Publications by authors named "Klaus Brandenburg"

100Publications

Encapsulation and release of As pidasept peptides in polysaccharide formulation for oral application.

Eur J Pharm Sci 2021 Jan 6;158:105687. Epub 2021 Jan 6.

Brandenburg Antiinfektiva GmbH, c/o Forschungszentrum Borstel, Parkallee 10b, D-23845, Borstel, Germany. Electronic address:

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January 2021

An update on endotoxin neutralization strategies in Gram-negative bacterial infections.

Expert Rev Anti Infect Ther 2020 Nov 19:1-23. Epub 2020 Nov 19.

Martin-Luther-Universität Halle-Wittenberg, Institut für Chemie , Halle/Saale, Germany.

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November 2020

Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides.

Biophys J 2019 11 18;117(10):1805-1819. Epub 2019 Oct 18.

Division of Biophysics, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

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November 2019

LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 10 1;1864(10):1503-1513. Epub 2019 Jun 1.

Institute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin, Berlin, Germany; Pharmaceutical Institute, Section Pharmacology and Toxicology, University of Bonn, Germany. Electronic address:

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October 2019

Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation.

Microb Pathog 2019 Aug 18;133:103546. Epub 2019 May 18.

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420, rue de la Terrasse, Québec, G1V 0A6, QC, Canada. Electronic address:

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August 2019

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds.

Front Pharmacol 2018 28;9:281. Epub 2018 Mar 28.

Pharmacology and Toxicology, Department of Biology, Chemistry, Pharmacy, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.

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March 2018

Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation.

Eur J Pharm Sci 2018 Mar 12;115:240-247. Epub 2018 Jan 12.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee, D-23845 Borstel, Germany.

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March 2018

Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses.

Biochem Pharmacol 2017 09 21;140:64-72. Epub 2017 May 21.

Freie Universität Berlin, Institute of Pharmacy (Pharmacology and Toxicology), Berlin, Germany. Electronic address:

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September 2017

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes.

Biochim Biophys Acta 2016 09 15;1858(9):2123-2131. Epub 2016 Jun 15.

Forschungszentrum Borstel, LG Biophysik, D-23845 Borstel, Germany. Electronic address:

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September 2016

Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5.

J Struct Biol 2016 Apr 29;194(1):68-77. Epub 2016 Jan 29.

European Molecular Biology Laboratory, Hamburg Outstation, EMBL c/o DESY, Notkestr. 85, 22603 Hamburg, Germany.

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April 2016

Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis.

Biochim Biophys Acta 2016 May 20;1858(5):971-9. Epub 2016 Jan 20.

Institute of Molecular Biosciences, Biophysics Division, University of Graz, NAWI Graz, BioTechMed Graz, Humboldtstr. 50/III, Graz, Austria.

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May 2016

Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications.

Open Biochem J 2015 31;9:49-72. Epub 2015 Aug 31.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 1-40, D-23845 Borstel, Germany.

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October 2015

Lack of new antiinfective agents: Passing into the pre-antibiotic age?

World J Biol Chem 2015 Aug;6(3):71-7

Klaus Brandenburg, Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, D-23845 Borstel, Germany.

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August 2015

Bacterial lipopolysaccharides form physically cross-linked, two-dimensional gels in the presence of divalent cations.

Soft Matter 2015 Aug 2;11(30):6037-44. Epub 2015 Jul 2.

Physical Chemistry of Biosystems, Institute of Physical Chemistry, University of Heidelberg, D69120 Heidelberg, Germany.

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August 2015

Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells.

J Phys Chem B 2015 Jun 11;119(25):7837-45. Epub 2015 Jun 11.

‡Institute of Physical Chemistry, University of Heidelberg, D69120 Heidelberg, Germany.

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June 2015

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.

Gut Microbes 2014 ;5(6):761-5

a Institute of Medical Microbiology and Hospital Epidemiology; Hannover Medical School ; Hannover , Germany.

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September 2015

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects.

Biochim Biophys Acta 2014 Oct 10;1838(10):2739-44. Epub 2014 Jul 10.

Forschungszentrum Borstel, Division of Biophysics, Parkallee 10, 23845 Borstel, Germany. Electronic address:

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October 2014

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide.

FEBS Open Bio 2014 2;4:432-40. Epub 2014 May 2.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany.

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June 2014

A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment.

Antiviral Res 2014 Apr 30;104:23-33. Epub 2014 Jan 30.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistr. 52, 20251 Hamburg, Germany. Electronic address:

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April 2014

Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines.

Open Biochem J 2013 30;7:82-93. Epub 2013 Sep 30.

Department. of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA.

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October 2013

Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages.

Innate Immun 2014 Nov 11;20(8):787-98. Epub 2013 Oct 11.

Division of Immunobiophysics, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

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November 2014

Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling.

Innate Immun 2013 Dec 12;19(6):588-95. Epub 2013 Feb 12.

1Klinikum der Friedrich-Schiller-Universität Jena, Elektronenmikoskopisches, Zentrum, Jena, Germany.

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December 2013

Antimicrobial peptides and their potential application in inflammation and sepsis.

Crit Care 2012 Dec 12;16(2):207. Epub 2012 Dec 12.

Department of Intensive Care, University Hospital, Pauwelsstr. 30, 52074 Aachen, Germany.

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December 2012

MARCKS as a negative regulator of lipopolysaccharide signaling.

J Immunol 2012 Apr 16;188(8):3893-902. Epub 2012 Mar 16.

Department of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia.

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April 2012

Biophysical investigations into the interactions of endotoxins with bile acids.

Innate Immun 2012 Apr 27;18(2):307-17. Epub 2011 Sep 27.

National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Japan.

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April 2012

Peptide-based treatment of sepsis.

Appl Microbiol Biotechnol 2011 May 3;90(3):799-808. Epub 2011 Mar 3.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin and Biowissenschaften, Parkallee 10, 23845 Borstel, Germany.

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May 2011

Conformation and supramolecular structure of lipid A.

Adv Exp Med Biol 2010 ;667:25-38

Division of Biophysics Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany.

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August 2011

Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence.

Proc Natl Acad Sci U S A 2010 May 4;107(20):9147-51. Epub 2010 May 4.

Physical Chemistry of Biosystems, Institute of Physical Chemistry, University of Heidelberg, D69120 Heidelberg, Germany.

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May 2010

Molecular basis for endotoxin neutralization by amphipathic peptides derived from the alpha-helical cationic core-region of NK-lysin.

Biophys Chem 2010 Aug 29;150(1-3):80-7. Epub 2010 Jan 29.

Division of Biophysics, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany.

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August 2010

Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering.

Phys Rev E Stat Nonlin Soft Matter Phys 2009 Oct 28;80(4 Pt 1):041929. Epub 2009 Oct 28.

Biophysical Chemistry II, Institute of Physical Chemistry and BIOQUANT, University of Heidelberg, D69120 Heidelberg, Germany.

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October 2009

Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis.

Innate Immun 2010 Aug 26;16(4):213-25. Epub 2009 Aug 26.

Department of Molecular Infection Biology, Emmy Noether Group of Immunobiophysics, Leibniz-Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany.

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August 2010

The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells.

Curr Med Chem 2009 ;16(21):2653-60

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Borstel, Germany.

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November 2009

The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: a physico-chemical study with lecithin phospholipids.

Biochim Biophys Acta 2009 Jun 6;1788(6):1296-303. Epub 2009 Feb 6.

Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, A.A. 1226, Medellín, Colombia.

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June 2009

Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation.

J Bacteriol 2009 May 13;191(10):3411-4. Epub 2009 Mar 13.

Section of Molecular Genetics and Microbiology and Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA.

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May 2009

Structural polymorphism of hydrated monoacylated maltose glycolipids.

Chem Phys Lipids 2008 Sep 10;155(1):31-7. Epub 2008 Jul 10.

Forschungszentrum Borstel, LG Biophysik, Parkallee 10, D-23845 Borstel, Germany.

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September 2008

Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides.

Biochim Biophys Acta 2008 Oct 6;1778(10):2051-7. Epub 2008 Apr 6.

National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, 761-0395, Japan.

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October 2008

Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis.

J Endotoxin Res 2007 ;13(6):343-57

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA.

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September 2008

Structural polymorphism of hydrated ether-linked dimyristyl maltoside and melibioside.

Chem Phys Lipids 2008 Jan 25;151(1):18-29. Epub 2007 Sep 25.

Martin-Luther-Universität Halle-Wittenberg, Institut für Physikalische Chemie, Mühlpforte 1, Halle/Saale, Germany.

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January 2008

Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins.

Biochim Biophys Acta 2007 Oct 22;1768(10):2421-31. Epub 2007 May 22.

Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, Stanford University School of Medicine, Stanford, CA 94305, USA.

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October 2007

The physicochemistry of endotoxins in relation to bioactivity.

Int J Med Microbiol 2007 Sep 23;297(5):341-52. Epub 2007 Apr 23.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany.

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September 2007

Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.

J Biol Chem 2007 Apr 17;282(15):11030-7. Epub 2007 Feb 17.

Research Center Borstel, Leibniz Center for Medicine and Biosciences, Department of Immunochemistry and Biochemical Microbiology, Emmy Noether Group of Immunobiophysics, Division of Biophysics, Borstel, Germany.

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April 2007

Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B.

Biophys J 2007 Apr 19;92(8):2796-805. Epub 2007 Jan 19.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, D-23845 Borstel, Germany.

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April 2007

Mechanisms of endotoxin neutralization by synthetic cationic compounds.

J Endotoxin Res 2006 ;12(5):261-77

Forschungszentrum Borstel, Biophysics Division, Leibniz-Zentrum für Medizin und Biowissenschaften, Borstel, Germany.

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December 2006

Biophysical characterization of synthetic rhamnolipids.

FEBS J 2006 Nov 24;273(22):5101-12. Epub 2006 Oct 24.

Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Borstel, Germany.

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November 2006

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids.

Chemistry 2006 Sep;12(27):7116-24

Medicinal Chemistry Division, Leibniz Institute for Molecular Pharmacology (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany.

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September 2006

Interactions of an anionic antimicrobial peptide with Staphylococcus aureus membranes.

Biochem Biophys Res Commun 2006 Sep 10;347(4):1006-10. Epub 2006 Jul 10.

Faculty of Science, University of Central Lancashire, Preston PR1 2HE, UK.

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September 2006

Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture.

Biomaterials 2006 Mar 20;27(9):1771-7. Epub 2005 Oct 20.

Immuno-Pharmacologique Cellulaire et Moléculaire, EA3796-IFR53, UFR Pharmacie, 51 rue Cognacq Jay 51100 Reims, France.

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March 2006