Kohei Kaku

Kohei Kaku

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Kohei Kaku

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Dramatic Improvement of Glycemic Control by Promptly Starting Steroid Therapy at an Early Stage of Autoimmune Pancreatitis in a Subject with Type 2 Diabetes.

Authors:
Shintaro Irie Takatoshi Anno Emiko Uji Jun Nakamura Fumiko Kawasaki Hirofumi Kawamoto Kohei Kaku Hideaki Kaneto

Intern Med 2019 Dec 31;58(23):3427-3431. Epub 2019 Jul 31.

Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.3198-19DOI Listing
December 2019

Superior efficacy with a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin-naïve Japanese patients with type 2 diabetes in a phase 3, open-label, randomized trial.

Authors:
Kohei Kaku Eiichi Araki Yukio Tanizawa Bue Ross Agner Tomoyuki Nishida Mattis Ranthe Nobuya Inagaki

Diabetes Obes Metab 2019 Dec 28;21(12):2674-2683. Epub 2019 Aug 28.

Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/dom.13856DOI Listing
December 2019

Correction to: Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.

Authors:
Atsushi Obata Tomohiko Kimura Yoshiyuki Obata Masashi Shimoda Tomoe Kinoshita Kenji Kohara Seizo Okauchi Hidenori Hirukawa Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diabetologia 2019 Dec;62(12):2375

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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http://dx.doi.org/10.1007/s00125-019-04982-yDOI Listing
December 2019

Long-term safety and efficacy of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week open-label, multicenter, post-marketing clinical study.

Authors:
Yasuo Terauchi Hisataka Fujiwara Yuji Kurihara Hideki Suganami Masahiro Tamura Masayuki Senda Ryoji Gunji Kohei Kaku

J Diabetes Investig 2019 Nov 28;10(6):1518-1526. Epub 2019 May 28.

Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.13066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825952PMC
November 2019

Benefit-Risk Assessment of Alogliptin for the Treatment of Type 2 Diabetes Mellitus.

Authors:
Kohei Kaku Koichi Kisanuki Mari Shibata Takashi Oohira

Drug Saf 2019 Nov;42(11):1311-1327

Global Patient Safety Evaluation Japan, Pharmacovigilance Department, Takeda Pharmaceutical Company Limited, 1-1, Doshomachi 4-chome, Chuo-ku, Osaka, 540-8645, Japan.

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http://dx.doi.org/10.1007/s40264-019-00857-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834733PMC
November 2019

Long-term (52-week) efficacy and safety of ipragliflozin add-on therapy to insulin in Japanese patients with type 1 diabetes mellitus: An uncontrolled, open-label extension of a phase 3 study.

Authors:
Kohei Kaku Hiroyuki Isaka Taishi Sakatani Junko Toyoshima

J Diabetes Investig 2019 Nov 19. Epub 2019 Nov 19.

Clinical Pharmacology and Exploratory Development, Astellas Pharma Inc, 2-5-1, Nihonbashi-honcho, Chuo-ku, Tokyo, 103-8411, Japan.

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http://dx.doi.org/10.1111/jdi.13181DOI Listing
November 2019

Impact of physical activity and sedentary time on HbA1c levels and body composition: Cross-sectional study using outpatient clinical data of Japanese patients with type 2 diabetes.

Authors:
Shuhei Nakanishi Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Seizo Okauchi Yukino Katakura Junpei Sanada Yoshiro Fushimi Momoyo Nishioka Yuki Kan Akiko Tomita-Mizoguchi Hayato Isobe Hideyuki Iwamoto Kaio Takahashi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2019 Nov 22. Epub 2019 Nov 22.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.13185DOI Listing
November 2019

Safety and effectiveness of empagliflozin in Japanese patients with type 2 diabetes: interim analysis from a post-marketing surveillance study.

Authors:
Kohei Kaku Rina Chin Yusuke Naito Hristo Iliev Rie Ikeda Kaori Ochiai Atsutaka Yasui

Expert Opin Drug Saf 2019 Nov 26:1-11. Epub 2019 Nov 26.

Medicine Division, Nippon Boehringer Ingelheim Co. Ltd, Tokyo, Japan.

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http://dx.doi.org/10.1080/14740338.2020.1694659DOI Listing
November 2019

Efficacy and safety of ipragliflozin add-on therapy to insulin in Japanese patients with type 1 diabetes mellitus: A randomized, double-blind, phase 3 trial.

Authors:
Kohei Kaku Hiroyuki Isaka Taishi Sakatani Junko Toyoshima

Diabetes Obes Metab 2019 Oct 11;21(10):2284-2293. Epub 2019 Jul 11.

Clinical Pharmacology and Exploratory Development, Astellas Pharma Inc., Tokyo, Japan.

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http://dx.doi.org/10.1111/dom.13807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772182PMC
October 2019

Cost-effectiveness Analysis of Empagliflozin in Japan Based on Results From the Asian subpopulation in the EMPA-REG OUTCOME Trial.

Authors:
Kohei Kaku Masakazu Haneda Hiroyuki Sakamaki Atsutaka Yasui Tatsunori Murata Anastasia Ustyugova Rina Chin Tetsuaki Hirase Tsunehisa Shibahara Naoyuki Hayashi Anuraag Kansal Stefan Kaspers Tomoo Okamura

Clin Ther 2019 Oct 25;41(10):2021-2040.e11. Epub 2019 Sep 25.

Nippon Boehringer Ingelheim Co Ltd, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.clinthera.2019.07.016DOI Listing
October 2019

Basal insulin secretion capacity predicts the initial response and maximum levels of beta-hydroxybutyrate during therapy with the sodium-glucose co-transporter-2 inhibitor tofogliflozin, in relation to weight loss.

Authors:
Yuichi Sato Kiyohide Nunoi Kohei Kaku Akihiro Yoshida Hideki Suganami

Diabetes Obes Metab 2019 Oct 13. Epub 2019 Oct 13.

Clinical Data Science Department, Kowa Company, Ltd, Tokyo, Japan.

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http://dx.doi.org/10.1111/dom.13890DOI Listing
October 2019

Safety and efficacy of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real-world clinical practice: Results of 3-month interim analysis of a long-term post-marketing surveillance study (J-STEP/LT).

Authors:
Kazunori Utsunomiya Masayuki Senda Seigo Kakiuchi Hiroyuki Kameda Masahiro Tamura Yuji Kurihara Ryoji Gunji Shoko Fujii Hisataka Fujiwara Kohei Kaku

J Diabetes Investig 2019 Sep 6;10(5):1272-1283. Epub 2019 Mar 6.

Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.13017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717810PMC
September 2019

Attenuation of Weight Loss Through Improved Antilipolytic Effect in Adipose Tissue Via the SGLT2 Inhibitor Tofogliflozin.

Authors:
Akihiro Yoshida Yasuhiro Matsubayashi Toshiaki Nojima Hideki Suganami Takahiro Abe Masahiro Ishizawa Kazuya Fujihara Shiro Tanaka Kohei Kaku Hirohito Sone

J Clin Endocrinol Metab 2019 Sep;104(9):3647-3660

Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan.

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http://dx.doi.org/10.1210/jc.2018-02254DOI Listing
September 2019

Future Possibility of Mizagliflozin on Functional Constipation and/or Irritable Bowel Syndrome With Constipation.

Authors:
Shin Fukudo Kohei Kaku

Gastroenterology 2019 09 19;157(3):898-899. Epub 2019 Jun 19.

Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1053/j.gastro.2019.03.075DOI Listing
September 2019

Comparison of HbA1c levels and body mass index for prevention of diabetic kidney disease: A retrospective longitudinal study using outpatient clinical data in Japanese patients with type 2 diabetes mellitus.

Authors:
Shuhei Nakanishi Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Seizo Okauchi Yukino Katakura Junpei Sanada Yoshiro Fushimi Yuki Kan Akiko Tomita Hayato Isobe Hideyuki Iwamoto Kaio Takahashi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diabetes Res Clin Pract 2019 Sep 5;155:107807. Epub 2019 Aug 5.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1016/j.diabres.2019.107807DOI Listing
September 2019

Efficacy and safety of trelagliptin in Japanese patients with type 2 diabetes with severe renal impairment or end-stage renal disease: Results from a randomized, phase 3 study.

Authors:
Kohei Kaku Kazuyuki Ishida Kohei Shimizu Meguru Achira Yuusuke Umeda

J Diabetes Investig 2019 Aug 7. Epub 2019 Aug 7.

Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, Japan.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdi.13126
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http://dx.doi.org/10.1111/jdi.13126DOI Listing
August 2019

Safety and effectiveness of tofogliflozin in elderly Japanese patients with type 2 diabetes mellitus: A subanalysis of a post-marketing study (J-STEP/EL Study).

Authors:
Kohei Kaku Yusuke Naito Masayuki Senda Yuji Kurihara Ryoji Gunji Seigo Kakiuchi Kazunori Utsunomiya

J Diabetes Investig 2019 Aug 7. Epub 2019 Aug 7.

Center for Preventive Medicine, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.13125DOI Listing
August 2019

Severe hypertriglyceridemia in a subject with disturbed life style and poor glycemic control without recurrence of acute pancreatitis: a case report.

Authors:
Shintaro Irie Takatoshi Anno Fumiko Kawasaki Ryo Shigemoto Shuhei Nakanishi Kohei Kaku Hideaki Kaneto

BMC Endocr Disord 2019 Aug 30;19(1):92. Epub 2019 Aug 30.

Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, 701-0192, Japan.

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http://dx.doi.org/10.1186/s12902-019-0425-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717367PMC
August 2019

New concept of the glucagon-like peptide-1 signaling pathway on pancreatic insulin secretion.

Authors:
Kohei Kaku

J Diabetes Investig 2019 Aug 31. Epub 2019 Aug 31.

Department of Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.13136DOI Listing
August 2019

Renal effects of a sodium-glucose cotransporter 2 inhibitor, tofogliflozin, in relation to sodium intake and glycaemic status.

Authors:
Kiyohide Nunoi Yuichi Sato Kohei Kaku Akihiro Yoshida Hideki Suganami

Diabetes Obes Metab 2019 Jul 6;21(7):1715-1724. Epub 2019 May 6.

Clinical Data Science Department, Kowa Company, Ltd., Tokyo, Japan.

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http://dx.doi.org/10.1111/dom.13731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619387PMC
July 2019

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.

Authors:
Atsushi Obata Tomohiko Kimura Yoshiyuki Obata Masashi Shimoda Tomoe Kinoshita Kenji Kohara Seizo Okauchi Hidenori Hirukawa Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diabetologia 2019 07 4;62(7):1225-1236. Epub 2019 May 4.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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http://dx.doi.org/10.1007/s00125-019-4878-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560212PMC
July 2019

Clinical pharmacology study of ipragliflozin in Japanese patients with type 1 diabetes mellitus: A phase 2, randomized, placebo-controlled trial.

Authors:
Kohei Kaku Hiroyuki Isaka Junko Toyoshima Taishi Sakatani

Diabetes Obes Metab 2019 06 8;21(6):1445-1454. Epub 2019 Apr 8.

Astellas Pharma Inc., Japan/Asia Data Science Development, Tokyo, Japan.

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http://doi.wiley.com/10.1111/dom.13679
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http://dx.doi.org/10.1111/dom.13679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594083PMC
June 2019

Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real-world practice: Results of 12-month interim analysis of a long-term post-marketing surveillance study (J-STEP/LT).

Authors:
Kazunori Utsunomiya Masayuki Senda Seigo Kakiuchi Hiroyuki Kameda Masahiro Tamura Yuji Kurihara Ryoji Gunji Shoko Fujii Kohei Kaku

J Diabetes Investig 2019 Jun 14. Epub 2019 Jun 14.

Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.13097DOI Listing
June 2019

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

Authors:
Makiko Taira Minako Imamura Atsushi Takahashi Yoichiro Kamatani Toshimasa Yamauchi Shin-Ichi Araki Nobue Tanaka Natalie R van Zuydam Emma Ahlqvist Masao Toyoda Tomoya Umezono Koichi Kawai Masahito Imanishi Hirotaka Watada Daisuke Suzuki Hiroshi Maegawa Tetsuya Babazono Kohei Kaku Ryuzo Kawamori Leif C Groop Mark I McCarthy Takashi Kadowaki Shiro Maeda

PLoS One 2018 19;13(12):e0208654. Epub 2018 Dec 19.

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300288PMC
May 2019

Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice.

Authors:
Sohji Nishina Akira Yamauchi Takumi Kawaguchi Kohei Kaku Moritaka Goto Kyo Sasaki Yuichi Hara Yasuyuki Tomiyama Futoshi Kuribayashi Takuji Torimura Keisuke Hino

Cell Mol Gastroenterol Hepatol 2019 11;7(1):115-134. Epub 2018 Sep 11.

Department of Hepatology and Gastroenterology, Kawasaki Medical School, Kurashiki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260362PMC
April 2019

Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study.

Authors:
Hidenori Hirukawa Shinji Kamei Tomohiko Kimura Atsushi Obata Kenji Kohara Fuminori Tatsumi Masashi Shimoda Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Res 2018 7;2018:9435401. Epub 2018 Nov 7.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.1155/2018/9435401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247477PMC
April 2019

Effect of Mizagliflozin on Postprandial Plasma Glucose in Patients With Functional Constipation.

Authors:
Shin Fukudo Kohei Kaku

J Neurogastroenterol Motil 2019 Apr;25(2):332-333

Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm1
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http://dx.doi.org/10.5056/jnm19010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474710PMC
April 2019

Idiopathic and isolated adrenocorticotropic hormone deficiency presenting as continuous epigastric discomfort without symptoms of hypoglycemia: a case report.

Authors:
Seizo Okauchi Fuminori Tatsumi Yuki Kan Megumi Horiya Akiko Mizoguchi Yoshiro Fushimi Junpei Sanada Momoyo Nishioka Masashi Shimoda Kenji Kohara Shuhei Nakanishi Kohei Kaku Tomoatsu Mune Hideaki Kaneto

J Med Case Rep 2019 Apr 30;13(1):113. Epub 2019 Apr 30.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-019-2050-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489309PMC
April 2019

Verification of Kumamoto Declaration 2013 and Glycemic Targets for Elderly Patients with Diabetes in Japan for prevention of diabetic complications: A retrospective longitudinal study using outpatient clinical data.

Authors:
Shuhei Nakanishi Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Tomohiko Kimura Seizo Okauchi Tomoe Kinoshita Junpei Sanada Yoshiro Fushimi Momoyo Nishioka Akiko Mizoguchi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2019 Mar 10;10(2):290-301. Epub 2018 Sep 10.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400169PMC
March 2019

Differential effect of concomitant antidiabetic agents on carotid atherosclerosis: a subgroup analysis of the PROLOGUE study.

Authors:
Atsushi Tanaka Atsushi Kawaguchi Jun-Ichi Oyama Tomoko Ishizu Hiroshi Ito Jun Fukui Taizo Kondo Shigetaka Kuroki Mamoru Nanasato Yukihito Higashi Kohei Kaku Teruo Inoue Toyoaki Murohara Koichi Node

Heart Vessels 2019 Feb 3;34(2):375-384. Epub 2018 Oct 3.

Department of Cardiovascular Medicine, Saga University, Saga, Japan.

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http://link.springer.com/10.1007/s00380-018-1275-5
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http://dx.doi.org/10.1007/s00380-018-1275-5DOI Listing
February 2019

Effect of mild exercise on glycemic and bodyweight control in Japanese type 2 diabetes patients: A retrospective analysis.

Authors:
Shuhei Nakanishi Masahiro Iwamoto Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Seizo Okauchi Tomoe Kinoshita Junpei Sanada Yoshiro Fushimi Momoyo Nishioka Akiko Mizoguchi Miyuki Kameyama Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2019 Jan 30;10(1):104-107. Epub 2018 Mar 30.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319490PMC
January 2019

Drug fever and acute inflammation from hypercytokinemia triggered by dipeptidyl peptidase-4 inhibitor vildagliptin.

Authors:
Takatoshi Anno Hideaki Kaneto Fumiko Kawasaki Ryo Shigemoto Yumi Aoyama Kohei Kaku Niro Okimoto

J Diabetes Investig 2019 Jan 2;10(1):182-185. Epub 2018 May 2.

Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.

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http://doi.wiley.com/10.1111/jdi.12847
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http://dx.doi.org/10.1111/jdi.12847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319481PMC
January 2019

Linagliptin as add-on to empagliflozin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a two-part, randomized, placebo-controlled trial.

Authors:
Kohei Kaku Masakazu Haneda Yuko Tanaka Ganghyuck Lee Kosuke Shiki Yuki Miyamoto Fernando Solimando Jisoo Lee Christopher Lee Jyothis George

Diabetes Obes Metab 2019 01 6;21(1):136-145. Epub 2018 Sep 6.

Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.

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http://dx.doi.org/10.1111/dom.13496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585831PMC
January 2019

Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus.

Authors:
Maiko Takai Takatoshi Anno Fumiko Kawasaki Tomohiko Kimura Hidenori Hirukawa Tomoatsu Mune Niro Okimoto Kohei Kaku Hideaki Kaneto

Intern Med 2019 Jan 24;58(2):167-173. Epub 2018 Aug 24.

Department of Diabete, Metabolism and Endocrinology, Kawasaki Medical School, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1053-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378157PMC
January 2019

Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.

Authors:
Kenji Kohara Atsushi Obata Tomohiko Kimura Masashi Shimoda Saeko Moriuchi Seizo Okauchi Hidenori Hirukawa Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Endocr J 2019 Jan 17;66(1):43-50. Epub 2018 Oct 17.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ18-0203DOI Listing
January 2019

Acute exacerbation of chronic osteomyelitis triggered by aggravation of type 2 diabetes mellitus: a case report.

Authors:
Shintaro Irie Takatoshi Anno Fumiko Kawasaki Ryo Shigemoto Hideaki Kaneto Kohei Kaku Niro Okimoto

J Med Case Rep 2019 Jan 7;13(1). Epub 2019 Jan 7.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1954-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323657PMC
January 2019

Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study.

Authors:
Shuhei Nakanishi Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Seizo Okauchi Tomoe Kinoshita Junpei Sanada Yoshiro Fushimi Momoyo Nishioka Yuki Kan Akiko Tomita Akiko Mashiko Megumi Horiya Yuichiro Iwamoto Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Lipids Health Dis 2019 Jan 31;18(1):36. Epub 2019 Jan 31.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

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http://dx.doi.org/10.1186/s12944-019-0983-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357375PMC
January 2019

Dipeptidyl peptidase 4 inhibitor anagliptin ameliorates hypercholesterolemia in hypercholesterolemic mice through inhibition of intestinal cholesterol transport.

Authors:
Moritaka Goto Shinji Furuta Satoko Yamashita Hiroyuki Hashimoto Wataru Yano Noriyuki Inoue Noriaki Kato Kohei Kaku

J Diabetes Investig 2018 Nov 5;9(6):1261-1269. Epub 2018 Jun 5.

Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.

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http://doi.wiley.com/10.1111/jdi.12860
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http://dx.doi.org/10.1111/jdi.12860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215941PMC
November 2018

Sitagliptin on carotid intima-media thickness in type 2 diabetes patients receiving primary or secondary prevention of cardiovascular disease: A subgroup analysis of the PROLOGUE study.

Authors:
Atsushi Tanaka Hisako Yoshida Mamoru Nanasato Jun-Ichi Oyama Tomoko Ishizu Masayoshi Ajioka Ryoji Ishiki Makoto Saito Yoshisato Shibata Kohei Kaku Koji Maemura Yukihito Higashi Teruo Inoue Toyoaki Murohara Koichi Node

Int J Cardiol 2018 Nov 19;271:331-335. Epub 2018 May 19.

Department of Cardiovascular Medicine, Saga University, Saga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.05.055DOI Listing
November 2018

Onset of type 1 diabetes mellitus and heparin-induced thrombocytopenia in a patient with Basedow's disease and idiopathic thrombocytopenic purpura: Novel combination as autoimmune polyglandular syndrome.

Authors:
Tomoe Kinoshita Shinji Kamei Yoshiko Nakamura Masashi Shimoda Takatoshi Anno Atsushi Obata Tomohiko Kimura Hidenori Hirukawa Fuminori Tatsumi Kenji Kohara Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2018 Nov 15;9(6):1381-1382. Epub 2018 Jun 15.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215937PMC
November 2018

Onset of fulminant type 1 diabetes mellitus under immunotolerance status after long-term therapy for chronic inflammatory demyelinating polyneuropathy.

Authors:
Ryo Shigemoto Takatoshi Anno Eiichi Ohnuki Satoru Kosaka Niro Okimoto Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2018 Nov 15;9(6):1378-1380. Epub 2018 Jun 15.

Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215944PMC
November 2018

Efficacy and Safety of Switching from Insulin Glargine 100 U/mL to the Same Dose of Glargine 300 U/mL in Japanese Type 1 and 2 Diabetes Patients: A Retrospective Analysis.

Authors:
Shuhei Nakanishi Masahiro Iwamoto Shinji Kamei Hidenori Hirukawa Masashi Shimoda Fuminori Tatsumi Kenji Kohara Atsushi Obata Tomohiko Kimura Tomoe Kinoshita Shintaro Irie Junpei Sanada Yoshiro Fushimi Momoyo Nishioka Akiko Mizoguchi Miyuki Kameyama Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Intern Med 2018 15;57(10):1381-1389. Epub 2018 May 15.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.9334-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995700PMC
October 2018

Efficacy and safety of trelagliptin in combination with insulin therapy in Japanese patients with type 2 diabetes: Results from a randomized, Phase IV study.

Authors:
Kohei Kaku Shingo Kuroda Kazuyuki Ishida Yuusuke Umeda

Diabetes Obes Metab 2018 10 2;20(10):2490-2493. Epub 2018 Jul 2.

Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, Japan.

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http://dx.doi.org/10.1111/dom.13397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175153PMC
October 2018

Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β-cells in db/db mice: The earlier and longer, the better.

Authors:
Tomohiko Kimura Atsushi Obata Masashi Shimoda Seizo Okauchi Yukiko Kanda-Kimura Yuka Nogami Saeko Moriuchi Hidenori Hirukawa Kenji Kohara Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diabetes Obes Metab 2018 10 5;20(10):2442-2457. Epub 2018 Jul 5.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/dom.13400DOI Listing
October 2018

A rare case of large pyosalpinx in an elderly patient with well-controlled type 2 diabetes mellitus: a case report.

Authors:
Mayuko Hida Takatoshi Anno Fumiko Kawasaki Hideaki Kaneto Kohei Kaku Niro Okimoto

J Med Case Rep 2018 Oct 6;12(1):286. Epub 2018 Oct 6.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1841-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173840PMC
October 2018

Remission of hyperglycemia after withdrawal of oral antidiabetic drugs in Japanese patients with early-stage type 2 diabetes.

Authors:
Hidenori Hirukawa Mitsuru Hashiramoto Yukio Tanizawa Kohei Kaku

J Diabetes Investig 2018 Sep 13;9(5):1119-1127. Epub 2018 Mar 13.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123043PMC
September 2018

Effect of Tofogliflozin on Body Composition and Glycemic Control in Japanese Subjects with Type 2 Diabetes Mellitus.

Authors:
Shinji Kamei Masahiro Iwamoto Miyuki Kameyama Masashi Shimoda Tomoe Kinoshita Atsushi Obata Tomohiko Kimura Hidenori Hirukawa Fuminori Tatsumi Kenji Kohara Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Res 2018 8;2018:6470137. Epub 2018 Jan 8.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1155/2018/6470137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817268PMC
September 2018

Fulminant Type 1 Diabetes Mellitus Complicated with a Life-threatening Electrolyte Abnormality and Abnormal Electrocardiogram Findings.

Authors:
Tomoe Kinoshita Hideaki Kaneto Fumiko Kawasaki Takatoshi Anno Takeyuki Kurihara Haruki Yamada Yoshiyuki Oshiro Naoyuki Miyashita Niro Okimoto Kohei Kaku

Intern Med 2018 Sep 27;57(18):2685-2688. Epub 2018 Apr 27.

Department of General Internal Medicine 1, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.0680-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191599PMC
September 2018

Safety and efficacy of the sodium-glucose cotransporter 1 inhibitor mizagliflozin for functional constipation: a randomised, placebo-controlled, double-blind phase 2 trial.

Authors:
Shin Fukudo Yuka Endo Michio Hongo Atsushi Nakajima Tatsuya Abe Hiroyuki Kobayashi Tomohiro Nakata Toshio Nakajima Kanako Sameshima Kohei Kaku

Lancet Gastroenterol Hepatol 2018 09 25;3(9):603-613. Epub 2018 Jul 25.

Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1016/S2468-1253(18)30165-1DOI Listing
September 2018

Saibokuto as a Possible Therapy for Type B Insulin Resistance Syndrome: The Disappearance of Anti-insulin Receptor Antibody and a Marked Amelioration of Glycemic Control by Saibokuto Treatment.

Authors:
Fumiko Kawasaki Takatoshi Anno Maiko Takai Shintaro Irie Hideaki Kaneto Kohei Kaku Niro Okimoto

Intern Med 2018 Aug 9;57(16):2359-2363. Epub 2018 Mar 9.

Department of General Internal Medicine 1, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.0523-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148171PMC
August 2018

This is in reply to the Letter by Kahathuduwa et al. titled "Unaccounted for regression to the mean renders conclusion of article titled 'Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin' unsubstantiated".

Authors:
Motoshi Ouchi Kenzo Oba Hideki Suganami Akihiro Yoshida Tomoe Fujita Tatsuya Suzuki Masahiro Yasutake Kohei Kaku

Diabetes Obes Metab 2018 08 5;20(8):2041-2042. Epub 2018 Jun 5.

Department of General Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/dom.13347DOI Listing
August 2018

There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study.

Authors:
Tomoe Kinoshita Masashi Shimoda Junpei Sanada Yoshiro Fushimi Yurie Hirata Shintaro Irie Atsushi Obata Tomohiko Kimura Hidenori Hirukawa Kenji Kohara Fuminori Tatsumi Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diabetes Ther 2018 Aug 21;9(4):1569-1580. Epub 2018 Jun 21.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1007/s13300-018-0447-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064595PMC
August 2018

Safety and efficacy of the combination of the glucagon-like peptide-1 receptor agonist liraglutide with an oral antidiabetic drug in Japanese patients with type 2 diabetes: Post-hoc analysis of a randomized, 52-week, open-label, parallel-group trial.

Authors:
Arihiro Kiyosue Yutaka Seino Keiji Nishijima Heidrun Bosch-Traberg Kohei Kaku

J Diabetes Investig 2018 Jul 24;9(4):831-839. Epub 2017 Nov 24.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031500PMC
July 2018

Sodium-glucose cotransporter 2 inhibitor, tofogliflozin, shows better improvements of blood glucose and insulin secretion in patients with high insulin levels at baseline.

Authors:
Kazuyuki Tobe Hideki Suganami Kohei Kaku

J Diabetes Investig 2018 Jul 13;9(4):862-869. Epub 2017 Nov 13.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031493PMC
July 2018

Switching from low-dose thiazide diuretics to sodium-glucose cotransporter 2 inhibitor improves various metabolic parameters without affecting blood pressure in patients with type 2 diabetes and hypertension.

Authors:
Tomohiko Kimura Junpei Sanada Masashi Shimoda Hidenori Hirukawa Yoshiro Fushimi Momoyo Nishioka Tomoe Kinoshita Seizo Okauchi Atsushi Obata Kenji Kohara Fuminori Tatsumi Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2018 Jul 4;9(4):875-881. Epub 2017 Dec 4.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031496PMC
July 2018

Efficacy and safety of adding liraglutide to existing insulin regimens in Japanese patients with type 2 diabetes mellitus: A post-hoc analysis of a phase 3 randomized clinical trial.

Authors:
Shizuka Kaneko Keiji Nishijima Heidrun Bosch-Traberg Kohei Kaku Yutaka Seino

J Diabetes Investig 2018 Jul 5;9(4):840-849. Epub 2018 Feb 5.

Kansai Electric Power Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/jdi.12793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031509PMC
July 2018

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity.

Authors:
Tomohiko Kimura Atsushi Obata Masashi Shimoda Ikki Shimizu Gabriela da Silva Xavier Seizo Okauchi Hidenori Hirukawa Kenji Kohara Tomoatsu Mune Saeko Moriuchi Arudo Hiraoka Kentaro Tamura Genta Chikazawa Atsuhisa Ishida Hidenori Yoshitaka Guy A Rutter Kohei Kaku Hideaki Kaneto

Sci Rep 2018 Jul 13;8(1):10644. Epub 2018 Jul 13.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1038/s41598-018-28849-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045606PMC
July 2018

Long-term safety and efficacy of tofogliflozin as add-on to insulin in patients with type 2 diabetes: Results from a 52-week, multicentre, randomized, double-blind, open-label extension, Phase 4 study in Japan (J-STEP/INS).

Authors:
Yasuo Terauchi Masahiro Tamura Masayuki Senda Ryoji Gunji Kohei Kaku

Diabetes Obes Metab 2018 05 11;20(5):1176-1185. Epub 2018 Feb 11.

Department of General Internal Medicine 1, Kawasaki Medical School, Kurashiki, Japan.

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http://doi.wiley.com/10.1111/dom.13213
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http://dx.doi.org/10.1111/dom.13213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947124PMC
May 2018

Safety and efficacy of once-weekly semaglutide vs additional oral antidiabetic drugs in Japanese people with inadequately controlled type 2 diabetes: A randomized trial.

Authors:
Kohei Kaku Yuichiro Yamada Hirotaka Watada Atsuko Abiko Tomoyuki Nishida Jeppe Zacho Arihiro Kiyosue

Diabetes Obes Metab 2018 05 21;20(5):1202-1212. Epub 2018 Feb 21.

Department of Internal Medicine, Tokyo-Eki Center-Building Clinic, Tokyo, Japan.

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http://dx.doi.org/10.1111/dom.13218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969242PMC
May 2018

Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus.

Authors:
Masashi Shimoda Maiko Miyoshi-Takai Shintaro Irie Akihito Tanabe Atsushi Obata Seizo Okauchi Hidenori Hirukawa Tomohiko Kimura Kenji Kohara Shinji Kamei Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Res 2017 25;2017:5856475. Epub 2017 May 25.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

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http://dx.doi.org/10.1155/2017/5856475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463141PMC
April 2018

Long-term efficacy and safety of canagliflozin in combination with insulin in Japanese patients with type 2 diabetes mellitus.

Authors:
Nobuya Inagaki Shin-Ichi Harashima Kohei Kaku Kazuoki Kondo Nobuko Maruyama Makiko Otsuka Yutaka Kawaguchi Hiroaki Iijima

Diabetes Obes Metab 2018 04 5;20(4):812-820. Epub 2017 Dec 5.

Ikuyaku Integrated Value Development Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan.

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http://dx.doi.org/10.1111/dom.13152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873413PMC
April 2018

Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin.

Authors:
Motoshi Ouchi Kenzo Oba Kohei Kaku Hideki Suganami Akihiro Yoshida Yasunori Fukunaka Promsuk Jutabha Asuka Morita Naoyuki Otani Keitaro Hayashi Tomoe Fujita Tatsuya Suzuki Masahiro Yasutake Naohiko Anzai

Diabetes Obes Metab 2018 04 8;20(4):1061-1065. Epub 2018 Jan 8.

Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.

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http://doi.wiley.com/10.1111/dom.13170
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http://dx.doi.org/10.1111/dom.13170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887894PMC
April 2018

Effects of sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on the indices of renal tubular function in patients with type 2 diabetes.

Authors:
Kiyohide Nunoi Yuichi Sato Kohei Kaku Akihiro Yoshida Hideki Suganami

Endocrinol Diabetes Metab 2018 Apr 26;1(2):e00015. Epub 2018 Mar 26.

Clinical Data Science Department Kowa Company, Ltd. Tokyo Japan.

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http://dx.doi.org/10.1002/edm2.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354802PMC
April 2018

Association of GA/HbA1c ratio and cognitive impairment in subjects with type 2 diabetes mellitus.

Authors:
Tomoe Kinoshita Masashi Shimoda Junpei Sanada Yoshiro Fushimi Yurie Hirata Shintaro Irie Akihito Tanabe Atsushi Obata Tomohiko Kimura Hidenori Hirukawa Kenji Kohara Fuminori Tatsumi Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Complications 2016 Nov - Dec;30(8):1452-1455. Epub 2016 Aug 12.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2016.08.008DOI Listing
March 2018

Efficacy and safety of once-weekly oral trelagliptin switched from once-daily dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes mellitus: An open-label, phase 3 exploratory study.

Authors:
Nobuya Inagaki Hiroki Sano Yoshifumi Seki Shingo Kuroda Kohei Kaku

J Diabetes Investig 2018 Mar 30;9(2):354-359. Epub 2017 Oct 30.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://doi.wiley.com/10.1111/jdi.12730
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http://dx.doi.org/10.1111/jdi.12730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835476PMC
March 2018

Werner Syndrome and Diabetes Mellitus Accompanied by Adrenal Cortex Cancer.

Authors:
Momoyo Nishioka Shinji Kamei Tomoe Kinoshita Junpei Sanada Yoshiro Fushimi Shintaro Irie Yurie Hirata Akihito Tanabe Hidenori Hirukawa Tomohiko Kimura Atsushi Obata Fuminori Tatsumi Kenji Kohara Masashi Shimoda Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Intern Med 2017 1;56(15):1987-1992. Epub 2017 Aug 1.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.56.8231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577075PMC
February 2018

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism.

Authors:
Koji Nakashima Hideaki Kaneto Masashi Shimoda Tomohiko Kimura Kohei Kaku

Sci Rep 2018 02 27;8(1):3725. Epub 2018 Feb 27.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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http://www.nature.com/articles/s41598-018-21751-w
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http://dx.doi.org/10.1038/s41598-018-21751-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829082PMC
February 2018

Hypoinsulinemic hypoglycemia triggered by liver injury in elderly subjects with low body weight: case reports.

Authors:
Takatoshi Anno Hideaki Kaneto Ryo Shigemoto Fumiko Kawasaki Yasuhiro Kawai Noriyo Urata Hirofumi Kawamoto Kohei Kaku Niro Okimoto

Endocrinol Diabetes Metab Case Rep 2018 23;2018. Epub 2018 Feb 23.

Department of General Internal Medicine 1Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1530/EDM-17-0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825835PMC
February 2018

Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis.

Authors:
Ryo Shigemoto Takatoshi Anno Fumiko Kawasaki Shintaro Irie Masayuki Yamamoto Shintaro Tokuoka Hideaki Kaneto Kohei Kaku Niro Okimoto

Acta Diabetol 2018 01 5;55(1):99-101. Epub 2017 Sep 5.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

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http://dx.doi.org/10.1007/s00592-017-1038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794821PMC
January 2018

Aggravation of type 2 diabetes mellitus triggered by acute exacerbation of chronic thyroiditis (Hashimoto's disease).

Authors:
Maiko Takai Takatoshi Anno Fumiko Kawasaki Ryo Shigemoto Yuki Kan Hideaki Kaneto Kohei Kaku Niro Okimoto

J Diabetes Investig 2018 Jan;9(1):226-227

Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754519PMC
January 2018

Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects.

Authors:
Yurie Hirata Shinji Kamei Fuminori Tatsumi Masashi Shimoda Akihito Tanabe Junpei Sanada Yoshiro Fushimi Shintaro Irie Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Intern Med 2017 15;56(12):1527-1529. Epub 2017 Jun 15.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.56.8120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505908PMC
December 2017

Safety and effectiveness of tofogliflozin in elderly Japanese patients with type 2 diabetes mellitus: A post-marketing study (J-STEP/EL Study).

Authors:
Kazunori Utsunomiya Naoki Shimmoto Masayuki Senda Yuji Kurihara Ryoji Gunji Shoko Fujii Seigo Kakiuchi Hisataka Fujiwara Hiroyuki Kameda Masahiro Tamura Kohei Kaku

J Diabetes Investig 2017 Nov 6;8(6):766-775. Epub 2017 Mar 6.

Department of General Internal Medicine 1, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668483PMC
November 2017

Safety evaluation of trelagliptin in the treatment of Japanese type 2 diabetes mellitus patients.

Authors:
Kohei Kaku

Expert Opin Drug Saf 2017 Nov 29;16(11):1313-1322. Epub 2017 Aug 29.

a Department of Internal Medicine , Kawasaki Medical School , Okayama , Japan.

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http://dx.doi.org/10.1080/14740338.2017.1369526DOI Listing
November 2017

Decreased glucagon-like peptide 1 receptor expression in endothelial and smooth muscle cells in diabetic db/db mice: TCF7L2 is a possible regulator of the vascular glucagon-like peptide 1 receptor.

Authors:
Tomohiko Kimura Atsushi Obata Masashi Shimoda Seizo Okauchi Hidenori Hirukawa Kenji Kohara Tomoe Kinoshita Yuka Nogami Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Diab Vasc Dis Res 2017 11 23;14(6):540-548. Epub 2017 Aug 23.

1 Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1177/1479164117725898DOI Listing
November 2017

Efficacy and safety of tofogliflozin in Japanese patients with type 2 diabetes mellitus with inadequate glycaemic control on insulin therapy (J-STEP/INS): Results of a 16-week randomized, double-blind, placebo-controlled multicentre trial.

Authors:
Yasuo Terauchi Masahiro Tamura Masayuki Senda Ryoji Gunji Kohei Kaku

Diabetes Obes Metab 2017 10 13;19(10):1397-1407. Epub 2017 Jul 13.

Department of General Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/dom.12957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637911PMC
October 2017

Bilateral lower limb edema induced by rapid improvement of glycemic control with insulin therapy in a subject with poorly controlled type 2 diabetes.

Authors:
Yuki Kan Takatoshi Anno Fumiko Kawasaki Maiko Takai Ryo Shigemoto Hideaki Kaneto Kohei Kaku Niro Okimoto

Acta Diabetol 2017 Jun 27;54(6):611-613. Epub 2017 Apr 27.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

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http://link.springer.com/10.1007/s00592-017-0997-7
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http://dx.doi.org/10.1007/s00592-017-0997-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429355PMC
June 2017

Advanced breast cancer in a relatively young man with severe obesity and type 2 diabetes mellitus.

Authors:
Atsushi Obata Seizo Okauchi Tomohiko Kimura Hidenori Hirukawa Akihito Tanabe Tomoe Kinoshita Kenji Kohara Fuminori Tatsumi Masashi Shimoda Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2017 May;8(3):395-396

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415471PMC
May 2017

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors and Stroke　- Reply.

Authors:
Kohei Kaku Jisoo Lee Stefan Kaspers Hans J Woerle Jyothis T George

Circ J 2017 05 10;81(6):899. Epub 2017 May 10.

Boehringer Ingelheim Ltd.

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http://dx.doi.org/10.1253/circj.CJ-17-0395DOI Listing
May 2017

A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.

Authors:
Makoto Shigeto Chae Young Cha Patrik Rorsman Kohei Kaku

J Mol Med (Berl) 2017 04 17;95(4):361-368. Epub 2017 Jan 17.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

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http://dx.doi.org/10.1007/s00109-017-1508-6DOI Listing
April 2017

Clinical course of pituitary function and image in IgG4-related hypophysitis.

Authors:
Takatoshi Anno Fumiko Kawasaki Maiko Takai Ryo Shigemoto Yuki Kan Hideaki Kaneto Tomoatsu Mune Kohei Kaku Niro Okimoto

Endocrinol Diabetes Metab Case Rep 2017 28;2017. Epub 2017 Apr 28.

Department of General Internal Medicine 1, Kawasaki Medical School, OkayamaJapan.

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http://dx.doi.org/10.1530/EDM-16-0148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409939PMC
April 2017

Seven-year Observational Study on the Association between Glycemic Control and the New Onset of Macroangiopathy in Japanese Subjects with Type 2 Diabetes.

Authors:
Tomohiko Kimura Hideaki Kaneto Yukiko Kanda-Kimura Masashi Shimoda Shinji Kamei Takatoshi Anno Fumiko Kawasaki Mitsuru Hashiramoto Michihiro Matsuki Tomoatsu Mune Kohei Kaku

Intern Med 2016 1;55(11):1419-24. Epub 2016 Jun 1.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.2169/internalmedicine.55.4952DOI Listing
March 2017

Insulin degludec in a simple or stepwise titration algorithm in a Japanese population of patients with type 2 diabetes: a randomized, 26-week, treat-to-target trial.

Authors:
Takashi Kadowaki Hideaki Jinnouchi Kohei Kaku Malene L Hersløv Jacob Hyllested-Winge Shuji Nakamura

Diabetol Int 2017 Mar 2;8(1):87-94. Epub 2016 Sep 2.

Iryo Houjin Shadan Kowakai, Heiwadai Hospital, Miyazaki, Japan.

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http://dx.doi.org/10.1007/s13340-016-0284-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224933PMC
March 2017

Temporal lobe epilepsy associated with GAD autoimmunity.

Authors:
Atsushi Obata Yumiko Kutoku Yoshihide Sunada Seizo Okauchi Tomohiko Kimura Hidenori Hirukawa Akihito Tanabe Tomoe Kinoshita Kenji Kohara Fuminori Tatsumi Masashi Shimoda Shinji Kamei Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Acta Diabetol 2017 Mar 8;54(3):321-323. Epub 2016 Sep 8.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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http://dx.doi.org/10.1007/s00592-016-0910-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329084PMC
March 2017

Beneficial effects of sodium-glucose cotransporter 2 inhibitors for preservation of pancreatic β-cell function and reduction of insulin resistance.

Authors:
Hideaki Kaneto Atsushi Obata Tomohiko Kimura Masashi Shimoda Seizo Okauchi Naoki Shimo Taka-Aki Matsuoka Kohei Kaku

J Diabetes 2017 Mar 1;9(3):219-225. Epub 2016 Dec 1.

General Internal Medicine 1, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/1753-0407.12494DOI Listing
March 2017

Mechanism of lipid-lowering action of the dipeptidyl peptidase-4 inhibitor, anagliptin, in low-density lipoprotein receptor-deficient mice.

Authors:
Wataru Yano Noriyuki Inoue Shiori Ito Takahiro Itou Misako Yasumura Yasunobu Yoshinaka Sumihiko Hagita Moritaka Goto Takashi Nakagawa Keisuke Inoue Sohei Tanabe Kohei Kaku

J Diabetes Investig 2017 Mar 15;8(2):155-160. Epub 2016 Dec 15.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://doi.wiley.com/10.1111/jdi.12593
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http://dx.doi.org/10.1111/jdi.12593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334308PMC
March 2017

Randomized, double-blind, phase III study to evaluate the efficacy and safety of once-daily treatment with alogliptin and metformin hydrochloride in Japanese patients with type 2 diabetes.

Authors:
Kohei Kaku Shuuji Sumino Masafumi Katou Yuya Nishiyama Yoshinobu Kinugawa

Diabetes Obes Metab 2017 03 19;19(3):463-467. Epub 2017 Jan 19.

Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, Japan.

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http://dx.doi.org/10.1111/dom.12837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599944PMC
March 2017

Promising Diabetes Therapy Based on the Molecular Mechanism for Glucose Toxicity: Usefulness of SGLT2 Inhibitors as well as Incretin-Related Drugs.

Authors:
Hideaki Kaneto Atsushi Obata Masashi Shimoda Tomohiko Kimura Hidenori Hirukawa Seizo Okauchi Taka-Aki Matsuoka Kohei Kaku

Curr Med Chem 2016 ;23(27):3044-3051

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

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http://dx.doi.org/10.2174/0929867323666160627102516DOI Listing
February 2017

Factors Affecting Canagliflozin-Induced Transient Urine Volume Increase in Patients with Type 2 Diabetes Mellitus.

Authors:
Hiroyuki Tanaka Kazuhiko Takano Hiroaki Iijima Hajime Kubo Nobuko Maruyama Toshio Hashimoto Kenji Arakawa Masanori Togo Nobuya Inagaki Kohei Kaku

Adv Ther 2017 02 15;34(2):436-451. Epub 2016 Dec 15.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1007/s12325-016-0457-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331075PMC
February 2017

Insulin Degludec in Clinical Practice: A Review of Japanese Real-World Data.

Authors:
Kohei Kaku Michael Lyng Wolden Jacob Hyllested-Winge Emil Nørtoft

Diabetes Ther 2017 Feb 13;8(1):189-195. Epub 2017 Jan 13.

Novo Nordisk A/S, Søborg, Denmark.

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http://dx.doi.org/10.1007/s13300-017-0225-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306124PMC
February 2017

Empagliflozin and Cardiovascular Outcomes in Asian Patients With Type 2 Diabetes and Established Cardiovascular Disease　- Results From EMPA-REG OUTCOME.

Authors:
Kohei Kaku Jisoo Lee Michaela Mattheus Stefan Kaspers Jyothis George Hans-Juergen Woerle

Circ J 2017 Jan 23;81(2):227-234. Epub 2016 Dec 23.

Department of General Internal Medicine, Kawasaki Medical School.

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http://dx.doi.org/10.1253/circj.CJ-16-1148DOI Listing
January 2017

Hamman's syndrome triggered by the onset of type 1 diabetes mellitus accompanied by diabetic ketoacidosis.

Authors:
Shinji Kamei Hideaki Kaneto Akihito Tanabe Ryo Shigemoto Shintaro Irie Yurie Hirata Maiko Takai Kenji Kohara Masashi Shimoda Tomoatsu Mune Kohei Kaku

Acta Diabetol 2016 Dec 13;53(6):1067-1068. Epub 2016 Jun 13.

Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.

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http://dx.doi.org/10.1007/s00592-016-0871-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114339PMC
December 2016

Influence of thyroid volume on the effect of methimazole in Japanese subjects with mild Graves' disease.

Authors:
Tomohiko Kimura Michihiro Matsuki Hideaki Kaneto Tomoatsu Mune Kohei Kaku

Eur J Intern Med 2016 Dec 3;36:e31-e32. Epub 2016 Sep 3.

Department of General Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.

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http://dx.doi.org/10.1016/j.ejim.2016.08.030DOI Listing
December 2016

Human serum albumin: Possible cause of insulin autoimmune syndrome.

Authors:
Shinji Kamei Hideaki Kaneto Ryo Shigemoto Sumiko Ejiri Akihito Tanabe Fuminori Tatsumi Tomohiko Kimura Atsushi Obata Masashi Shimoda Kazuhito Tawaramoto Kenji Kohara Takatoshi Anno Fumiko Kawasaki Tomoatsu Mune Kohei Kaku

J Diabetes Investig 2016 Nov;7(6):919-920

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089957PMC
November 2016

Dramatic mitigation of bone pain after phosphorus replacement therapy in a subject with FGF23-related hypophosphatemic osteomalacia.

Authors:
Fuminori Tatsumi Megumi Horiya Akihito Tanabe Momoyo Nishioka Yoshiro Fushimi Junpei Sanada Yurie Hirata Shintaro Irie Tomoe Kinoshita Shinji Kamei Masashi Shimoda Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Springerplus 2016 2;5(1):1904. Epub 2016 Nov 2.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192 Japan.

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http://dx.doi.org/10.1186/s40064-016-3602-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093104PMC
November 2016

Strawberry milk-like blood in a subject with diabetic lipemia: dramatic change to transparent color after insulin therapy.

Authors:
Atsushi Obata Shinji Kamei Seizo Okauchi Tomohiko Kimura Hidenori Hirukawa Akihito Tanabe Tomoe Kinoshita Kenji Kohara Fuminori Tatsumi Masashi Shimoda Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Hideaki Kaneto

Springerplus 2016 7;5(1):1499. Epub 2016 Sep 7.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192 Japan.

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http://dx.doi.org/10.1186/s40064-016-3202-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014774PMC
September 2016

Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic β-cell function in subjects with type 2 diabetes mellitus.

Authors:
Akihito Tanabe Hideaki Kaneto Shinji Kamei Hidenori Hirukawa Masashi Shimoda Tomohiko Kimura Atsushi Obata Seizo Okauchi Fuminori Tatsumi Kenji Kohara Tomoatsu Mune Kohei Kaku

J Diabetes Complications 2016 08 11;30(6):1201-3. Epub 2016 Apr 11.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School.

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http://dx.doi.org/10.1016/j.jdiacomp.2016.04.005DOI Listing
August 2016

Combination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: A 36-week, randomized, double-blind, parallel-group trial.

Authors:
Yutaka Seino Shizuka Kaneko Shuichi Fukuda Takeshi Osonoi Toshihiko Shiraiwa Keiji Nishijima Heidrun Bosch-Traberg Kohei Kaku

J Diabetes Investig 2016 Jul 23;7(4):565-73. Epub 2016 Jan 23.

Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1111/jdi.12457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931207PMC
July 2016

Optimal cut-off value of alanine aminotransferase level to precisely estimate the presence of fatty liver in patients with poorly controlled type 2 diabetes.

Authors:
Akihito Tanabe Fuminori Tatsumi Seizo Okauchi Hiroki Yabe Tomohiro Tsuda Kazuma Okutani Kazuki Yamashita Koji Nakashima Kohei Kaku Hideaki Kaneto

J Diabetes Investig 2016 Jul;7(4):645-6

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1111/jdi.12418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931219PMC
July 2016

The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial.

Authors:
Jun-Ichi Oyama Toyoaki Murohara Masafumi Kitakaze Tomoko Ishizu Yasunori Sato Kazuo Kitagawa Haruo Kamiya Masayoshi Ajioka Masaharu Ishihara Kazuoki Dai Mamoru Nanasato Masataka Sata Koji Maemura Hirofumi Tomiyama Yukihito Higashi Kohei Kaku Hirotsugu Yamada Munehide Matsuhisa Kentaro Yamashita Yasuko K Bando Naoki Kashihara Shinichiro Ueda Teruo Inoue Atsushi Tanaka Koichi Node

PLoS Med 2016 Jun 28;13(6):e1002051. Epub 2016 Jun 28.

Department of Cardiovascular Medicine, Saga University, Saga, Japan.

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http://dx.doi.org/10.1371/journal.pmed.1002051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924847PMC
June 2016

Case of iliopsoas abscess that was markedly recovered after percutaneous and surgical drainage in a patient with poorly controlled type 2 diabetes.

Authors:
Atsushi Obata Hideaki Kaneto Shinji Kamei Masashi Shimoda Tomohiko Kimura Hidenori Hirukawa Seizo Okauchi Fuminori Tatsumi Kenji Kohara Tomoatsu Mune Kohei Kaku

J Diabetes Investig 2016 May 27;7(3):440-1. Epub 2016 Apr 27.

Department of Diabetes, Endocrinology and Metabolism Kawasaki Medical School Kurashiki Japan.

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http://dx.doi.org/10.1111/jdi.12394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847901PMC
May 2016