Kokichi Sugano

Kokichi Sugano

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Kokichi Sugano

Kokichi Sugano

Publications by authors named "Kokichi Sugano"

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Germline pathogenic variants in 7,636 Japanese patients with prostate cancer and 12,366 controls.

J Natl Cancer Inst 2019 Jun 19. Epub 2019 Jun 19.

RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/jnci/djz124DOI Listing
June 2019

Extremely young case of small bowel intussusception due to Peutz-Jeghers syndrome with nonsense mutation of STK11.

Clin J Gastroenterol 2019 Mar 19. Epub 2019 Mar 19.

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Utsunomiya, Tochigi, Japan.

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http://dx.doi.org/10.1007/s12328-019-00964-0DOI Listing
March 2019

Peritoneal cancer arising after total abdominal hysterectomy and bilateral salpingo-oophorectomy for cervical cancer in a patient with right breast cancer and germline mutation of BRCA1 gene: a case report and literature review.

Breast Cancer 2018 Mar 1;25(2):243-249. Epub 2017 Nov 1.

Clinic of Cancer Prevention and Genetic Counseling, Tochigi Cancer Center, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan.

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http://dx.doi.org/10.1007/s12282-017-0813-9DOI Listing
March 2018

Cytoplasmic MSH2 immunoreactivity in a patient with Lynch syndrome with an EPCAM-MSH2 fusion.

Histopathology 2017 Mar 28;70(4):664-669. Epub 2016 Nov 28.

Department of Genetic Medicine and Services, National Cancer Centre Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/his.13104DOI Listing
March 2017

Carcinoma of the lower uterine segment diagnosed with Lynch syndrome based on MSH6 germline mutation: A case report.

J Obstet Gynaecol Res 2017 Feb 8;43(2):416-420. Epub 2016 Dec 8.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jog.13202DOI Listing
February 2017

Muir-Torre syndrome caused by exonic deletion of MLH1 due to homologous recombination.

Eur J Dermatol 2017 Feb;27(1):54-58

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1684/ejd.2016.2916DOI Listing
February 2017

Age- and Gender-Specific Risk of Thyroid Cancer in Patients With Familial Adenomatous Polyposis.

J Clin Endocrinol Metab 2016 12 13;101(12):4611-4617. Epub 2016 Sep 13.

Noguchi Thyroid Clinic and Hospital Foundation (S.U., S.N.), Oita, Japan 874-0902; Department of Molecular-Targeting Cancer Prevention (H.I., T.S.), Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan 602-0841; Ishikawa Gastrointestinal Clinic (H.I., M.M.), Osaka, Japan 541-0042; Kuma Hospital (A.M., M.H.), Kobe, Japan 650-0011; Division of Genetics (M.U., T.Y.), National Cancer Center Research Institute, Tokyo, Japan 104-0045; and Oncogene Research Unit/Cancer Prevention Unit (K.S.), Tochigi Cancer Center, Utsunomiya, Japan 320-0834.

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http://dx.doi.org/10.1210/jc.2016-2043DOI Listing
December 2016

BRCA2: a grown-up cancer susceptibility gene.

Endocr Relat Cancer 2016 10;23(10):E1-3

Oncogene Research Unit/Cancer Prevention UnitTochigi Cancer Center Research Institute, Tochigi, Japan.

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http://dx.doi.org/10.1530/ERC-16-0354DOI Listing
October 2016

Mismatch repair deficiency in Lynch syndrome-associated colorectal adenomas is more prevalent in older patients.

Histopathology 2016 Aug 21;69(2):322-8. Epub 2016 Mar 21.

Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/his.12941DOI Listing
August 2016

Mutation analysis of MUTYH in Japanese colorectal adenomatous polyposis patients.

Fam Cancer 2016 Apr;15(2):261-5

Clinical Genetic Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

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http://dx.doi.org/10.1007/s10689-015-9857-1DOI Listing
April 2016

Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene.

Hum Genome Var 2016 3;3:16002. Epub 2016 Mar 3.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan; Oncogene Research Unit / Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi, Japan.

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http://dx.doi.org/10.1038/hgv.2016.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775769PMC
April 2016

Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features.

Histopathology 2015 Nov 14;67(5):689-98. Epub 2015 May 14.

Division of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.

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http://doi.wiley.com/10.1111/his.12705
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http://dx.doi.org/10.1111/his.12705DOI Listing
November 2015

Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer.

Int J Gynecol Cancer 2015 Sep;25(7):1165-72

*Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo; †Department of Pathology, Tochigiken Saiseikai Utsunomiya Hospital, Tochigi; and ‡Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi, Japan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/IGC.0000000000000482DOI Listing
September 2015

Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers.

BMC Res Notes 2014 Nov 24;7:835. Epub 2014 Nov 24.

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, 4-9-13, Yohnan, Utsunomiya, Tochigi 320-0834, Japan.

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http://dx.doi.org/10.1186/1756-0500-7-835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253604PMC
November 2014

Clinicopathological study of SDHB mutation-related pheochromocytoma and sympathetic paraganglioma.

Endocr Relat Cancer 2014 Jun 6;21(3):L13-6. Epub 2014 May 6.

Pathology Division, Department of Clinical Research National Hospital Organization, Hakodate Hospital, 18-16 Kawahara, Hakodate, Hokkaido, 041-8512 Japan Division of Sports Medicine, Faculty of Medicine University of Tsukuba, Tsukuba Japan Division of Molecular Pathology, Department of Pathology School of Medicine, Tohoku University, Sendai Japan Division of Nephrology, Endocrinology and Vascular Medicine Department of Medicine, School of Medicine, Tohoku University, Sendai Japan Department of Breast and Endocrine Surgery, Aichi Medical School of Medicine, Nagoya Japan Department of Endocrinology and Metabolism Hamamatsu Medical School, Hamamatsu Japan Division of Thoracic Surgery, Department of Thoracic and Cardiovascular Surgery Kansai Medical University, Hirakata Japan Department of Diabetes, Endocrinology and Metabolism Fukushima Medical School, Fukushima Japan First Department of Internal Medicine, School of Medicine University of Occupational and Environmental Health, Kitakyusyu Japan Department of Medicine and Molecular Science Graduate School of Medicine, Gunma University, Maebashi Japan Department of Surgery, Nippon Telegraph and Telephone East Corporation Medical Center, Tokyo Japan Department of Internal Medicine School of Medicine, Keio University, Tokyo Japan Genetic Counseling Clinic National Cancer Center, Tokyo Japan Department of Oncology Musashino Red Cross Hospital, Tokyo Japan Department of Breast and Endocrine Surgery Mitsui Memorial Hospital, Tokyo Japan Department of Endocrinology and Metabolism Japan Labour Health and Welfare Organization, Yokohama Rosai Hospital, Yokohama Japan Department of Endocrinology, Metabolism and Hypertension National Hospital Organization Kyoto Medical Center, Kyoto Japan.

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http://dx.doi.org/10.1530/ERC-13-0530DOI Listing
June 2014

The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.

Mol Cancer Ther 2014 May 27;13(5):1170-80. Epub 2014 Feb 27.

Authors' Affiliations: Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Department of Surgery, Tochigi Cancer Center, Utsunomiya; and Department of Gastrointestinal Surgery and Division of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0683DOI Listing
May 2014

A Case Report of Hepatocellular Carcinoma in a Non-cirrhotic Patient With Liver Iron Overload Associated With Myelodysplastic Syndrome.

World J Oncol 2013 Dec 16;4(6):248-251. Epub 2014 Jan 16.

Department of Surgery, Saiseikai Utsunomiya Hospital, 911-1 Takebayashimachi, Utsunomiya, Tochigi 321-0974, Japan.

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http://dx.doi.org/10.4021/wjon611eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649850PMC
December 2013

Cell diameter measurements obtained with a handheld cell counter could be used as a surrogate marker of G2/M arrest and apoptosis in colon cancer cell lines exposed to SN-38.

Biochem Biophys Res Commun 2013 May 11;434(4):753-9. Epub 2013 Apr 11.

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Utsunomiya, Tochigi, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X130060
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http://dx.doi.org/10.1016/j.bbrc.2013.03.128DOI Listing
May 2013

Impact of recent parity on histopathological tumor features and breast cancer outcome in premenopausal Japanese women.

Breast Cancer Res Treat 2013 Apr 4;138(3):941-50. Epub 2013 Apr 4.

Division of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1007/s10549-013-2507-0DOI Listing
April 2013

Pathogenicity of A600V variant in exon 12 of the MSH2 gene detected in a Japanese kindred with Lynch syndrome.

Jpn J Clin Oncol 2012 Jan 14;42(1):78-82. Epub 2011 Nov 14.

Department of Surgery, Jichi Medical University, 3311-1 Yakushiji Shimotsuke, Tochigi 329-0498, Japan.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
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http://dx.doi.org/10.1093/jjco/hyr162DOI Listing
January 2012

[Discussion meeting on the relevance of genetic testing in clinical practice].

Nihon Naika Gakkai Zasshi 2011 Nov;100(11):3292-313

Department of Laboratory Medicine, School of Medicine, Keio University, Japan.

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http://dx.doi.org/10.2169/naika.100.3292DOI Listing
November 2011

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue.

Cancer Res 2010 Oct 14;70(20):8169-78. Epub 2010 Sep 14.

Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA.

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http://cancerres.aacrjournals.org/content/early/2010/10/07/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955801PMC
October 2010

[NCC-ST-439].

Authors:
Kokichi Sugano

Nihon Rinsho 2010 Jul;68 Suppl 7:726-8

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute.

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July 2010

Gene expression profiles and microsatellite instability in uterine corpus endometrioid adenocarcinoma.

J Obstet Gynaecol Res 2010 Apr;36(2):336-43

Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8, Kandasurugadai, Chiyodaku, Tokyo 101-0034, Japan.

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http://dx.doi.org/10.1111/j.1447-0756.2009.01142.xDOI Listing
April 2010

siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines.

Photochem Photobiol 2009 Jul-Aug;85(4):1020-7. Epub 2009 Mar 20.

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi, Japan.

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http://dx.doi.org/10.1111/j.1751-1097.2009.00543.xDOI Listing
September 2009

Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping.

Biochem Biophys Res Commun 2007 Nov 27;362(4):865-71. Epub 2007 Aug 27.

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, 4-9-13 Yonan, Utsunomiya, Tochigi 320-0834, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.092DOI Listing
November 2007

[Present conditions and problems in gene diagnosis of colon neoplasms].

Authors:
Kokichi Sugano

Nihon Naika Gakkai Zasshi 2007 Feb;96(2):231-8

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http://dx.doi.org/10.2169/naika.96.231DOI Listing
February 2007

Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.

Nat Clin Pract Urol 2006 Dec;3(12):642-52

Oncogene Research Unit/Cancer Prevention Unit in Tochigi Cancer Center Research Institute, Utsunomiya, Japan.

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http://dx.doi.org/10.1038/ncpuro0649DOI Listing
December 2006

Allelic status of chromosomes 17p, 18q, 22q [corrected] 3p and their clinical usefulness in colorectal cancer.

Anticancer Res 2006 Jul-Aug;26(4B):2833-40

Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.

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September 2006

[Genetic testing and gene-based testing for familial tumor].

Authors:
Kokichi Sugano

Nihon Rinsho 2005 Dec;63 Suppl 12:191-5

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute.

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December 2005

[NCC-ST-439].

Authors:
Kokichi Sugano

Nihon Rinsho 2005 Aug;63 Suppl 8:681-3

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute.

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August 2005

Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability-positive endometrial cancer.

Clin Cancer Res 2005 May;11(10):3949-57

Division of Cellular Signaling, Institute for Advanced Medical Research, Department of Obstetrics and Gynecology, School of Medicine, Keio University, Department of Advanced Medical Science, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1702DOI Listing
May 2005

Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot.

J Hum Genet 2004 8;49(11):635-41. Epub 2004 Oct 8.

Tumor Suppression and the Functional Genomics Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1007/s10038-004-0201-0DOI Listing
April 2005

High resolution for single-strand conformation polymorphism analysis by capillary electrophoresis.

Anal Chem 2004 Oct;76(20):6122-9

Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo 185-8601, Japan.

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http://dx.doi.org/10.1021/ac049385kDOI Listing
October 2004

Association of HNPCC and endometrial cancers.

Int J Clin Oncol 2004 Aug;9(4):262-9

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10147-004-0402-8DOI Listing
August 2004

Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma.

Cancer 2004 Jul;101(2):395-403

Psycho-Oncology Division, National Cancer Center Research Institute East, Chiba, Japan.

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http://dx.doi.org/10.1002/cncr.20363DOI Listing
July 2004

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability.

Clin Gastroenterol Hepatol 2004 Feb;2(2):147-56

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi, Japan.

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February 2004

Outpatient clinic for genetic counseling and gene testing of retinoblastoma.

Int J Clin Oncol 2004 Feb;9(1):25-30

Genetic Counseling Clinic, National Cancer Center Hospital, Tokyo, Japan.

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February 2004

Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer.

Clin Cancer Res 2003 Nov;9(15):5675-82

Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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November 2003

Promoter hypermethylation in cancer silences LDHB, eliminating lactate dehydrogenase isoenzymes 1-4.

Clin Chem 2003 Sep;49(9):1518-20

Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

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September 2003

[Cancer susceptibility and familial predisposition in colorectal cancer].

Nihon Rinsho 2003 Sep;61 Suppl 7:47-51

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Research Institute.

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September 2003

Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ.

J Urol 2003 Apr;169(4):1541-5

Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute and Department of Urology, Tochigi Cancer Hospital, Japan.

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http://dx.doi.org/10.1097/01.ju.0000046242.55722.1cDOI Listing
April 2003

[Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system].

Rinsho Byori 2003 Apr;51(4):306-12

Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192.

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April 2003

Electrophoretic variant of a lactate dehydrogenase isoenzyme and selective promoter methylation of the LDHA gene in a human retinoblastoma cell line.

Clin Chem 2002 Nov;48(11):1938-45

Department of Laboratory Medicine,Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

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November 2002

Frequent detection of human papilloma viruses in cervical dysplasia by PCR single-strand DNA-conformational polymorphism analysis.

Anticancer Res 2002 May-Jun;22(3):1655-60

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

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September 2002

A novel germline mutation of hMLH1 in a patient with hereditary non-polyposis colorectal cancer.

Jpn J Clin Oncol 2002 Jun;32(6):215-8

Department of Surgery, Hoshi General Hospital, Koriyama, Fukushima, Japan.

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http://dx.doi.org/10.1093/jjco/hyf048DOI Listing
June 2002

Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.

Jpn J Clin Oncol 2002 Jun;32(6):219-21

Department of Surgery, Jichi Medical School, Minami Kawachi, Tochigi, Japan.

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http://dx.doi.org/10.1093/jjco/hyf043DOI Listing
June 2002

Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer.

Jpn J Clin Oncol 2002 Jan;32(1):9-13

Division of Gastrointestinal Oncology, Department of Medicine, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1093/jjco/hyf007DOI Listing
January 2002