Publications



A case series of histoplasmosis patients with elevated serum soluble interleukin-2 receptor levels.
J Infect Chemother 2017 Sep 8;23(9):642-647. Epub 2017 Apr 8.
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan.

Tedizolid inhibits MUC5AC production induced by methicillin-resistant Staphylococcus aureus in human airway epithelial cells.
J Infect Chemother 2017 Sep 17;23(9):598-603. Epub 2017 Jul 17.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address:

Comparative efficacies of daptomycin, vancomycin, and linezolid in experimental enterococcal peritonitis.
J Infect Chemother 2017 Jul 17;23(7):498-501. Epub 2017 Jan 17.
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.






Quantitative detection of periodontopathic bacteria in lower respiratory tract specimens by real-time PCR.
J Infect Chemother 2017 Feb 26;23(2):69-73. Epub 2016 Nov 26.
Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Global COE Program, Nagasaki University, Nagasaki, Japan.

Efficacy of High-Dose Meropenem (Six Grams per Day) in Treatment of Experimental Murine Pneumonia Induced by Meropenem-Resistant Pseudomonas aeruginosa.
Antimicrob Agents Chemother 2017 Jan 27;61(1). Epub 2016 Dec 27.
Unit of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection.
Int J Med Microbiol 2016 Sep 19;306(6):421-8. Epub 2016 May 19.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.



The world first two cases of severe fever with thrombocytopenia syndrome: An epidemiological study in Nagasaki, Japan.
J Infect Chemother 2016 Jul 30;22(7):461-5. Epub 2016 Apr 30.
Infection Control and Education Center, Nagasaki University Hospital, Japan; Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan. Electronic address:

A mortality prediction rule for non-elderly patients with community-acquired pneumonia.
BMC Pulm Med 2016 Mar 8;16:39. Epub 2016 Mar 8.
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.




Partial lung resection of supernumerary tracheal bronchus combined with pulmonary artery sling in an adult: report of a case.
Gen Thorac Cardiovasc Surg 2015 Mar 13;63(3):173-6. Epub 2013 Jul 13.
Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan,

Clinical significance of methicillin-resistant coagulase-negative staphylococci obtained from sterile specimens.
Diagn Microbiol Infect Dis 2015 Jan 30;81(1):71-5. Epub 2014 Sep 30.
Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address:

Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan.
J Infect Chemother 2015 Jan 29;21(1):23-30. Epub 2014 Oct 29.
Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Contribution of the Slt2-regulated transcription factors to echinocandin tolerance in Candida glabrata.
FEMS Yeast Res 2014 Nov 19;14(7):1128-31. Epub 2014 Sep 19.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.


Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells.
Pulm Pharmacol Ther 2014 Aug 6;28(2):165-70. Epub 2014 Jun 6.
Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki, Japan; Global COE Program, Nagasaki University, Nagasaki, Japan.

Immunomodulatory effect of linezolid on methicillin-resistant Staphylococcus aureus supernatant-induced MUC5AC overexpression in human airway epithelial cells.
Antimicrob Agents Chemother 2014 Jul 12;58(7):4131-7. Epub 2014 May 12.
Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.


Predictors of the pathogenicity of methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Respirology 2014 May 8;19(4):556-62. Epub 2014 Apr 8.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; First Department of Internal Medicine, Hokkaido University Hospital, Hokkaido, Japan.


Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature.
J Infect Chemother 2014 Mar 11;20(3):181-5. Epub 2013 Dec 11.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.




Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report.
BMC Infect Dis 2014 Feb 28;14:114. Epub 2014 Feb 28.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan.

Establishment of a new murine model of liver abscess induced by Fusobacterium necrophorum injected into the caudal vein.
J Med Microbiol 2013 Nov 23;62(Pt 11):1755-9. Epub 2013 Aug 23.
1Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Pulmonary artery pseudoaneurysm caused by Streptococcus constellatus.
Int J Infect Dis 2013 Nov 30;17(11):e1064-6. Epub 2013 Apr 30.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki 852-8501, Japan.


Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia.
Antimicrob Agents Chemother 2013 Aug 20;57(8):3653-8. Epub 2013 May 20.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.


Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae.
Clin Vaccine Immunol 2013 Jul 1;20(7):977-85. Epub 2013 May 1.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan.





Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan.
J Infect Chemother 2013 Apr 24;19(2):291-8. Epub 2013 Jan 24.
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, Japan.

Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC production in human airway epithelial cells.
Antimicrob Agents Chemother 2013 Apr 4;57(4):1844-9. Epub 2013 Feb 4.
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.





The efficacy and safety of high-dose arbekacin sulfate therapy (once-daily treatment) in patients with MRSA infection.
J Infect Chemother 2012 Apr 8;18(2):241-6. Epub 2012 Mar 8.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.












Roles of vacuolar H+-ATPase in the oxidative stress response of Candida glabrata.
FEMS Yeast Res 2016 08 1;16(5). Epub 2016 Jul 1.
Second Department of Internal Medicine, Nagasaki University, Nagasaki 852-8501, Japan Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.


Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model.
J Pharmacol Exp Ther 2016 09 11;358(3):457-63. Epub 2016 Jul 11.
Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology (T.H., K.I.), Department of Cardiopulmonary Rehabilitation Sciences (Y.I.), Department of Respiratory Medicine (N.S., H.M.), and Department of Laboratory Medicine (K.K, K.Y.), Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan (T.H., A.H., T.M., S.N., T.K., N.S., H.M., S.K.).




OF