Publications by authors named "Klaus H Kaestner"

100Publications

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.

Cell Metab 2020 12 13;32(6):1028-1040.e4. Epub 2020 Nov 13.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; VA Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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December 2020

Organisation of the human pancreas in health and in diabetes.

Diabetologia 2020 10 7;63(10):1966-1973. Epub 2020 Sep 7.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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October 2020

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D.

Mol Metab 2020 Dec 30;42:101057. Epub 2020 Jul 30.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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December 2020

Collapse of the hepatic gene regulatory network in the absence of FoxA factors.

Genes Dev 2020 Aug 19;34(15-16):1039-1050. Epub 2020 Jun 19.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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August 2020

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression.

Immunity 2020 02 11;52(2):257-274.e11. Epub 2020 Feb 11.

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; The Human Pancreas Analysis Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA, https://hpap.pmacs.upenn.edu/. Electronic address:

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February 2020

Tracking Dysbiosis Where It Matters.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2020 19;9(3):547-548. Epub 2019 Dec 19.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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August 2020

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes.

Nat Commun 2019 12 13;10(1):5697. Epub 2019 Dec 13.

Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939, Munich, Germany.

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December 2019

A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice.

Gastroenterology 2020 03 20;158(4):1044-1057.e17. Epub 2019 Nov 20.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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March 2020

A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells.

iScience 2019 Nov 1;21:681-694. Epub 2019 Nov 1.

Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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November 2019

The Dynamic Chromatin Architecture of the Regenerating Liver.

Cell Mol Gastroenterol Hepatol 2020 17;9(1):121-143. Epub 2019 Oct 17.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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October 2019

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.

Cell Stem Cell 2019 12 26;25(6):830-845.e8. Epub 2019 Sep 26.

Institute for Diabetes, Obesity & Metabolism, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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December 2019

A New Era of CMGH.

Cell Mol Gastroenterol Hepatol 2019 10;8(3):527. Epub 2019 Sep 10.

Cellular and Molecular Gastroenterology and Hepatology. Electronic address:

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September 2019

The dynamic methylome of islets in health and disease.

Mol Metab 2019 09;27S:S25-S32

University of Pennsylvania, Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Philadelphia, PA, USA. Electronic address:

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September 2019

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity.

Mol Metab 2019 09;27S:S122-S128

Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939, Munich, Germany; Deutsches Zentrum für Diabetesforschung (DZD), Ingolstaedter Landstrasse 1, 85764, Munich-Neuherberg, Germany; Division of Clinical Pharmacology, Department of Medicine IV, Ludwig-Maximilians-Universität München, 80337, Munich, Germany. Electronic address:

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September 2019

Emerging diverse roles of telocytes.

Development 2019 07 16;146(14). Epub 2019 Jul 16.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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July 2019

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).

Diabetes 2019 07 24;68(7):1394-1402. Epub 2019 May 24.

Departments of Pathology and Pediatrics, University of Florida Diabetes Institute, Gainesville, FL.

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July 2019

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

JCI Insight 2019 04 23;5. Epub 2019 Apr 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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April 2019

The Intestinal Stem Cell Niche: A Central Role for Foxl1-Expressing Subepithelial Telocytes.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2019 6;8(1):111-117. Epub 2019 Apr 6.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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April 2020

Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence.

Am J Cancer Res 2019 1;9(2):424-428. Epub 2019 Feb 1.

Department of Cancer Biology, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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February 2019

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Cell Metab 2019 03 31;29(3):769-783.e4. Epub 2019 Jan 31.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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March 2019

Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

Cell Metab 2019 03 20;29(3):539-544. Epub 2018 Dec 20.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6145, USA. Electronic address:

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March 2019

Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication.

J Clin Invest 2019 01 26;129(1):209-214. Epub 2018 Nov 26.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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January 2019

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Diabetes 2018 10;67(10):1923-1931

Department of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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October 2018

The Dysregulation of the - Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs.

Diabetes 2018 09 3;67(9):1807-1815. Epub 2018 Jul 3.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA

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September 2018

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.

Cell Metab 2018 11 26;28(5):787-792.e3. Epub 2018 Jul 26.

Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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November 2018

Pax6 regulation of in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.

Development 2018 08 9;145(15). Epub 2018 Aug 9.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel

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August 2018

Author Correction: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Nature 2018 08;560(7718):E29

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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August 2018

Lipid malabsorption from altered hormonal signaling changes early gut microbial responses.

Am J Physiol Gastrointest Liver Physiol 2018 10 28;315(4):G580-G591. Epub 2018 Jun 28.

Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.

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October 2018

Postnatal DNA demethylation and its role in tissue maturation.

Nat Commun 2018 05 23;9(1):2040. Epub 2018 May 23.

Department of Developmental Biology and Cancer Research, Hebrew University Medical School, P.O.B. 12272, , Jerusalem, 91120, Israel.

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May 2018

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Nature 2018 05 2;557(7704):242-246. Epub 2018 May 2.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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May 2018

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Mol Metab 2018 05 23;11:212-217. Epub 2018 Mar 23.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

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May 2018

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity.

Diabetes 2018 06 23;67(6):1079-1085. Epub 2018 Feb 23.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel

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June 2018

Transcriptional Noise and Somatic Mutations in the Aging Pancreas.

Cell Metab 2017 12;26(6):809-811

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address:

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December 2017

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Proc Natl Acad Sci U S A 2017 10 16;114(44):11739-11744. Epub 2017 Oct 16.

Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037;

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October 2017

Islet biology.

Mol Metab 2017 09 13;6(9):vi. Epub 2017 Jun 13.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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September 2017

Epigenetics in formation, function, and failure of the endocrine pancreas.

Mol Metab 2017 09 31;6(9):1066-1076. Epub 2017 May 31.

University of Pennsylvania, Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Philadelphia, PA, USA.

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September 2017

β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells.

Diabetes Obes Metab 2017 09;19 Suppl 1:147-152

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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September 2017

Reprogramming human gallbladder cells into insulin-producing β-like cells.

PLoS One 2017 16;12(8):e0181812. Epub 2017 Aug 16.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, United States of America.

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October 2017

Insights From the Crypt: Regionalization, Adaptation, and Renewal of the Intestinal Epithelium.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2017 May 31;3(3):297-298. Epub 2017 Mar 31.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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May 2017

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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July 2017

Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

Cell Metab 2017 Apr;25(4):911-926.e6

Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address:

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April 2017

High-fidelity mouse line generated by CRISPR-Cas9 assisted gene targeting.

Mol Metab 2017 03 12;6(3):236-244. Epub 2017 Jan 12.

Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA; Department of Genetics, Perelman School of Medicine, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address:

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March 2017

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

PLoS Pathog 2017 02 24;13(2):e1006239. Epub 2017 Feb 24.

Department of Microbiology and Immunology College of Medicine University of Illinois at Chicago 909 South Wolcott Avenue Chicago, IL, United States of America.

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February 2017

The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice.

Cell Mol Gastroenterol Hepatol 2016 Nov;2(6):783-795

Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia.

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November 2016

Fox transcription factors: from development to disease.

Development 2016 12;143(24):4558-4570

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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December 2016

Epigenetic control of β-cell function and failure.

Diabetes Res Clin Pract 2017 Jan 21;123:24-36. Epub 2016 Nov 21.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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January 2017

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.

Genes Dev 2016 11 17;30(21):2433-2442. Epub 2016 Nov 17.

Department of Genetics, Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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November 2016

Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets.

Methods Mol Biol 2017 ;1507:95-111

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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January 2018

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Cell Metab 2016 10;24(4):616-626

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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October 2016

Human islets contain four distinct subtypes of β cells.

Nat Commun 2016 07 11;7:11756. Epub 2016 Jul 11.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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July 2016

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Diabetes 2016 10 30;65(10):3028-38. Epub 2016 Jun 30.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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October 2016

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.

Hepatology 2016 10 28;64(4):1163-1177. Epub 2016 May 28.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA, USA.

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October 2016

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation.

Mol Cell 2016 Apr;62(1):79-91

Department of Cell and Developmental Biology and Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5157, USA. Electronic address:

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April 2016

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

Mol Metab 2016 Mar 11;5(3):233-244. Epub 2016 Jan 11.

Institute of Diabetes, Obesity, and Metabolism, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA; Department of Genetics, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address:

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March 2016

Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.

Cell Mol Gastroenterol Hepatol 2016 Feb;2(2):175-188

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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February 2016

Foxa1 is essential for mammary duct formation.

Genesis 2016 05 29;54(5):277-85. Epub 2016 Mar 29.

Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.

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May 2016

DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation.

Cancer Prev Res (Phila) 2016 Jul 16;9(7):534-46. Epub 2016 Feb 16.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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July 2016

The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.

Elife 2016 Jan 25;5. Epub 2016 Jan 25.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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January 2016

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of in Mice.

Cell Mol Gastroenterol Hepatol 2015 09;1(5):550-569

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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September 2015

CREB pathway links PGE2 signaling with macrophage polarization.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):15642-7. Epub 2015 Dec 7.

Peptide Biology Laboratories, The Salk Institute, La Jolla, CA 92037-1002;

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December 2015

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function.

Cell Metab 2015 Oct 27;22(4):619-32. Epub 2015 Aug 27.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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October 2015

The BisPCR(2) method for targeted bisulfite sequencing.

Epigenetics Chromatin 2015 1;8:27. Epub 2015 Aug 1.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104 USA.

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August 2015

Epigenetic regulation of the intestinal epithelium.

Cell Mol Life Sci 2015 Nov 29;72(21):4139-56. Epub 2015 Jul 29.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, 12-126 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

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November 2015

The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.

Nat Commun 2015 Jun 2;6:7216. Epub 2015 Jun 2.

Peptide Biology Laboratories, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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June 2015

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

Development 2015 Jun 28;142(12):2163-72. Epub 2015 May 28.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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June 2015

A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.

Genes Dev 2015 May;29(9):904-9

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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May 2015

Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer.

Am J Pathol 2015 May;185(5):1385-95

Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania; Division of Urology, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address:

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May 2015

An epigenomic road map for endoderm development.

Authors:
Klaus H Kaestner

Cell Stem Cell 2015 Apr;16(4):343-4

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, 3400 Civic Center Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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April 2015

Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.

Learn Mem 2015 Feb 15;22(2):109-15. Epub 2015 Jan 15.

Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA

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February 2015

Betatrophin--promises fading and lessons learned.

Authors:
Klaus H Kaestner

Cell Metab 2014 Dec;20(6):932-3

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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December 2014

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.

BMJ Open Diabetes Res Care 2014 1;2(1):e000052. Epub 2014 Dec 1.

Division of Human Genetics , The Children's Hospital of Philadelphia , Philadelphia, Pennsylvania , USA ; Department of Genetics and Institute of Diabetes, Obesity and Metabolism , Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA ; Department of Pediatrics , Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA.

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December 2014

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.

Mol Metab 2014 Nov 23;3(8):803-12. Epub 2014 Aug 23.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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November 2014

Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.

Am J Physiol Gastrointest Liver Physiol 2015 Jan 6;308(2):G85-91. Epub 2014 Nov 6.

Department of Genetics and Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania, School of Medicine Philadelphia, Pennsylvania;

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January 2015

Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.

Gastroenterology 2015 Jan 5;148(1):192-202.e3. Epub 2014 Oct 5.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address:

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January 2015

Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.

Am J Physiol Gastrointest Liver Physiol 2014 Nov 11;307(10):G979-91. Epub 2014 Sep 11.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Division of Gastroenterology and Nutrition, Department of Pediatrics, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania; and.

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November 2014

Dysgenesis of enteroendocrine cells in Aristaless-Related Homeobox polyalanine expansion mutations.

J Pediatr Gastroenterol Nutr 2015 Feb;60(2):192-9

*Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia †Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania ‡Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.

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February 2015

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.

Stem Cell Res 2014 Sep 27;13(2):275-83. Epub 2014 Jul 27.

Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

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September 2014