs-Raine

Am J Med Genet A 2004 Jun;127A(2):158-66

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada.

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June 2004

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine.

Authors:
Melanie Kölzer Norbert Werth Konrad Sandhoff

FEBS Lett 2004 Feb;559(1-3):96-8

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.

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February 2004

Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization.

Authors:
Michaela Wendeler Joerg Hoernschemeyer Michael John Norbert Werth Maike Schoeniger Thorsten Lemm Rudolf Hartmann Horst Kessler Konrad Sandhoff

Protein Expr Purif 2004 Mar;34(1):147-57

Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, Bonn D-53121, Germany.

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March 2004

Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation.

Authors:
Michaela Wendeler Joerg Hoernschemeyer Daniel Hoffmann Thomas Kolter Guenter Schwarzmann Konrad Sandhoff

Eur J Biochem 2004 Feb;271(3):614-27

Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, D-53121 Bonn, Germany.

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February 2004

Saposin C is required for lipid presentation by human CD1b.

Authors:
Florian Winau Vera Schwierzeck Robert Hurwitz Natascha Remmel Peter A Sieling Robert L Modlin Steven A Porcelli Volker Brinkmann Masahiko Sugita Konrad Sandhoff Stefan H E Kaufmann Ulrich E Schaible

Nat Immunol 2004 Feb 11;5(2):169-74. Epub 2004 Jan 11.

Max-Planck-Institute for Infection Biology, Department of Immunology, Schumannstrasse 21-22, D-10117 Berlin, Germany.

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February 2004

Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay.

Authors:
Michaela Wendeler Helmut Reilaender Joerg Hoernschemeyer Guenter Schwarzmann Thomas Kolter Konrad Sandhoff

Methods Enzymol 2003 ;363:476-89

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

Interaction of the GM2 activator protein with sulfated and sialylated glycosphingolipids.

Authors:
Stefan T Hepbildikler Michaela Wendeler Roger Sandhoff Konrad Sandhoff

Methods Enzymol 2003 ;363:207-22

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

RNA interference: analyzing the function of glycoproteins and glycosylating proteins in mammalian cells.

Authors:
Mustapha Diallo Christoph Arenz Katja Schmitz Konrad Sandhoff Ute Schepers

Methods Enzymol 2003 ;363:173-90

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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December 2003

Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase.

Authors:
Melanie Kölzer Christoph Arenz Klaus Ferlinz Norbert Werth Heike Schulze Ralf Klingenstein Konrad Sandhoff

Biol Chem 2003 Sep;384(9):1293-8

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strassel, D-53121 Bonn, Germany.

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September 2003