Kiwamu Akagi

Kiwamu Akagi

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Kiwamu Akagi

Kiwamu Akagi

Publications by authors named "Kiwamu Akagi"

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63Publications

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A germline MBD4 mutation was identified in a patient with colorectal oligopolyposis and early‑onset cancer: A case report.

Oncol Rep 2019 Sep 17;42(3):1133-1140. Epub 2019 Jul 17.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350‑8550, Japan.

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http://dx.doi.org/10.3892/or.2019.7239DOI Listing
September 2019

[Lynch Syndrome].

Authors:
Kiwamu Akagi

Gan To Kagaku Ryoho 2019 Jul;46(7):1097-1102

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center.

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July 2019

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome.

Breast Cancer 2019 May 16;26(3):359-364. Epub 2018 Nov 16.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, 700-8558, Okayama, Japan.

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http://link.springer.com/10.1007/s12282-018-0931-z
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http://dx.doi.org/10.1007/s12282-018-0931-zDOI Listing
May 2019

The single-base-pair deletion, MSH2 c.2635-3delC affecting intron 15 splicing can be a cause of Lynch syndrome.

Jpn J Clin Oncol 2019 May;49(5):477-480

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.1093/jjco/hyz031DOI Listing
May 2019

Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report.

J Med Case Rep 2019 Apr 27;13(1):117. Epub 2019 Apr 27.

Department of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan.

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http://dx.doi.org/10.1186/s13256-019-2044-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486685PMC
April 2019

[A Case of Cecal Cancer Associated with Preoperatively Diagnosed Lynch Syndrome Caused by EPCAM Deletion].

Gan To Kagaku Ryoho 2018 Dec;45(13):2202-2204

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

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December 2018

Utility of the quasi-monomorphic variation range in unresectable metastatic colorectal cancer patients.

Cancer Sci 2018 Nov 2;109(11):3411-3415. Epub 2018 Oct 2.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://doi.wiley.com/10.1111/cas.13774
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http://dx.doi.org/10.1111/cas.13774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215873PMC
November 2018

The RAS mutation status predicts survival in patients undergoing hepatic resection for colorectal liver metastases: The results from a genetic analysis of all-RAS.

J Surg Oncol 2018 Mar 30;117(4):745-755. Epub 2017 Nov 30.

Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama, Japan.

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http://dx.doi.org/10.1002/jso.24910DOI Listing
March 2018

[I. Key Points of the Guidelines for Clinical Practice of Hereditary Colorectal Cancer].

Gan To Kagaku Ryoho 2017 Nov;44(11):986-989

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

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November 2017

Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.

Surg Today 2017 Sep 3;47(9):1135-1146. Epub 2017 Mar 3.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.

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http://dx.doi.org/10.1007/s00595-017-1486-xDOI Listing
September 2017

The silent mutation MLH1 c.543C>T resulting in aberrant splicing can cause Lynch syndrome: a case report.

Jpn J Clin Oncol 2017 Jun;47(6):576-580

Division of Molecular Diagnosis & Cancer Prevention, Saitama Cancer Center, Saitama, Japan.

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http://dx.doi.org/10.1093/jjco/hyx023DOI Listing
June 2017

Lymph Node Ratio as a Risk Factor for Recurrence After Adjuvant Chemotherapy in Stage III Colorectal Cancer.

J Gastrointest Surg 2017 05 1;21(5):867-878. Epub 2017 Mar 1.

Department of Gastroenterology, Saitama Cancer Center, 780 Komuro, Ina, Kita-adachi-gun, Saitama, 362-0806, Japan.

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http://dx.doi.org/10.1007/s11605-017-3382-5DOI Listing
May 2017

DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer.

Cancer Med 2017 May 4;6(5):1023-1035. Epub 2017 Apr 4.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1002/cam4.1061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430106PMC
May 2017

Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population.

Jpn J Clin Oncol 2017 Feb;47(2):108-117

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Japan.

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http://dx.doi.org/10.1093/jjco/hyw178DOI Listing
February 2017

High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases.

Oncol Rep 2017 Feb 15;37(2):785-792. Epub 2016 Dec 15.

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama 362-0806, Japan.

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http://dx.doi.org/10.3892/or.2016.5323DOI Listing
February 2017

Rapid detection of germline mutations for hereditary gastrointestinal polyposis/cancers using HaloPlex target enrichment and high-throughput sequencing technologies.

Fam Cancer 2016 10;15(4):553-62

Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan.

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http://dx.doi.org/10.1007/s10689-016-9872-xDOI Listing
October 2016

12-Gene Recurrence Score Assay Stratifies the Recurrence Risk in Stage II/III Colon Cancer With Surgery Alone: The SUNRISE Study.

J Clin Oncol 2016 08 20;34(24):2906-13. Epub 2016 Jun 20.

Takeharu Yamanaka, National Cancer Center; Atsushi Ochiai, Atsushi Ohtsu, and Takayuki Yoshino, National Cancer Center Hospital East Chiba, Japan; Takeharu Yamanaka, Yokohama City University, Yokohama; Eiji Oki, Kyushu University; Tetsuya Kusumoto, National Kyushu Medical Center, Fukuoka; Kentaro Yamazaki, Shizuoka Cancer Center, Shizuoka; Kensei Yamaguchi and Kiwamu Akagi, Saitama Cancer Center, Saitama; Kensei Yamaguchi, Cancer Institute Hospital of Japanese Foundation for Cancer Research; Hiroyuki Uetake, Tokyo Medical and Dental University; Yasuo Ohashi, Chuo University, Tokyo; Kei Muro, Aichi Cancer Center Hospital, Nagoya; Takeo Sato, Kitasato University School of Medicine, Kanagawa; Tomohiro Nishina, National Hospital Organization Shikoku Cancer Center, Matsuyama; Masataka Ikeda, Osaka National Hospital; Akiyoshi Kanazawa, Kitano Hospital, Osaka; Takeshi Kato, Kansai Rosai Hospital, Amagasaki, Japan; Calvin Chao, Margarita Lopatin, Jayadevi Krishnakumar, and Helen Bailey, Genomic Health, Redwood City, CA

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http://dx.doi.org/10.1200/JCO.2016.67.0414DOI Listing
August 2016

[A Case of Metachronous Multiple Thyroid Papillary Carcinoma with FAP].

Gan To Kagaku Ryoho 2015 Nov;42(12):1833-5

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

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November 2015

[A Case of Colon Cancer with Familial Adenomatous Polyposis Showing MSI-H and Deletion of MSH2/MSH6 Protein].

Gan To Kagaku Ryoho 2015 Nov;42(12):2208-10

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

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November 2015

A Case of Atypical Carcinoid: Harboring Variant 3a/b EML4-ALK Rearrangement.

J Thorac Oncol 2015 Oct;10(10):e104-6

Department of Thoracic Oncology, Saitama Cancer Center, Saitama, Japan Department of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan Department of Thoracic Oncology, Saitama Cancer Center, Saitama, Japan.

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http://dx.doi.org/10.1097/JTO.0000000000000635DOI Listing
October 2015

Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer.

World J Gastroenterol 2015 Jan;21(4):1275-83

Shigenori Kadowaki, Akira Ooki, Kensei Yamaguchi, Division of Gastroenterology, Saitama Cancer Center, Saitama 362-0806, Japan.

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http://dx.doi.org/10.3748/wjg.v21.i4.1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306173PMC
January 2015

Inverse effect of mucinous component on survival in stage III colorectal cancer.

J Surg Oncol 2014 Dec 11;110(7):851-7. Epub 2014 Aug 11.

Department of Gastroenterology, Saitama Cancer Center, Saitama, Japan.

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http://dx.doi.org/10.1002/jso.23742DOI Listing
December 2014

Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer.

J Surg Oncol 2014 Dec 22;110(8):982-8. Epub 2014 Aug 22.

Department of Gastroenterology, Saitama Cancer Center, Saitama, Japan.

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http://dx.doi.org/10.1002/jso.23755DOI Listing
December 2014

[Effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome].

Gan To Kagaku Ryoho 2014 Nov;41(12):1770-2

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

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November 2014

Clinicopathological characteristics and prognostic impact of colorectal cancers with NRAS mutations.

Oncol Rep 2014 Jul 6;32(1):50-6. Epub 2014 May 6.

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama 362-0806, Japan.

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http://dx.doi.org/10.3892/or.2014.3165DOI Listing
July 2014

Molecular and clinical characteristics of MSH6 germline variants detected in colorectal cancer patients.

Oncol Rep 2013 Dec 2;30(6):2909-16. Epub 2013 Oct 2.

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama 362-0806, Japan.

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http://dx.doi.org/10.3892/or.2013.2781DOI Listing
December 2013

CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein.

J Biomed Sci 2013 Apr 28;20:25. Epub 2013 Apr 28.

The Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Otsuka, Bunkyo, Tokyo 112-8610, Japan.

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http://dx.doi.org/10.1186/1423-0127-20-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651391PMC
April 2013

Colorectal cancer susceptibility associated with the hMLH1 V384D variant.

Mol Med Rep 2009 Nov-Dec;2(6):887-91

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama 362-0806, Japan.

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http://dx.doi.org/10.3892/mmr_00000187DOI Listing
October 2012

Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma.

Am J Pathol 2012 Feb 21;180(2):616-25. Epub 2011 Nov 21.

Genome Science Division, Research Center for Advanced Science and Technology (RCAST), Graduate School of Medicine, The University of Tokyo, Toyko, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2011.10.010DOI Listing
February 2012

[Tm analysis method using a quenching probe is a simple and rapid way to simultaneously detect KRAS and BRAF mutations].

Rinsho Byori 2011 Aug;59(8):757-62

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Kitaadachi-gun, Saitama-pref. 362-0806, Japan.

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August 2011

Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome.

Genes Chromosomes Cancer 2011 Jul 11;50(7):535-45. Epub 2011 Apr 11.

Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.

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http://dx.doi.org/10.1002/gcc.20878DOI Listing
July 2011

Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma.

Genes Chromosomes Cancer 2010 May;49(5):487-96

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Tokyo, Japan.

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http://dx.doi.org/10.1002/gcc.20759DOI Listing
May 2010

Three DNA methylation epigenotypes in human colorectal cancer.

Clin Cancer Res 2010 Jan 22;16(1):21-33. Epub 2009 Dec 22.

Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2006DOI Listing
January 2010

Heterocyclic organobismuth(III) compound targets tubulin to induce G2/M arrest in HeLa cells.

J Pharmacol Sci 2009 Apr 7;109(4):573-82. Epub 2009 Apr 7.

Department of Bioscience, Faculty of Science and Technology, Kwansei Gakuin University, Sanda, Japan.

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http://dx.doi.org/10.1254/jphs.09020fpDOI Listing
April 2009

Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.

Carcinogenesis 2009 Mar 15;30(3):494-9. Epub 2009 Jan 15.

Division of Molecular Diagnosis and Cancer Prevention, , SaitamaCancer Center, Kitaadati-gun, Saitama, Japan.

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http://dx.doi.org/10.1093/carcin/bgp017DOI Listing
March 2009

RNA aptamers targeting the carboxyl terminus of KRAS oncoprotein generated by an improved SELEX with isothermal RNA amplification.

Oligonucleotides 2007 ;17(1):12-21

Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama 362-0806, Japan., Department of Basic Medical Science, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1089/oli.2006.0035R1DOI Listing
June 2007

Characterization of a novel oncogenic K-ras mutation in colon cancer.

Biochem Biophys Res Commun 2007 Jan 27;352(3):728-32. Epub 2006 Nov 27.

Molecular Diagnosis and Cancer Prevention Division, Saitama Cancer Center, 818 Komuro Ina, Kitaadachigun, Saitama 362-0806, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.091DOI Listing
January 2007

Immunohistochemical and mutational analysis of c-kit in gastrointestinal neuroendocrine cell carcinoma.

Jpn J Clin Oncol 2006 Aug 14;36(8):494-8. Epub 2006 Jul 14.

Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Kitaadachigun, Saitama 362-0806, Japan.

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http://dx.doi.org/10.1093/jjco/hyl061DOI Listing
August 2006

MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).

Genes Chromosomes Cancer 2005 May;43(1):45-53

Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.

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http://dx.doi.org/10.1002/gcc.20165DOI Listing
May 2005

The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males.

Cancer Lett 2004 Dec;216(1):55-62

Laboratory of Cancer Genetic Diagnosis, Saitama Cancer Center, 818 Komuro Ina, Kitaadachigun, Saitama 362-0806, Japan.

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http://dx.doi.org/10.1016/j.canlet.2004.07.017DOI Listing
December 2004

Expression of apolipoprotein A1 in colonic adenocarcinoma.

Anticancer Res 2003 Sep-Oct;23(5b):4161-7

Research Division, Saitama Cancer Center, Rational Evolutionary Design of Advanced Biomolecules (REDS) Group, Saitama Small Enterprise Promotion Cooperation, SKIP City, Kawaguchi, Saitama, Japan.

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December 2003

Estrogen receptor beta is expressed in human stomach adenocarcinoma.

J Cancer Res Clin Oncol 2002 Jun 11;128(6):319-24. Epub 2002 Apr 11.

Department of Surgery, Saga Medical School, 5-1-1 Nabeshima, Saga-city, Saga 849-8501, Japan.

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http://dx.doi.org/10.1007/s00432-002-0336-3DOI Listing
June 2002

Strain-dependency of chromosomal abnormalities in lymphomas developed in E(mu)-myc transgenic mice.

Jpn J Cancer Res 2002 Feb;93(2):229

Saitama Cancer Center Research Institute, 818 Komuro, Ina, Kitaadachigun, Saitama 362-0806.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926945PMC
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01263.xDOI Listing
February 2002