Publications by authors named "Klaus Elenius"

62Publications

Erbb4 regulates the oocyte microenvironment during folliculogenesis.

Hum Mol Genet 2020 Oct;29(17):2813-2830

Organogenesis Laboratory, Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.

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http://dx.doi.org/10.1093/hmg/ddaa161DOI Listing
October 2020

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation.

J Vis Exp 2020 05 20(159). Epub 2020 May 20.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University;

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http://dx.doi.org/10.3791/61125DOI Listing
May 2020

Genetic and functional implications of an exonic TRIM55 variant in heart failure.

J Mol Cell Cardiol 2020 01 19;138:222-233. Epub 2019 Dec 19.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Biomedicum 2U, Tukholmankatu 8, FI-00290 Helsinki, Finland; Department of Mathematics and Statistics, University of Turku, Vesilinnantie 5, FI-20014 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.12.008DOI Listing
January 2020

Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation.

PLoS One 2019 19;14(9):e0222814. Epub 2019 Sep 19.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752865PMC
March 2020

Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling.

Circulation 2019 05 29;139(22):2570-2584. Epub 2019 Mar 29.

Wihuri Research Institute, Helsinki, Finland and Translational Cancer Biology Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Finland (R.K., K.A.H., M.R., K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553980PMC
May 2019

ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos.

Mol Biol Cell 2019 01 21;30(2):209-218. Epub 2018 Nov 21.

Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1091/mbc.E18-07-0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589560PMC
January 2019

Gamma-secretase-dependent signaling of receptor tyrosine kinases.

Oncogene 2019 01 30;38(2):151-163. Epub 2018 Aug 30.

Institute of Biomedicine, University of Turku, 20520, Turku, Finland.

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http://www.nature.com/articles/s41388-018-0465-z
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http://dx.doi.org/10.1038/s41388-018-0465-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756091PMC
January 2019

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase.

J Biol Chem 2017 12 3;292(48):19890-19904. Epub 2017 Oct 3.

From the Department of Medical Biochemistry and Genetics, and MediCity Research Laboratory, University of Turku, FI-20520 Turku, Finland,

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http://dx.doi.org/10.1074/jbc.M117.794271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712627PMC
December 2017

Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases.

Mol Biol Cell 2017 Nov 13;28(22):3123-3131. Epub 2017 Sep 13.

Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku, Finland

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http://dx.doi.org/10.1091/mbc.E17-04-0261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662267PMC
November 2017

Human Metaplastic Breast Carcinoma and Decorin.

Cancer Microenviron 2017 Dec 26;10(1-3):39-48. Epub 2017 Jun 26.

Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.

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http://dx.doi.org/10.1007/s12307-017-0195-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750199PMC
December 2017

ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis.

Mol Endocrinol 2014 Sep 24;28(9):1534-46. Epub 2014 Jul 24.

Oulu Centre for Cell-Matrix Research (F.N., S.J.V.), Biocenter Oulu, Infotech Oulu, Laboratory of Developmental Biology, Faculty of Biochemistry and Molecular Medicine, University of Oulu, FI-90220 Oulu, Finland; Department of Medical Biochemistry and Genetics (V.V., K.E.), and Medicity Research Laboratory, University of Turku, FI-20520 Turku, Finland; Electron Microscopy Unit (I.M.), FI-90220 Oulu, Finland; Laboratory Animal Center (P.S.), University of Helsinki, FIN-00014 Helsinki, Finland; Department of Physiology (M.P.), Turku University Hospital, FI-2001 4 Turku, Finland; and Department of Oncology (K.E.), Turku University Hospital, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1210/me.2013-1244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414798PMC
September 2014

ERBB4 promoter polymorphism is associated with poor distant disease-free survival in high-risk early breast cancer.

PLoS One 2014 18;9(7):e102388. Epub 2014 Jul 18.

Department of Medical Biochemistry and Genetics and Medicity Research Laboratories, University of Turku, Turku, Finland; Department of Oncology, Turku University Hospital, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102388PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103820PMC
March 2015

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland.

J Biol Chem 2014 Aug 25;289(32):22459-69. Epub 2014 Jun 25.

From the Department of Medical Biochemistry and Genetics, and MediCity Research Laboratory, University of Turku, 20520 Turku, Finland, the Department of Oncology, Turku University Hospital, 20520 Turku, Finland

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http://dx.doi.org/10.1074/jbc.M113.533497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139252PMC
August 2014

High frequency of BRAF V600E mutations in ameloblastoma.

J Pathol 2014 Apr 31;232(5):492-8. Epub 2014 Jan 31.

Department of Medical Biochemistry and Genetics and MediCity Research Laboratories, University of Turku, Finland; Turku Doctoral Programme of Molecular Medicine, Turku, Finland.

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http://dx.doi.org/10.1002/path.4317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255689PMC
April 2014

CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro.

Gynecol Oncol 2013 Apr 9;129(1):179-87. Epub 2013 Jan 9.

Department of Medical Biochemistry and Genetics, and MediCity Research Laboratory, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.ygyno.2012.12.044DOI Listing
April 2013

Translation of a research-based genetic test on a rare syndrome into clinical service testing, with sotos syndrome as an example.

Genet Test Mol Biomarkers 2012 Oct 27;16(10):1188-94. Epub 2012 Aug 27.

Department of Medical Biochemistry and Genetics, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://www.liebertpub.com/doi/10.1089/gtmb.2012.0153
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http://dx.doi.org/10.1089/gtmb.2012.0153DOI Listing
October 2012

Proteolytic processing of ErbB4 in breast cancer.

PLoS One 2012 22;7(6):e39413. Epub 2012 Jun 22.

Medicity Research Laboratories, Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382207PMC
March 2013

Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling.

J Biol Chem 2012 Mar 3;287(13):9659-71. Epub 2012 Feb 3.

Department of Medical Biochemistry and Genetics, and MediCity Research Laboratory, University of Turku, FI-20520 Turku, Finland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.299537
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http://dx.doi.org/10.1074/jbc.M111.299537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322979PMC
March 2012

ErbB4 modulates tubular cell polarity and lumen diameter during kidney development.

J Am Soc Nephrol 2012 Jan 10;23(1):112-22. Epub 2011 Nov 10.

Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1681/ASN.2011020160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269924PMC
January 2012

Function of ERBB4 is determined by alternative splicing.

Cell Cycle 2011 Aug 15;10(16):2647-57. Epub 2011 Aug 15.

Department of Medical Biochemistry and Genetics and MediCity Research Laboratory, University of Turku, Turku, Finland.

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http://dx.doi.org/10.4161/cc.10.16.17194DOI Listing
August 2011

Cell death or survival promoted by alternative isoforms of ErbB4.

Mol Biol Cell 2010 Dec 13;21(23):4275-86. Epub 2010 Oct 13.

Department of Medical Biochemistry and Genetics, and Medicity Research Laboratory, University of Turku, Turku, Finland; Department of Oncology, Turku University Hospital, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1091/mbc.E10-04-0332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993754PMC
December 2010

EGFR targeting drugs in the treatment of head and neck squamous cell carcinoma.

Expert Opin Emerg Drugs 2010 Jun;15(2):185-201

University of Turku, Department of Medical Biochemistry and Genetics, MediCity Research Laboratories, FIN-20520 Turku, Finland.

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http://www.tandfonline.com/doi/full/10.1517/1472821100371644
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http://dx.doi.org/10.1517/14728211003716442DOI Listing
June 2010

Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth.

Exp Cell Res 2010 Apr 12;316(7):1169-78. Epub 2010 Feb 12.

Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2010.02.012DOI Listing
April 2010

Potential of ErbB4 antibodies for cancer therapy.

Future Oncol 2010 Jan;6(1):37-53

Department of Medical Biochemistry and Genetics, and Medicity Research Laboratory, University of Turku, and Turku Graduate School of Biomedical Sciences, Turku, Finland.

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http://dx.doi.org/10.2217/fon.09.144DOI Listing
January 2010

Mutated ERBB4: a novel drug target in metastatic melanoma?

Pigment Cell Melanoma Res 2009 Dec 7;22(6):708-10. Epub 2009 Sep 7.

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http://doi.wiley.com/10.1111/j.1755-148X.2009.00635.x
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http://dx.doi.org/10.1111/j.1755-148X.2009.00635.xDOI Listing
December 2009

ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.

Mol Cell Biol 2009 Sep 13;29(18):4935-48. Epub 2009 Jul 13.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.01705-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738276PMC
September 2009

The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels.

Microvasc Res 2009 Dec 9;78(3):278-85. Epub 2009 Jul 9.

Department of Medical Biochemistry and Genetics, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.mvr.2009.06.010DOI Listing
December 2009

ErbB targeted drugs and angiogenesis.

Curr Vasc Pharmacol 2010 May;8(3):421-31

Department of Oncology and Radiotherapy, Turku University Central Hospital, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.2174/157016110791112241DOI Listing
May 2010

Concurrent cetuximab, cisplatin, and radiation for squamous cell carcinoma of the head and neck in vitro.

Radiother Oncol 2009 Sep 15;92(3):388-92. Epub 2009 May 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1016/j.radonc.2009.04.019DOI Listing
September 2009

Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor.

BMC Cell Biol 2009 Jan 26;10. Epub 2009 Jan 26.

Turku Center for Disease Modeling/Department of Cell Biology and Anatomy, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1186/1471-2121-10-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636757PMC
January 2009

Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

J Biol Chem 2009 Feb 19;284(9):5582-91. Epub 2008 Dec 19.

MediCity Research Laboratory and Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1074/jbc.M805438200DOI Listing
February 2009

ErbB4 and its isoforms: patentable drug targets?

Recent Pat DNA Gene Seq 2008 ;2(1):27-33

Department of Medical Biochemistry and Molecular Biology, and Medicity Research Laboratory, University of Turku, Finland.

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http://dx.doi.org/10.2174/187221508783406602DOI Listing
May 2009

Role of ErbB4 in breast cancer.

J Mammary Gland Biol Neoplasia 2008 Jun 3;13(2):259-68. Epub 2008 May 3.

Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.

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http://dx.doi.org/10.1007/s10911-008-9079-3DOI Listing
June 2008

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

Proc Natl Acad Sci U S A 2008 Mar 11;105(11):4162-7. Epub 2008 Mar 11.

MediCity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1073/pnas.0708333105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393780PMC
March 2008

Concomitant chemoirradiation with vinorelbine and gefitinib induces additive effect in head and neck squamous cell carcinoma cell lines in vitro.

Radiother Oncol 2007 Oct;85(1):138-45

Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Central Hospital, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S016781400700465
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http://dx.doi.org/10.1016/j.radonc.2007.09.011DOI Listing
October 2007

Association of Wwox with ErbB4 in breast cancer.

Cancer Res 2007 Oct;67(19):9330-6

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2147DOI Listing
October 2007

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

Semin Thromb Hemost 2007 Jul;33(5):547-56

Department of Medical Biochemistry and Molecular Biology, Turku Centre for Biotechnology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1055/s-2007-982087DOI Listing
July 2007

Intra- and extracellular signaling by endothelial neuregulin-1.

Exp Cell Res 2007 Aug 18;313(13):2896-909. Epub 2007 Apr 18.

Department of Medical Biochemistry and Molecular Biology, and Medicity Research Laboratories, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2007.03.042DOI Listing
August 2007

[Not Available].

Authors:
Klaus Elenius

Duodecim 2006 ;122(11):1331-8

Turun yliopisto, lääketieteellinen biokemia ja molekyylibiologia ja MediCity sekä TYKS:n syöpätautien klinikka.

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April 2008

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

Mol Biol Cell 2006 Sep 12;17(9):4118-29. Epub 2006 Jul 12.

Lineberger Comprehensive Cancer Center and Departments of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1091/mbc.e06-02-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1556387PMC
September 2006

Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.

Mol Biol Cell 2006 Jan 26;17(1):67-79. Epub 2005 Oct 26.

Medicity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1091/mbc.e05-05-0402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345647PMC
January 2006

Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells.

Cancer Res 2005 Feb;65(4):1384-93

Medicity Research Laboratory, Departments of Medical Biochemistry and Molecular Biology, and Turku Postgraduate School of Biomedical Sciences, University of Turku, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3150DOI Listing
February 2005

Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer.

Mol Cancer Ther 2004 Dec;3(12):1585-92

Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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December 2004

Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1.

J Biol Chem 2004 Oct 25;279(40):41928-35. Epub 2004 Jun 25.

Department of Pediatrics, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M404506200DOI Listing
October 2004

Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients.

Clin Cancer Res 2003 Nov;9(14):5346-57

Medicity Research Laboratories, and Department of Medical Biochemistry and Molecular Biology, Turku Graduate School of Biomedical Sciences, University of Turku, FIN-20520 Turku.

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November 2003

Endothelial cell-matrix interactions.

Microsc Res Tech 2003 Jan;60(1):13-22

Medicity Research Laboratory, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1002/jemt.10238DOI Listing
January 2003

ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.

Clin Cancer Res 2002 Oct;8(10):3054-64

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Richard.

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October 2002