Klas G Wiman

Klas G Wiman

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Klas G Wiman

Publications by authors named "Klas G Wiman"

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Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

Cell Death Dis 2019 Oct 10;10(10):769. Epub 2019 Oct 10.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, SE-17177, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41419-019-1997-zDOI Listing
October 2019

Functional characterization of novel germline TP53 variants in Swedish families.

Clin Genet 2019 Sep 2;96(3):216-225. Epub 2019 Jul 2.

Department of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13564
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http://dx.doi.org/10.1111/cge.13564DOI Listing
September 2019

p53 as a hub in cellular redox regulation and therapeutic target in cancer.

J Mol Cell Biol 2019 Apr;11(4):330-341

Karolinska Institutet, Department of Oncology-Pathology, BioClinicum, Stockholm, Sweden.

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https://academic.oup.com/jmcb/advance-article/doi/10.1093/jm
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http://dx.doi.org/10.1093/jmcb/mjz005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734141PMC
April 2019

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells.

Transl Oncol 2018 Dec 6;11(6):1343-1349. Epub 2018 Sep 6.

UCD School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; UCD Clinical Research Centre, St. Vincent's University Hospital, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132178PMC
December 2018

Role of Thiol Reactivity for Targeting Mutant p53.

Cell Chem Biol 2018 10 26;25(10):1219-1230.e3. Epub 2018 Jul 26.

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Stockholm SE-17176, Sweden.

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http://dx.doi.org/10.1016/j.chembiol.2018.06.013DOI Listing
October 2018

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246.

Sci Rep 2018 08 23;8(1):12671. Epub 2018 Aug 23.

Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-31048-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107631PMC
August 2018

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

Cell Death Dis 2018 05 1;9(5):439. Epub 2018 May 1.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, SE-17177, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41419-018-0463-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906465PMC
May 2018

Targeting mutant p53 for efficient cancer therapy.

Nat Rev Cancer 2018 02 15;18(2):89-102. Epub 2017 Dec 15.

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska (CCK), SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrc.2017.109DOI Listing
February 2018

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.

Front Oncol 2017 4;7:323. Epub 2018 Jan 4.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fonc.2017.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758538PMC
January 2018

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.

Cell Death Dis 2017 06 1;8(6):e2848. Epub 2017 Jun 1.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/cddis.2017.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520886PMC
June 2017

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response.

Cell Cycle 2016 05;15(9):1267-75

a Department of Microbiology , Tumor and Cell Biology, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/15384101.2016.1160975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889243PMC
May 2016

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy.

Front Oncol 2016 3;6:21. Epub 2016 Feb 3.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.3389/fonc.2016.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737887PMC
February 2016

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Gut 2015 Oct 17;64(10):1506-16. Epub 2015 Jul 17.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia University of Melbourne Department of Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia.

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http://gut.bmj.com/content/64/10/1506.full.pdf
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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2015-309770
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http://dx.doi.org/10.1136/gutjnl-2015-309770DOI Listing
October 2015

Mutant p53 reactivation by small molecules makes its way to the clinic.

FEBS Lett 2014 Aug 24;588(16):2622-7. Epub 2014 Apr 24.

Karolinska Institutet, Cancer Center Karolinska (CCK), Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.04.017DOI Listing
August 2014

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP.

Cell Cycle 2012 Dec 19;11(24):4563-9. Epub 2012 Nov 19.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4161/cc.22810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562301PMC
December 2012

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.

PLoS Biol 2010 Nov 2;8(11):e1000521. Epub 2010 Nov 2.

Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pbio.1000521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970535PMC
November 2010

Regulation of tumor suppressor p53 at the RNA level.

J Mol Med (Berl) 2010 Jul 21;88(7):645-52. Epub 2010 Mar 21.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00109-010-0609
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http://link.springer.com/10.1007/s00109-010-0609-2
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http://dx.doi.org/10.1007/s00109-010-0609-2DOI Listing
July 2010

Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.

Carcinogenesis 2010 Jun 28;31(6):1045-53. Epub 2010 Apr 28.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska University Hospital, Karolinska Institutet, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1093/carcin/bgq084DOI Listing
June 2010

The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer.

Biochem Biophys Res Commun 2010 May;396(1):85-9

Dept. of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2010.02.152DOI Listing
May 2010

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

Authors:
Klas G Wiman

Adv Cancer Res 2007 ;97:321-38

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0065-230X(06)97014-6DOI Listing
October 2009

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival.

Leuk Lymphoma 2009 Sep;50(9):1512-8

Department of Medicine and Haematology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1080/10428190903111914DOI Listing
September 2009

30 years and a long way into p53 research.

Lancet Oncol 2009 Sep;10(9):913-9

International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1016/S1470-2045(09)70198-6DOI Listing
September 2009

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.

Proc Natl Acad Sci U S A 2009 Sep 1;106(37):15756-61. Epub 2009 Sep 1.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0900862106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773521PMC
September 2009

Mutant p53 rescue and modulation of p53 redox state.

Cell Cycle 2009 Aug 29;8(16):2509-17. Epub 2009 Aug 29.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4161/cc.8.16.9382DOI Listing
August 2009

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.

Cancer Cell 2009 May;15(5):376-88

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-171 76 Stockholm, Sweden; International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1016/j.ccr.2009.03.003DOI Listing
May 2009

Regulation of p53R2 and its role as potential target for cancer therapy.

Cancer Lett 2009 Apr 29;276(1):1-7. Epub 2008 Aug 29.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2008.07.019DOI Listing
April 2009

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.

Mol Cancer 2009 Mar 26;8:23. Epub 2009 Mar 26.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1476-4598-8-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667484PMC
March 2009

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

Mol Cell 2009 Feb;33(4):462-71

Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.molcel.2009.01.028DOI Listing
February 2009

PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.

Cell Oncol 2008 ;30(5):411-8

Department of Oncology-Pathology, Karolinska Institutet, Cancer Centrum Karolinska (CCK), Karolinska University Hospital, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618963PMC
November 2008

In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.

Carcinogenesis 2008 Jul 28;29(7):1428-34. Epub 2007 Nov 28.

International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1093/carcin/bgm266DOI Listing
July 2008

The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.

FEBS Lett 2008 Jun 2;582(15):2173-7. Epub 2008 Jun 2.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.febslet.2008.04.065DOI Listing
June 2008

Mutant p53 targeting by the low molecular weight compound STIMA-1.

Mol Oncol 2008 Jun 7;2(1):70-80. Epub 2008 Mar 7.

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.molonc.2008.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527782PMC
June 2008

Shaping genetic alterations in human cancer: the p53 mutation paradigm.

Cancer Cell 2007 Oct;12(4):303-12

Université P.M. Curie, 4 place Jussieu, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.ccr.2007.10.001DOI Listing
October 2007

p53 targets identified by protein expression profiling.

Proc Natl Acad Sci U S A 2007 Mar 19;104(13):5401-6. Epub 2007 Mar 19.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0700794104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828709PMC
March 2007

The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.

FEBS Lett 2006 Aug 17;580(18):4401-8. Epub 2006 Jul 17.

Department of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska, CCK, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.febslet.2006.07.005DOI Listing
August 2006

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

J Biol Chem 2005 Aug 1;280(34):30384-91. Epub 2005 Jul 1.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M501664200DOI Listing
August 2005

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

Oncogene 2005 May;24(21):3484-91

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1208419DOI Listing
May 2005

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.

Oncogene 2005 Feb;24(8):1320-7

Department of Oncology-Pathology, Cancer Center Karolinska, R8:04, Karolinska Institute, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1208232DOI Listing
February 2005

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

Ann Med 2003 ;35(7):458-65

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1080/07853890310017152DOI Listing
August 2004

The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man.

Int J Oncol 2004 Jun;24(6):1559-64

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, Stockholm, Sweden.

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June 2004

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.

Proc Natl Acad Sci U S A 2003 Nov 31;100(23):13303-7. Epub 2003 Oct 31.

Department of Oncology-Pathology, Cancer Center Karolinska, R8:00, Karolinska Institutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.1835733100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263793PMC
November 2003

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts.

Oncogene 2003 Aug;22(32):4993-5005

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), R8:04, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1206659DOI Listing
August 2003

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

Carcinogenesis 2002 Dec;23(12):2011-8

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska (CCK), R8:04 Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1093/carcin/23.12.2011DOI Listing
December 2002

Role of genetic and epigenetic changes in Burkitt lymphoma.

Semin Cancer Biol 2002 Oct;12(5):381-7

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:04 Karolinska Hospital, SE-17176 Stockholm, Sweden.

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October 2002

A novel high-through-put assay for screening of pro-apoptotic drugs.

Invest New Drugs 2002 Aug;20(3):253-9

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1023/A:1016249728664
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August 2002

Identification of functional p53-binding motifs in the mouse wig-1 promoter.

FEBS Lett 2002 Jul;524(1-3):69-72

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0014-5793(02)03004-1DOI Listing
July 2002

A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF.

Cancer Lett 2002 Jun;180(2):211-21

Department of Oncology-Pathology, Research Laboratory of Radiumhemmet, Cancer Center Karolinska, R8:03, Karolinska Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0304-3835(02)00027-7DOI Listing
June 2002

The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity.

Nucleic Acids Res 2002 May;30(9):1991-6

Karolinska Institute, Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Hospital, S-171 76 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113850PMC
http://dx.doi.org/10.1093/nar/30.9.1991DOI Listing
May 2002

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Nat Med 2002 Mar;8(3):282-8

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nm0302-282DOI Listing
March 2002

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

Oncogene 2002 Mar;21(14):2119-29

Cambridge University Chemical Laboratory and Cambridge Center for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/sj.onc.1205362DOI Listing
March 2002