Publications by authors named "Klaus D Feussner"

5 Publications

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Six novel species of the obligate marine actinobacterium , sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov., and emended description of the genus .

Int J Syst Evol Microbiol 2020 Aug 23;70(8):4668-4682. Epub 2020 Jul 23.

Departamento de Microbiología y Genética, Campus Miguel de Unamuno, Universidad de Salamanca, 37007 Salamanca, Spain.

Ten representative actinobacterial strains isolated from marine sediments collected worldwide were studied to determine their taxonomic status. The strains were previously identified as members of the genus and shared >99 % 16S rRNA gene sequence similarity to the three currently recognized species. Comparative genomic analyses resulted in the delineation of six new species based on average nucleotide identity and digital DNA-DNA hybridization values below 95 and 70 %, respectively. The species status of the six new groups was supported by a core-genome phylogeny reconstructed from 2106 orthologs detected in 118 publicly available genomes. Chemotaxonomic and physiological studies were used to complete the phenotypic characterization of the strains. The fatty acid profiles contained the major components iso-C, C, iso- and anteiso C. Galactose and xylose were common in all whole-sugar patterns but differences were found between the six groups of strains. Polar lipid compositions were also unique for each species. Distinguishable physiological and biochemical characteristics were also recorded. The names proposed are sp. nov., CNY-202 (=DSM 108615=CECT 9739); sp. nov., CNT-569 (=DSM 108614=CECT 9740); sp. nov., CNY-666 (=DSM 108616=CECT 9738); sp. nov., CNT-150 (=DSM 45549=CECT 9741); sp. nov., CNT-138 (=DSM 45547=CECT 9742); and sp. nov., CNT-148 (=DSM 45548=CECT 9743).
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http://dx.doi.org/10.1099/ijsem.0.004330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660244PMC
August 2020

Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4.

Tetrahedron 2017 Apr 6;73(16):2234-2241. Epub 2017 Mar 6.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, USA.

Six cytotoxic and antimicrobial metabolites of a new bromo-phenazinone class, the marinocyanins A-F (-), were isolated together with the known bacterial metabolites 2-bromo-1-hydroxyphenazine (), lavanducyanin ( WS-9659A) and its chlorinated analog WS-9659B (). These metabolites were purified by bioassay-guided fractionation of the extracts of our MAR4 marine actinomycete strains CNS-284 and CNY-960. The structures of the new compounds were determined by detailed spectroscopic methods and marinocyanin A () was confirmed by crystallographic methods. The marinocyanins represent the first bromo-phenazinones with an -isoprenoid substituent in the skeleton. Marinocyanins A-F show strong to weak cytotoxicity against HCT-116 human colon carcinoma and possess modest antimicrobial activities against and amphotericin-resistant .
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http://dx.doi.org/10.1016/j.tet.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555602PMC
April 2017

Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens.

3 Biotech 2017 Jul 29;7(3):172. Epub 2017 Jun 29.

Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Laucala Campus, Suva, Fiji.

Antibiotic resistance is becoming a pivotal concern for public health that has accelerated the search for new antimicrobial molecules from nature. Numbers of human pathogens have inevitably evolved to become resistant to various currently available drugs causing considerable mortality and morbidity worldwide. It is apparent that novel antibiotics are urgently warranted to combat these life-threatening pathogens. In recent years, there have been an increasing number of studies to discover new bioactive compounds from plant origin with the hope to control antibiotic-resistant bacteria. This review attempts to focus and record the plant-derived compounds and plant extracts against multi-drug-resistant (MDR) pathogens including methicillin-resistant Staphylococcus aureus (MRSA), MDR-Mycobacterium tuberculosis and malarial parasites Plasmodium spp. reported between 2005 and 2015. During this period, a total of 110 purified compounds and 60 plant extracts were obtained from 112 different plants. The plants reviewed in this study belong to 70 different families reported from 36 countries around the world. The present review also discusses the drug resistance in bacteria and emphasizes the urge for new drugs.
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http://dx.doi.org/10.1007/s13205-017-0848-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489455PMC
July 2017

Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus.

Mar Drugs 2012 Jan 18;10(1):200-8. Epub 2012 Jan 18.

Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Suva, Fiji Islands.

A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
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http://dx.doi.org/10.3390/md10010200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280539PMC
January 2012

Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.

Tetrahedron 2011 Nov;67(44):8529-8531

Institute of Applied Science, Faculty of Science, Technology and Environment, The University of the South Pacific, Laucala Campus, Suva, Fiji Islands.

Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 μg/mL.
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http://dx.doi.org/10.1016/j.tet.2011.08.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192506PMC
November 2011