Kok-Seong Lim

Kok-Seong Lim

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Kok-Seong Lim

Kok-Seong Lim

Publications by authors named "Kok-Seong Lim"

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16Publications

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The mA pathway facilitates sex determination in Drosophila.

Nat Commun 2017 07 4;8:15737. Epub 2017 Jul 4.

Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York City, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms15737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500889PMC
July 2017

m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome.

Nat Methods 2016 08 4;13(8):692-8. Epub 2016 Jul 4.

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704921PMC
August 2016

A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications.

Methods Enzymol 2015 17;560:29-71. Epub 2015 Jul 17.

Singapore-MIT Alliance for Research and Technology, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774897PMC
May 2016

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Cell Stem Cell 2014 Dec 16;15(6):707-19. Epub 2014 Oct 16.

Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278749PMC
December 2014

Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry.

Nat Protoc 2014 Apr 13;9(4):828-41. Epub 2014 Mar 13.

1] Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Singapore-MIT Alliance for Research and Technology, Campus for Research Excellence and Technical Enterprise (CREATE), Singapore. [3] Center for Environmental Health Science, MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2014.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313537PMC
April 2014

In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra.

J Am Chem Soc 2012 Oct 22;134(43):18053-64. Epub 2012 Oct 22.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/ja307525hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503518PMC
October 2012

Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation.

Chem Res Toxicol 2012 Feb 2;25(2):366-73. Epub 2011 Dec 2.

Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/tx200422gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288455PMC
February 2012

Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin.

Molecules 2011 Jun 21;16(6):5168-81. Epub 2011 Jun 21.

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.3390/molecules16065168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264175PMC
June 2011

Determination of DNA mutation load in human tissues using denaturing HPLC-based heteroduplex analysis.

Methods Mol Biol 2009 ;554:287-99

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://link.springer.com/10.1007/978-1-59745-521-3_18
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http://dx.doi.org/10.1007/978-1-59745-521-3_18DOI Listing
October 2009

Pitfalls in the denaturing high-performance liquid chromatography analysis of mitochondrial DNA mutation.

J Mol Diagn 2008 Jan 28;10(1):102-8. Epub 2007 Dec 28.

Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.2353/jmoldx.2008.070081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175549PMC
January 2008

Quantitative gas chromatography mass spectrometric analysis of 2'-deoxyinosine in tissue DNA.

Nat Protoc 2006 ;1(4):1995-2002

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/nprot.2006.301DOI Listing
October 2007

Quantitative mitochondrial DNA mutation analysis by denaturing HPLC.

Clin Chem 2007 Jun 19;53(6):1046-52. Epub 2007 Apr 19.

Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093-0935, USA.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2006.083303
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http://dx.doi.org/10.1373/clinchem.2006.083303DOI Listing
June 2007

Potential artifacts in the measurement of DNA deamination.

Free Radic Biol Med 2006 Jun 20;40(11):1939-48. Epub 2006 Feb 20.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.01.030DOI Listing
June 2006

Oxidative damage in mitochondrial DNA is not extensive.

Ann N Y Acad Sci 2005 May;1042:210-20

Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597.

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http://doi.wiley.com/10.1196/annals.1338.023
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http://dx.doi.org/10.1196/annals.1338.023DOI Listing
May 2005

Do mitochondria make nitric oxide? no?

Free Radic Res 2004 Jun;38(6):591-9

Department of Biochemistry, Faculty of Medicine, National University of Singapore, MD 7 #02-07, 8 Medical Drive, Singapore 117597, Singapore.

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http://dx.doi.org/10.1080/10715760410001694008DOI Listing
June 2004