Klaus Warnatz

Klaus Warnatz

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Klaus Warnatz

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A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Nat Commun 2020 Jun 19;11(1):3150. Epub 2020 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1038/s41467-020-16819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305203PMC
June 2020

Interstitial lung disease in primary immunodeficiency: towards a brighter future.

Eur Respir J 2020 Apr 3;55(4). Epub 2020 Apr 3.

Dept of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1183/13993003.00089-2020DOI Listing
April 2020

Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations.

J Allergy Clin Immunol 2020 Apr 9. Epub 2020 Apr 9.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS (Centre for Integrative Biological Signalling Studies), University of Freiburg, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital and University College London, London, United Kingdom; DZIF (German Center for Infection Research) Satellite Center Freiburg, Freiburg, Germany; Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.11.051DOI Listing
April 2020

Preserved Cellular Immunity Upon Influenza Vaccination in Most Patients with Common Variable Immunodeficiency.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2332-2340.e5. Epub 2020 Apr 21.

Division of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.04.019DOI Listing
April 2020

Structural Noninfectious Manifestations of the Central Nervous System in Common Variable Immunodeficiency Disorders.

J Allergy Clin Immunol Pract 2020 Mar 16;8(3):1047-1062.e6. Epub 2019 Dec 16.

Department of Rheumatology and Clinical Immunology, Division of Immunodeficiency, Medical Center of the University Hospital, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.11.039DOI Listing
March 2020

Exhausted phenotype of follicular CD8 T cells in CVID.

J Allergy Clin Immunol 2020 Mar 10. Epub 2020 Mar 10.

Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.02.025DOI Listing
March 2020

Impaired polysaccharide responsiveness without agammaglobulinaemia in three patients with hypomorphic mutations in Bruton Tyrosine Kinase-No detection by newborn screening for primary immunodeficiencies.

Scand J Immunol 2020 Jan 30;91(1):e12811. Epub 2019 Oct 30.

Department of Pediatric Pneumology, Immunology and Intensive Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1111/sji.12811DOI Listing
January 2020

Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.

Clin Immunol 2020 01 23;210:108316. Epub 2019 Nov 23.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.108316DOI Listing
January 2020

[Development of an Intervention to Enhance Health Literacy of Patients with Common Variable Immunodeficiency (CVID)].

Gesundheitswesen 2019 Oct 15. Epub 2019 Oct 15.

Medizinische Fakultät, Zentrum für Chronische Immundefizienz (CCI), Albert-Ludwigs-Universität Freiburg, Freiburg.

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http://dx.doi.org/10.1055/a-1005-7235DOI Listing
October 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201970107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350392PMC
October 2019

Severe eosinophilic myocarditis associated with modafinil in a patient with normal peripheral eosinophil count.

Clin Res Cardiol 2019 Aug 12;108(8):963-966. Epub 2019 Feb 12.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00392-019-01434-wDOI Listing
August 2019

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659583PMC
July 2019

Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency.

Clin Immunol 2019 06 17;203:59-62. Epub 2019 Apr 17.

Department for Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.04.001DOI Listing
June 2019

Corrigendum: Assessing the Functional Relevance of Variants in the () in a Cohort of Patients With Primary Immunodeficiency.

Front Immunol 2019;10:1490. Epub 2019 Jun 28.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611354PMC
June 2019

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Front Immunol 2018 16;9:543. Epub 2018 Mar 16.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00
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http://dx.doi.org/10.3389/fimmu.2018.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863269PMC
May 2019

Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab.

N Engl J Med 2019 04 10;380(17):1676-1677. Epub 2019 Apr 10.

Albert Ludwigs University, Freiburg, Germany.

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http://dx.doi.org/10.1056/NEJMc1817193DOI Listing
April 2019

Assessing the Functional Relevance of Variants in the () in a Cohort of Patients With Primary Immunodeficiency.

Front Immunol 2019 16;10:568. Epub 2019 Apr 16.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477086PMC
April 2019

TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.

Front Immunol 2019 30;10:951. Epub 2019 Apr 30.

Clinic for Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503035PMC
April 2019

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

J Allergy Clin Immunol 2018 12 4;142(6):1932-1946. Epub 2018 May 4.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215742PMC
December 2018

Deficiencies in the CD19 complex.

Clin Immunol 2018 10 31;195:82-87. Epub 2018 Jul 31.

Dept. of Immunology, Erasmus MC, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.07.017DOI Listing
October 2018

Follicular Helper T Cells in DiGeorge Syndrome.

Front Immunol 2018 23;9:1730. Epub 2018 Jul 23.

Department of Immunology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia.

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http://dx.doi.org/10.3389/fimmu.2018.01730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065053PMC
July 2018

Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.

J Exp Med 2018 05 10;215(5):1327-1336. Epub 2018 Apr 10.

Institute of Cellular & Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany

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http://dx.doi.org/10.1084/jem.20170534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940257PMC
May 2018

T NK IL-2 Receptor γ Chain Mutation: a Challenging Diagnosis of Atypical Severe Combined Immunodeficiency.

J Clin Immunol 2018 05 9;38(4):527-536. Epub 2018 Jun 9.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-018-0514-yDOI Listing
May 2018

Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation.

J Clin Immunol 2017 Nov 21;37(8):759-769. Epub 2017 Sep 21.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstr. 115, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-017-0444-0DOI Listing
November 2017

Fatal ulcerative enteritis of the small intestine in a patient with ulcerative colitis treated with vedolizumab.

Z Gastroenterol 2017 Oct 27;55(10):1014-1020. Epub 2017 Jun 27.

Dept. of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.1055/s-0043-111805DOI Listing
October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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http://doi.wiley.com/10.1002/eji.201646632
Publisher Site
http://dx.doi.org/10.1002/eji.201646632DOI Listing
October 2017

Increase of circulating α4β7 conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID).

Clin Immunol 2017 07 18;180:80-83. Epub 2017 Mar 18.

Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.03.006DOI Listing
July 2017

IgG4-related disease in autoimmune lymphoproliferative syndrome.

Clin Immunol 2017 07 3;180:97-99. Epub 2017 May 3.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616173004
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http://dx.doi.org/10.1016/j.clim.2017.05.003DOI Listing
July 2017

Advances in the Care of Primary Immunodeficiencies (PIDs): from Birth to Adulthood.

J Clin Immunol 2017 Jul 18;37(5):452-460. Epub 2017 May 18.

Great North Children's Hospital, & Institute for Cellular Medicine University of Newcastle, Newcastle upon Tyne, NE4 1LP, UK.

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http://dx.doi.org/10.1007/s10875-017-0401-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489581PMC
July 2017

High SYK Expression Drives Constitutive Activation of CD21 B Cells.

J Immunol 2017 06 3;198(11):4285-4292. Epub 2017 May 3.

Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany;

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http://dx.doi.org/10.4049/jimmunol.1700079DOI Listing
June 2017

[Primary Immunodeficiency in Adults].

Dtsch Med Wochenschr 2017 Jun 31;142(11):829-832. Epub 2017 May 31.

Centrum für Chronische Immundefizienz - CCI, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Deutschland.

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http://dx.doi.org/10.1055/s-0043-105094DOI Listing
June 2017

Autosomal dominant gain of function STAT1 mutation and severe bronchiectasis.

Respir Med 2017 05 22;126:39-45. Epub 2017 Mar 22.

Department of Pediatrics and Pediatric Pulmonary Unit, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.rmed.2017.03.018DOI Listing
May 2017

Rescue of Cytokine Storm Due to HLH by Hemoadsorption in a CTLA4-Deficient Patient.

J Clin Immunol 2017 04 6;37(3):273-276. Epub 2017 Mar 6.

Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Breisacher Str. 115, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-017-0377-7DOI Listing
April 2017

Disturbed canonical nuclear factor of κ light chain signaling in B cells of patients with common variable immunodeficiency.

J Allergy Clin Immunol 2017 01 14;139(1):220-231.e8. Epub 2016 Jun 14.

Center for Chronic Immunodeficiency, University Medical Center and University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.04.043DOI Listing
January 2017

Phenotypic and Functional Comparison of Class Switch Recombination Deficiencies with a Subgroup of Common Variable Immunodeficiencies.

J Clin Immunol 2016 10 2;36(7):656-66. Epub 2016 Aug 2.

Department of Pediatric Hematology, Immunology and Infectious Diseases, Academic Medical Center (AMC), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10875-016-0321-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018261PMC
October 2016

Protein Kinase C δ: a Gatekeeper of Immune Homeostasis.

J Clin Immunol 2016 10 19;36(7):631-40. Epub 2016 Aug 19.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, Vienna, Austria.

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http://dx.doi.org/10.1007/s10875-016-0323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018258PMC
October 2016

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

J Exp Med 2016 06 30;213(7):1185-99. Epub 2016 May 30.

Monique and Jacques Roboh Department of Genetic Research, Hadassah Medical Center, Hebrew University, Jerusalem 91120, Israel Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University, Jerusalem 91120, Israel

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http://dx.doi.org/10.1084/jem.20151110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925012PMC
June 2016

Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency.

J Clin Immunol 2016 05 15;36(4):406-12. Epub 2016 Mar 15.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Str. 117, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-016-0264-7DOI Listing
May 2016

Deep intronic mis-splicing mutation in JAK3 gene underlies T-B+NK- severe combined immunodeficiency phenotype.

Clin Immunol 2016 Feb 6;163:91-5. Epub 2016 Jan 6.

Monique and Jacques Roboh Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.clim.2016.01.001DOI Listing
February 2016

The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects.

J Allergy Clin Immunol 2016 Jan;137(1):3-17

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2015.11.004DOI Listing
January 2016

The autoimmune conundrum in common variable immunodeficiency disorders.

Curr Opin Allergy Clin Immunol 2015 Dec;15(6):514-24

aDivision of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, the Netherlands bCenter for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1097/ACI.0000000000000218DOI Listing
December 2015

Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.

Am J Hum Genet 2015 Sep 13;97(3):389-403. Epub 2015 Aug 13.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg 79108, Germany; Institute of Immunity and Transplantation, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564940PMC
September 2015

Autoimmune lymphoproliferative syndrome-like disease in patients with LRBA mutation.

Clin Immunol 2015 Jul 27;159(1):84-92. Epub 2015 Apr 27.

Pediatric Hematology/Oncology and Bone Marrow Transplantation, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.clim.2015.04.007DOI Listing
July 2015

Late-onset hemophagocytic lymphohistiocytosis (HLH) in an adult female with Griscelli syndrome type 2 (GS2).

Ann Hematol 2015 Jun 30;94(6):1057-60. Epub 2014 Dec 30.

Department of Hematology and Oncology, Schwarzwald-Baar Clinic, Academic Teaching Hospital University of Freiburg, Klinikstr. 11, 78052, Villingen-Schwenningen, Germany,

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http://dx.doi.org/10.1007/s00277-014-2284-9DOI Listing
June 2015

Recurrence of persistent polyclonal B lymphocytosis (PPBL) after rituximab treatment.

Ann Hematol 2015 Jun 1;94(6):1075-6. Epub 2015 Feb 1.

Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, University of Freiburg, Breisacherstrasse 117, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00277-015-2302-6DOI Listing
June 2015

Generalized verrucosis and HPV-3 susceptibility associated with CD4 T-cell lymphopenia caused by inherited human interleukin-7 deficiency.

J Am Acad Dermatol 2015 Jun;72(6):1082-4

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; The Center for Genetic Diseases of the Skin and Hair, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2015.02.1118DOI Listing
June 2015

Enteroviral Infection in a Patient with BLNK Adaptor Protein Deficiency.

J Clin Immunol 2015 May 17;35(4):356-60. Epub 2015 Apr 17.

Pediatric Division, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s10875-015-0164-2DOI Listing
May 2015

Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency.

Haematologica 2015 Feb 14;100(2):e72-6. Epub 2014 Nov 14.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Germany

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http://dx.doi.org/10.3324/haematol.2014.112508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803132PMC
February 2015

Classification of common variable immunodeficiencies using flow cytometry and a memory B-cell functionality assay.

J Allergy Clin Immunol 2015 Jan 10;135(1):198-208. Epub 2014 Aug 10.

Institute for Medical Immunology, Charité University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jaci.2014.06.022DOI Listing
January 2015

Immunodeficiency in adults a practical guide for the allergist.

Allergo J Int 2014;23(7):261-268. Epub 2014 Nov 6.

Center for Chronic Immunodeficiency (CCI), Freiburg University Clinic, Freiburg, Germany.

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http://dx.doi.org/10.1007/s40629-014-0030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479546PMC
November 2014

Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge.

J Clin Immunol 2014 Jul 15;34(5):524-43. Epub 2014 May 15.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s10875-014-0053-0DOI Listing
July 2014

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):16556-61. Epub 2013 Sep 23.

Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.1218219110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799326PMC
October 2013

Common variable immunodeficiency-associated granulomatous and interstitial lung disease.

Curr Opin Pulm Med 2013 Sep;19(5):503-9

Department of Pneumology, University Medical Clinic Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1097/MCP.0b013e3283642c47DOI Listing
September 2013

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency.

J Clin Immunol 2013 Jul 23;33(5):909-16. Epub 2013 Apr 23.

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10875-013-9892-3DOI Listing
July 2013

Elevated serum osteopontin levels in idiopathic retroperitoneal fibrosis.

Clin Exp Rheumatol 2012 Sep-Oct;30(5):772-5. Epub 2012 Oct 17.

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.

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February 2013

Common variable immunodeficiency: an update.

Arthritis Res Ther 2012 Sep 24;14(5):223. Epub 2012 Sep 24.

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http://dx.doi.org/10.1186/ar4032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580506PMC
September 2012

Pathogenesis of autoimmunity in common variable immunodeficiency.

Front Immunol 2012 18;3:210. Epub 2012 Jul 18.

Centre of Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2012.00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399211PMC
August 2012