Koen Mertens

Koen Mertens

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Koen Mertens

Publications by authors named "Koen Mertens"

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Unique surface-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding.

J Thromb Haemost 2020 Feb 28;18(2):364-372. Epub 2019 Nov 28.

Department of Molecular and Cellular Hemostasis, Sanquin Research, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/jth.14668DOI Listing
February 2020

D'domain Region Arg782-Cys799 of Von Willebrand Factor contributes to Factor VIII binding.

Haematologica 2019 Sep 26. Epub 2019 Sep 26.

Department of Molecular and Cellular Hemostasis, Sanquin Research, Amsterdam, the Netherlands

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http://dx.doi.org/10.3324/haematol.2019.221994DOI Listing
September 2019

Integrated proteomic analysis of tumor necrosis factor α and interleukin 1β-induced endothelial inflammation.

J Proteomics 2019 02 25;192:89-101. Epub 2018 Aug 25.

Department of Molecular and Cellular Hemostasis, Sanquin Research, Amsterdam 1066 CX, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.08.011DOI Listing
February 2019

The D' domain of von Willebrand factor requires the presence of the D3 domain for optimal factor VIII binding.

Biochem J 2018 09 11;475(17):2819-2830. Epub 2018 Sep 11.

Department of Plasma Proteins, Sanquin Research, 1066 CX Amsterdam, The Netherlands

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http://dx.doi.org/10.1042/BCJ20180431DOI Listing
September 2018

Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics.

Arterioscler Thromb Vasc Biol 2017 10 17;37(10):1891-1902. Epub 2017 Aug 17.

From the Department Plasma Proteins (B.L.v.d.E., A.J.H., P.J.S., K.M., A.B.M., M.v.d.B.), Department of Research Facilities (F.P.J.v.A., A.B.M.), Sanquin Research, Amsterdam, The Netherlands; Tumour Microenvironment and Proteomics Laboratory, Cancer Research UK Beatson Institute, Glasgow, United Kingdom (S.Z.); Tumour Microenvironment and Proteomics Laboratory, Institute of Cancer Sciences, University of Glasgow, United Kingdom (S.Z.); Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, The Netherlands (K.M., A.B.M.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309926DOI Listing
October 2017

Cellular uptake of coagulation factor VIII: Elusive role of the membrane-binding spikes in the C1 domain.

Int J Biochem Cell Biol 2017 08 27;89:34-41. Epub 2017 May 27.

From the Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.05.027DOI Listing
August 2017

Development of a Stereovision-Based Technique to Measure the Spread Patterns of Granular Fertilizer Spreaders.

Sensors (Basel) 2017 Jun 15;17(6). Epub 2017 Jun 15.

Fisheries and Food Research, Institute of Agricultural, Burg. Van Gansberghelaan 115, 9820 Merelbeke, Belgium.

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http://dx.doi.org/10.3390/s17061396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492561PMC
June 2017

Role of glycine 221 in catalytic activity of hyaluronan-binding protein 2.

J Biol Chem 2017 04 27;292(15):6381-6388. Epub 2017 Feb 27.

From the Department of Plasma Proteins, Sanquin Research, 1066 CX Amsterdam, The Netherlands and

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http://dx.doi.org/10.1074/jbc.M116.757849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391765PMC
April 2017

Development of a High Irradiance LED Configuration for Small Field of View Motion Estimation of Fertilizer Particles.

Sensors (Basel) 2015 Nov 12;15(11):28627-45. Epub 2015 Nov 12.

Institute of Agricultural and Fisheries Research, Burg. van Gansberghelaan 115, Merelbeke 9820, Belgium.

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http://dx.doi.org/10.3390/s151128627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701300PMC
November 2015

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

J Biol Chem 2015 Jul 21;290(27):16463-76. Epub 2015 Apr 21.

From the Department of Plasma Proteins, Sanquin Blood Supply Foundation, 1066 CX Amsterdam, The Netherlands, the Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TC Utrecht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M115.650911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505400PMC
July 2015

High speed stereovision setup for position and motion estimation of fertilizer particles leaving a centrifugal spreader.

Sensors (Basel) 2014 Nov 13;14(11):21466-82. Epub 2014 Nov 13.

Department of Biosystems Engineering, Ghent University, Coupure links 653, Gent 9000, Belgium.

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http://dx.doi.org/10.3390/s141121466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279543PMC
November 2014

A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

J Biol Chem 2013 Sep 24;288(36):26105-11. Epub 2013 Jul 24.

Department of Plasma Proteins, Sanquin Research, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M113.500884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764813PMC
September 2013

Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study.

J Neuroimaging 2013 Jul 28;23(3):431-6. Epub 2012 Dec 28.

Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/j.1552-6569.2012.00760.xDOI Listing
July 2013

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease.

Blood 2013 Apr 20;121(14):2762-72. Epub 2013 Feb 20.

Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1182/blood-2012-06-434373DOI Listing
April 2013

Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.

J Clin Neurosci 2012 Aug 31;19(8):1167-9. Epub 2012 May 31.

Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, Gent 9000, Belgium.

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http://dx.doi.org/10.1016/j.jocn.2011.08.043DOI Listing
August 2012

Factors VIII and V swap fatty feet.

Blood 2012 Aug;120(9):1761-3

Sanquin Blood Supply Foundation; Utrecht Institute For Pharmaceutical Sciences.

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http://dx.doi.org/10.1182/blood-2012-07-434027DOI Listing
August 2012

In vitro 2-deoxy-2-[18F]fluoro-D-glucose uptake: practical considerations.

Cancer Biother Radiopharm 2012 Apr 28;27(3):183-8. Epub 2012 Feb 28.

Department of Nuclear Medicine, University Hospital Ghent, Belgium.

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http://dx.doi.org/10.1089/cbr.2011.1125DOI Listing
April 2012

Novel role for galectin-8 protein as mediator of coagulation factor V endocytosis by megakaryocytes.

J Biol Chem 2012 Mar 20;287(11):8327-35. Epub 2012 Jan 20.

Department of Plasma Proteins, Sanquin Research, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M111.305151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318750PMC
March 2012

99mTc-labeled tricarbonyl his-CNA35 as an imaging agent for the detection of tumor vasculature.

J Nucl Med 2012 Mar 13;53(3):464-71. Epub 2012 Feb 13.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.111.095794DOI Listing
March 2012

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies.

Blood 2011 Nov 22;118(22):5947-56. Epub 2011 Sep 22.

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-05-355354DOI Listing
November 2011

C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII.

Int J Biochem Cell Biol 2011 Aug 8;43(8):1114-21. Epub 2011 Apr 8.

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.biocel.2011.03.014DOI Listing
August 2011

HLA-DR-presented peptide repertoires derived from human monocyte-derived dendritic cells pulsed with blood coagulation factor VIII.

Mol Cell Proteomics 2011 Jun 5;10(6):M110.002246. Epub 2011 Apr 5.

Department of Plasma Proteins, Van Creveld Laboratory of UMC Utrecht and Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/mcp.M110.002246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108829PMC
June 2011

PET with (18)F-labelled choline-based tracers for tumour imaging: a review of the literature.

Eur J Nucl Med Mol Imaging 2010 Nov 11;37(11):2188-93. Epub 2010 Jun 11.

Department of Nuclear Medicine, University Hospital Ghent, De Pintelaan, Gent, Belgium.

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http://dx.doi.org/10.1007/s00259-010-1496-zDOI Listing
November 2010

Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization.

Eur J Nucl Med Mol Imaging 2010 Nov 18;37(11):2136-45. Epub 2010 Jun 18.

Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00259-010-1508-zDOI Listing
November 2010

Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain.

Ann Nucl Med 2010 Jul 18;24(6):501-5. Epub 2010 Mar 18.

Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1007/s12149-010-0359-9DOI Listing
July 2010

Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity.

Blood 2009 Oct 17;114(18):3938-46. Epub 2009 Aug 17.

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2009-01-197707DOI Listing
October 2009

Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men.

Blood 2009 Oct 25;114(17):3656-61. Epub 2009 Aug 25.

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2009-03-212910DOI Listing
October 2009

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells.

Haematologica 2009 May 31;94(5):670-8. Epub 2009 Mar 31.

Department of Plasma Proteins, Sanquin Research, Plesmanlaan 125, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675679PMC
May 2009

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles.

Blood 2009 Mar 16;113(13):3102-9. Epub 2008 Dec 16.

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-05-15
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http://dx.doi.org/10.1182/blood-2008-05-159699DOI Listing
March 2009

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.

Blood 2008 Jul 16;112(1):56-63. Epub 2008 Apr 16.

Department of Plasma Proteins, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2007-07-099309DOI Listing
July 2008

Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism.

Nat Clin Pract Rheumatol 2008 Apr 19;4(4):192-9. Epub 2008 Feb 19.

Department of Plasma Proteins/Blood coagulation at Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncprheum0740DOI Listing
April 2008

Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor.

Blood Coagul Fibrinolysis 2008 Apr;19(3):190-6

Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/MBC.0b013e3282faa8c1DOI Listing
April 2008

The interface between the EGF2 domain and the protease domain in blood coagulation factor IX contributes to factor VIII binding and factor X activation.

Biochemistry 2006 Sep;45(35):10777-85

Department of Plasma Proteins, Sanquin Research, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1021/bi060451hDOI Listing
September 2006

LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.

Blood 2005 Aug 19;106(3):906-12. Epub 2005 Apr 19.

Department of Plasma Proteins, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2004-11-4230DOI Listing
August 2005

Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII.

Thromb Haemost 2005 May;93(5):833-41

Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1160/TH04-11-0729DOI Listing
May 2005

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.

Br J Haematol 2004 Sep;126(5):722-5

Department of Plasma Proteins, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1365-2141.2004.05093.xDOI Listing
September 2004

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.

Blood 2003 May 9;101(10):3933-9. Epub 2003 Jan 9.

Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2002-07-2081DOI Listing
May 2003

Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.

J Biol Chem 2003 Mar 8;278(11):9370-7. Epub 2003 Jan 8.

Department of Plasma Proteins, Sanquin Research at CLB, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M212053200DOI Listing
March 2003

Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein.

J Biol Chem 2003 Mar 9;278(11):9394-401. Epub 2003 Jan 9.

Department of Plasma Proteins, Sanquin Research at CLB, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M209097200DOI Listing
March 2003

The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain.

J Biol Chem 2002 Jun 29;277(23):20214-20. Epub 2002 Mar 29.

Department of Plasma Proteins, Sanquin Research at CLB, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M108446200DOI Listing
June 2002

Phospholipid-binding domain of factor VIII is involved in endothelial cell-mediated activation of factor X by factor IXa.

Arterioscler Thromb Vasc Biol 2002 Mar;22(3):511-6

Department of Plasma Proteins and Blood Coagulation, CLB, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/hq0302.105359DOI Listing
March 2002