Klaus Strebhardt

Klaus Strebhardt

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Klaus Strebhardt

Publications by authors named "Klaus Strebhardt"

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Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.

Sci Rep 2019 Jul 18;9(1):10462. Epub 2019 Jul 18.

Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, CB2 1Q, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-019-45627-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639320PMC
July 2019

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability.

Neoplasia 2019 04 7;21(4):363-375. Epub 2019 Mar 7.

Department of Gynecology, Goethe-University, Frankfurt am Main; German Cancer Consortium (DKTK) / German Cancer Research Center, partner site, Frankfurt a. M.. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407080PMC
April 2019

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.

J Med Chem 2019 Mar 21;62(5):2618-2637. Epub 2019 Feb 21.

Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research , London SM2 5NG , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421522PMC
March 2019

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region.

BMC Res Notes 2018 Dec 6;11(1):869. Epub 2018 Dec 6.

Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3976-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282339PMC
December 2018

The role of PLK1 in cancer exhibiting chromosomal instability.

Mol Cell Oncol 2018 20;5(6):e1485539. Epub 2018 Sep 20.

Department of Gynecology, Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1080/23723556.2018.1485539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276849PMC
September 2018

Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.

Mol Cancer Res 2018 03 12;16(3):378-389. Epub 2017 Dec 12.

Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0404DOI Listing
March 2018

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Nat Commun 2017 07 12;8:16001. Epub 2017 Jul 12.

Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1038/ncomms16001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510181PMC
July 2017

Human papilloma virus load and PD-1/PD-L1, CD8 and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy.

Oncoimmunology 2017 6;6(3):e1288331. Epub 2017 Feb 6.

Department of Radiotherapy and Oncology, Goethe-University, Frankfurt am Main, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK) partner site: Frankfurt/Mainz, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2017.1288331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384387PMC
February 2017

Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).

Cell Cycle 2015 ;14(19):3030-9

a Department of Biochemistry ; Purdue University ; West Lafayette , IN USA.

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http://dx.doi.org/10.1080/15384101.2015.1080397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825546PMC
August 2016

Drugging Plk1: An attractive approach to inhibit androgen receptor signaling.

Authors:
Klaus Strebhardt

Cell Cycle 2015 1;14(14):2193-4. Epub 2015 Jun 1.

a Department of Gynecology ; School of Medicine; Goethe University ; Frankfurt , Germany.

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http://dx.doi.org/10.1080/15384101.2015.1056611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242295PMC
April 2016

Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer.

Mol Cell Biol 2015 Dec 5;35(24):4185-98. Epub 2015 Oct 5.

Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA

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http://dx.doi.org/10.1128/MCB.00825-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648817PMC
December 2015

Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function.

Int J Biol Markers 2015 Jul 22;30(3):e275-81. Epub 2015 Jul 22.

Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (Forlì-Cesena) - Italy.

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http://dx.doi.org/10.5301/jbm.5000149DOI Listing
July 2015

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.

Mol Oncol 2015 Jan 11;9(1):140-54. Epub 2014 Aug 11.

Department of Gynecology, School of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528686PMC
January 2015

Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery.

Expert Opin Drug Discov 2015 Jan 29;10(1):1-8. Epub 2014 Sep 29.

J.W. Goethe University, School of Medicine, Department of Obstetrics and Gynecology , Theodor-Stern-Kai 7, 60590 Frankfurt , Germany +49 69 6301 6894 ; +49 69 6301 6364 ;

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http://dx.doi.org/10.1517/17460441.2015.962510DOI Listing
January 2015

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells.

Cell Res 2014 Sep 1;24(9):1141-5. Epub 2014 Jul 1.

1] Department of Gynecology, School of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany [2] German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://www.nature.com/articles/cr201486
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http://dx.doi.org/10.1038/cr.2014.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152744PMC
September 2014

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.

Mol Oncol 2014 May 17;8(3):596-608. Epub 2014 Jan 17.

Department of Obstetrics and Gynecology, School of Medicine, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528627PMC
May 2014

pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner.

Mol Oncol 2014 Mar 20;8(2):232-49. Epub 2013 Nov 20.

Department of Gynaecology and Obstetrics, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528548PMC
March 2014

Plk1: unexpected roles in DNA replication.

Cell Res 2013 Nov 17;23(11):1251-3. Epub 2013 Sep 17.

Department of Gynecology and Obstetrics, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/cr.2013.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817549PMC
November 2013

Polo-like kinases in AML.

Expert Opin Investig Drugs 2012 Aug 6;21(8):1069-74. Epub 2012 Jun 6.

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http://dx.doi.org/10.1517/13543784.2012.691163DOI Listing
August 2012

A fluorescence polarization assay for the discovery of inhibitors of the polo-box domain of polo-like kinase 1.

Methods Mol Biol 2012 ;795:69-81

Department of Molecular Biology, and Center for Integrated Protein Science Munich (CIPSM), Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1007/978-1-61779-337-0_5DOI Listing
January 2012

Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ.

Int J Cancer 2011 Nov 25;129(10):2522-6. Epub 2011 Mar 25.

Department of Gynaecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1002/ijc.25895DOI Listing
November 2011

Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.

Am J Pathol 2011 Oct 10;179(4):2091-9. Epub 2011 Aug 10.

Department of Gynecology and Obstetrics, School of Medicine, J. W. Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.ajpath.2011.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181368PMC
October 2011

Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

Mol Cell Biol 2010 Dec 11;30(24):5726-40. Epub 2010 Oct 11.

Department of Obstetrics and Gynecology, School of Medicine, J W Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1128/MCB.00731-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004266PMC
December 2010

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.

Authors:
Klaus Strebhardt

Nat Rev Drug Discov 2010 Aug;9(8):643-60

Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany.

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http://www.nature.com/articles/nrd3184
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http://dx.doi.org/10.1038/nrd3184DOI Listing
August 2010

Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.

Mol Cell Biol 2010 Jun 5;30(11):2594-607. Epub 2010 Apr 5.

Department of Gynecology and Obstetrics, School of Medicine, J. W. Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1128/MCB.00098-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876524PMC
June 2010

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Immunity 2010 Apr 25;32(4):541-56. Epub 2010 Mar 25.

Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q.

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http://dx.doi.org/10.1016/j.immuni.2010.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812847PMC
April 2010

Biological impact of freezing Plk1 in its inactive conformation in cancer cells.

Cell Cycle 2010 Feb 16;9(4):761-73. Epub 2010 Feb 16.

Department of Obstetrics and Gynecology, Medical School, Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.4161/cc.9.4.10644DOI Listing
February 2010

Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3.

Anal Biochem 2009 Dec 27;395(2):189-94. Epub 2009 Aug 27.

Department of Molecular Biology, Max Planck Institute of Biochemistry, and Center for Integrated Protein Science Munich, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.ab.2009.08.031DOI Listing
December 2009

Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression.

J Drug Target 2009 Sep;17(8):627-37

Institute of Pharmaceutical Technology, Biocenter of Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1080/10611860903118823DOI Listing
September 2009

A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis.

Chembiochem 2009 May;10(7):1145-8

Department of Molecular Biology, Max Planck Institute of Biochemistry, Center for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1002/cbic.200900059DOI Listing
May 2009

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

Cell Cycle 2009 Feb 18;8(3):460-72. Epub 2009 Feb 18.

Department of Gynecology and Obstetrics, School of Medicine, JW Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.4161/cc.8.3.7651DOI Listing
February 2009

Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.

Proc Natl Acad Sci U S A 2009 Feb 30;106(6):1725-30. Epub 2009 Jan 30.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0812135106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633213PMC
February 2009

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.

Anal Biochem 2008 Dec 22;383(2):205-9. Epub 2008 Aug 22.

Department of Molecular Biology, Max Planck Institute of Biochemistry, Munich Center for Integrated Protein Science (CIPSM), Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.ab.2008.08.014DOI Listing
December 2008

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol.

BMC Cancer 2008 Dec 29;8:391. Epub 2008 Dec 29.

Department of Obstetrics and Gynecology, School of Medicine, J,W, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1186/1471-2407-8-391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639606PMC
December 2008

Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation.

Biomaterials 2008 Oct 23;29(29):4022-8. Epub 2008 Jul 23.

Institute of Pharmaceutical Technology, Biocenter of Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2008.07.001DOI Listing
October 2008

Paul Ehrlich's magic bullet concept: 100 years of progress.

Nat Rev Cancer 2008 06 12;8(6):473-80. Epub 2008 May 12.

Klaus Strebhardt is at the Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-University, Theodour-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1038/nrc2394DOI Listing
June 2008

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.

Chem Biol 2008 May;15(5):459-66

Department of Molecular Biology, Max Planck Institute of Biochemistry and Munich Center for Integrated Protein Science (CiPS(M)), Martinsried, Germany.

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http://dx.doi.org/10.1016/j.chembiol.2008.03.013DOI Listing
May 2008

Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles.

Neoplasia 2008 Mar;10(3):223-34

Department of Obstetrics and Gynecology, School of Medicine, Johann Wolfgang Goethe-University, D-60590 Frankfurt, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259452PMC
http://dx.doi.org/10.1593/neo.07916DOI Listing
March 2008

Silencing of mammalian genes by tetracycline-inducible shRNA expression.

Nat Protoc 2007 ;2(12):3257-69

Department of Gynaecology and Obstetrics, School of Medicine, J.W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

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http://www.nature.com/articles/nprot.2007.458
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http://dx.doi.org/10.1038/nprot.2007.458DOI Listing
February 2008

FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells.

Cell Cycle 2007 Jul;6(14):1779-88

Department of Gynecology and Obstetrics, Medical School, J.W. Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.4161/cc.6.14.4448DOI Listing
July 2007

Demands on caring relatives of head and neck cancer patients.

Laryngoscope 2007 Apr;117(4):712-6

Department of Otorhinolaryngology, School of Medicine, J.W. Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1097/mlg.0b013e318031d0b4DOI Listing
April 2007

The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.

Anticancer Res 2007 Jan-Feb;27(1A):55-61

Department of Gynecology and Obstetrics, Medical School, J.W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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March 2007

Another look at imatinib mesylate.

N Engl J Med 2006 Dec;355(23):2481-2

Department of Obstetrics and Gynecology, School of Medicine, J.W. Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1056/NEJMcibr065325DOI Listing
December 2006

Polo-like kinase 1: target and regulator of transcriptional control.

Cell Cycle 2006 Dec 15;5(24):2881-5. Epub 2006 Dec 15.

Department of Gynecology and Obstetric, Medical School, J.W. Goethe-University, Frankfurt, Germany.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.24.3538
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http://dx.doi.org/10.4161/cc.5.24.3538DOI Listing
December 2006

Small molecules keep mitotic kinases in check.

Authors:
Klaus Strebhardt

ACS Chem Biol 2006 Dec;1(11):683-6

Department of Obstetrics and Gynecology, School of Medicine, J. W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1021/cb600462zDOI Listing
December 2006

Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells.

Biomaterials 2006 Oct 6;27(28):4975-83. Epub 2006 Jun 6.

Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2006.05.016DOI Listing
October 2006

Tumor inhibition by genomically integrated inducible RNAi-cassettes.

Nucleic Acids Res 2006 31;34(16):4527-36. Epub 2006 Aug 31.

Department of Gynecology and Obstetrics, School of Medicine, J.W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkl628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636372PMC
October 2006

Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS.

Pathol Res Pract 2006 2;202(1):1-7. Epub 2005 Dec 2.

Department of Gynecology and Obstetrics, University of Frankfurt, Theodor-Stern-Kai 7-9, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.prp.2005.10.003DOI Listing
August 2006

Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.

Cancer Res 2006 Jul;66(14):6895-8

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.

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http://cancerres.aacrjournals.org/content/66/14/6895.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-06-0358DOI Listing
July 2006

Down-regulation of Polo-like kinase 1 elevates drug sensitivity of breast cancer cells in vitro and in vivo.

Cancer Res 2006 Jun;66(11):5836-46

Department of Obstetrics and Gynecology, Medical School, J.W. Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0343DOI Listing
June 2006

Targeting polo-like kinase 1 for cancer therapy.

Nat Rev Cancer 2006 04;6(4):321-30

Department of Obstetrics and Gynecology, School of Medicine, J.W. Goethe-University, Theodore-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1038/nrc1841DOI Listing
April 2006

Reduction of cisplatin dosage by ZD 1839.

Anticancer Res 2005 Nov-Dec;25(6B):3985-8

Department of Otorhonolaryngology, School of Medicine, J. W. Goethe University, 60590 Frankfurt, Germany.

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January 2006

RNA interference-based gene silencing in mice: the development of a novel therapeutical strategy.

Curr Pharm Des 2005 ;11(26):3405-19

Department of Obstetrics and Gynecology, Medical School, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.2174/138161205774370834DOI Listing
December 2005

Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.

J Biol Chem 2005 Nov 23;280(44):36575-83. Epub 2005 Aug 23.

Department of Gynecology and Obstetrics, J. W. Goethe-University, Theodor-Stern-Kai 7, Frankfurt D-60590, Germany.

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http://dx.doi.org/10.1074/jbc.M504548200DOI Listing
November 2005

Iressa (ZD 1839) inhibits phosphorylation of three different downstream signal transducers in head and neck cancer (SCCHN).

Anticancer Res 2005 May-Jun;25(3B):1871-5

Department of Otorhinolaryngology, School of Medicine, J. W. Goethe University, 60590 Frankfurt, Germany.

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November 2005

Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells.

Neoplasia 2004 Nov-Dec;6(6):786-95

Department of Obstetrics and Gynecology, Medical School, J. W. Goethe University, Theodor-Stern-Kai 7, Frankfurt 60590, Germany.

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http://dx.doi.org/10.1593/neo.04313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1531682PMC
April 2005

Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1.

Oncogene 2005 Apr;24(18):2973-80

Department of Gynecology and Obstetrics, School of Medicine, JW Goethe-University, Theodor-Stern-Kai 7, Haus 15, Frankfurt 60590, Germany.

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http://www.nature.com/articles/1208472
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http://dx.doi.org/10.1038/sj.onc.1208472DOI Listing
April 2005

Highly specific HER2-mediated cellular uptake of antibody-modified nanoparticles in tumour cells.

J Drug Target 2004 ;12(7):461-71

Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe-University, Marie-Curie-Strasse 9, D-60439 Frankfurt, Germany.

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http://dx.doi.org/10.1080/10611860400010697 DOI Listing
March 2005

STAT 3 activation in head and neck squamous cell carcinomas is controlled by the EGFR.

Anticancer Res 2004 Nov-Dec;24(6):3881-6

Department of Otorhinolaryngology, School of Medicine, J. W. Goethe University, 60590 Frankfurt, Germany.

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March 2005

Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.

J Biol Chem 2005 Jan 9;280(2):923-32. Epub 2004 Nov 9.

Rammelkamp Center for Research, MetroHealth Campus, and Department of Pharmacology and Ireland Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M411383200
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http://dx.doi.org/10.1074/jbc.M411383200DOI Listing
January 2005

Polo-like kinases and oncogenesis.

Oncogene 2005 Jan;24(2):267-76

Department of Gynecology and Obstetrics, Medical School, JW Goethe-University, Theodor-Stern-Kai 7, Frankfurt D-60590, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208273DOI Listing
January 2005

The role of early expression of inducible nitric oxide synthase in human breast cancer.

Eur J Cancer 2005 Jan;41(2):265-71

Department of Gynaecology and Obstetrics, J.W. Goethe-University of Frankfurt, Theodor-Stern-Kai 7-9, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.ejca.2004.07.010DOI Listing
January 2005

Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells.

Oncogene 2004 Jul;23(34):5843-52

Department of Gynaecology and Obstetrics, Medical School, JW Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207757DOI Listing
July 2004

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

J Natl Cancer Inst 2004 Jun;96(11):862-72

Department of Obstetrics and Gynecology, School of Medicine, J. W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1093/jnci/djh146DOI Listing
June 2004

Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles.

J Control Release 2004 May;96(3):483-95

Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe-University, Marie-Curie-Strasse 9, D-60439 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.jconrel.2004.01.029DOI Listing
May 2004

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells.

J Natl Cancer Inst 2002 Dec;94(24):1863-77

Department of Obstetrics and Gynecology, School of Medicine, J. W. Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1093/jnci/94.24.1863DOI Listing
December 2002

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

Oncogene 2002 Nov;21(54):8282-92

Department of Obstetrics and Gynecology, JW Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206011DOI Listing
November 2002

Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation.

Cancer Res 2002 Aug;62(15):4186-90

Department of Obstetrics and Gynecology, Medical School, J.W. Goethe-University, 60590 Frankfurt, Germany.

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August 2002

Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease.

J Cutan Pathol 2002 Jul;29(6):354-8

Department of Dermatology, Johann Wolfgang Goethe-University, School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1034/j.1600-0560.2002.290605.xDOI Listing
July 2002

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells.

Oncogene 2002 May;21(20):3162-71

Department of Obstetrics and Gynecology, School of Medicine, JW Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.

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http://dx.doi.org/10.1038/sj.onc.1205412DOI Listing
May 2002