Ko Willems van Dijk

Ko Willems van Dijk

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Ko Willems van Dijk

Ko Willems van Dijk

Publications by authors named "Ko Willems van Dijk"

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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Authors:
Raymond Noordam Maxime M Bos Heming Wang Thomas W Winkler Amy R Bentley Tuomas O Kilpeläinen Paul S de Vries Yun Ju Sung Karen Schwander Brian E Cade Alisa Manning Hugues Aschard Michael R Brown Han Chen Nora Franceschini Solomon K Musani Melissa Richard Dina Vojinovic Stella Aslibekyan Traci M Bartz Lisa de Las Fuentes Mary Feitosa Andrea R Horimoto Marjan Ilkov Minjung Kho Aldi Kraja Changwei Li Elise Lim Yongmei Liu Dennis O Mook-Kanamori Tuomo Rankinen Salman M Tajuddin Ashley van der Spek Zhe Wang Jonathan Marten Vincent Laville Maris Alver Evangelos Evangelou Maria E Graff Meian He Brigitte Kühnel Leo-Pekka Lyytikäinen Pedro Marques-Vidal Ilja M Nolte Nicholette D Palmer Rainer Rauramaa Xiao-Ou Shu Harold Snieder Stefan Weiss Wanqing Wen Lisa R Yanek Correa Adolfo Christie Ballantyne Larry Bielak Nienke R Biermasz Eric Boerwinkle Niki Dimou Gudny Eiriksdottir Chuan Gao Sina A Gharib Daniel J Gottlieb José Haba-Rubio Tamara B Harris Sami Heikkinen Raphaël Heinzer James E Hixson Georg Homuth M Arfan Ikram Pirjo Komulainen Jose E Krieger Jiwon Lee Jingmin Liu Kurt K Lohman Annemarie I Luik Reedik Mägi Lisa W Martin Thomas Meitinger Andres Metspalu Yuri Milaneschi Mike A Nalls Jeff O'Connell Annette Peters Patricia Peyser Olli T Raitakari Alex P Reiner Patrick C N Rensen Treva K Rice Stephen S Rich Till Roenneberg Jerome I Rotter Pamela J Schreiner James Shikany Stephen S Sidney Mario Sims Colleen M Sitlani Tamar Sofer Konstantin Strauch Morris A Swertz Kent D Taylor André G Uitterlinden Cornelia M van Duijn Henry Völzke Melanie Waldenberger Robert B Wallance Ko Willems van Dijk Caizheng Yu Alan B Zonderman Diane M Becker Paul Elliott Tõnu Esko Christian Gieger Hans J Grabe Timo A Lakka Terho Lehtimäki Kari E North Brenda W J H Penninx Peter Vollenweider Lynne E Wagenknecht Tangchun Wu Yong-Bing Xiang Wei Zheng Donna K Arnett Claude Bouchard Michele K Evans Vilmundur Gudnason Sharon Kardia Tanika N Kelly Stephen B Kritchevsky Ruth J F Loos Alexandre C Pereira Mike Province Bruce M Psaty Charles Rotimi Xiaofeng Zhu Najaf Amin L Adrienne Cupples Myriam Fornage Ervin F Fox Xiuqing Guo W James Gauderman Kenneth Rice Charles Kooperberg Patricia B Munroe Ching-Ti Liu Alanna C Morrison Dabeeru C Rao Diana van Heemst Susan Redline

Nat Commun 2019 Nov 12;10(1):5121. Epub 2019 Nov 12.

Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851116PMC
November 2019

Metabolomics: a search for biomarkers of visceral fat and liver fat content.

Metabolomics 2019 Oct 5;15(10):139. Epub 2019 Oct 5.

Department of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-019-1599-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778586PMC
October 2019

The association of genetic variants in the cholesteryl ester transfer protein gene with hemostatic factors and a first venous thrombosis.

J Thromb Haemost 2019 Sep 21;17(9):1535-1543. Epub 2019 Jun 21.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/jth.14528DOI Listing
September 2019

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.

Authors:
Cassandra N Spracklen Tugce Karaderi Hanieh Yaghootkar Claudia Schurmann Rebecca S Fine Zoltan Kutalik Michael H Preuss Yingchang Lu Laura B L Wittemans Linda S Adair Matthew Allison Najaf Amin Paul L Auer Traci M Bartz Matthias Blüher Michael Boehnke Judith B Borja Jette Bork-Jensen Linda Broer Daniel I Chasman Yii-Der Ida Chen Paraskevi Chirstofidou Ayse Demirkan Cornelia M van Duijn Mary F Feitosa Melissa E Garcia Mariaelisa Graff Harald Grallert Niels Grarup Xiuqing Guo Jeffrey Haesser Torben Hansen Tamara B Harris Heather M Highland Jaeyoung Hong M Arfan Ikram Erik Ingelsson Rebecca Jackson Pekka Jousilahti Mika Kähönen Jorge R Kizer Peter Kovacs Jennifer Kriebel Markku Laakso Leslie A Lange Terho Lehtimäki Jin Li Ruifang Li-Gao Lars Lind Jian'an Luan Leo-Pekka Lyytikäinen Stuart MacGregor David A Mackey Anubha Mahajan Massimo Mangino Satu Männistö Mark I McCarthy Barbara McKnight Carolina Medina-Gomez James B Meigs Sophie Molnos Dennis Mook-Kanamori Andrew P Morris Renee de Mutsert Mike A Nalls Ivana Nedeljkovic Kari E North Craig E Pennell Aruna D Pradhan Michael A Province Olli T Raitakari Chelsea K Raulerson Alex P Reiner Paul M Ridker Samuli Ripatti Neil Roberston Jerome I Rotter Veikko Salomaa America A Sandoval-Zárate Colleen M Sitlani Tim D Spector Konstantin Strauch Michael Stumvoll Kent D Taylor Betina Thuesen Anke Tönjes Andre G Uitterlinden Cristina Venturini Mark Walker Carol A Wang Shuai Wang Nicholas J Wareham Sara M Willems Ko Willems van Dijk James G Wilson Ying Wu Jie Yao Kristin L Young Claudia Langenberg Timothy M Frayling Tuomas O Kilpeläinen Cecilia M Lindgren Ruth J F Loos Karen L Mohlke

Am J Hum Genet 2019 Sep;105(3):670-671

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http://dx.doi.org/10.1016/j.ajhg.2019.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732522PMC
September 2019

Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study.

J Clin Lipidol 2018 Jan - Feb;12(1):137-144.e1. Epub 2017 Nov 2.

Department of Cardiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2017.10.023DOI Listing
July 2019

Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts.

J Clin Endocrinol Metab 2019 Jul;104(7):2903-2910

Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1210/jc.2018-02532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543772PMC
July 2019

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.

Authors:
Cassandra N Spracklen Tugce Karaderi Hanieh Yaghootkar Claudia Schurmann Rebecca S Fine Zoltan Kutalik Michael H Preuss Yingchang Lu Laura B L Wittemans Linda S Adair Matthew Allison Najaf Amin Paul L Auer Traci M Bartz Matthias Blüher Michael Boehnke Judith B Borja Jette Bork-Jensen Linda Broer Daniel I Chasman Yii-Der Ida Chen Paraskevi Chirstofidou Ayse Demirkan Cornelia M van Duijn Mary F Feitosa Melissa E Garcia Mariaelisa Graff Harald Grallert Niels Grarup Xiuqing Guo Jeffrey Haesser Torben Hansen Tamara B Harris Heather M Highland Jaeyoung Hong M Arfan Ikram Erik Ingelsson Rebecca Jackson Pekka Jousilahti Mika Kähönen Jorge R Kizer Peter Kovacs Jennifer Kriebel Markku Laakso Leslie A Lange Terho Lehtimäki Jin Li Ruifang Li-Gao Lars Lind Jian'an Luan Leo-Pekka Lyytikäinen Stuart MacGregor David A Mackey Anubha Mahajan Massimo Mangino Satu Männistö Mark I McCarthy Barbara McKnight Carolina Medina-Gomez James B Meigs Sophie Molnos Dennis Mook-Kanamori Andrew P Morris Renee de Mutsert Mike A Nalls Ivana Nedeljkovic Kari E North Craig E Pennell Aruna D Pradhan Michael A Province Olli T Raitakari Chelsea K Raulerson Alex P Reiner Paul M Ridker Samuli Ripatti Neil Roberston Jerome I Rotter Veikko Salomaa America A Sandoval-Zárate Colleen M Sitlani Tim D Spector Konstantin Strauch Michael Stumvoll Kent D Taylor Betina Thuesen Anke Tönjes Andre G Uitterlinden Cristina Venturini Mark Walker Carol A Wang Shuai Wang Nicholas J Wareham Sara M Willems Ko Willems van Dijk James G Wilson Ying Wu Jie Yao Kristin L Young Claudia Langenberg Timothy M Frayling Tuomas O Kilpeläinen Cecilia M Lindgren Ruth J F Loos Karen L Mohlke

Am J Hum Genet 2019 Jul 6;105(1):15-28. Epub 2019 Jun 6.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612516PMC
July 2019

Repeat length variations in polyglutamine disease-associated genes affect body mass index.

Int J Obes (Lond) 2019 03 17;43(3):440-449. Epub 2018 Aug 17.

Department of Neurology, Leiden University Medical Centre, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41366-018-0161-7DOI Listing
March 2019

Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice.

Biochim Biophys Acta Mol Basis Dis 2019 02 15;1865(2):494-501. Epub 2018 Nov 15.

Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Gorlaeus Laboratories, Leiden University, 2333CC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2018.11.009DOI Listing
February 2019

GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples.

Methods Mol Biol 2018 ;1730:247-256

Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://link.springer.com/10.1007/978-1-4939-7592-1_17
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http://dx.doi.org/10.1007/978-1-4939-7592-1_17DOI Listing
December 2018

GC-MS Analysis of Medium- and Long-Chain Fatty Acids in Blood Samples.

Methods Mol Biol 2018 ;1730:257-265

Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://link.springer.com/10.1007/978-1-4939-7592-1_18
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http://dx.doi.org/10.1007/978-1-4939-7592-1_18DOI Listing
December 2018

Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin.

Peptides 2018 09 1;107:25-31. Epub 2018 Aug 1.

Department of Clinical Epidemiology, Leiden University Medical Center (LUMC), PO-Box 9600, 2300RC, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2018.07.008DOI Listing
September 2018

Fusing metabolomics data sets with heterogeneous measurement errors.

PLoS One 2018 26;13(4):e0195939. Epub 2018 Apr 26.

Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919515PMC
July 2018

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.

Diabetologia 2018 06 3;61(6):1447-1458. Epub 2018 Mar 3.

Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, the Netherlands.

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http://dx.doi.org/10.1007/s00125-018-4583-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449003PMC
June 2018

In vivo and in silico dynamics of the development of Metabolic Syndrome.

PLoS Comput Biol 2018 06 7;14(6):e1006145. Epub 2018 Jun 7.

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1006145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991635PMC
June 2018

Genetics of fasting and postprandial metabolite levels are overlapping.

Physiol Genomics 2018 04 26;50(4):235-236. Epub 2018 Jan 26.

Department of Clinical Epidemiology; Leiden University Medical Center , Leiden , the Netherlands.

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http://dx.doi.org/10.1152/physiolgenomics.00101.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966804PMC
April 2018

Relation of Overall and Abdominal Adiposity With Electrocardiogram Parameters of Subclinical Cardiovascular Disease in Individuals Aged 45 to 65 Years (from the Netherlands Epidemiology of Obesity Study).

Am J Cardiol 2018 03 11;121(5):570-578. Epub 2017 Dec 11.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00029149173185
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http://dx.doi.org/10.1016/j.amjcard.2017.11.030DOI Listing
March 2018

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice.

Nutrients 2018 Feb 3;10(2). Epub 2018 Feb 3.

Department of Human Genetics and Einthoven Laboratory for Experimental Medicine, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3390/nu10020172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852748PMC
February 2018

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Diabetes 2017 11 28;66(11):2915-2926. Epub 2017 Aug 28.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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http://dx.doi.org/10.2337/db17-0199DOI Listing
November 2017

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Authors:
Felix R Day Deborah J Thompson Hannes Helgason Daniel I Chasman Hilary Finucane Patrick Sulem Katherine S Ruth Sean Whalen Abhishek K Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina M Barbieri Thibaud Boutin Archie Campbell Ellen Demerath Ayush Giri Chunyan He Jouke J Hottenga Robert Karlsson Ivana Kolcic Po-Ru Loh Kathryn L Lunetta Massimo Mangino Brumat Marco George McMahon Sarah E Medland Ilja M Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M Rose Katharina E Schraut Ayellet V Segrè Albert V Smith Lisette Stolk Alexander Teumer Irene L Andrulis Stefania Bandinelli Matthias W Beckmann Javier Benitez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E Bojesen Manjeet K Bolla Judith S Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E Buring Harry Campbell Eulalia Catamo Stephen Chanock Georgia Chenevix-Trench Tanguy Corre Fergus J Couch Diana L Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J C N de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel Dos-Santos-Silva Alison M Dunning Johan G Eriksson Peter A Fasching Lindsay Fernández-Rhodes Luigi Ferrucci Dieter Flesch-Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G Giles Harald Grallert Daniel F Gudbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B Harris Catharina A Hartman Gerardo Heiss Maartje J Hooning John L Hopper Frank Hu David J Hunter M Arfan Ikram Hae Kyung Im Marjo-Riitta Järvelin Peter K Joshi David Karasik Manolis Kellis Zoltan Kutalik Genevieve LaChance Diether Lambrechts Claudia Langenberg Lenore J Launer Joop S E Laven Stefania Lenarduzzi Jingmei Li Penelope A Lind Sara Lindstrom YongMei Liu Jian'an Luan Reedik Mägi Arto Mannermaa Hamdi Mbarek Mark I McCarthy Christa Meisinger Thomas Meitinger Cristina Menni Andres Metspalu Kyriaki Michailidou Lili Milani Roger L Milne Grant W Montgomery Anna M Mulligan Mike A Nalls Pau Navarro Heli Nevanlinna Dale R Nyholt Albertine J Oldehinkel Tracy A O'Mara Sandosh Padmanabhan Aarno Palotie Nancy Pedersen Annette Peters Julian Peto Paul D P Pharoah Anneli Pouta Paolo Radice Iffat Rahman Susan M Ring Antonietta Robino Frits R Rosendaal Igor Rudan Rico Rueedi Daniela Ruggiero Cinzia F Sala Marjanka K Schmidt Robert A Scott Mitul Shah Rossella Sorice Melissa C Southey Ulla Sovio Meir Stampfer Maristella Steri Konstantin Strauch Toshiko Tanaka Emmi Tikkanen Nicholas J Timpson Michela Traglia Thérèse Truong Jonathan P Tyrer André G Uitterlinden Digna R Velez Edwards Veronique Vitart Uwe Völker Peter Vollenweider Qin Wang Elisabeth Widen Ko Willems van Dijk Gonneke Willemsen Robert Winqvist Bruce H R Wolffenbuttel Jing Hua Zhao Magdalena Zoledziewska Marek Zygmunt Behrooz Z Alizadeh Dorret I Boomsma Marina Ciullo Francesco Cucca Tõnu Esko Nora Franceschini Christian Gieger Vilmundur Gudnason Caroline Hayward Peter Kraft Debbie A Lawlor Patrik K E Magnusson Nicholas G Martin Dennis O Mook-Kanamori Ellen A Nohr Ozren Polasek David Porteous Alkes L Price Paul M Ridker Harold Snieder Tim D Spector Doris Stöckl Daniela Toniolo Sheila Ulivi Jenny A Visser Henry Völzke Nicholas J Wareham James F Wilson Amanda B Spurdle Unnur Thorsteindottir Katherine S Pollard Douglas F Easton Joyce Y Tung Jenny Chang-Claude David Hinds Anna Murray Joanne M Murabito Kari Stefansson Ken K Ong John R B Perry

Nat Genet 2017 Jun 24;49(6):834-841. Epub 2017 Apr 24.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841952PMC
June 2017

Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass.

Metabolism 2016 Nov 16;65(11):1614-1620. Epub 2016 Aug 16.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.07.013DOI Listing
November 2016

Energy restriction and Roux-en-Y gastric bypass reduce postprandial α-dicarbonyl stress in obese women with type 2 diabetes.

Diabetologia 2016 09 16;59(9):2013-7. Epub 2016 Jun 16.

Department of Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, Peter Debeyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-4009-1
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http://dx.doi.org/10.1007/s00125-016-4009-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969347PMC
September 2016

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

Authors:
Elisabeth M van Leeuwen Aniko Sabo Joshua C Bis Jennifer E Huffman Ani Manichaikul Albert V Smith Mary F Feitosa Serkalem Demissie Peter K Joshi Qing Duan Jonathan Marten Jan B van Klinken Ida Surakka Ilja M Nolte Weihua Zhang Hamdi Mbarek Ruifang Li-Gao Stella Trompet Niek Verweij Evangelos Evangelou Leo-Pekka Lyytikäinen Bamidele O Tayo Joris Deelen Peter J van der Most Sander W van der Laan Dan E Arking Alanna Morrison Abbas Dehghan Oscar H Franco Albert Hofman Fernando Rivadeneira Eric J Sijbrands Andre G Uitterlinden Josyf C Mychaleckyj Archie Campbell Lynne J Hocking Sandosh Padmanabhan Jennifer A Brody Kenneth M Rice Charles C White Tamara Harris Aaron Isaacs Harry Campbell Leslie A Lange Igor Rudan Ivana Kolcic Pau Navarro Tatijana Zemunik Veikko Salomaa Angad S Kooner Jaspal S Kooner Benjamin Lehne William R Scott Sian-Tsung Tan Eco J de Geus Yuri Milaneschi Brenda W J H Penninx Gonneke Willemsen Renée de Mutsert Ian Ford Ron T Gansevoort Marcelo P Segura-Lepe Olli T Raitakari Jorma S Viikari Kjell Nikus Terrence Forrester Colin A McKenzie Anton J M de Craen Hester M de Ruijter Gerard Pasterkamp Harold Snieder Albertine J Oldehinkel P Eline Slagboom Richard S Cooper Mika Kähönen Terho Lehtimäki Paul Elliott Pim van der Harst J Wouter Jukema Dennis O Mook-Kanamori Dorret I Boomsma John C Chambers Morris Swertz Samuli Ripatti Ko Willems van Dijk Veronique Vitart Ozren Polasek Caroline Hayward James G Wilson James F Wilson Vilmundur Gudnason Stephen S Rich Bruce M Psaty Ingrid B Borecki Eric Boerwinkle Jerome I Rotter L Adrienne Cupples Cornelia M van Duijn

J Med Genet 2016 07 1;53(7):441-9. Epub 2016 Apr 1.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/jmedgenet-2015-103439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941146PMC
July 2016

FluxModeCalculator: an efficient tool for large-scale flux mode computation.

Bioinformatics 2016 04 18;32(8):1265-6. Epub 2015 Dec 18.

Department of Human Genetics Einthoven Laboratory for Experimental Vascular Medicine Department of Medicine, Division of Endocrinology, LUMC, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btv742DOI Listing
April 2016

Serum CETP concentration is not associated with measures of body fat: The NEO study.

Atherosclerosis 2016 Mar 19;246:267-73. Epub 2016 Jan 19.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.01.031DOI Listing
March 2016

Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism.

Eur J Hum Genet 2016 Jan 27;24(1):142-5. Epub 2015 May 27.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2015.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795225PMC
January 2016

Type 2 diabetes is associated with postprandial amino acid measures.

Arch Biochem Biophys 2016 Jan 10;589:138-44. Epub 2015 Aug 10.

Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.abb.2015.08.003DOI Listing
January 2016

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

Arch Biochem Biophys 2016 Jan 16;589:152-7. Epub 2015 Sep 16.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Epidemiology Section, BESC Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1016/j.abb.2015.09.001DOI Listing
January 2016

FcRγ-chain deficiency reduces the development of diet-induced obesity.

Obesity (Silver Spring) 2015 Dec 2;23(12):2435-44. Epub 2015 Nov 2.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/oby.21309DOI Listing
December 2015

Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance.

Nutr Metab (Lond) 2015 18;12:57. Epub 2015 Dec 18.

Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.

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http://dx.doi.org/10.1186/s12986-015-0053-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683731PMC
December 2015

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.

J Lipid Res 2015 Nov 4;56(11):2085-93. Epub 2015 Sep 4.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.jlr.org/content/56/11/2085.full.pdf
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http://www.jlr.org/lookup/doi/10.1194/jlr.M057794
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http://dx.doi.org/10.1194/jlr.M057794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617395PMC
November 2015

Smoking is associated with increased resting energy expenditure in the general population: The NEO study.

Metabolism 2015 Nov 18;64(11):1548-55. Epub 2015 Aug 18.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands; Department of Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Aarhus University, DK-8000 Aarhus C, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S00260495150022
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http://dx.doi.org/10.1016/j.metabol.2015.08.008DOI Listing
November 2015

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice.

FASEB J 2015 Jul 7;29(7):3027-39. Epub 2015 Apr 7.

Departments of *Parasitology, Human Genetics, Molecular Cell Biology, and Endocrinology and Metabolic Diseases, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1096/fj.14-266239DOI Listing
July 2015

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.

J Nutr Biochem 2015 Feb 25;26(2):155-64. Epub 2014 Oct 25.

Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, NL-5600 MB Eindhoven, The Netherlands; Netherlands Consortium for Systems Biology, PO Box 94215, NL-1090GE Amsterdam, The Netherlands; Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, Building 3226, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jnutbio.2014.09.014DOI Listing
February 2015

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

PLoS Genet 2015 Jan 8;11(1):e1004835. Epub 2015 Jan 8.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1004835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287344PMC
January 2015

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects.

Clin Endocrinol (Oxf) 2014 Dec 12;81(6):862-70. Epub 2014 Jun 12.

Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/cen.12496DOI Listing
December 2014

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.

Diabetes Care 2014 Dec 14;37(12):3150-6. Epub 2014 Oct 14.

Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, the Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/dc14-0195DOI Listing
December 2014

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile.

J Lipid Res 2014 Dec 15;55(12):2532-40. Epub 2014 Oct 15.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M051938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242446PMC
December 2014

Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans.

Am J Physiol Endocrinol Metab 2014 Nov 23;307(10):E885-95. Epub 2014 Sep 23.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1152/ajpendo.00215.2014DOI Listing
November 2014

Genetics of the human metabolome, what is next?

Biochim Biophys Acta 2014 Oct 4;1842(10):1923-1931. Epub 2014 Jun 4.

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands; Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439140015
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http://dx.doi.org/10.1016/j.bbadis.2014.05.030DOI Listing
October 2014

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

PLoS One 2013 16;8(9):e74083. Epub 2013 Sep 16.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands ; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074083PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774620PMC
May 2014

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance.

Metabolism 2014 Apr 10;63(4):492-501. Epub 2013 Dec 10.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2013.12.002DOI Listing
April 2014

CD36 is important for adipocyte recruitment and affects lipolysis.

Obesity (Silver Spring) 2013 Oct 29;21(10):2037-45. Epub 2013 May 29.

Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/oby.20354
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http://dx.doi.org/10.1002/oby.20354DOI Listing
October 2013

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Diabetes 2013 Oct 8;62(10):3589-98. Epub 2013 Jul 8.

Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/db13-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781444PMC
October 2013

Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals.

Am J Physiol Endocrinol Metab 2013 May 19;304(9):E1012-21. Epub 2013 Mar 19.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00008.2013DOI Listing
May 2013

Practical aspects of estimating energy components in rodents.

Front Physiol 2013 1;4:94. Epub 2013 May 1.

Department of Human Genetics, Leiden University Medical Center Leiden, Netherlands.

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http://dx.doi.org/10.3389/fphys.2013.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640188PMC
May 2013

Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity.

FASEB J 2013 Apr 9;27(4):1721-32. Epub 2013 Jan 9.

Leiden University Medical Center, Department of Molecular Cell Biology, Laboratory of Neurophysiology, Bldg. 2, Room T5-32, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, the Netherlands.

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http://dx.doi.org/10.1096/fj.12-210898DOI Listing
April 2013

META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse.

Nutrition 2013 Jan 15;29(1):276-83. Epub 2012 Sep 15.

Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S08999007120022
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http://dx.doi.org/10.1016/j.nut.2012.05.004DOI Listing
January 2013