Publications


H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.
From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,

Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.
Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13505-10. Epub 2014 Sep 2.
Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan; and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 192-0392, Japan

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.
Neurobiol Dis 2013 Dec 19;60:11-7. Epub 2013 Aug 19.
Laboratory of Neurobiology, Belgium; Leuven Research Institute of Neuroscience and Disease (LIND), KU Leuven, Belgium; Vesalius Research Center, VIB, Belgium. Electronic address:



Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Cancer Res 2010 Nov 9;70(22):9381-90. Epub 2010 Nov 9.
Divison of Cancer Biology, The Cancer Institute of Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.

GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice.
J Neurochem 2010 Jul 19;114(1):302-10. Epub 2010 Apr 19.
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka, Japan.

Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
J Biol Chem 2010 Feb 7;285(7):4837-46. Epub 2009 Dec 7.
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka 812-8582, Japan.

Illuminating cell-cycle progression in the developing zebrafish embryo.
Proc Natl Acad Sci U S A 2009 Dec 18;106(49):20812-7. Epub 2009 Nov 18.
Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan.

Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development.
FASEB J 2008 Mar 15;22(3):841-9. Epub 2007 Oct 15.
Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan.

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression.
Cell 2008 Feb;132(3):487-98
Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan.

Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.
J Neurosci 2007 Feb;27(7):1692-701
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka 812-8582, Japan.

Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
J Biochem 2006 Nov 23;140(5):619-25. Epub 2006 Sep 23.
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8550.


A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.
J Cell Biol 2006 Feb 6;172(4):497-504. Epub 2006 Feb 6.
Laboratory of Molecular Biochemistry and 6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan.

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