Klaus H Kaestner

Klaus H Kaestner

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Klaus H Kaestner

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.

Cell Stem Cell 2019 Dec 26;25(6):830-845.e8. Epub 2019 Sep 26.

Institute for Diabetes, Obesity & Metabolism, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898778PMC
December 2019

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes.

Nat Commun 2019 Dec 13;10(1):5697. Epub 2019 Dec 13.

Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939, Munich, Germany.

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http://dx.doi.org/10.1038/s41467-019-13587-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910913PMC
December 2019

Tracking Dysbiosis Where It Matters.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2019 Dec 19. Epub 2019 Dec 19.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.11.015DOI Listing
December 2019

A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells.

iScience 2019 Nov 1;21:681-694. Epub 2019 Nov 1.

Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.10.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889369PMC
November 2019

High-content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice.

Gastroenterology 2019 Nov 20. Epub 2019 Nov 20.

Professor, University of Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.11.025DOI Listing
November 2019

The Dynamic Chromatin Architecture of the Regenerating Liver.

Cell Mol Gastroenterol Hepatol 2020 17;9(1):121-143. Epub 2019 Oct 17.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909351PMC
October 2019

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity.

Mol Metab 2019 Sep;27S:S122-S128

Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939, Munich, Germany; Deutsches Zentrum für Diabetesforschung (DZD), Ingolstaedter Landstrasse 1, 85764, Munich-Neuherberg, Germany; Division of Clinical Pharmacology, Department of Medicine IV, Ludwig-Maximilians-Universität München, 80337, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768498PMC
September 2019

The dynamic methylome of islets in health and disease.

Mol Metab 2019 Sep;27S:S25-S32

University of Pennsylvania, Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768570PMC
September 2019

A New Era of CMGH.

Cell Mol Gastroenterol Hepatol 2019 10;8(3):527. Epub 2019 Sep 10.

Cellular and Molecular Gastroenterology and Hepatology. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819868PMC
September 2019

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).

Diabetes 2019 Jul 24;68(7):1394-1402. Epub 2019 May 24.

Departments of Pathology and Pediatrics, University of Florida Diabetes Institute, Gainesville, FL.

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http://dx.doi.org/10.2337/db19-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609987PMC
July 2019

Emerging diverse roles of telocytes.

Development 2019 Jul 16;146(14). Epub 2019 Jul 16.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.175018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679369PMC
July 2019

The Intestinal Stem Cell Niche: A Central Role for Foxl1-Expressing Subepithelial Telocytes.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2019 6;8(1):111-117. Epub 2019 Apr 6.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538877PMC
April 2019

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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http://insight.jci.org/articles/view/127994
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http://dx.doi.org/10.1172/jci.insight.127994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542600PMC
April 2019

Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?

Cell Metab 2019 03 20;29(3):539-544. Epub 2018 Dec 20.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6145, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402960PMC
March 2019

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Cell Metab 2019 03 31;29(3):769-783.e4. Epub 2019 Jan 31.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436557PMC
March 2019

Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence.

Am J Cancer Res 2019 1;9(2):424-428. Epub 2019 Feb 1.

Department of Cancer Biology, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405962PMC
February 2019

Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication.

J Clin Invest 2019 01 26;129(1):209-214. Epub 2018 Nov 26.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI99170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307972PMC
January 2019

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.

Cell Metab 2018 11 26;28(5):787-792.e3. Epub 2018 Jul 26.

Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183044
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http://dx.doi.org/10.1016/j.cmet.2018.07.002DOI Listing
November 2018

Lipid malabsorption from altered hormonal signaling changes early gut microbial responses.

Am J Physiol Gastrointest Liver Physiol 2018 10 28;315(4):G580-G591. Epub 2018 Jun 28.

Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.

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https://www.physiology.org/doi/10.1152/ajpgi.00135.2018
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http://dx.doi.org/10.1152/ajpgi.00135.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230693PMC
October 2018

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Diabetes 2018 10;67(10):1923-1931

Department of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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http://dx.doi.org/10.2337/db18-0537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463748PMC
October 2018

Author Correction: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Nature 2018 08;560(7718):E29

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41586-018-0286-9DOI Listing
August 2018

Pax6 regulation of in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.

Development 2018 08 9;145(15). Epub 2018 Aug 9.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel

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http://dev.biologists.org/lookup/doi/10.1242/dev.163691
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http://dx.doi.org/10.1242/dev.163691DOI Listing
August 2018

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity.

Diabetes 2018 06 23;67(6):1079-1085. Epub 2018 Feb 23.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel

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http://dx.doi.org/10.2337/db17-1028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961409PMC
June 2018

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Mol Metab 2018 05 23;11:212-217. Epub 2018 Mar 23.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001393PMC
May 2018

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.

Nature 2018 05 2;557(7704):242-246. Epub 2018 May 2.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41586-018-0084-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966331PMC
May 2018

Postnatal DNA demethylation and its role in tissue maturation.

Nat Commun 2018 05 23;9(1):2040. Epub 2018 May 23.

Department of Developmental Biology and Cancer Research, Hebrew University Medical School, P.O.B. 12272, , Jerusalem, 91120, Israel.

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http://dx.doi.org/10.1038/s41467-018-04456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966414PMC
May 2018

Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets.

Methods Mol Biol 2017 ;1507:95-111

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-6518-2_8DOI Listing
January 2018

Transcriptional Noise and Somatic Mutations in the Aging Pancreas.

Cell Metab 2017 12;26(6):809-811

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.11.009DOI Listing
December 2017

Reprogramming human gallbladder cells into insulin-producing β-like cells.

PLoS One 2017 16;12(8):e0181812. Epub 2017 Aug 16.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558938PMC
October 2017

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Proc Natl Acad Sci U S A 2017 10 16;114(44):11739-11744. Epub 2017 Oct 16.

Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1712616114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676928PMC
October 2017

β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells.

Diabetes Obes Metab 2017 09;19 Suppl 1:147-152

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/dom.13019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659199PMC
September 2017

Epigenetics in formation, function, and failure of the endocrine pancreas.

Mol Metab 2017 09 31;6(9):1066-1076. Epub 2017 May 31.

University of Pennsylvania, Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.molmet.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605720PMC
September 2017

Islet biology.

Mol Metab 2017 09 13;6(9):vi. Epub 2017 Jun 13.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molmet.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605722PMC
September 2017

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.2337/db17-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482088PMC
July 2017

Insights From the Crypt: Regionalization, Adaptation, and Renewal of the Intestinal Epithelium.

Authors:
Klaus H Kaestner

Cell Mol Gastroenterol Hepatol 2017 May 31;3(3):297-298. Epub 2017 Mar 31.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404098PMC
May 2017

Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

Cell Metab 2017 Apr;25(4):911-926.e6

Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.017DOI Listing
April 2017

High-fidelity mouse line generated by CRISPR-Cas9 assisted gene targeting.

Mol Metab 2017 03 12;6(3):236-244. Epub 2017 Jan 12.

Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA; Department of Genetics, Perelman School of Medicine, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323890PMC
March 2017

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

PLoS Pathog 2017 02 24;13(2):e1006239. Epub 2017 Feb 24.

Department of Microbiology and Immunology College of Medicine University of Illinois at Chicago 909 South Wolcott Avenue Chicago, IL, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342274PMC
February 2017

Epigenetic control of β-cell function and failure.

Diabetes Res Clin Pract 2017 Jan 21;123:24-36. Epub 2016 Nov 21.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250585PMC
January 2017

Fox transcription factors: from development to disease.

Development 2016 12;143(24):4558-4570

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.112672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201025PMC
December 2016

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.

Genes Dev 2016 11 17;30(21):2433-2442. Epub 2016 Nov 17.

Department of Genetics, Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.288035.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131782PMC
November 2016

The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice.

Cell Mol Gastroenterol Hepatol 2016 Nov;2(6):783-795

Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X163009
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http://dx.doi.org/10.1016/j.jcmgh.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235342PMC
November 2016

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice.

Hepatology 2016 10 28;64(4):1163-1177. Epub 2016 May 28.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1002/hep.28602
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http://dx.doi.org/10.1002/hep.28602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033674PMC
October 2016

Single-Cell Transcriptomics of the Human Endocrine Pancreas.

Diabetes 2016 10 30;65(10):3028-38. Epub 2016 Jun 30.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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http://dx.doi.org/10.2337/db16-0405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033269PMC
October 2016

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Cell Metab 2016 10;24(4):616-626

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131163048
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http://dx.doi.org/10.1016/j.cmet.2016.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123805PMC
October 2016

DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation.

Cancer Prev Res (Phila) 2016 Jul 16;9(7):534-46. Epub 2016 Feb 16.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930698PMC
July 2016

Human islets contain four distinct subtypes of β cells.

Nat Commun 2016 07 11;7:11756. Epub 2016 Jul 11.

Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1038/ncomms11756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942571PMC
July 2016

Foxa1 is essential for mammary duct formation.

Genesis 2016 05 29;54(5):277-85. Epub 2016 Mar 29.

Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.

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http://dx.doi.org/10.1002/dvg.22929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419034PMC
May 2016

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation.

Mol Cell 2016 Apr;62(1):79-91

Department of Cell and Developmental Biology and Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5157, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826471PMC
April 2016

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

Mol Metab 2016 Mar 11;5(3):233-244. Epub 2016 Jan 11.

Institute of Diabetes, Obesity, and Metabolism, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA; Department of Genetics, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770267PMC
March 2016

Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.

Cell Mol Gastroenterol Hepatol 2016 Feb;2(2):175-188

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jcmgh.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772878PMC
February 2016

The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.

Elife 2016 Jan 25;5. Epub 2016 Jan 25.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.12975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786433PMC
January 2016

CREB pathway links PGE2 signaling with macrophage polarization.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):15642-7. Epub 2015 Dec 7.

Peptide Biology Laboratories, The Salk Institute, La Jolla, CA 92037-1002;

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http://www.pnas.org/content/112/51/15642.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1519644112
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http://dx.doi.org/10.1073/pnas.1519644112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697393PMC
December 2015

Epigenetic regulation of the intestinal epithelium.

Cell Mol Life Sci 2015 Nov 29;72(21):4139-56. Epub 2015 Jul 29.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, 12-126 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00018-015-1997-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607638PMC
November 2015

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function.

Cell Metab 2015 Oct 27;22(4):619-32. Epub 2015 Aug 27.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598285PMC
October 2015

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of in Mice.

Cell Mol Gastroenterol Hepatol 2015 09;1(5):550-569

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2015.06.007DOI Listing
September 2015

The BisPCR(2) method for targeted bisulfite sequencing.

Epigenetics Chromatin 2015 1;8:27. Epub 2015 Aug 1.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s13072-015-0020-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522100PMC
August 2015

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

Development 2015 Jun 28;142(12):2163-72. Epub 2015 May 28.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.117341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483766PMC
June 2015

The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.

Nat Commun 2015 Jun 2;6:7216. Epub 2015 Jun 2.

Peptide Biology Laboratories, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://www.nature.com/articles/ncomms8216
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545657PMC
June 2015

Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer.

Am J Pathol 2015 May;185(5):1385-95

Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Hershey, Pennsylvania; Division of Urology, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419202PMC
May 2015

A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.

Genes Dev 2015 May;29(9):904-9

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://dx.doi.org/10.1101/gad.258855.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421979PMC
May 2015

An epigenomic road map for endoderm development.

Authors:
Klaus H Kaestner

Cell Stem Cell 2015 Apr;16(4):343-4

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, 3400 Civic Center Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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April 2015

Dysgenesis of enteroendocrine cells in Aristaless-Related Homeobox polyalanine expansion mutations.

J Pediatr Gastroenterol Nutr 2015 Feb;60(2):192-9

*Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia †Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania ‡Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1097/MPG.0000000000000542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308495PMC
February 2015

Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.

Learn Mem 2015 Feb 15;22(2):109-15. Epub 2015 Jan 15.

Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA

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http://learnmem.cshlp.org/lookup/doi/10.1101/lm.037044.114
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341363PMC
February 2015

Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.

Gastroenterology 2015 Jan 5;148(1):192-202.e3. Epub 2014 Oct 5.

Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387775PMC
January 2015

Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.

Am J Physiol Gastrointest Liver Physiol 2015 Jan 6;308(2):G85-91. Epub 2014 Nov 6.

Department of Genetics and Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania, School of Medicine Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpgi.00084.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380483PMC
January 2015

Islet-1 Is essential for pancreatic β-cell function.

Diabetes 2014 Dec 15;63(12):4206-17. Epub 2014 Jul 15.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Janssen Research & Development, Spring House, PA

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http://dx.doi.org/10.2337/db14-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237994PMC
December 2014

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.

BMJ Open Diabetes Res Care 2014 1;2(1):e000052. Epub 2014 Dec 1.

Division of Human Genetics , The Children's Hospital of Philadelphia , Philadelphia, Pennsylvania , USA ; Department of Genetics and Institute of Diabetes, Obesity and Metabolism , Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA ; Department of Pediatrics , Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA.

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http://drc.bmj.com/lookup/doi/10.1136/bmjdrc-2014-000052
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http://dx.doi.org/10.1136/bmjdrc-2014-000052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250976PMC
December 2014

Betatrophin--promises fading and lessons learned.

Authors:
Klaus H Kaestner

Cell Metab 2014 Dec;20(6):932-3

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410809PMC
December 2014

Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.

Am J Physiol Gastrointest Liver Physiol 2014 Nov 11;307(10):G979-91. Epub 2014 Sep 11.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Division of Gastroenterology and Nutrition, Department of Pediatrics, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania; and.

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http://www.physiology.org/doi/10.1152/ajpgi.00390.2013
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233286PMC
November 2014

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.

Mol Metab 2014 Nov 23;3(8):803-12. Epub 2014 Aug 23.

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molmet.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216406PMC
November 2014

Activated FoxM1 attenuates streptozotocin-mediated β-cell death.

Mol Endocrinol 2014 Sep 29;28(9):1435-47. Epub 2014 Jul 29.

Tennessee Valley Healthcare System Department of Veteran Affairs (M.L.G., M.F.M., J.C.D., G.P., M.A.G.), Nashville, Tennessee 37212; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism (M.L.G., M.F.M., J.C.D., G.P., M.A.G.), and Departments of Cell and Developmental Biology (M.A.G.) and Molecular Physiology and Biophysics (M.A.G.), Vanderbilt University Medical Center, Nashville, Tennessee 37232; and Department of Genetics and Institute for Diabetes, Obesity and Metabolism (J.S., K.H.K.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1210/me.2014-1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154244PMC
September 2014

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.

Stem Cell Res 2014 Sep 27;13(2):275-83. Epub 2014 Jul 27.

Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2014.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243830PMC
September 2014

Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.

J Clin Endocrinol Metab 2014 Aug 30;99(8):E1580-5. Epub 2014 May 30.

Division of Human Genetics (M.E.J., S.F.A.G.) and Department of Pathology and Laboratory Medicine (A.D.W.), The Children's Hospital of Philadelphia, and Department of Genetics and Institute of Diabetes, Obesity, and Metabolism (J.S., K.H.K., S.F.A.G.), and Department of Pediatrics (S.F.A.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1210/jc.2013-4503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121035PMC
August 2014

5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation.

BMC Genomics 2014 Aug 9;15:670. Epub 2014 Aug 9.

Department of Genetics, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, 3400 Civic Center Blvd, 19104 Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/1471-2164-15-670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133056PMC
August 2014

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype.

Lab Invest 2014 Jul 19;94(7):726-39. Epub 2014 May 19.

1] Department of Pathology, Pennsylvania State University, Hershey, PA, USA [2] Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA [3] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/labinvest.2014.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451837PMC
July 2014

Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII.

Mol Metab 2014 Jul 15;3(4):484-9. Epub 2014 Apr 15.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), P.O. Box 6109, Campinas, SP, CEP 13083-865, Brazil.

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http://dx.doi.org/10.1016/j.molmet.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060215PMC
July 2014

The Missing lnc(RNA) between the pancreatic β-cell and diabetes.

Front Genet 2014 1;5:200. Epub 2014 Jul 1.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077016PMC
July 2014

The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice.

Diabetologia 2014 Jun 5;57(6):1242-8. Epub 2014 Mar 5.

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, PA, 19104-6145, USA.

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http://dx.doi.org/10.1007/s00125-014-3203-2DOI Listing
June 2014

The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Genes Dev 2014 Apr;28(8):829-34

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.235499.113
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http://dx.doi.org/10.1101/gad.235499.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003275PMC
April 2014

DNA methylation is required for the control of stem cell differentiation in the small intestine.

Genes Dev 2014 Mar;28(6):652-64

Department of Genetics, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://dx.doi.org/10.1101/gad.230318.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967052PMC
March 2014

A cistrome roadmap for understanding pancreatic islet biology.

Nat Genet 2014 Feb;46(2):95-6

Department of Genetics and the Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.nature.com/articles/ng.2880
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351417PMC
February 2014